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Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction.

Ozeir M, Huyet J, Burgevin MC, Pinson B, Chesney F, Remy JM, Siddiqi AR, Lupoli R, Pinon G, Saint-Marc C, Gibert JF, Morales R, Ceballos-Picot I, Barouki R, Daignan-Fornier B, Olivier-Bandini A, Augé F, Nioche P.

J Biol Chem. 2019 Aug 9;294(32):11980-11991. doi: 10.1074/jbc.RA119.009087. Epub 2019 Jun 3.


Dual control of NAD+ synthesis by purine metabolites in yeast.

Pinson B, Ceschin J, Saint-Marc C, Daignan-Fornier B.

Elife. 2019 Mar 12;8. pii: e43808. doi: 10.7554/eLife.43808.


Purine Homeostasis Is Necessary for Developmental Timing, Germline Maintenance and Muscle Integrity in Caenorhabditis elegans.

Marsac R, Pinson B, Saint-Marc C, Olmedo M, Artal-Sanz M, Daignan-Fornier B, Gomes JE.

Genetics. 2019 Apr;211(4):1297-1313. doi: 10.1534/genetics.118.301062. Epub 2019 Jan 30.


Yeast to Study Human Purine Metabolism Diseases.

Daignan-Fornier B, Pinson B.

Cells. 2019 Jan 17;8(1). pii: E67. doi: 10.3390/cells8010067. Review.


Metabolomics and proteomics identify the toxic form and the associated cellular binding targets of the anti-proliferative drug AICAR.

Douillet DC, Pinson B, Ceschin J, Hürlimann HC, Saint-Marc C, Laporte D, Claverol S, Konrad M, Bonneu M, Daignan-Fornier B.

J Biol Chem. 2019 Jan 18;294(3):805-815. doi: 10.1074/jbc.RA118.004964. Epub 2018 Nov 26.


AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.

Philippe C, Pinson B, Dompierre J, Pantesco V, Viollet B, Daignan-Fornier B, Moenner M.

Neoplasia. 2018 Jun;20(6):555-562. doi: 10.1016/j.neo.2018.03.006. Epub 2018 May 3.


Multiple chemo-genetic interactions between a toxic metabolite and the ubiquitin pathway in yeast.

Albrecht D, Hürlimann HC, Ceschin J, Saint-Marc C, Pinson B, Daignan-Fornier B.

Curr Genet. 2018 Dec;64(6):1275-1286. doi: 10.1007/s00294-018-0843-7. Epub 2018 May 2.


Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase.

Huyet J, Ozeir M, Burgevin MC, Pinson B, Chesney F, Remy JM, Siddiqi AR, Lupoli R, Pinon G, Saint-Marc C, Gibert JF, Morales R, Ceballos-Picot I, Barouki R, Daignan-Fornier B, Olivier-Bandini A, Augé F, Nioche P.

Cell Chem Biol. 2018 Jun 21;25(6):666-676.e4. doi: 10.1016/j.chembiol.2018.02.011. Epub 2018 Mar 22.


Functional PTB phosphate transporters are present in streptophyte algae and early diverging land plants.

Bonnot C, Proust H, Pinson B, Colbalchini FP, Lesly-Veillard A, Breuninger H, Champion C, Hetherington AJ, Kelly S, Dolan L.

New Phytol. 2017 May;214(3):1158-1171. doi: 10.1111/nph.14431. Epub 2017 Jan 30.


Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans.

Albrecht D, Ceschin J, Dompierre J, Gueniot F, Pinson B, Daignan-Fornier B.

Genetics. 2016 Dec;204(4):1447-1460. Epub 2016 Oct 5.


Disruption of Nucleotide Homeostasis by the Antiproliferative Drug 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside Monophosphate (AICAR).

Ceschin J, Hürlimann HC, Saint-Marc C, Albrecht D, Violo T, Moenner M, Daignan-Fornier B, Pinson B.

J Biol Chem. 2015 Sep 25;290(39):23947-59. doi: 10.1074/jbc.M115.656017. Epub 2015 Aug 17.


A chemical genetic strategy identify the PHOSTIN, a synthetic molecule that triggers phosphate starvation responses in Arabidopsis thaliana.

Bonnot C, Pinson B, Clément M, Bernillon S, Chiarenza S, Kanno S, Kobayashi N, Delannoy E, Nakanishi TM, Nussaume L, Desnos T.

New Phytol. 2016 Jan;209(1):161-76. doi: 10.1111/nph.13591. Epub 2015 Aug 4.


A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.

Laporte D, Courtout F, Pinson B, Dompierre J, Salin B, Brocard L, Sagot I.

J Cell Biol. 2015 Jul 6;210(1):99-113. doi: 10.1083/jcb.201502025. Epub 2015 Jun 29.


Serine hydroxymethyltransferase: a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae.

Saint-Marc C, Hürlimann HC, Daignan-Fornier B, Pinson B.

Curr Genet. 2015 Nov;61(4):633-40. doi: 10.1007/s00294-015-0489-7. Epub 2015 Apr 17.


