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GDP-l-fucose synthase is a CD4+ T cell-specific autoantigen in DRB3*02:02 patients with multiple sclerosis.

Planas R, Santos R, Tomas-Ojer P, Cruciani C, Lutterotti A, Faigle W, Schaeren-Wiemers N, Espejo C, Eixarch H, Pinilla C, Martin R, Sospedra M.

Sci Transl Med. 2018 Oct 10;10(462). pii: eaat4301. doi: 10.1126/scitranslmed.aat4301.


Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis.

Jelcic I, Al Nimer F, Wang J, Lentsch V, Planas R, Jelcic I, Madjovski A, Ruhrmann S, Faigle W, Frauenknecht K, Pinilla C, Santos R, Hammer C, Ortiz Y, Opitz L, Grönlund H, Rogler G, Boyman O, Reynolds R, Lutterotti A, Khademi M, Olsson T, Piehl F, Sospedra M, Martin R.

Cell. 2018 Sep 20;175(1):85-100.e23. doi: 10.1016/j.cell.2018.08.011. Epub 2018 Aug 30.


Identification of a small molecule inhibitor of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] using mixture-based combinatorial libraries.

Tran T, Chiem K, Jani S, Arivett BA, Lin DL, Lad R, Jimenez V, Farone MB, Debevec G, Santos R, Giulianotti M, Pinilla C, Tolmasky ME.

Int J Antimicrob Agents. 2018 May;51(5):752-761. doi: 10.1016/j.ijantimicag.2018.01.019. Epub 2018 Feb 2.


Extraction and partial characterisation of antioxidant pigment produced by Chryseobacterium sp. kr6.

Jiménez MEP, Pinilla CMB, Rodrigues E, Brandelli A.

Nat Prod Res. 2018 Jan 5:1-9. doi: 10.1080/14786419.2017.1423304. [Epub ahead of print]


High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems.

Haynes MK, Garcia M, Peters R, Waller A, Tedesco P, Ursu O, Bologa CG, Santos RG, Pinilla C, Wu TH, Lovchik JA, Oprea TI, Sklar LA, Tegos GP.

Methods Mol Biol. 2018;1700:293-318. doi: 10.1007/978-1-4939-7454-2_16.


Comparing Efficacy and Costs of Four Facial Fillers in Human Immunodeficiency Virus-Associated Lipodystrophy: A Clinical Trial.

Vallejo A, Garcia-Ruano AA, Pinilla C, Castellano M, Deleyto E, Perez-Cano R.

Plast Reconstr Surg. 2018 Mar;141(3):613-623. doi: 10.1097/PRS.0000000000004173.


Correction: Methodological approach to the ex vivo expansion and detection of T. cruzi-specific T cells from chronic Chagas disease patients.

Acevedo GR, Longhi SA, Bunying A, Sabri N, Atienza A, Zago MP, Santos R, Judkowski VA, Pinilla C, Gómez KA.

PLoS One. 2017 Aug 31;12(8):e0184467. doi: 10.1371/journal.pone.0184467. eCollection 2017.


Methodological approach to the ex vivo expansion and detection of T. cruzi-specific T cells from chronic Chagas disease patients.

Acevedo GR, Longhi SA, Bunying A, Sabri N, Atienza A, Zago MP, Santos R, Judkowski VA, Pinilla C, Gómez KA.

PLoS One. 2017 May 26;12(5):e0178380. doi: 10.1371/journal.pone.0178380. eCollection 2017. Erratum in: PLoS One. 2017 Aug 31;12 (8):e0184467.


Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2.

Doering SR, Freeman KT, Schnell SM, Haslach EM, Dirain M, Debevec G, Geer P, Santos RG, Giulianotti MA, Pinilla C, Appel JR, Speth RC, Houghten RA, Haskell-Luevano C.

J Med Chem. 2017 May 25;60(10):4342-4357. doi: 10.1021/acs.jmedchem.7b00301. Epub 2017 May 15.


Development and characterization of phosphatidylcholine nanovesicles, containing garlic extract, with antilisterial activity in milk.

Pinilla CM, Noreña CP, Brandelli A.

Food Chem. 2017 Apr 1;220:470-476. doi: 10.1016/j.foodchem.2016.10.027. Epub 2016 Oct 8.


Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.

