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NOP Receptor Antagonists Decrease Alcohol Drinking in the Dark in C57BL/6J Mice.

Brunori G, Weger M, Schoch J, Targowska-Duda K, Barnes M, Borruto AM, Rorick-Kehn LM, Zaveri NT, Pintar JE, Ciccocioppo R, Toll L, Cippitelli A.

Alcohol Clin Exp Res. 2019 Oct;43(10):2167-2178. doi: 10.1111/acer.14165. Epub 2019 Aug 21.


7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects.

Kruegel AC, Uprety R, Grinnell SG, Langreck C, Pekarskaya EA, Le Rouzic V, Ansonoff M, Gassaway MM, Pintar JE, Pasternak GW, Javitch JA, Majumdar S, Sames D.

ACS Cent Sci. 2019 Jun 26;5(6):992-1001. doi: 10.1021/acscentsci.9b00141. Epub 2019 May 29.


Editorial: Current Perspectives on Insulin-Like Growth Factor Binding Protein (IGFBP) Research.

Hoeflich A, Pintar J, Forbes B.

Front Endocrinol (Lausanne). 2018 Nov 20;9:667. doi: 10.3389/fendo.2018.00667. eCollection 2018. No abstract available.


Contrasting effects of IGF binding protein-3 expression in mammary tumor cells and the tumor microenvironment.

Scully T, Scott CD, Firth SM, Pintar JE, Twigg SM, Baxter RC.

Exp Cell Res. 2019 Jan 1;374(1):38-45. doi: 10.1016/j.yexcr.2018.11.006. Epub 2018 Nov 9.


Enhancement of mammary tumour growth by IGFBP-3 involves impaired T cell accumulation.

Scully T, Scott CD, Firth SM, Sedger LM, Pintar JE, Twigg SM, Baxter RC.

Endocr Relat Cancer. 2018 Feb;25(2):111-122. doi: 10.1530/ERC-17-0384. Epub 2017 Dec 7.


ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine.

Berezniuk I, Rodriguiz RM, Zee ML, Marcus DJ, Pintar J, Morgan DJ, Wetsel WC, Fricker LD.

J Neurochem. 2017 Nov;143(3):268-281. doi: 10.1111/jnc.14209.


Opioids and opioid receptors orchestrate wound repair.

Wang Y, Gupta M, Poonawala T, Farooqui M, Li Y, Peng F, Rao S, Ansonoff M, Pintar JE, Gupta K.

Transl Res. 2017 Jul;185:13-23. doi: 10.1016/j.trsl.2017.05.003. Epub 2017 May 18.


Mexneurin is a novel precursor of peptides in the central nervous system of rodents.

Matus-Ortega ME, Leff Gelman P, Calva-Nieves JC, Flores-Zamora A, Salazar-Juárez A, Torner-Aguilar CA, Gamba G, De Los Heros P, Peng B, Pintar JE, Gompf HS, Allen CN, Antón-Palma B.

FEBS Lett. 2017 Jun;591(12):1627-1636. doi: 10.1002/1873-3468.12679. Epub 2017 Jun 1.


The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor.

Samuels BA, Nautiyal KM, Kruegel AC, Levinstein MR, Magalong VM, Gassaway MM, Grinnell SG, Han J, Ansonoff MA, Pintar JE, Javitch JA, Sames D, Hen R.

Neuropsychopharmacology. 2017 Sep;42(10):2052-2063. doi: 10.1038/npp.2017.60. Epub 2017 Mar 17.


Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors.

Witkin JM, Rorick-Kehn LM, Benvenga MJ, Adams BL, Gleason SD, Knitowski KM, Li X, Chaney S, Falcone JF, Smith JW, Foss J, Lloyd K, Catlow JT, McKinzie DL, Svensson KA, Barth VN, Toledo MA, Diaz N, Lafuente C, Jiménez A, Benito A, Pedregal C, Martínez-Grau MA, Post A, Ansonoff MA, Pintar JE, Statnick MA.

Pharmacol Res Perspect. 2016 Nov 7;4(6):e00275. doi: 10.1002/prp2.275. eCollection 2016 Dec.


Tetrapeptide Endomorphin Analogs Require Both Full Length and Truncated Splice Variants of the Mu Opioid Receptor Gene Oprm1 for Analgesia.

Marrone GF, Lu Z, Rossi G, Narayan A, Hunkele A, Marx S, Xu J, Pintar J, Majumdar S, Pan YX, Pasternak GW.

