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Items: 1 to 50 of 86

1.

Deposition of Host Matrix Proteins on Breast Implant Surfaces Facilitates Staphylococcus Epidermidis Biofilm Formation: In Vitro Analysis.

Walker JN, Pinkner CL, Lynch AJL, Ortbal S, Pinkner JS, Hultgren SJ, Myckatyn TM.

Aesthet Surg J. 2019 Apr 6. pii: sjz099. doi: 10.1093/asj/sjz099. [Epub ahead of print]

PMID:
30953053
2.

The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants.

Walker JN, Pinkner CL, Pinkner JS, Hultgren SJ, Myckatyn TM.

Plast Reconstr Surg Glob Open. 2019 Feb 8;7(2):e2037. doi: 10.1097/GOX.0000000000002037. eCollection 2019 Feb.

3.

Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design.

Maddirala AR, Klein R, Pinkner JS, Kalas V, Hultgren SJ, Janetka JW.

J Med Chem. 2019 Jan 24;62(2):467-479. doi: 10.1021/acs.jmedchem.8b01561. Epub 2019 Jan 2.

PMID:
30540910
4.

Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli.

Omattage NS, Deng Z, Pinkner JS, Dodson KW, Almqvist F, Yuan P, Hultgren SJ.

Nat Microbiol. 2018 Dec;3(12):1362-1368. doi: 10.1038/s41564-018-0255-y. Epub 2018 Oct 1.

5.

Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation.

Klein RD, Shu Q, Cusumano ZT, Nagamatsu K, Gualberto NC, Lynch AJL, Wu C, Wang W, Jain N, Pinkner JS, Amarasinghe GK, Hultgren SJ, Frieden C, Chapman MR.

MBio. 2018 Jul 17;9(4). pii: e01349-18. doi: 10.1128/mBio.01349-18.

6.

Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection.

Kalas V, Hibbing ME, Maddirala AR, Chugani R, Pinkner JS, Mydock-McGrane LK, Conover MS, Janetka JW, Hultgren SJ.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2819-E2828. doi: 10.1073/pnas.1720140115. Epub 2018 Mar 5.

7.

Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract.

Walker JN, Flores-Mireles AL, Pinkner CL, Schreiber HL 4th, Joens MS, Park AM, Potretzke AM, Bauman TM, Pinkner JS, Fitzpatrick JAJ, Desai A, Caparon MG, Hultgren SJ.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8721-E8730. doi: 10.1073/pnas.1707572114. Epub 2017 Sep 25.

8.

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.

Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ.

Nature. 2017 Jun 22;546(7659):528-532. doi: 10.1038/nature22972. Epub 2017 Jun 14.

9.

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.

Kalas V, Pinkner JS, Hannan TJ, Hibbing ME, Dodson KW, Holehouse AS, Zhang H, Tolia NH, Gross ML, Pappu RV, Janetka J, Hultgren SJ.

Sci Adv. 2017 Feb 10;3(2):e1601944. doi: 10.1126/sciadv.1601944. eCollection 2017 Feb.

10.

Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections.

Flores-Mireles AL, Walker JN, Potretzke A, Schreiber HL 4th, Pinkner JS, Bauman TM, Park AM, Desai A, Hultgren SJ, Caparon MG.

MBio. 2016 Oct 25;7(5). pii: e01653-16. doi: 10.1128/mBio.01653-16.

11.

The Catabolite Repressor Protein-Cyclic AMP Complex Regulates csgD and Biofilm Formation in Uropathogenic Escherichia coli.

Hufnagel DA, Evans ML, Greene SE, Pinkner JS, Hultgren SJ, Chapman MR.

J Bacteriol. 2016 Nov 18;198(24):3329-3334. Print 2016 Dec 15.

12.

Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections.

Mydock-McGrane L, Cusumano Z, Han Z, Binkley J, Kostakioti M, Hannan T, Pinkner JS, Klein R, Kalas V, Crowley J, Rath NP, Hultgren SJ, Janetka JW.

