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Items: 1 to 50 of 57

1.

Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping.

Di Liberto G, Pantelyushin S, Kreutzfeldt M, Page N, Musardo S, Coras R, Steinbach K, Vincenti I, Klimek B, Lingner T, Salinas G, Lin-Marq N, Staszewski O, Costa Jordão MJ, Wagner I, Egervari K, Mack M, Bellone C, Blümcke I, Prinz M, Pinschewer DD, Merkler D.

Cell. 2018 Oct 4;175(2):458-471.e19. doi: 10.1016/j.cell.2018.07.049. Epub 2018 Aug 30.

PMID:
30173917
2.

Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells.

Page N, Klimek B, De Roo M, Steinbach K, Soldati H, Lemeille S, Wagner I, Kreutzfeldt M, Di Liberto G, Vincenti I, Lingner T, Salinas G, Brück W, Simons M, Murr R, Kaye J, Zehn D, Pinschewer DD, Merkler D.

Immunity. 2018 May 15;48(5):937-950.e8. doi: 10.1016/j.immuni.2018.04.005.

PMID:
29768177
3.

Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein.

Khamina K, Lercher A, Caldera M, Schliehe C, Vilagos B, Sahin M, Kosack L, Bhattacharya A, Májek P, Stukalov A, Sacco R, James LC, Pinschewer DD, Bennett KL, Menche J, Bergthaler A.

PLoS Pathog. 2017 Dec 20;13(12):e1006758. doi: 10.1371/journal.ppat.1006758. eCollection 2017 Dec.

4.

Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever.

Remy MM, Sahin M, Flatz L, Regen T, Xu L, Kreutzfeldt M, Fallet B, Doras C, Rieger T, Bestmann L, Hanisch UK, Kaufmann BA, Merkler D, Pinschewer DD.

Cell Host Microbe. 2017 Sep 13;22(3):354-365.e5. doi: 10.1016/j.chom.2017.07.008. Epub 2017 Aug 17.

5.

Virally vectored vaccine delivery: medical needs, mechanisms, advantages and challenges.

Pinschewer DD.

Swiss Med Wkly. 2017 Aug 8;147:w14465. doi: 10.4414/smw.2017.14465. eCollection 2017. Review.

6.

Recombinant LCMV Vectors Induce Protective Immunity following Homologous and Heterologous Vaccinations.

Wingerath J, Ostroumov D, Woller N, Manns MP, Pinschewer DD, Orlinger K, Berka U, Kühnel F, Wirth TC.

Mol Ther. 2017 Nov 1;25(11):2533-2545. doi: 10.1016/j.ymthe.2017.07.012. Epub 2017 Jul 20.

PMID:
28803862
7.

Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization.

Zeltina A, Krumm SA, Sahin M, Struwe WB, Harlos K, Nunberg JH, Crispin M, Pinschewer DD, Doores KJ, Bowden TA.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7031-7036. doi: 10.1073/pnas.1702127114. Epub 2017 Jun 19.

8.

Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy.

Kallert SM, Darbre S, Bonilla WV, Kreutzfeldt M, Page N, Müller P, Kreuzaler M, Lu M, Favre S, Kreppel F, Löhning M, Luther SA, Zippelius A, Merkler D, Pinschewer DD.

Nat Commun. 2017 May 26;8:15327. doi: 10.1038/ncomms15327.

9.

Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens.

Penaloza MacMaster P, Shields JL, Alayo QA, Cabral C, Jimenez J, Mondesir J, Chandrashekar A, Cabral JM, Lim M, Iampietro MJ, Provine NM, Bricault CA, Seaman M, Orlinger K, Aspoeck A, Fuhrmann G, Lilja AE, Monath T, Mangeat B, Pinschewer DD, Barouch DH.

Vaccine. 2017 Jan 3;35(1):1-9. doi: 10.1016/j.vaccine.2016.11.063. Epub 2016 Nov 26.

10.

Interferon-driven deletion of antiviral B cells at the onset of chronic infection.

Fallet B, Narr K, Ertuna YI, Remy M, Sommerstein R, Cornille K, Kreutzfeldt M, Page N, Zimmer G, Geier F, Straub T, Pircher H, Larimore K, Greenberg PD, Merkler D, Pinschewer DD.

Sci Immunol. 2016 Oct 21;1(4). pii: eaah6817. doi: 10.1126/sciimmunol.aah6817.

11.

Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector.