New biomarkers for early diagnosis of Lesch-Nyhan disease revealed by metabolic analysis on a large cohort of patients.

Ceballos-Picot I, Le Dantec A, Brassier A, Jaïs JP, Ledroit M, Cahu J, Ea HK, Daignan-Fornier B, Pinson B.

Orphanet J Rare Dis. 2015 Jan 23;10:7. doi: 10.1186/s13023-014-0219-0.


Role of p53-fibrinolytic system cross-talk in the regulation of quartz-induced lung injury.

Bhandary YP, Shetty SK, Marudamuthu AS, Fu J, Pinson BM, Levin J, Shetty S.

Toxicol Appl Pharmacol. 2015 Mar 1;283(2):92-8. doi: 10.1016/j.taap.2015.01.007. Epub 2015 Jan 14.


Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission.

Murphy-Royal C, Dupuis JP, Varela JA, Panatier A, Pinson B, Baufreton J, Groc L, Oliet SH.

Nat Neurosci. 2015 Feb;18(2):219-26. doi: 10.1038/nn.3901. Epub 2015 Jan 12.


Comparative genomic and expression analysis of the adenosine signaling pathway members in Xenopus.

Tocco A, Pinson B, Thiébaud P, Thézé N, Massé K.

Purinergic Signal. 2015 Mar;11(1):59-77. doi: 10.1007/s11302-014-9431-6. Epub 2014 Oct 16.


Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transporters.

Ceschin J, Saint-Marc C, Laporte J, Labriet A, Philippe C, Moenner M, Daignan-Fornier B, Pinson B.

J Biol Chem. 2014 Jun 13;289(24):16844-54. doi: 10.1074/jbc.M114.551192. Epub 2014 Apr 28.


A pharmaco-epistasis strategy reveals a new cell size controlling pathway in yeast.

Moretto F, Sagot I, Daignan-Fornier B, Pinson B.

Mol Syst Biol. 2013 Nov 12;9:707. doi: 10.1038/msb.2013.60.


Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction.

Deffieu M, Bhatia-Kiššová I, Salin B, Klionsky DJ, Pinson B, Manon S, Camougrand N.

J Cell Sci. 2013 Jan 15;126(Pt 2):415-26. doi: 10.1242/jcs.103713. Epub 2012 Dec 10.


cAMP-induced mitochondrial compartment biogenesis: role of glutathione redox state.

Yoboue ED, Augier E, Galinier A, Blancard C, Pinson B, Casteilla L, Rigoulet M, Devin A.

J Biol Chem. 2012 Apr 27;287(18):14569-78. doi: 10.1074/jbc.M111.302786. Epub 2012 Mar 6.


Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress.

Servant G, Pinson B, Tchalikian-Cosson A, Coulpier F, Lemoine S, Pennetier C, Bridier-Nahmias A, Todeschini AL, Fayol H, Daignan-Fornier B, Lesage P.

Nucleic Acids Res. 2012 Jul;40(12):5271-82. doi: 10.1093/nar/gks166. Epub 2012 Feb 29.


Physiological and toxic effects of purine intermediate 5-amino-4-imidazolecarboxamide ribonucleotide (AICAR) in yeast.

Hürlimann HC, Laloo B, Simon-Kayser B, Saint-Marc C, Coulpier F, Lemoine S, Daignan-Fornier B, Pinson B.

J Biol Chem. 2011 Sep 2;286(35):30994-1002. doi: 10.1074/jbc.M111.262659. Epub 2011 Jul 12.


Hypothyroidism among former workers of a nuclear weapons facility.

Leavey A, Frank AL, Pinson B, Shepherd S, Burstyn I.

Am J Ind Med. 2011 Dec;54(12):955-64. doi: 10.1002/ajim.20979. Epub 2011 Jun 20.


Metabolic status rather than cell cycle signals control quiescence entry and exit.

Laporte D, Lebaudy A, Sahin A, Pinson B, Ceschin J, Daignan-Fornier B, Sagot I.

J Cell Biol. 2011 Mar 21;192(6):949-57. doi: 10.1083/jcb.201009028. Epub 2011 Mar 14.


Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion.

Anton F, Fres JM, Schauss A, Pinson B, Praefcke GJ, Langer T, Escobar-Henriques M.

J Cell Sci. 2011 Apr 1;124(Pt 7):1126-35. doi: 10.1242/jcs.073080. Epub 2011 Mar 8.


Phenotypic consequences of purine nucleotide imbalance in Saccharomyces cerevisiae.

Saint-Marc C, Pinson B, Coulpier F, Jourdren L, Lisova O, Daignan-Fornier B.

Genetics. 2009 Oct;183(2):529-38, 1SI-7SI. doi: 10.1534/genetics.109.105858. Epub 2009 Jul 27.


The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity.

Hürlimann HC, Pinson B, Stadler-Waibel M, Zeeman SC, Freimoser FM.

EMBO Rep. 2009 Sep;10(9):1003-8. doi: 10.1038/embor.2009.105. Epub 2009 Jul 10.


Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways.

Pinson B, Vaur S, Sagot I, Coulpier F, Lemoine S, Daignan-Fornier B.

Genes Dev. 2009 Jun 15;23(12):1399-407. doi: 10.1101/gad.521809.


The necrotic signal induced by mycophenolic acid overcomes apoptosis-resistance in tumor cells.

Guidicelli G, Chaigne-Delalande B, Dilhuydy MS, Pinson B, Mahfouf W, Pasquet JM, Mahon FX, Pourquier P, Moreau JF, Legembre P.

PLoS One. 2009;4(5):e5493. doi: 10.1371/journal.pone.0005493. Epub 2009 May 11.


The immunosuppressor mycophenolic acid kills activated lymphocytes by inducing a nonclassical actin-dependent necrotic signal.

Chaigne-Delalande B, Guidicelli G, Couzi L, Merville P, Mahfouf W, Bouchet S, Molimard M, Pinson B, Moreau JF, Legembre P.

J Immunol. 2008 Dec 1;181(11):7630-8.


Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate. A possible role in Crabtree effect induction?

Díaz-Ruiz R, Avéret N, Araiza D, Pinson B, Uribe-Carvajal S, Devin A, Rigoulet M.

J Biol Chem. 2008 Oct 3;283(40):26948-55. doi: 10.1074/jbc.M800408200. Epub 2008 Aug 5.


Transdermal progesterone: effects on menopausal symptoms and on thrombotic, anticoagulant, and inflammatory factors in postmenopausal women.

Stephenson K, Neuenschwander PF, Kurdowska AK, Pinson B, Price C.

Int J Pharm Compd. 2008 Jul-Aug;12(4):295-304.


Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations.

Gauthier S, Coulpier F, Jourdren L, Merle M, Beck S, Konrad M, Daignan-Fornier B, Pinson B.

Mol Microbiol. 2008 Jun;68(6):1583-94. doi: 10.1111/j.1365-2958.2008.06261.x. Epub 2008 Apr 21.


Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants.

Breton A, Pinson B, Coulpier F, Giraud MF, Dautant A, Daignan-Fornier B.

Genetics. 2008 Feb;178(2):815-24. doi: 10.1534/genetics.107.083295. Epub 2008 Feb 3.


Actin bodies in yeast quiescent cells: an immediately available actin reserve?

Sagot I, Pinson B, Salin B, Daignan-Fornier B.

Mol Biol Cell. 2006 Nov;17(11):4645-55. Epub 2006 Aug 16.


Low affinity orthophosphate carriers regulate PHO gene expression independently of internal orthophosphate concentration in Saccharomyces cerevisiae.

Pinson B, Merle M, Franconi JM, Daignan-Fornier B.

J Biol Chem. 2004 Aug 20;279(34):35273-80. Epub 2004 Jun 12.


Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid.

Desmoucelles C, Pinson B, Saint-Marc C, Daignan-Fornier B.

J Biol Chem. 2002 Jul 26;277(30):27036-44. Epub 2002 May 16.


Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate.

Rébora K, Desmoucelles C, Borne F, Pinson B, Daignan-Fornier B.

Mol Cell Biol. 2001 Dec;21(23):7901-12.


Highly conserved features of DNA binding between two divergent members of the Myb family of transcription factors.

Pinson B, Brendeford EM, Gabrielsen OS, Daignan-Fornier B.

Nucleic Acids Res. 2001 Jan 15;29(2):527-35.


Signaling through regulated transcription factor interaction: mapping of a regulatory interaction domain in the Myb-related Bas1p.

Pinson B, Kongsrud TL, Ording E, Johansen L, Daignan-Fornier B, Gabrielsen OS.

Nucleic Acids Res. 2000 Dec 1;28(23):4665-73.


Redox regulation of AMP synthesis in yeast: a role of the Bas1p and Bas2p transcription factors.

Pinson B, Gabrielsen OS, Daignan-Fornier B.

Mol Microbiol. 2000 Jun;36(6):1460-9.


Identification of genes affecting selenite toxicity and resistance in Saccharomyces cerevisiae.

Pinson B, Sagot I, Daignan-Fornier B.

Mol Microbiol. 2000 May;36(3):679-87.


Mutations in the yeast Myb-like protein Bas1p resulting in discrimination between promoters in vivo but notin vitro.

Pinson B, Sagot I, Borne F, Gabrielsen OS, Daignan-Fornier B.

Nucleic Acids Res. 1998 Sep 1;26(17):3977-85.


Post-translational fate of CAN1 permease of Saccharomyces cerevisiae.

Opekarová M, Caspari T, Pinson B, Bréthes D, Tanner W.

Yeast. 1998 Feb;14(3):215-24.


Characterization of the Saccharomyces cerevisiae cytosine transporter using energizable plasma membrane vesicles.

Pinson B, Napias C, Chevallier J, Van den Broek PJ, Brèthes D.

J Biol Chem. 1997 Nov 14;272(46):28918-24.

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