J Med Chem. 2016 Oct 27;59(20):9390-9408. Epub 2016 Oct 14.

13.

Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.

Conover MS, Ruer S, Taganna J, Kalas V, De Greve H, Pinkner JS, Dodson KW, Remaut H, Hultgren SJ.

Cell Host Microbe. 2016 Oct 12;20(4):482-492. doi: 10.1016/j.chom.2016.08.013. Epub 2016 Sep 22.

14.

Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation.

Shu Q, Krezel AM, Cusumano ZT, Pinkner JS, Klein R, Hultgren SJ, Frieden C.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7130-5. doi: 10.1073/pnas.1607222113. Epub 2016 Jun 13.

15.

Fibrinogen Release and Deposition on Urinary Catheters Placed during Urological Procedures.

Flores-Mireles AL, Walker JN, Bauman TM, Potretzke AM, Schreiber HL 4th, Park AM, Pinkner JS, Caparon MG, Hultgren SJ, Desai A.

J Urol. 2016 Aug;196(2):416-421. doi: 10.1016/j.juro.2016.01.100. Epub 2016 Jan 28.

16.

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.

Jarvis C, Han Z, Kalas V, Klein R, Pinkner JS, Ford B, Binkley J, Cusumano CK, Cusumano Z, Mydock-McGrane L, Hultgren SJ, Janetka JW.

ChemMedChem. 2016 Feb 17;11(4):367-73. doi: 10.1002/cmdc.201600006. Epub 2016 Jan 26.

17.

Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli.

Greene SE, Pinkner JS, Chorell E, Dodson KW, Shaffer CL, Conover MS, Livny J, Hadjifrangiskou M, Almqvist F, Hultgren SJ.

MBio. 2014 Oct 28;5(6):e02038. doi: 10.1128/mBio.02038-14.

18.

EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice.

Flores-Mireles AL, Pinkner JS, Caparon MG, Hultgren SJ.

Sci Transl Med. 2014 Sep 17;6(254):254ra127. doi: 10.1126/scitranslmed.3009384.

19.

Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG.

Goyal P, Krasteva PV, Van Gerven N, Gubellini F, Van den Broeck I, Troupiotis-Tsaïlaki A, Jonckheere W, Péhau-Arnaudet G, Pinkner JS, Chapman MR, Hultgren SJ, Howorka S, Fronzes R, Remaut H.

Nature. 2014 Dec 11;516(7530):250-3. doi: 10.1038/nature13768. Epub 2014 Sep 14.

20.

Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity.

Dang HT, Chorell E, Uvell H, Pinkner JS, Hultgren SJ, Almqvist F.

Org Biomol Chem. 2014 Mar 28;12(12):1942-56. doi: 10.1039/c3ob42478b. Epub 2014 Feb 17.

21.

Molecular basis of usher pore gating in Escherichia coli pilus biogenesis.

Volkan E, Kalas V, Pinkner JS, Dodson KW, Henderson NS, Pham T, Waksman G, Delcour AH, Thanassi DG, Hultgren SJ.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20741-6. doi: 10.1073/pnas.1320528110. Epub 2013 Dec 2.

22.

Community behavior and amyloid-associated phenotypes among a panel of uropathogenic E. coli.

Lim JY, Pinkner JS, Cegelski L.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):345-50. doi: 10.1016/j.bbrc.2013.11.026. Epub 2013 Nov 15.

23.

Escherichia coli biofilms have an organized and complex extracellular matrix structure.

Hung C, Zhou Y, Pinkner JS, Dodson KW, Crowley JR, Heuser J, Chapman MR, Hadjifrangiskou M, Henderson JP, Hultgren SJ.

MBio. 2013 Sep 10;4(5):e00645-13. doi: 10.1128/mBio.00645-13.

24.

Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation.

Schwartz DJ, Kalas V, Pinkner JS, Chen SL, Spaulding CN, Dodson KW, Hultgren SJ.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15530-7. doi: 10.1073/pnas.1315203110. Epub 2013 Sep 3.

25.

Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis.

Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ.

