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Items: 30


Analysis of cell-free circulating tumor DNA in 419 patients with glioblastoma and other primary brain tumors.

Piccioni DE, Achrol AS, Kiedrowski LA, Banks KC, Boucher N, Barkhoudarian G, Kelly DF, Juarez T, Lanman RB, Raymond VM, Nguyen M, Truong JD, Heng A, Gill J, Saria M, Pingle SC, Kesari S.

CNS Oncol. 2019 Mar 11. doi: 10.2217/cns-2018-0015. [Epub ahead of print]


Pritumumab, the first therapeutic antibody for glioma patients.

Babic I, Nurmemmedov E, Yenugonda VM, Juarez T, Nomura N, Pingle SC, Glassy MC, Kesari S.

Hum Antibodies. 2018 Feb 5;26(2):95-101. doi: 10.3233/HAB-170326. Review.


Monitoring Daily Dynamics of Early Tumor Response to Targeted Therapy by Detecting Circulating Tumor DNA in Urine.

Husain H, Melnikova VO, Kosco K, Woodward B, More S, Pingle SC, Weihe E, Park BH, Tewari M, Erlander MG, Cohen E, Lippman SM, Kurzrock R.

Clin Cancer Res. 2017 Aug 15;23(16):4716-4723. doi: 10.1158/1078-0432.CCR-17-0454. Epub 2017 Apr 18.


Intrinsic Photosensitivity Enhances Motility of T Lymphocytes.

Phan TX, Jaruga B, Pingle SC, Bandyopadhyay BC, Ahern GP.

Sci Rep. 2016 Dec 20;6:39479. doi: 10.1038/srep39479.


Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells.

Jiang P, Zhang P, Mukthavaram R, Nomura N, Pingle SC, Teng D, Chien S, Guo F, Kesari S.

Oncotarget. 2016 Sep 6;7(36):57932-57942. doi: 10.18632/oncotarget.10773.


Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies.

Xiu J, Piccioni D, Juarez T, Pingle SC, Hu J, Rudnick J, Fink K, Spetzler DB, Maney T, Ghazalpour A, Bender R, Gatalica Z, Reddy S, Sanai N, Idbaih A, Glantz M, Kesari S.

Oncotarget. 2016 Apr 19;7(16):21556-69. doi: 10.18632/oncotarget.7722.


Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma.

Tsigelny IF, Mukthavaram R, Kouznetsova VL, Chao Y, Babic I, Nurmemmedov E, Pastorino S, Jiang P, Calligaris D, Agar N, Scadeng M, Pingle SC, Wrasidlo W, Makale MT, Kesari S.

Oncotarget. 2017 Apr 4;8(14):22370-22384. doi: 10.18632/oncotarget.5633.


Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres.

Mukthavaram R, Ouyang X, Saklecha R, Jiang P, Nomura N, Pingle SC, Guo F, Makale M, Kesari S.

J Transl Med. 2015 Aug 18;13:269. doi: 10.1186/s12967-015-0627-5.


Molecular profiling of gliomas: potential therapeutic implications.

Alentorn A, Duran-Peña A, Pingle SC, Piccioni DE, Idbaih A, Kesari S.

Expert Rev Anticancer Ther. 2015;15(8):955-62. doi: 10.1586/14737140.2015.1062368. Epub 2015 Jun 28. Review.


Plexin-B2 promotes invasive growth of malignant glioma.

Le AP, Huang Y, Pingle SC, Kesari S, Wang H, Yong RL, Zou H, Friedel RH.

Oncotarget. 2015 Mar 30;6(9):7293-304.


T lymphocytes possess the machinery for 5-HT synthesis, storage, degradation and release.

Chen Y, Leon-Ponte M, Pingle SC, O'Connell PJ, Ahern GP.

Acta Physiol (Oxf). 2015 Apr;213(4):860-7. doi: 10.1111/apha.12470. Epub 2015 Feb 28.


Hierarchical control of coherent gene clusters defines the molecular mechanisms of glioblastoma.

Tsigelny IF, Kouznetsova VL, Jiang P, Pingle SC, Kesari S.

Mol Biosyst. 2015 Apr;11(4):1012-28. doi: 10.1039/c5mb00007f.


Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction.

Fogal V, Babic I, Chao Y, Pastorino S, Mukthavaram R, Jiang P, Cho YJ, Pingle SC, Crawford JR, Piccioni DE, Kesari S.

Oncotarget. 2015 Jan 20;6(2):1157-70.


In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.

Jiang P, Mukthavaram R, Chao Y, Nomura N, Bharati IS, Fogal V, Pastorino S, Teng D, Cong X, Pingle SC, Kapoor S, Shetty K, Aggrawal A, Vali S, Abbasi T, Chien S, Kesari S.