Schleiss MR, Berka U, Watson E, Aistleithner M, Kiefmann B, Mangeat B, Swanson EC, Gillis PA, Hernandez-Alvarado N, Fernández-Alarcón C, Zabeli JC, Pinschewer DD, Lilja AE, Schwendinger M, Guirakhoo F, Monath TP, Orlinger KK.

Clin Vaccine Immunol. 2017 Jan 5;24(1). pii: e00300-16. doi: 10.1128/CVI.00300-16. Print 2017 Jan.

12.

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival.

Utzschneider DT, Alfei F, Roelli P, Barras D, Chennupati V, Darbre S, Delorenzi M, Pinschewer DD, Zehn D.

J Exp Med. 2016 Aug 22;213(9):1819-34. doi: 10.1084/jem.20150598. Epub 2016 Jul 25.

13.

Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection.

Sommerstein R, Flatz L, Remy MM, Malinge P, Magistrelli G, Fischer N, Sahin M, Bergthaler A, Igonet S, Ter Meulen J, Rigo D, Meda P, Rabah N, Coutard B, Bowden TA, Lambert PH, Siegrist CA, Pinschewer DD.

PLoS Pathog. 2015 Nov 20;11(11):e1005276. doi: 10.1371/journal.ppat.1005276. eCollection 2015 Nov.

14.

The Nucleoprotein Is Required for Lymphocytic Choriomeningitis Virus-Based Vaccine Vector Immunogenicity.

Darbre S, Johnson S, Kallert S, Lambert PH, Siegrist CA, Pinschewer DD.

J Virol. 2015 Nov;89(22):11734-8. doi: 10.1128/JVI.01613-15. Epub 2015 Sep 9.

15.

T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses.

Baumann C, Bonilla WV, Fröhlich A, Helmstetter C, Peine M, Hegazy AN, Pinschewer DD, Löhning M.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4056-61. doi: 10.1073/pnas.1418549112. Epub 2015 Mar 17.

16.

Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection.

Penaloza-MacMaster P, Barber DL, Wherry EJ, Provine NM, Teigler JE, Parenteau L, Blackmore S, Borducchi EN, Larocca RA, Yates KB, Shen H, Haining WN, Sommerstein R, Pinschewer DD, Ahmed R, Barouch DH.

Science. 2015 Jan 16;347(6219):278-82. doi: 10.1126/science.aaa2148.

17.

Protective efficacy of individual CD8+ T cell specificities in chronic viral infection.

Johnson S, Bergthaler A, Graw F, Flatz L, Bonilla WV, Siegrist CA, Lambert PH, Regoes RR, Pinschewer DD.

J Immunol. 2015 Feb 15;194(4):1755-62. doi: 10.4049/jimmunol.1401771. Epub 2015 Jan 7.

18.

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses.

Fasnacht N, Huang HY, Koch U, Favre S, Auderset F, Chai Q, Onder L, Kallert S, Pinschewer DD, MacDonald HR, Tacchini-Cottier F, Ludewig B, Luther SA, Radtke F.

J Exp Med. 2014 Oct 20;211(11):2265-79. doi: 10.1084/jem.20132528. Epub 2014 Oct 13.

19.

Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis.

Du Pasquier RA, Pinschewer DD, Merkler D.

CNS Drugs. 2014 Jun;28(6):535-58. doi: 10.1007/s40263-014-0160-8. Review.

20.

Functional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in early life.

Belnoue E, Fontannaz P, Rochat AF, Tougne C, Bergthaler A, Lambert PH, Pinschewer DD, Siegrist CA.

PLoS One. 2013 Dec 23;8(12):e85302. doi: 10.1371/journal.pone.0085302. eCollection 2013.

21.

Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss.

Kreutzfeldt M, Bergthaler A, Fernandez M, Brück W, Steinbach K, Vorm M, Coras R, Blümcke I, Bonilla WV, Fleige A, Forman R, Müller W, Becher B, Misgeld T, Kerschensteiner M, Pinschewer DD, Merkler D.

J Exp Med. 2013 Sep 23;210(10):2087-103. doi: 10.1084/jem.20122143. Epub 2013 Sep 2.

22.

Gene-based vaccination with a mismatched envelope protects against simian immunodeficiency virus infection in nonhuman primates.

Flatz L, Cheng C, Wang L, Foulds KE, Ko SY, Kong WP, Roychoudhuri R, Shi W, Bao S, Todd JP, Asmal M, Shen L, Donaldson M, Schmidt SD, Gall JG, Pinschewer DD, Letvin NL, Rao S, Mascola JR, Roederer M, Nabel GJ.