Welsh K, Milutinovic S, Ardecky RJ, Gonzalez-Lopez M, Ganji SR, Teriete P, Finlay D, Riedl S, Matsuzawa S, Pinilla C, Houghten R, Vuori K, Reed JC, Cosford ND.

PLoS One. 2016 Sep 12;11(9):e0161952. doi: 10.1371/journal.pone.0161952. eCollection 2016.


Investigating the Role of the Host Multidrug Resistance Associated Protein Transporter Family in Burkholderia cepacia Complex Pathogenicity Using a Caenorhabditis elegans Infection Model.

Tedesco P, Visone M, Parrilli E, Tutino ML, Perrin E, Maida I, Fani R, Ballestriero F, Santos R, Pinilla C, Di Schiavi E, Tegos G, de Pascale D.

PLoS One. 2015 Nov 20;10(11):e0142883. doi: 10.1371/journal.pone.0142883. eCollection 2015.


Kidney transplant in pediatric patients with severe bladder pathology.

Sierralta MC, González G, Nome C, Pinilla C, Correa R, Mansilla J, Rodríguez J, Delucchi A, Ossandón F.

Pediatr Transplant. 2015 Nov;19(7):675-83. doi: 10.1111/petr.12567. Epub 2015 Aug 10.


Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice.

Falta MT, Tinega AN, Mack DG, Bowerman NA, Crawford F, Kappler JW, Pinilla C, Fontenot AP.

Mucosal Immunol. 2016 Jan;9(1):218-28. doi: 10.1038/mi.2015.54. Epub 2015 Jul 1.


New Refinements in Greater Omentum Free Flap Transfer for Severe Secondary Lymphedema Surgical Treatment.

Lasso JM, Pinilla C, Castellano M.

Plast Reconstr Surg Glob Open. 2015 Jun 5;3(5):e387. doi: 10.1097/GOX.0000000000000358. eCollection 2015 May.


Biosorption of cadmium with brown macroalgae.

Gutiérrez C, Hansen HK, Hernández P, Pinilla C.

Chemosphere. 2015 Nov;138:164-9. doi: 10.1016/j.chemosphere.2015.06.002. Epub 2015 Jun 8.


Correction: Santos, R.S., et al. Improvement of IFNγ ELISPOT Performance Following Overnight Resting of Frozen PBMC Samples Confirmed Through Rigorous Statistical Analysis. Cells 2015, 4, 1-18.

Santos R, Buying A, Sabri N, Yu J, Gringeri A, Bender J, Janetzki S, Pinilla C, Judkowski VA.

Cells. 2015 Apr 21;4(2):133-4. doi: 10.3390/cells4020133.


Improvement of IFNg ELISPOT Performance Following Overnight Resting of Frozen PBMC Samples Confirmed Through Rigorous Statistical Analysis.

Santos R, Buying A, Sabri N, Yu J, Gringeri A, Bender J, Janetzki S, Pinilla C, Judkowski VA.

Cells. 2014 Dec 24;4(1):1-18. doi: 10.3390/cells4010001. Erratum in: Cells. 2015;4(2):133-4.


Invasive basal cell carcinoma in a xeroderma pigmentosum patient: facing secondary and tertiary aggressive recurrences.

Lasso JM, Yordanov YP, Pinilla C, Shef A.

J Craniofac Surg. 2014 Jul;25(4):e336-8. doi: 10.1097/SCS.0000000000000596.


Cytokine production but lack of proliferation in peripheral blood mononuclear cells from chronic Chagas' disease cardiomyopathy patients in response to T. cruzi ribosomal P proteins.

Longhi SA, Atienza A, Perez Prados G, Buying A, Balouz V, Buscaglia CA, Santos R, Tasso LM, Bonato R, Chiale P, Pinilla C, Judkowski VA, Gómez KA.

PLoS Negl Trop Dis. 2014 Jun 5;8(6):e2906. doi: 10.1371/journal.pntd.0002906. eCollection 2014 Jun.


Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).

Haslach EM, Huang H, Dirain M, Debevec G, Geer P, Santos RG, Giulianotti MA, Pinilla C, Appel JR, Doering SR, Walters MA, Houghten RA, Haskell-Luevano C.

J Med Chem. 2014 Jun 12;57(11):4615-28. doi: 10.1021/jm500064t. Epub 2014 May 14.


High energy density mixed polymeric phase from carbon monoxide and nitrogen.

Raza Z, Pickard CJ, Pinilla C, Saitta AM.