J Bacteriol. 2013 Oct;195(19):4484-95. doi: 10.1128/JB.00451-13. Epub 2013 Aug 2.

26.

Transposon mutagenesis identifies uropathogenic Escherichia coli biofilm factors.

Hadjifrangiskou M, Gu AP, Pinkner JS, Kostakioti M, Zhang EW, Greene SE, Hultgren SJ.

J Bacteriol. 2012 Nov;194(22):6195-205. doi: 10.1128/JB.01012-12. Epub 2012 Sep 14.

27.

The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection.

Nielsen HV, Guiton PS, Kline KA, Port GC, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ.

MBio. 2012 Jul 24;3(4):e00177-12. doi: 10.1128/mBio.00177-12. Print 2012.

28.

Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine.

Volkan E, Ford BA, Pinkner JS, Dodson KW, Henderson NS, Thanassi DG, Waksman G, Hultgren SJ.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9563-8. doi: 10.1073/pnas.1207085109. Epub 2012 May 29.

29.

The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.

Shu Q, Crick SL, Pinkner JS, Ford B, Hultgren SJ, Frieden C.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6502-7. doi: 10.1073/pnas.1204161109. Epub 2012 Apr 9.

30.

Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study.

Chorell E, Pinkner JS, Bengtsson C, Banchelin TS, Edvinsson S, Linusson A, Hultgren SJ, Almqvist F.

Bioorg Med Chem. 2012 May 1;20(9):3128-42. doi: 10.1016/j.bmc.2012.01.048. Epub 2012 Feb 4.

31.

Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.

Han Z, Pinkner JS, Ford B, Chorell E, Crowley JM, Cusumano CK, Campbell S, Henderson JP, Hultgren SJ, Janetka JW.

J Med Chem. 2012 Apr 26;55(8):3945-59. doi: 10.1021/jm300165m. Epub 2012 Apr 13.

32.

Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms.

Chorell E, Pinkner JS, Bengtsson C, Edvinsson S, Cusumano CK, Rosenbaum E, Johansson LB, Hultgren SJ, Almqvist F.

Chemistry. 2012 Apr 10;18(15):4522-32. doi: 10.1002/chem.201103936. Epub 2012 Mar 16.

33.

Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization.

Lin LY, Tiemann KM, Li Y, Pinkner JS, Walker JN, Hultgren SJ, Hunstad DA, Wooley KL.

J Am Chem Soc. 2012 Mar 7;134(9):3938-41. doi: 10.1021/ja2091917. Epub 2012 Feb 23.

34.

Impairment of the biomechanical compliance of P pili: a novel means of inhibiting uropathogenic bacterial infections?

Klinth JE, Pinkner JS, Hultgren SJ, Almqvist F, Uhlin BE, Axner O.

Eur Biophys J. 2012 Mar;41(3):285-95. doi: 10.1007/s00249-011-0784-2. Epub 2012 Jan 12.

35.

Treatment and prevention of urinary tract infection with orally active FimH inhibitors.

Cusumano CK, Pinkner JS, Han Z, Greene SE, Ford BA, Crowley JR, Henderson JP, Janetka JW, Hultgren SJ.

Sci Transl Med. 2011 Nov 16;3(109):109ra115. doi: 10.1126/scitranslmed.3003021.

36.

Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate.

Phan G, Remaut H, Wang T, Allen WJ, Pirker KF, Lebedev A, Henderson NS, Geibel S, Volkan E, Yan J, Kunze MB, Pinkner JS, Ford B, Kay CW, Li H, Hultgren SJ, Thanassi DG, Waksman G.

Nature. 2011 Jun 2;474(7349):49-53. doi: 10.1038/nature10109.

37.

Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity.

Chorell E, Bengtsson C, Sainte-Luce Banchelin T, Das P, Uvell H, Sinha AK, Pinkner JS, Hultgren SJ, Almqvist F.

Eur J Med Chem. 2011 Apr;46(4):1103-16. doi: 10.1016/j.ejmech.2011.01.025. Epub 2011 Jan 21.

38.

Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin.