ACS Chem Neurosci. 2016 Dec 21;7(12):1717-1727. doi: 10.1021/acschemneuro.6b00240. Epub 2016 Oct 10.


Insulin-like growth factor binding protein-3 links obesity and breast cancer progression.

Scully T, Firth SM, Scott CD, de Silva HC, Pintar JE, Chan-Ling T, Twigg SM, Baxter RC.

Oncotarget. 2016 Aug 23;7(34):55491-55505. doi: 10.18632/oncotarget.10675.


Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants.

Grinnell SG, Ansonoff M, Marrone GF, Lu Z, Narayan A, Xu J, Rossi G, Majumdar S, Pan YX, Bassoni DL, Pintar J, Pasternak GW.

Synapse. 2016 Oct;70(10):395-407. doi: 10.1002/syn.21914. Epub 2016 Jul 12.


Hepatocutaneous syndrome in Shih Tzus: 31 cases (1996-2014).

Hall-Fonte DL, Center SA, McDonough SP, Peters-Kennedy J, Trotter TS, Lucy JM, Berger E, Byers C, Cummings CG, Burke E, Stegemen J, Pintar J, Kantrowitz L, Sharpe K, Weinkle T.

J Am Vet Med Assoc. 2016 Apr 1;248(7):802-13. doi: 10.2460/javma.248.7.802.


Ductal Plate Malformation in the Liver of Boxer Dogs: Clinical and Histological Features.

Pillai S, Center SA, McDonough SP, Demarco J, Pintar J, Henderson AK, Cooper J, Bolton T, Sharpe K, Hill S, Benedict AG, Haviland R.

Vet Pathol. 2016 May;53(3):602-13. doi: 10.1177/0300985815610567. Epub 2016 Jan 21.


A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism for the Treatment of Binge Eating Disorder.

Statnick MA, Chen Y, Ansonoff M, Witkin JM, Rorick-Kehn L, Suter TM, Song M, Hu C, Lafuente C, Jiménez A, Benito A, Diaz N, Martínez-Grau MA, Toledo MA, Pintar JE.

J Pharmacol Exp Ther. 2016 Feb;356(2):493-502. doi: 10.1124/jpet.115.228221. Epub 2015 Dec 9.


Abdominal Ultrasound Examination Findings in 534 Hyperthyroid Cats Referred for Radioiodine Treatment Between 2007-2010.

Nussbaum LK, Scavelli TD, Scavelli DM, Pintar J, Henderson AK, DeMarco JA, Worwag S, Bastian RP, Kittner HS.

J Vet Intern Med. 2015 Jul-Aug;29(4):1069-73. doi: 10.1111/jvim.13369. Epub 2015 Jun 25.


IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine.

Austin K, Imam NA, Pintar JE, Brubaker PL.

Endocrinology. 2015 Feb;156(2):429-36. doi: 10.1210/en.2014-1829. Epub 2014 Dec 16.


The effect of abdominal strength or endurance exercises on abdominal peak torque and endurance field tests of healthy participants: A randomized controlled trial.

Learman K, Pintar J, Ellis A.

Phys Ther Sport. 2015 May;16(2):140-7. doi: 10.1016/j.ptsp.2014.08.009. Epub 2014 Sep 9.


Loss of the mu opioid receptor induces strain-specific alterations in hippocampal neurogenesis and spatial learning.

Cominski TP, Ansonoff MA, Turchin CE, Pintar JE.

Neuroscience. 2014 Oct 10;278:11-9. doi: 10.1016/j.neuroscience.2014.07.039. Epub 2014 Jul 31.


Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA.

Grinnell SG, Majumdar S, Narayan A, Le Rouzic V, Ansonoff M, Pintar JE, Pasternak GW.

J Pharmacol Exp Ther. 2014 Sep;350(3):710-8. doi: 10.1124/jpet.114.213199. Epub 2014 Jun 26.


Presumed primary and secondary hepatic copper accumulation in cats.

Hurwitz BM, Center SA, Randolph JF, McDonough SP, Warner KL, Hazelwood KS, Chiapella AM, Mazzei MJ, Leavey K, Acquaviva AE, Lindsay MM, Sanders L, Pintar J.

J Am Vet Med Assoc. 2014 Jan 1;244(1):68-77. doi: 10.2460/javma.244.1.68.


The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.