Phys Rev Lett. 2013 Dec 6;111(23):235501. Epub 2013 Dec 4.


Identification of novel human leukocyte antigen-A*0201-restricted, cytotoxic T lymphocyte epitopes on CD133 for cancer stem cell immunotherapy.

Ji J, Judkowski VA, Liu G, Wang H, Bunying A, Li Z, Xu M, Bender J, Pinilla C, Yu JS.

Stem Cells Transl Med. 2014 Mar;3(3):356-64. doi: 10.5966/sctm.2013-0135. Epub 2013 Dec 27.


Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease.

Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP.

J Exp Med. 2013 Jul 1;210(7):1403-18.


Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries.

Pinilla C, Edwards BS, Appel JR, Yates-Gibbins T, Giulianotti MA, Medina-Franco JL, Young SM, Santos RG, Sklar LA, Houghten RA.

Mol Pharmacol. 2013 Sep;84(3):314-24. doi: 10.1124/mol.113.086595. Epub 2013 Jun 20.


The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors.

Santos RG, Appel JR, Giulianotti MA, Edwards BS, Sklar LA, Houghten RA, Pinilla C.

Molecules. 2013 May 30;18(6):6408-24. doi: 10.3390/molecules18066408.


Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches.

Medina-Franco JL, Edwards BS, Pinilla C, Appel JR, Giulianotti MA, Santos RG, Yongye AB, Sklar LA, Houghten RA.

J Chem Inf Model. 2013 Jun 24;53(6):1475-85. doi: 10.1021/ci400192y. Epub 2013 Jun 7.


Measurement of MHC/peptide interactions by gel filtration or monoclonal antibody capture.

Sidney J, Southwood S, Moore C, Oseroff C, Pinilla C, Grey HM, Sette A.

Curr Protoc Immunol. 2013 Feb;Chapter 18:Unit 18.3.. doi: 10.1002/0471142735.im1803s100.


HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.

Wu B, Zhang Z, Noberini R, Barile E, Giulianotti M, Pinilla C, Houghten RA, Pasquale EB, Pellecchia M.

Chem Biol. 2013 Jan 24;20(1):19-33. doi: 10.1016/j.chembiol.2012.10.015.


Identification of B cell and T cell epitopes using synthetic peptide combinatorial libraries.

Pinilla C, Appel JR, Judkowski V, Houghten RA.

Curr Protoc Immunol. 2012 Nov;Chapter 9:Unit9.5. doi: 10.1002/0471142735.im0905s99.


Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis.

Quandt JA, Huh J, Baig M, Yao K, Ito N, Bryant M, Kawamura K, Pinilla C, McFarland HF, Martin R, Ito K.

J Immunol. 2012 Sep 15;189(6):2897-908. doi: 10.4049/jimmunol.1103087. Epub 2012 Aug 10.


Ab initio parameterization of an all-atom polarizable and dissociable force field for water.

Pinilla C, Irani AH, Seriani N, Scandolo S.

J Chem Phys. 2012 Mar 21;136(11):114511. doi: 10.1063/1.3691603.


Dispersion interactions in room-temperature ionic liquids: results from a non-empirical density functional.

Kohanoff J, Pinilla C, Youngs TG, Artacho E, Soler JM.

J Chem Phys. 2011 Oct 21;135(15):154505. doi: 10.1063/1.3652897.


Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes.

Rideout MC, Boldt JL, Vahi-Ferguson G, Salamon P, Nefzi A, Ostresh JM, Giulianotti M, Pinilla C, Segall AM.

Mol Divers. 2011 Nov;15(4):989-1005. doi: 10.1007/s11030-011-9333-2. Epub 2011 Sep 22.


GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4+ T cells following smallpox vaccination.

Judkowski V, Bunying A, Ge F, Appel JR, Law K, Sharma A, Raja-Gabaglia C, Norori P, Santos RG, Giulianotti MA, Slifka MK, Douek DC, Graham BS, Pinilla C.

PLoS One. 2011;6(9):e24091. doi: 10.1371/journal.pone.0024091. Epub 2011 Sep 9.


A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers.

Yin L, Huseby E, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S, Kappler JW.

Immunity. 2011 Jul 22;35(1):23-33. doi: 10.1016/j.immuni.2011.04.017. Epub 2011 Jun 16.


Use and implications of the harmonic mean model on mixtures for basic research and drug discovery.

