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The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis.

Jensen C, Bæk KT, Gallay C, Thalsø-Madsen I, Xu L, Jousselin A, Ruiz Torrubia F, Paulander W, Pereira AR, Veening JW, Pinho MG, Frees D.

PLoS Pathog. 2019 Sep 13;15(9):e1008044. doi: 10.1371/journal.ppat.1008044. [Epub ahead of print]


BPEI-Induced Delocalization of PBP4 Potentiates β-Lactams against MRSA.

Hill MA, Lam AK, Reed P, Harney MC, Wilson BA, Moen EL, Wright SN, Pinho MG, Rice CV.

Biochemistry. 2019 Sep 10;58(36):3813-3822. doi: 10.1021/acs.biochem.9b00523. Epub 2019 Aug 26.


Comparing Different Residential Neighborhood Definitions and the Association Between Density of Restaurants and Home Cooking Among Dutch Adults.

Pinho MGM, Mackenbach JD, Charreire H, Oppert JM, Rutter H, Beulens JWJ, Brug J, Lakerveld J.

Nutrients. 2019 Aug 3;11(8). pii: E1796. doi: 10.3390/nu11081796.


A comparative genomics approach for identifying host-range determinants in Streptococcus thermophilus bacteriophages.

Szymczak P, Rau MH, Monteiro JM, Pinho MG, Filipe SR, Vogensen FK, Zeidan AA, Janzen T.

Sci Rep. 2019 May 29;9(1):7991. doi: 10.1038/s41598-019-44481-z.


SEDS-bPBP pairs direct lateral and septal peptidoglycan synthesis in Staphylococcus aureus.

Reichmann NT, Tavares AC, Saraiva BM, Jousselin A, Reed P, Pereira AR, Monteiro JM, Sobral RG, VanNieuwenhze MS, Fernandes F, Pinho MG.

Nat Microbiol. 2019 Aug;4(8):1368-1377. doi: 10.1038/s41564-019-0437-2. Epub 2019 May 13.


The pentaglycine bridges of Staphylococcus aureus peptidoglycan are essential for cell integrity.

Monteiro JM, Covas G, Rausch D, Filipe SR, Schneider T, Sahl HG, Pinho MG.

Sci Rep. 2019 Mar 21;9(1):5010. doi: 10.1038/s41598-019-41461-1.


Parental Perceived Travel Time to and Reported Use of Food Retailers in Association with School Children's Dietary Patterns.

Alves MA, Pinho MGM, Corrêa EN, das Neves J, de Assis Guedes de Vasconcelos F.

Int J Environ Res Public Health. 2019 Mar 7;16(5). pii: E824. doi: 10.3390/ijerph16050824.


The association between population density and blood lipid levels in Dutch blood donors.

de Groot R, Hoenink JC, Mackenbach JD, den Braver NR, Pinho MGM, Brassinga D, Prinsze FJ, Timmer TC, de Kort WLAM, Brug J, van den Hurk K, Lakerveld J.

Int J Health Geogr. 2019 Feb 4;18(1):3. doi: 10.1186/s12942-019-0167-y.


Peptidoglycan synthesis drives an FtsZ-treadmilling-independent step of cytokinesis.

Monteiro JM, Pereira AR, Reichmann NT, Saraiva BM, Fernandes PB, Veiga H, Tavares AC, Santos M, Ferreira MT, Macário V, VanNieuwenhze MS, Filipe SR, Pinho MG.

Nature. 2018 Feb 22;554(7693):528-532. doi: 10.1038/nature25506. Epub 2018 Feb 14.


PBP4 activity and its overexpression are necessary for PBP4-mediated high-level β-lactam resistance.

Basuino L, Jousselin A, Alexander JAN, Strynadka NCJ, Pinho MG, Chambers HF, Chatterjee SS.

J Antimicrob Chemother. 2018 May 1;73(5):1177-1180. doi: 10.1093/jac/dkx531.


Spatial access to restaurants and grocery stores in relation to frequency of home cooking.

Pinho MGM, Mackenbach JD, Charreire H, Oppert JM, Bárdos H, Rutter H, Compernolle S, Beulens JWJ, Brug J, Lakerveld J.

Int J Behav Nutr Phys Act. 2018 Jan 16;15(1):6. doi: 10.1186/s12966-017-0640-6.


Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms.

Catteau L, Reichmann NT, Olson J, Pinho MG, Nizet V, Van Bambeke F, Quetin-Leclercq J.

Molecules. 2017 Dec 16;22(12). pii: E2245. doi: 10.3390/molecules22122245.