Smith CL, Ghosh J, Elam JS, Pinkner JS, Hultgren SJ, Caparon MG, Ellenberger T.

Structure. 2011 Feb 9;19(2):192-202. doi: 10.1016/j.str.2010.12.013.

39.

Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity.

Chorell E, Pinkner JS, Phan G, Edvinsson S, Buelens F, Remaut H, Waksman G, Hultgren SJ, Almqvist F.

J Med Chem. 2010 Aug 12;53(15):5690-5. doi: 10.1021/jm100470t.

40.

Structure-based drug design and optimization of mannoside bacterial FimH antagonists.

Han Z, Pinkner JS, Ford B, Obermann R, Nolan W, Wildman SA, Hobbs D, Ellenberger T, Cusumano CK, Hultgren SJ, Janetka JW.

J Med Chem. 2010 Jun 24;53(12):4779-92. doi: 10.1021/jm100438s.

41.

The differential affinity of the usher for chaperone-subunit complexes is required for assembly of complete pili.

Li Q, Ng TW, Dodson KW, So SS, Bayle KM, Pinkner JS, Scarlata S, Hultgren SJ, Thanassi DG.

Mol Microbiol. 2010 Apr;76(1):159-72. doi: 10.1111/j.1365-2958.2010.07089.x. Epub 2010 Feb 24.

42.

Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding.

Chen SL, Hung CS, Pinkner JS, Walker JN, Cusumano CK, Li Z, Bouckaert J, Gordon JI, Hultgren SJ.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22439-44. doi: 10.1073/pnas.0902179106. Epub 2009 Dec 16.

43.

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation.

Cegelski L, Pinkner JS, Hammer ND, Cusumano CK, Hung CS, Chorell E, Aberg V, Walker JN, Seed PC, Almqvist F, Chapman MR, Hultgren SJ.

Nat Chem Biol. 2009 Dec;5(12):913-9. doi: 10.1038/nchembio.242. Epub 2009 Oct 25.

44.

QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli.

Kostakioti M, Hadjifrangiskou M, Pinkner JS, Hultgren SJ.

Mol Microbiol. 2009 Sep;73(6):1020-31. doi: 10.1111/j.1365-2958.2009.06826.x. Epub 2009 Aug 23.

45.

Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis.

Kline KA, Kau AL, Chen SL, Lim A, Pinkner JS, Rosch J, Nallapareddy SR, Murray BE, Henriques-Normark B, Beatty W, Caparon MG, Hultgren SJ.

J Bacteriol. 2009 May;191(10):3237-47. doi: 10.1128/JB.01837-08. Epub 2009 Mar 13.

46.

Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli.

Henderson JP, Crowley JR, Pinkner JS, Walker JN, Tsukayama P, Stamm WE, Hooton TM, Hultgren SJ.

PLoS Pathog. 2009 Feb;5(2):e1000305. doi: 10.1371/journal.ppat.1000305. Epub 2009 Feb 20.

47.

Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli.

Berg V, Das P, Chorell E, Hedenström M, Pinkner JS, Hultgren SJ, Almqvist F.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3536-40. doi: 10.1016/j.bmcl.2008.05.020. Epub 2008 May 7.

48.

Fiber formation across the bacterial outer membrane by the chaperone/usher pathway.

Remaut H, Tang C, Henderson NS, Pinkner JS, Wang T, Hultgren SJ, Thanassi DG, Waksman G, Li H.

Cell. 2008 May 16;133(4):640-52. doi: 10.1016/j.cell.2008.03.033.

49.

Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract.

Rosen DA, Pinkner JS, Walker JN, Elam JS, Jones JM, Hultgren SJ.

Infect Immun. 2008 Jul;76(7):3346-56. doi: 10.1128/IAI.00340-08. Epub 2008 May 12.

50.

Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression.

Rosen DA, Pinkner JS, Jones JM, Walker JN, Clegg S, Hultgren SJ.

Infect Immun. 2008 Jul;76(7):3337-45. doi: 10.1128/IAI.00090-08. Epub 2008 Apr 14.

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