Santos RG, Giulianotti MA, Dooley CT, Pinilla C, Appel JR, Houghten RA.

ACS Comb Sci. 2011 May 9;13(3):337-44. doi: 10.1021/co100065a. Epub 2011 Mar 11. Erratum in: ACS Comb Sci.2011 May 9;13(3):344.


A high-content screening (HCS) assay for the identification of chemical inducers of PML oncogenic domains (PODs).

Yip KW, Cuddy M, Pinilla C, Giulanotti M, Heynen-Genel S, Matsuzawa S, Reed JC.

J Biomol Screen. 2011 Feb;16(2):251-8. doi: 10.1177/1087057110394181. Epub 2011 Jan 13.


Integrating computational and mixture-based screening of combinatorial libraries.

Yongye AB, Pinilla C, Medina-Franco JL, Giulianotti MA, Dooley CT, Appel JR, Nefzi A, Scior T, Houghten RA, Martínez-Mayorga K.

J Mol Model. 2011 Jun;17(6):1473-82. doi: 10.1007/s00894-010-0850-1. Epub 2010 Sep 21.


Small molecule functional analogs of peptides that inhibit lambda site-specific recombination and bind Holliday junctions.

Ranjit DK, Rideout MC, Nefzi A, Ostresh JM, Pinilla C, Segall AM.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4531-4. doi: 10.1016/j.bmcl.2010.06.029. Epub 2010 Jun 8.


The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype.

Solomon C, Southwood S, Hoof I, Rudersdorf R, Peters B, Sidney J, Pinilla C, Marcondes MC, Ling B, Marx P, Sette A, Mothé BR.

Immunogenetics. 2010 Jul;62(7):451-64. doi: 10.1007/s00251-010-0450-3. Epub 2010 May 18.


Combining positional scanning peptide libraries, HLA-DR transfectants and bioinformatics to dissect the epitope spectrum of HLA class II cross-restricted CD4+ T cell clones.

Sospedra M, Zhao Y, Giulianotti M, Simon R, Pinilla C, Martin R.

J Immunol Methods. 2010 Feb 28;353(1-2):93-101. doi: 10.1016/j.jim.2009.12.006. Epub 2009 Dec 28.


Derivation of an amino acid similarity matrix for peptide: MHC binding and its application as a Bayesian prior.

Kim Y, Sidney J, Pinilla C, Sette A, Peters B.

BMC Bioinformatics. 2009 Nov 30;10:394. doi: 10.1186/1471-2105-10-394.


A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC.

Dean EJ, Ward T, Pinilla C, Houghten R, Welsh K, Makin G, Ranson M, Dive C.

Br J Cancer. 2010 Jan 5;102(1):97-103. doi: 10.1038/sj.bjc.6605418. Epub 2009 Nov 10.


Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML.

Carter BZ, Mak DH, Schober WD, Koller E, Pinilla C, Vassilev LT, Reed JC, Andreeff M.

Blood. 2010 Jan 14;115(2):306-14. doi: 10.1182/blood-2009-03-212563. Epub 2009 Nov 6.


[Mortality by avoidable causes in preschool children].

Lurán A, López E, Pinilla C, Sierra P.

Biomedica. 2009 Mar;29(1):98-107. Spanish.


Characterization of activity landscapes using 2D and 3D similarity methods: consensus activity cliffs.

Medina-Franco JL, Martínez-Mayorga K, Bender A, Marín RM, Giulianotti MA, Pinilla C, Houghten RA.

J Chem Inf Model. 2009 Feb;49(2):477-91. doi: 10.1021/ci800379q.


Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository.

Singh N, Guha R, Giulianotti MA, Pinilla C, Houghten RA, Medina-Franco JL.

J Chem Inf Model. 2009 Apr;49(4):1010-24. doi: 10.1021/ci800426u.


Monkeypox virus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate T cell activation.

Hammarlund E, Dasgupta A, Pinilla C, Norori P, Früh K, Slifka MK.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14567-72. doi: 10.1073/pnas.0800589105. Epub 2008 Sep 16.


Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor.

Voelter V, Rufer N, Reynard S, Greub G, Brookes R, Guillaume P, Grosjean F, Fagerberg T, Michelin O, Rowland-Jones S, Pinilla C, Leyvraz S, Romero P, Appay V.

Int Immunol. 2008 Aug;20(8):1087-96. doi: 10.1093/intimm/dxn066. Epub 2008 Jun 23.


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