J Virol. 2012 Aug;86(15):7760-70. doi: 10.1128/JVI.00599-12. Epub 2012 May 16.

23.

Synchronization of dendritic cell activation and antigen exposure is required for the induction of Th1/Th17 responses.

Kamath AT, Mastelic B, Christensen D, Rochat AF, Agger EM, Pinschewer DD, Andersen P, Lambert PH, Siegrist CA.

J Immunol. 2012 May 15;188(10):4828-37. doi: 10.4049/jimmunol.1103183. Epub 2012 Apr 13.

24.

The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses.

Bonilla WV, Fröhlich A, Senn K, Kallert S, Fernandez M, Johnson S, Kreutzfeldt M, Hegazy AN, Schrick C, Fallon PG, Klemenz R, Nakae S, Adler H, Merkler D, Löhning M, Pinschewer DD.

Science. 2012 Feb 24;335(6071):984-9. doi: 10.1126/science.1215418. Epub 2012 Feb 9.

25.

Multiparameter telemetry as a sensitive screening method to detect vaccine reactogenicity in mice.

Arras M, Glauser DL, Jirkof P, Rettich A, Schade B, Cinelli P, Pinschewer DD, Ackermann M.

PLoS One. 2012;7(1):e29726. doi: 10.1371/journal.pone.0029726. Epub 2012 Jan 19.

26.

Homing and adhesion patterns determine the cellular composition of the bone marrow plasma cell niche.

Belnoue E, Tougne C, Rochat AF, Lambert PH, Pinschewer DD, Siegrist CA.

J Immunol. 2012 Feb 1;188(3):1283-91. doi: 10.4049/jimmunol.1103169.

27.

Cross-species analysis of the replication complex of Old World arenaviruses reveals two nucleoprotein sites involved in L protein function.

Kerber R, Rieger T, Busch C, Flatz L, Pinschewer DD, Kümmerer BM, Günther S.

J Virol. 2011 Dec;85(23):12518-28. doi: 10.1128/JVI.05091-11. Epub 2011 Sep 14.

28.

Impact of sphingosine 1-phosphate modulation on immune outcomes.

Pinschewer DD, Brinkmann V, Merkler D.

Neurology. 2011 Feb 22;76(8 Suppl 3):S15-9. doi: 10.1212/WNL.0b013e31820d9596. Review.

PMID:
21339486
29.

Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression.

Bergthaler A, Flatz L, Hegazy AN, Johnson S, Horvath E, Löhning M, Pinschewer DD.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21641-6. doi: 10.1073/pnas.1011998107. Epub 2010 Nov 22.

30.

The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus.

Grujic M, Bartholdy C, Remy M, Pinschewer DD, Christensen JP, Thomsen AR.

J Immunol. 2010 Aug 1;185(3):1730-43. doi: 10.4049/jimmunol.0903894. Epub 2010 Jul 2.

31.

Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes.

Pinschewer DD, Flatz L, Steinborn R, Horvath E, Fernandez M, Lutz H, Suter M, Bergthaler A.

Int Immunol. 2010 Sep;22(9):749-56. doi: 10.1093/intimm/dxq061. Epub 2010 Jun 28.

32.

T cell-dependence of Lassa fever pathogenesis.

Flatz L, Rieger T, Merkler D, Bergthaler A, Regen T, Schedensack M, Bestmann L, Verschoor A, Kreutzfeldt M, Brück W, Hanisch UK, Günther S, Pinschewer DD.

PLoS Pathog. 2010 Mar 26;6(3):e1000836. doi: 10.1371/journal.ppat.1000836.

33.

T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner.

Pinschewer DD, Schedensack M, Bergthaler A, Horvath E, Brück W, Löhning M, Merkler D.

Brain. 2010 Apr;133(Pt 4):1054-66. doi: 10.1093/brain/awq028. Epub 2010 Mar 30.

PMID:
20354003
34.

Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity.

Flatz L, Hegazy AN, Bergthaler A, Verschoor A, Claus C, Fernandez M, Gattinoni L, Johnson S, Kreppel F, Kochanek S, Broek Mv, Radbruch A, Lévy F, Lambert PH, Siegrist CA, Restifo NP, Löhning M, Ochsenbein AF, Nabel GJ, Pinschewer DD.