Br J Cancer. 2014 Oct 14;111(8):1562-71. doi: 10.1038/bjc.2014.431. Epub 2014 Aug 5.


In silico modeling predicts drug sensitivity of patient-derived cancer cells.

Pingle SC, Sultana Z, Pastorino S, Jiang P, Mukthavaram R, Chao Y, Bharati IS, Nomura N, Makale M, Abbasi T, Kapoor S, Kumar A, Usmani S, Agrawal A, Vali S, Kesari S.

J Transl Med. 2014 May 21;12:128. doi: 10.1186/1479-5876-12-128.


bHLH Transcription factors inhibitors for cancer therapy: general features for in silico drug design.

Tsigelny IF, Kouznetsova VL, Pingle SC, Kesari S.

Curr Med Chem. 2014;21(28):3227-43. Review.


Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases.

Nomura N, Pastorino S, Jiang P, Lambert G, Crawford JR, Gymnopoulos M, Piccioni D, Juarez T, Pingle SC, Makale M, Kesari S.

Cancer Cell Int. 2014 Mar 20;14(1):26. doi: 10.1186/1475-2867-14-26.


Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs.

Jiang P, Mukthavaram R, Chao Y, Bharati IS, Fogal V, Pastorino S, Cong X, Nomura N, Gallagher M, Abbasi T, Vali S, Pingle SC, Makale M, Kesari S.

J Transl Med. 2014 Jan 17;12:13. doi: 10.1186/1479-5876-12-13. Erratum in: J Transl Med. 2014;12:126. Mukthavavam, Rajesh [corrected to Mukthavaram, Rajesh].


High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile.

Mukthavaram R, Jiang P, Saklecha R, Simberg D, Bharati IS, Nomura N, Chao Y, Pastorino S, Pingle SC, Fogal V, Wrasidlo W, Makale M, Kesari S.

Int J Nanomedicine. 2013;8:3991-4006. doi: 10.2147/IJN.S51949. Epub 2013 Oct 21.


An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII.

Li L, Chakraborty S, Yang CR, Hatanpaa KJ, Cipher DJ, Puliyappadamba VT, Rehman A, Jiwani AJ, Mickey B, Madden C, Raisanen J, Burma S, Saha D, Wang Z, Pingle SC, Kesari S, Boothman DA, Habib AA.

Oncogene. 2014 Aug 14;33(33):4253-64. doi: 10.1038/onc.2013.400. Epub 2013 Sep 30.


Store-operated Ca²+ signaling in dendritic cells occurs independently of STIM1.

Bandyopadhyay BC, Pingle SC, Ahern GP.

J Leukoc Biol. 2011 Jan;89(1):57-62. doi: 10.1189/jlb.0610381. Epub 2010 Oct 22.


Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthase.

Pingle SC, Jajoo S, Mukherjea D, Sniderhan LF, Jhaveri KA, Marcuzzi A, Rybak LP, Maggirwar SB, Ramkumar V.

Mol Pharmacol. 2007 Oct;72(4):856-67. Epub 2007 Jul 3.


Capsaicin receptor: TRPV1 a promiscuous TRP channel.

Pingle SC, Matta JA, Ahern GP.

Handb Exp Pharmacol. 2007;(179):155-71. Review.


Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation.

Premkumar LS, Raisinghani M, Pingle SC, Long C, Pimentel F.

J Neurosci. 2005 Dec 7;25(49):11322-9.


A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells.

O'Connell PJ, Wang X, Leon-Ponte M, Griffiths C, Pingle SC, Ahern GP.

Blood. 2006 Feb 1;107(3):1010-7. Epub 2005 Oct 13.


Dendritic cells do not transduce inflammatory stimuli via the capsaicin receptor TRPV1.

O'Connell PJ, Pingle SC, Ahern GP.

FEBS Lett. 2005 Sep 26;579(23):5135-9.


Osmotic diuretics induce adenosine A1 receptor expression and protect renal proximal tubular epithelial cells against cisplatin-mediated apoptosis.

Pingle SC, Mishra S, Marcuzzi A, Bhat SG, Sekino Y, Rybak LP, Ramkumar V.

J Biol Chem. 2004 Oct 8;279(41):43157-67. Epub 2004 Jul 22.


Noise induces A1 adenosine receptor expression in the chinchilla cochlea.

Ramkumar V, Whitworth CA, Pingle SC, Hughes LF, Rybak LP.

Hear Res. 2004 Feb;188(1-2):47-56.


Hypertonicity inhibits lipopolysaccharide-induced nitric oxide synthase expression in smooth muscle cells by inhibiting nuclear factor kappaB.

Pingle SC, Sanchez JF, Hallam DM, Williamson AL, Maggirwar SB, Ramkumar V.

Mol Pharmacol. 2003 Jun;63(6):1238-47.


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