The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus.

Stahlhut SG, Alqarzaee AA, Jensen C, Fisker NS, Pereira AR, Pinho MG, Thomas VC, Frees D.

Sci Rep. 2017 Sep 18;7(1):11739. doi: 10.1038/s41598-017-12122-y.


Role of SCCmec type in resistance to the synergistic activity of oxacillin and cefoxitin in MRSA.

Reichmann NT, Pinho MG.

Sci Rep. 2017 Jul 21;7(1):6154. doi: 10.1038/s41598-017-06329-2.


A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism.

Nair DR, Chen J, Monteiro JM, Josten M, Pinho MG, Sahl HG, Wu J, Cheung A.

J Antibiot (Tokyo). 2017 Oct;70(10):1009-1019. doi: 10.1038/ja.2017.79. Epub 2017 Jul 12.


Erratum to: The Holliday junction resolvase RecU is required for chromosome segregation and DNA damage repair in Staphylococcus aureus.

Pereira AR, Reed P, Veiga H, Pinho MG.

BMC Microbiol. 2017 May 22;17(1):119. doi: 10.1186/s12866-017-1026-2. No abstract available.


Exploring the relationship between perceived barriers to healthy eating and dietary behaviours in European adults.

Pinho MGM, Mackenbach JD, Charreire H, Oppert JM, Bárdos H, Glonti K, Rutter H, Compernolle S, De Bourdeaudhuij I, Beulens JWJ, Brug J, Lakerveld J.

Eur J Nutr. 2018 Aug;57(5):1761-1770. doi: 10.1007/s00394-017-1458-3. Epub 2017 Apr 26.


FtsZ-Dependent Elongation of a Coccoid Bacterium.

Pereira AR, Hsin J, Król E, Tavares AC, Flores P, Hoiczyk E, Ng N, Dajkovic A, Brun YV, VanNieuwenhze MS, Roemer T, Carballido-Lopez R, Scheffers DJ, Huang KC, Pinho MG.

MBio. 2016 Sep 6;7(5). pii: e00908-16. doi: 10.1128/mBio.00908-16.


Analysis of Cell Wall Teichoic Acids in Staphylococcus aureus.

Covas G, Vaz F, Henriques G, Pinho MG, Filipe SR.

Methods Mol Biol. 2016;1440:201-13. doi: 10.1007/978-1-4939-3676-2_15.


Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets.

Mann PA, Müller A, Wolff KA, Fischmann T, Wang H, Reed P, Hou Y, Li W, Müller CE, Xiao J, Murgolo N, Sher X, Mayhood T, Sheth PR, Mirza A, Labroli M, Xiao L, McCoy M, Gill CJ, Pinho MG, Schneider T, Roemer T.

PLoS Pathog. 2016 May 4;12(5):e1005585. doi: 10.1371/journal.ppat.1005585. eCollection 2016 May.


The Staphylococcus aureus Chaperone PrsA Is a New Auxiliary Factor of Oxacillin Resistance Affecting Penicillin-Binding Protein 2A.

Jousselin A, Manzano C, Biette A, Reed P, Pinho MG, Rosato AE, Kelley WL, Renzoni A.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1656-66. doi: 10.1128/AAC.02333-15.


The SpoIIQ-SpoIIIAH complex of Clostridium difficile controls forespore engulfment and late stages of gene expression and spore morphogenesis.

Serrano M, Crawshaw AD, Dembek M, Monteiro JM, Pereira FC, Pinho MG, Fairweather NF, Salgado PS, Henriques AO.

Mol Microbiol. 2016 Apr;100(1):204-28. doi: 10.1111/mmi.13311. Epub 2016 Feb 12.


Antimicrobial Contact-Active Oligo(2-oxazoline)s-Grafted Surfaces for Fast Water Disinfection at the Point-of-Use.

Correia VG, Ferraria AM, Pinho MG, Aguiar-Ricardo A.

Biomacromolecules. 2015 Dec 14;16(12):3904-15. doi: 10.1021/acs.biomac.5b01243. Epub 2015 Dec 1.


MreC and MreD Proteins Are Not Required for Growth of Staphylococcus aureus.

Tavares AC, Fernandes PB, Carballido-López R, Pinho MG.

PLoS One. 2015 Oct 15;10(10):e0140523. doi: 10.1371/journal.pone.0140523. eCollection 2015.


Cell shape dynamics during the staphylococcal cell cycle.

Monteiro JM, Fernandes PB, Vaz F, Pereira AR, Tavares AC, Ferreira MT, Pereira PM, Veiga H, Kuru E, VanNieuwenhze MS, Brun YV, Filipe SR, Pinho MG.

