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Items: 26

1.

Intranasal Immunization with DnaK Protein Induces Protective Mucosal Immunity against Tuberculosis in CD4-Depleted Mice.

Chuang YM, Pinn ML, Karakousis PC, Hung CF.

Front Cell Infect Microbiol. 2018 Feb 8;8:31. doi: 10.3389/fcimb.2018.00031. eCollection 2018.

2.

Erratum for Dutta et al., "Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice".

Dutta NK, Pinn ML, Karakousis PC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02493-17. doi: 10.1128/AAC.02493-17. Print 2018 Feb. No abstract available.

3.

Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice.

Dutta NK, Pinn ML, Karakousis PC.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00652-17. doi: 10.1128/AAC.00652-17. Print 2017 Aug. Erratum in: Antimicrob Agents Chemother. 2018 Jan 25;62(2):.

4.

Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen.

Dutta NK, He R, Pinn ML, He Y, Burrows F, Zhang ZY, Karakousis PC.

ACS Infect Dis. 2016 Mar 11;2(3):231-239. Epub 2015 Dec 24.

5.

Statin adjunctive therapy shortens the duration of TB treatment in mice.

Dutta NK, Bruiners N, Pinn ML, Zimmerman MD, Prideaux B, Dartois V, Gennaro ML, Karakousis PC.

J Antimicrob Chemother. 2016 Jun;71(6):1570-7. doi: 10.1093/jac/dkw014. Epub 2016 Feb 21.

6.

Sterilizing activity of thioridazine in combination with the first-line regimen against acute murine tuberculosis.

Dutta NK, Pinn ML, Karakousis PC.

Antimicrob Agents Chemother. 2014 Sep;58(9):5567-9. doi: 10.1128/AAC.03408-14. Epub 2014 Jun 16.

7.

Simvastatin increases the in vivo activity of the first-line tuberculosis regimen.

Skerry C, Pinn ML, Bruiners N, Pine R, Gennaro ML, Karakousis PC.

J Antimicrob Chemother. 2014 Sep;69(9):2453-7. doi: 10.1093/jac/dku166. Epub 2014 May 22.

8.

Reduced emergence of isoniazid resistance with concurrent use of thioridazine against acute murine tuberculosis.

Dutta NK, Pinn ML, Karakousis PC.

Antimicrob Agents Chemother. 2014 Jul;58(7):4048-53. doi: 10.1128/AAC.02981-14. Epub 2014 May 5.

9.

Potent rifamycin-sparing regimen cures guinea pig tuberculosis as rapidly as the standard regimen.

Dutta NK, Alsultan A, Gniadek TJ, Belchis DA, Pinn ML, Mdluli KE, Nuermberger EL, Peloquin CA, Karakousis PC.

Antimicrob Agents Chemother. 2013 Aug;57(8):3910-6. doi: 10.1128/AAC.00761-13. Epub 2013 Jun 3.

10.

Thioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis.

Dutta NK, Pinn ML, Zhao M, Rudek MA, Karakousis PC.

J Antimicrob Chemother. 2013 Jun;68(6):1327-30. doi: 10.1093/jac/dkt037. Epub 2013 Mar 5.

11.

Rifapentine is not more active than rifampin against chronic tuberculosis in guinea pigs.

Dutta NK, Illei PB, Peloquin CA, Pinn ML, Mdluli KE, Nuermberger EL, Grosset JH, Karakousis PC.

Antimicrob Agents Chemother. 2012 Jul;56(7):3726-31. doi: 10.1128/AAC.00500-12. Epub 2012 Apr 30.

12.

Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models.

Ahmad Z, Fraig MM, Pinn ML, Tyagi S, Nuermberger EL, Grosset JH, Karakousis PC.

J Antimicrob Chemother. 2011 Jul;66(7):1560-6. doi: 10.1093/jac/dkr188. Epub 2011 May 20.

13.

The potent bactericidal activity of streptomycin in the guinea pig model of tuberculosis ceases due to the presence of persisters.

Ahmad Z, Pinn ML, Nuermberger EL, Peloquin CA, Grosset JH, Karakousis PC.

J Antimicrob Chemother. 2010 Oct;65(10):2172-5. doi: 10.1093/jac/dkq277. Epub 2010 Aug 6.

14.

Comparison of the 'Denver regimen' against acute tuberculosis in the mouse and guinea pig.

Ahmad Z, Nuermberger EL, Tasneen R, Pinn ML, Williams KN, Peloquin CA, Grosset JH, Karakousis PC.

J Antimicrob Chemother. 2010 Apr;65(4):729-34. doi: 10.1093/jac/dkq007. Epub 2010 Jan 31.

15.

Experimental ocular tuberculosis in guinea pigs.

Rao NA, Albini TA, Kumaradas M, Pinn ML, Fraig MM, Karakousis PC.

Arch Ophthalmol. 2009 Sep;127(9):1162-6. doi: 10.1001/archophthalmol.2009.220.

16.

Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig.

Ahmad Z, Klinkenberg LG, Pinn ML, Fraig MM, Peloquin CA, Bishai WR, Nuermberger EL, Grosset JH, Karakousis PC.

J Infect Dis. 2009 Oct 1;200(7):1136-43. doi: 10.1086/605605.

PMID:
19686043
17.

Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells.

Zhou W, Han WF, Landree LE, Thupari JN, Pinn ML, Bililign T, Kim EK, Vadlamudi A, Medghalchi SM, El Meskini R, Ronnett GV, Townsend CA, Kuhajda FP.

Cancer Res. 2007 Apr 1;67(7):2964-71.

18.

Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase.

McFadden JM, Medghalchi SM, Thupari JN, Pinn ML, Vadlamudi A, Miller KI, Kuhajda FP, Townsend CA.

J Med Chem. 2005 Feb 24;48(4):946-61.

PMID:
15715465
19.

C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure.

Tu Y, Thupari JN, Kim EK, Pinn ML, Moran TH, Ronnett GV, Kuhajda FP.

Endocrinology. 2005 Jan;146(1):486-93. Epub 2004 Oct 21.

PMID:
15498887
20.

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice.

Alli PM, Pinn ML, Jaffee EM, McFadden JM, Kuhajda FP.

Oncogene. 2005 Jan 6;24(1):39-46.

PMID:
15489885
21.

Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.

Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Pinn ML, Ronnett GV, Kuhajda FP.

Cancer Res. 2003 Nov 1;63(21):7330-7.

22.

Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity.

Thupari JN, Pinn ML, Kuhajda FP.

Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23. Erratum in: Biochem Biophys Res Commun 2002 Jul 12;295(2):570.

PMID:
11444828
23.

Increased fatty acid synthase is a therapeutic target in mesothelioma.

Gabrielson EW, Pinn ML, Testa JR, Kuhajda FP.

Clin Cancer Res. 2001 Jan;7(1):153-7.

24.

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.

Pizer ES, Thupari J, Han WF, Pinn ML, Chrest FJ, Frehywot GL, Townsend CA, Kuhajda FP.

Cancer Res. 2000 Jan 15;60(2):213-8.

25.

Local delivery of chemotherapy and concurrent external beam radiotherapy prolongs survival in metastatic brain tumor models.

Ewend MG, Williams JA, Tabassi K, Tyler BM, Babel KM, Anderson RC, Pinn ML, Brat DJ, Brem H.

Cancer Res. 1996 Nov 15;56(22):5217-23.

26.

Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema.

Tamargo RJ, Sills AK Jr, Reinhard CS, Pinn ML, Long DM, Brem H.

J Neurosurg. 1991 Jun;74(6):956-61.

PMID:
2033457

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