Nat Med. 2010 Mar;16(3):339-45. doi: 10.1038/nm.2104. Epub 2010 Feb 7.

35.

Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.

Hegazy AN, Peine M, Helmstetter C, Panse I, Fröhlich A, Bergthaler A, Flatz L, Pinschewer DD, Radbruch A, Löhning M.

Immunity. 2010 Jan 29;32(1):116-28. doi: 10.1016/j.immuni.2009.12.004. Epub 2010 Jan 14.

36.

Impaired antibody response causes persistence of prototypic T cell-contained virus.

Bergthaler A, Flatz L, Verschoor A, Hegazy AN, Holdener M, Fink K, Eschli B, Merkler D, Sommerstein R, Horvath E, Fernandez M, Fitsche A, Senn BM, Verbeek JS, Odermatt B, Siegrist CA, Pinschewer DD.

PLoS Biol. 2009 Apr 7;7(4):e1000080. doi: 10.1371/journal.pbio.1000080. Erratum in: PLoS Biol. 2009 Aug;7(8). doi: 10.1371/annotation/42dca769-eca8-4e8f-a6b5-236355b631ff.

37.

Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors.

Löhning M, Hegazy AN, Pinschewer DD, Busse D, Lang KS, Höfer T, Radbruch A, Zinkernagel RM, Hengartner H.

J Exp Med. 2008 Jan 21;205(1):53-61. doi: 10.1084/jem.20071855. Epub 2008 Jan 14.

38.

Decreased tumor surveillance after adoptive T-cell therapy.

Matter M, Pavelic V, Pinschewer DD, Mumprecht S, Eschli B, Giroglou T, von Laer D, Ochsenbein AF.

Cancer Res. 2007 Aug 1;67(15):7467-76.

39.

Contributions of the lymphocytic choriomeningitis virus glycoprotein and polymerase to strain-specific differences in murine liver pathogenicity.

Bergthaler A, Merkler D, Horvath E, Bestmann L, Pinschewer DD.

J Gen Virol. 2007 Feb;88(Pt 2):592-603.

PMID:
17251578
40.

Envelope exchange for the generation of live-attenuated arenavirus vaccines.

Bergthaler A, Gerber NU, Merkler D, Horvath E, de la Torre JC, Pinschewer DD.

PLoS Pathog. 2006 Jun;2(6):e51. Epub 2006 Jun 2.

41.

"Viral déjà vu" elicits organ-specific immune disease independent of reactivity to self.

Merkler D, Horvath E, Bruck W, Zinkernagel RM, Del la Torre JC, Pinschewer DD.

J Clin Invest. 2006 May;116(5):1254-63. Epub 2006 Apr 6.

42.

Recovery of an arenavirus entirely from RNA polymerase I/II-driven cDNA.

Flatz L, Bergthaler A, de la Torre JC, Pinschewer DD.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4663-8. Epub 2006 Mar 13.

43.

Virus-induced polyclonal B cell activation improves protective CTL memory via retained CD27 expression on memory CTL.

Matter M, Mumprecht S, Pinschewer DD, Pavelic V, Yagita H, Krautwald S, Borst J, Ochsenbein AF.

Eur J Immunol. 2005 Nov;35(11):3229-39.

44.
45.

Kinetics of protective antibodies are determined by the viral surface antigen.

Pinschewer DD, Perez M, Jeetendra E, Bächi T, Horvath E, Hengartner H, Whitt MA, de la Torre JC, Zinkernagel RM.

J Clin Invest. 2004 Oct;114(7):988-93.

46.

Rapid induction of autoantibodies against Nogo-A and MOG in the absence of an encephalitogenic T cell response: implication for immunotherapeutic approaches in neurological diseases.

Merkler D, Oertle T, Buss A, Pinschewer DD, Schnell L, Bareyre FM, Kerschensteiner M, Buddeberg BS, Schwab ME.

FASEB J. 2003 Dec;17(15):2275-7. Epub 2003 Oct 16.

PMID:
14563689
47.

Recombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein.

Pinschewer DD, Perez M, Sanchez AB, de la Torre JC.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7895-900. Epub 2003 Jun 13.

48.
49.
50.

Effects of promyelocytic leukemia protein on virus-host balance.

Bonilla WV, Pinschewer DD, Klenerman P, Rousson V, Gaboli M, Pandolfi PP, Zinkernagel RM, Salvato MS, Hengartner H.

J Virol. 2002 Apr;76(8):3810-8.

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