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Human papillomavirus (HPV) prevalence and associated risk factors in women from Curaçao.

Hooi DJ, Lissenberg-Witte BI, Kenter G, de Koning MNC, Gomes Bravio I, Ardts K, Kleinmoedig S, Benita E, Pinedo HM, Berkhof J, Quint WGV, Meijer CJLM.

PLoS One. 2018 Jul 13;13(7):e0199624. doi: 10.1371/journal.pone.0199624. eCollection 2018.


Human papillomavirus (HPV) types prevalence in cervical samples of female sex-workers on Curaçao.

Hooi DJ, Quint WGV, Lissenberg-Witte BI, Kenter G, Pinedo HM, de Koning MNC, Meijer CJLM.

Prev Med Rep. 2018 Jun 2;11:120-124. doi: 10.1016/j.pmedr.2018.06.001. eCollection 2018 Sep.


Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala.

Lou H, Gharzouzi E, Guerra SP, Domgue JF, Sawitzke J, Villagran G, Garland L, Boland JF, Wagner S, Rosas H, Troxler J, McMillen H, Kessing B, Alvirez E, Castillo M, Morales H, Argueta V, Rosingh A, van Aerde-van Nunen FJHB, Lopez G, Pinedo HM, Schiffman M, Dean M, Orozco R.

BMC Cancer. 2018 May 15;18(1):562. doi: 10.1186/s12885-018-4438-y.


Supravaginal hysterectomy in Curaçao prevalence and impact on screening for cervical cancer.

Hooi DJ, Meijer CJLM, Witte BI, Bravio IG, Pinedo HM, Kenter GG.

Prev Med Rep. 2017 Nov 8;8:238-241. doi: 10.1016/j.pmedr.2017.11.005. eCollection 2017 Dec.


High prevalence of high-risk HPV genotypes other than 16 and 18 in cervical cancers of Curaçao: implications for choice of prophylactic HPV vaccine.

Hooi DJ, Lissenberg-Witte BI, de Koning MNC, Pinedo HM, Kenter GG, Meijer CJ, Quint WG.

Sex Transm Infect. 2018 Jun;94(4):263-267. doi: 10.1136/sextrans-2017-053109. Epub 2017 Oct 11.


The 42nd David A. Karnofsky Memorial Award Lecture: Understanding.

Pinedo HM.

J Clin Oncol. 2015 Feb 10;33(5):510-7. doi: 10.1200/JCO.2014.59.4036. Epub 2015 Jan 5. No abstract available.


A Bill of Rights for patients with cancer in Europe.

Lawler M, Le Chevalier T, Banks I, Conte P, De Lorenzo F, Meunier F, Pinedo HM, Selby P, Murphy MJ, Johnston PG; European Cancer Concord (ECC).

Lancet Oncol. 2014 Mar;15(3):258-60. doi: 10.1016/S1470-2045(13)70552-7. Epub 2014 Feb 4. No abstract available.


A catalyst for change: the European cancer Patient's Bill of Rights.

Lawler M, Le Chevalier T, Murphy MJ Jr, Banks I, Conte P, De Lorenzo F, Meunier F, Pinedo HM, Selby P, Armand JP, Barbacid M, Barzach M, Bergh J, Bode G, Cameron DA, de Braud F, de Gramont A, Diehl V, Diler S, Erdem S, Fitzpatrick JM, Geissler J, Hollywood D, Højgaard L, Horgan D, Jassem J, Johnson PW, Kapitein P, Kelly J, Kloezen S, La Vecchia C, Löwenberg B, Oliver K, Sullivan R, Tabernero J, Van de Velde CJ, Wilking N, Wilson R, Zielinski C, Zur Hausen H, Johnston PG.

Oncologist. 2014 Mar;19(3):217-24. doi: 10.1634/theoncologist.2013-0452. Epub 2014 Feb 3. No abstract available.


IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation.