Witkin JM, Statnick MA, Rorick-Kehn LM, Pintar JE, Ansonoff M, Chen Y, Tucker RC, Ciccocioppo R.

Pharmacol Ther. 2014 Mar;141(3):283-99. doi: 10.1016/j.pharmthera.2013.10.011. Epub 2013 Nov 1. Review. Erratum in: Pharmacol Ther. 2014 Sep;143(3):351.


GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.

Gomes I, Aryal DK, Wardman JH, Gupta A, Gagnidze K, Rodriguiz RM, Kumar S, Wetsel WC, Pintar JE, Fricker LD, Devi LA.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16211-6. doi: 10.1073/pnas.1312938110. Epub 2013 Sep 16.


IGFBP-3 and TNF-α regulate retinal endothelial cell apoptosis.

Zhang Q, Jiang Y, Miller MJ, Peng B, Liu L, Soderland C, Tang J, Kern TS, Pintar J, Steinle JJ.

Invest Ophthalmol Vis Sci. 2013 Aug 9;54(8):5376-84. doi: 10.1167/iovs.13-12497.


Mice lacking δ-opioid receptors resist the development of diet-induced obesity.

Czyzyk TA, Romero-Picó A, Pintar J, McKinzie JH, Tschöp MH, Statnick MA, Nogueiras R.

FASEB J. 2012 Aug;26(8):3483-92. doi: 10.1096/fj.12-208041. Epub 2012 May 16.


IGF-II promotes stemness of neural restricted precursors.

Ziegler AN, Schneider JS, Qin M, Tyler WA, Pintar JE, Fraidenraich D, Wood TL, Levison SW.

Stem Cells. 2012 Jun;30(6):1265-76. doi: 10.1002/stem.1095.


Exogenous GLP-2 and IGF-I induce a differential intestinal response in IGF binding protein-3 and -5 double knockout mice.

Murali SG, Brinkman AS, Solverson P, Pun W, Pintar JE, Ney DM.

Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G794-804. doi: 10.1152/ajpgi.00372.2011. Epub 2012 Jan 26.


Loss of the mu opioid receptor on different genetic backgrounds leads to increased bromodeoxyuridine labeling in the dentate gyrus only after repeated injection.

Cominski TP, Turchin CE, Hsu MS, Ansonoff MA, Pintar JE.

Neuroscience. 2012 Mar 29;206:49-59. doi: 10.1016/j.neuroscience.2011.12.046. Epub 2012 Jan 16.


Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects.

Majumdar S, Grinnell S, Le Rouzic V, Burgman M, Polikar L, Ansonoff M, Pintar J, Pan YX, Pasternak GW.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19778-83. doi: 10.1073/pnas.1115231108. Epub 2011 Nov 21.


A comprehensive study on the putative δ-opioid receptor (sub)types using the highly selective δ-antagonist, Tyr-Tic-(2S,3R)-β-MePhe-Phe-OH.

Birkas E, Bakota L, Gulya K, Wen T, Pintar J, Tóth G, Szucs M.

Neurochem Int. 2011 Aug;59(2):192-201. doi: 10.1016/j.neuint.2011.04.015. Epub 2011 Jun 6.


Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits.

Atkins N Jr, Mitchell JW, Romanova EV, Morgan DJ, Cominski TP, Ecker JL, Pintar JE, Sweedler JV, Gillette MU.

PLoS One. 2010 Sep 7;5(9):e12612. doi: 10.1371/journal.pone.0012612.


Potentiating effect of morphine on oral Salmonella enterica serovar Typhimurium infection is μ-opioid receptor-dependent.

Breslow JM, Feng P, Meissler JJ, Pintar JE, Gaughan J, Adler MW, Eisenstein TK.

Microb Pathog. 2010 Dec;49(6):330-5. doi: 10.1016/j.micpath.2010.07.006. Epub 2010 Aug 3.


The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation.

Morgan DJ, Wei S, Gomes I, Czyzyk T, Mzhavia N, Pan H, Devi LA, Fricker LD, Pintar JE.

J Neurochem. 2010 Jun;113(5):1275-84. doi: 10.1111/j.1471-4159.2010.06706.x. Epub 2010 Mar 26.


Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands.

Ansonoff MA, Portoghese PS, Pintar JE.

Psychopharmacology (Berl). 2010 Jun;210(2):161-8. doi: 10.1007/s00213-010-1826-7. Epub 2010 Mar 24.