Nat Commun. 2015 Aug 17;6:8055. doi: 10.1038/ncomms9055.


An Activity-Based Probe for Studying Crosslinking in Live Bacteria.

Gautam S, Kim T, Shoda T, Sen S, Deep D, Luthra R, Ferreira MT, Pinho MG, Spiegel DA.

Angew Chem Int Ed Engl. 2015 Sep 1;54(36):10492-6. doi: 10.1002/anie.201503869. Epub 2015 Jul 17.


Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance.

Reed P, Atilano ML, Alves R, Hoiczyk E, Sher X, Reichmann NT, Pereira PM, Roemer T, Filipe SR, Pereira-Leal JB, Ligoxygakis P, Pinho MG.

PLoS Pathog. 2015 May 7;11(5):e1004891. doi: 10.1371/journal.ppat.1004891. eCollection 2015 May.


Characterization of a novel small molecule that potentiates β-lactam activity against gram-positive and gram-negative pathogens.

Nair DR, Monteiro JM, Memmi G, Thanassi J, Pucci M, Schwartzman J, Pinho MG, Cheung AL.

Antimicrob Agents Chemother. 2015 Apr;59(4):1876-85. doi: 10.1128/AAC.04164-14. Epub 2015 Jan 12.


Reduction of the peptidoglycan crosslinking causes a decrease in stiffness of the Staphylococcus aureus cell envelope.

Loskill P, Pereira PM, Jung P, Bischoff M, Herrmann M, Pinho MG, Jacobs K.

Biophys J. 2014 Sep 2;107(5):1082-1089. doi: 10.1016/j.bpj.2014.07.029.


Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the Drosophila innate immune system.

Atilano ML, Pereira PM, Vaz F, Catalão MJ, Reed P, Grilo IR, Sobral RG, Ligoxygakis P, Pinho MG, Filipe SR.

Elife. 2014 Apr 1;3:e02277. doi: 10.7554/eLife.02277.


Differential localization of LTA synthesis proteins and their interaction with the cell division machinery in Staphylococcus aureus.

Reichmann NT, Piçarra Cassona C, Monteiro JM, Bottomley AL, Corrigan RM, Foster SJ, Pinho MG, Gründling A.

Mol Microbiol. 2014 Apr;92(2):273-86. doi: 10.1111/mmi.12551. Epub 2014 Mar 20.


Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.

Mann PA, Müller A, Xiao L, Pereira PM, Yang C, Ho Lee S, Wang H, Trzeciak J, Schneeweis J, Dos Santos MM, Murgolo N, She X, Gill C, Balibar CJ, Labroli M, Su J, Flattery A, Sherborne B, Maier R, Tan CM, Black T, Onder K, Kargman S, Monsma FJ Jr, Pinho MG, Schneider T, Roemer T.

ACS Chem Biol. 2013 Nov 15;8(11):2442-51. doi: 10.1021/cb400487f. Epub 2013 Sep 5.


How to get (a)round: mechanisms controlling growth and division of coccoid bacteria.

Pinho MG, Kjos M, Veening JW.

Nat Rev Microbiol. 2013 Sep;11(9):601-14. doi: 10.1038/nrmicro3088. Review.


Auxiliary factors: a chink in the armor of MRSA resistance to β-lactam antibiotics.

Roemer T, Schneider T, Pinho MG.

Curr Opin Microbiol. 2013 Oct;16(5):538-48. doi: 10.1016/j.mib.2013.06.012. Epub 2013 Jul 26. Review.


Effect of oxygen on glucose metabolism: utilization of lactate in Staphylococcus aureus as revealed by in vivo NMR studies.

Ferreira MT, Manso AS, Gaspar P, Pinho MG, Neves AR.

PLoS One. 2013;8(3):e58277. doi: 10.1371/journal.pone.0058277. Epub 2013 Mar 5.


Anti-biofouling 3D porous systems: the blend effect of oxazoline-based oligomers on chitosan scaffolds.

Correia VG, Coelho M, Barroso T, Raje VP, Bonifácio VD, Casimiro T, Pinho MG, Aguiar-Ricardo A.

Biofouling. 2013;29(3):273-82. doi: 10.1080/08927014.2013.766172.


The Holliday junction resolvase RecU is required for chromosome segregation and DNA damage repair in Staphylococcus aureus.

Pereira AR, Reed P, Veiga H, Pinho MG.

BMC Microbiol. 2013 Jan 28;13:18. doi: 10.1186/1471-2180-13-18. Erratum in: BMC Microbiol. 2017 May 22;17 (1):119.


The Staphylococcus aureus Membrane Protein SA2056 Interacts with Peptidoglycan Synthesis Enzymes.

Quiblier C, Luczak-Kadlubowska A, Holdener E, Alborn D, Schneider T, Wiedemann I, Pinho MG, Sahl HG, Rohrer S, Berger-Bächi B, Senn MM.

Antibiotics (Basel). 2013 Jan 22;2(1):11-27. doi: 10.3390/antibiotics2010011.


Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams.

Farha MA, Leung A, Sewell EW, D'Elia MA, Allison SE, Ejim L, Pereira PM, Pinho MG, Wright GD, Brown ED.

ACS Chem Biol. 2013 Jan 18;8(1):226-33. doi: 10.1021/cb300413m. Epub 2012 Oct 19.


Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.

Tan CM, Therien AG, Lu J, Lee SH, Caron A, Gill CJ, Lebeau-Jacob C, Benton-Perdomo L, Monteiro JM, Pereira PM, Elsen NL, Wu J, Deschamps K, Petcu M, Wong S, Daigneault E, Kramer S, Liang L, Maxwell E, Claveau D, Vaillancourt J, Skorey K, Tam J, Wang H, Meredith TC, Sillaots S, Wang-Jarantow L, Ramtohul Y, Langlois E, Landry F, Reid JC, Parthasarathy G, Sharma S, Baryshnikova A, Lumb KJ, Pinho MG, Soisson SM, Roemer T.

Sci Transl Med. 2012 Mar 21;4(126):126ra35. doi: 10.1126/scitranslmed.3003592.


EzrA contributes to the regulation of cell size in Staphylococcus aureus.

Jorge AM, Hoiczyk E, Gomes JP, Pinho MG.

PLoS One. 2011;6(11):e27542. doi: 10.1371/journal.pone.0027542. Epub 2011 Nov 14.


New role of the disulfide stress effector YjbH in β-lactam susceptibility of Staphylococcus aureus.

Göhring N, Fedtke I, Xia G, Jorge AM, Pinho MG, Bertsche U, Peschel A.

Antimicrob Agents Chemother. 2011 Dec;55(12):5452-8. doi: 10.1128/AAC.00286-11. Epub 2011 Sep 26.


Oxazoline-based antimicrobial oligomers: synthesis by CROP using supercritical CO2.

Correia VG, Bonifácio VD, Raje VP, Casimiro T, Moutinho G, da Silva CL, Pinho MG, Aguiar-Ricardo A.

Macromol Biosci. 2011 Aug 11;11(8):1128-37. doi: 10.1002/mabi.201100126. Epub 2011 Jun 15.


Absence of nucleoid occlusion effector Noc impairs formation of orthogonal FtsZ rings during Staphylococcus aureus cell division.

Veiga H, Jorge AM, Pinho MG.

Mol Microbiol. 2011 Jun;80(5):1366-80. doi: 10.1111/j.1365-2958.2011.07651.x. Epub 2011 Apr 17.


Monofunctional transglycosylases are not essential for Staphylococcus aureus cell wall synthesis.

Reed P, Veiga H, Jorge AM, Terrak M, Pinho MG.

J Bacteriol. 2011 May;193(10):2549-56. doi: 10.1128/JB.01474-10. Epub 2011 Mar 25.


Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus.

Atilano ML, Pereira PM, Yates J, Reed P, Veiga H, Pinho MG, Filipe SR.

Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18991-6. doi: 10.1073/pnas.1004304107. Epub 2010 Oct 13.


Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2.

Bernal P, Lemaire S, Pinho MG, Mobashery S, Hinds J, Taylor PW.

J Biol Chem. 2010 Jul 30;285(31):24055-65. doi: 10.1074/jbc.M110.114793. Epub 2010 Jun 1.


Fluorescent reporters for studies of cellular localization of proteins in Staphylococcus aureus.

Pereira PM, Veiga H, Jorge AM, Pinho MG.

Appl Environ Microbiol. 2010 Jul;76(13):4346-53. doi: 10.1128/AEM.00359-10. Epub 2010 May 7.


Evidence for a dual role of PBP1 in the cell division and cell separation of Staphylococcus aureus.

Pereira SF, Henriques AO, Pinho MG, de Lencastre H, Tomasz A.

Mol Microbiol. 2009 May;72(4):895-904. doi: 10.1111/j.1365-2958.2009.06687.x. Epub 2009 Apr 27.


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