Lack of genotype effect on D1, D2 receptors and dopamine transporter binding in triple MOP-, DOP-, and KOP-opioid receptor knockout mice of three different genetic backgrounds.

Yoo JH, Bailey A, Ansonoff M, Pintar JE, Matifas A, Kieffer BL, Kitchen I.

Synapse. 2010 Jul;64(7):520-7. doi: 10.1002/syn.20757.


Kappa opioid receptor contributes to EGF-stimulated neurite extension in development.

Tsai NP, Tsui YC, Pintar JE, Loh HH, Wei LN.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3216-21. doi: 10.1073/pnas.0912367107. Epub 2010 Jan 26.


Kappa2 opioid receptor subtype binding requires the presence of the DOR-1 gene.

Ansonoff MA, Wen T, Pintar JE.

Front Biosci (Schol Ed). 2010 Jan 1;2:772-80.


Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis.

Zhang X, Pan H, Peng B, Steiner DF, Pintar JE, Fricker LD.

J Neurochem. 2010 Mar;112(5):1168-79. doi: 10.1111/j.1471-4159.2009.06530.x. Epub 2009 Dec 7.


Role of Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) in Organismal and Pancreatic β-Cell Growth.

Gleason CE, Ning Y, Cominski TP, Gupta R, Kaestner KH, Pintar JE, Birnbaum MJ.

Endocr Rev. 2009 Dec 1;30(7):930. doi: 10.1210/edrv.30.7.9990. No abstract available.


kappa-Opioid receptors control the metabolic response to a high-energy diet in mice.

Czyzyk TA, Nogueiras R, Lockwood JF, McKinzie JH, Coskun T, Pintar JE, Hammond C, Tschöp MH, Statnick MA.

FASEB J. 2010 Apr;24(4):1151-9. doi: 10.1096/fj.09-143610. Epub 2009 Nov 16.


Role of opioid receptor like-1 receptor in modulation of endocrine, immunological, and behavioral responses to the T-cell superantigen staphylococcal enterotoxin A.

Mallimo EM, Ansonoff MA, Pintar JE, Kusnecov AW.

J Neuroimmunol. 2010 Jan 25;218(1-2):48-56. doi: 10.1016/j.jneuroim.2009.10.014. Epub 2009 Nov 13.


Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth.

Gleason CE, Ning Y, Cominski TP, Gupta R, Kaestner KH, Pintar JE, Birnbaum MJ.

Mol Endocrinol. 2010 Jan;24(1):178-92. doi: 10.1210/me.2009-0167. Epub 2009 Nov 6.


Traditional exercises do not have a significant impact on abdominal peak force in healthy young adults.

Pintar JA, Learman KE, Rogers R.

J Strength Cond Res. 2009 Oct;23(7):2083-9. doi: 10.1519/JSC.0b013e3181b3e121.


Electroacupuncture analgesia is enhanced in transgenic nociceptin/orphanin FQ knock-out mice.

Wan Y, Han JS, Pintar JE.

Beijing Da Xue Xue Bao Yi Xue Ban. 2009 Jun 18;41(3):376-9.


The MOR-1 opioid receptor regulates glucose homeostasis by modulating insulin secretion.

Wen T, Peng B, Pintar JE.

Mol Endocrinol. 2009 May;23(5):671-8. doi: 10.1210/me.2008-0345. Epub 2009 Feb 12.


PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions.

Miyako K, Cobb LJ, Francis M, Huang A, Peng B, Pintar JE, Ariga H, Cohen P.

Mol Endocrinol. 2009 Feb;23(2):169-75. doi: 10.1210/me.2008-0168. Epub 2008 Dec 18.


Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper.

Bousquet-Moore D, Ma XM, Nillni EA, Czyzyk TA, Pintar JE, Eipper BA, Mains RE.

Endocrinology. 2009 Apr;150(4):1739-47. doi: 10.1210/en.2008-1202. Epub 2008 Nov 20.


Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.

Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D.

FASEB J. 2009 Mar;23(3):709-19. doi: 10.1096/fj.08-118976. Epub 2008 Oct 24.


The tail pigmentation pattern of C57BL/6J mice affects nociception/pain quantification in the tail flick test.

Wen T, Ansonoff MA, Pintar JE.

Eur J Pain. 2009 Jul;13(6):564-7. doi: 10.1016/j.ejpain.2008.07.012. Epub 2008 Sep 19.

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