Lindenberg JJ, Oosterhoff D, Sombroek CC, Lougheed SM, Hooijberg E, Stam AG, Santegoets SJ, Tijssen HJ, Buter J, Pinedo HM, van den Eertwegh AJ, Scheper RJ, Koenen HJ, van de Ven R, de Gruijl TD.

PLoS One. 2013 Jul 18;8(7):e70237. doi: 10.1371/journal.pone.0070237. Print 2013.


Commentary: fifty years of the European Organisation for Research and Treatment Of Cancer (EORTC)--making the difference for the European oncology community.

Meunier F, Lawler M, Pinedo HM.

Oncologist. 2012;17(6):e6-7. doi: 10.1634/theoncologist.2012-0237. No abstract available.


Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial.

van den Eertwegh AJ, Versluis J, van den Berg HP, Santegoets SJ, van Moorselaar RJ, van der Sluis TM, Gall HE, Harding TC, Jooss K, Lowy I, Pinedo HM, Scheper RJ, Stam AG, von Blomberg BM, de Gruijl TD, Hege K, Sacks N, Gerritsen WR.

Lancet Oncol. 2012 May;13(5):509-17. doi: 10.1016/S1470-2045(12)70007-4. Epub 2012 Feb 10.


Clinical effects of adjuvant active specific immunotherapy differ between patients with microsatellite-stable and microsatellite-instable colon cancer.

de Weger VA, Turksma AW, Voorham QJ, Euler Z, Bril H, van den Eertwegh AJ, Bloemena E, Pinedo HM, Vermorken JB, van Tinteren H, Meijer GA, Hooijberg E.

Clin Cancer Res. 2012 Feb 1;18(3):882-9. doi: 10.1158/1078-0432.CCR-11-1716. Epub 2011 Dec 12.


Molecular tests for colorectal cancer screening.

Bosch LJ, Carvalho B, Fijneman RJ, Jimenez CR, Pinedo HM, van Engeland M, Meijer GA.

Clin Colorectal Cancer. 2011 Mar 1;10(1):8-23. doi: 10.3816/CCC.2011.n.002. Review.


The high tide of cancer research in Europe.

Johnston PG, Pinedo HM.

Oncologist. 2011;16(5):539-42. doi: 10.1634/theoncologist.2011-0119. No abstract available.


Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.

Mauritz R, Giovannetti E, Beumer IJ, Smid K, Van Groeningen CJ, Pinedo HM, Peters GJ.

Clin Colorectal Cancer. 2009 Jul;8(3):146-54. doi: 10.3816/CCC.2009.n.024.


Preoperative [18F] FDG-PET after chemotherapy in locally advanced breast cancer: prognostic value as compared with histopathology.

Emmering J, Krak NC, Van der Hoeven JJ, Spreeuwenberg MD, Twisk JW, Meijer S, Pinedo HM, Hoekstra OS.

Ann Oncol. 2008 Sep;19(9):1573-7. doi: 10.1093/annonc/mdn185. Epub 2008 Jun 13.


Whole-cell cancer vaccination: from autologous to allogeneic tumor- and dendritic cell-based vaccines.

de Gruijl TD, van den Eertwegh AJ, Pinedo HM, Scheper RJ.

Cancer Immunol Immunother. 2008 Oct;57(10):1569-77. doi: 10.1007/s00262-008-0536-z. Epub 2008 Jun 4. Review.


Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial.

Park BH, Hwang T, Liu TC, Sze DY, Kim JS, Kwon HC, Oh SY, Han SY, Yoon JH, Hong SH, Moon A, Speth K, Park C, Ahn YJ, Daneshmand M, Rhee BG, Pinedo HM, Bell JC, Kirn DH.

Lancet Oncol. 2008 Jun;9(6):533-42. doi: 10.1016/S1470-2045(08)70107-4. Epub 2008 May 19. Erratum in: Lancet Oncol. 2008 Jul;9(7):613.


Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo.

Mauritz R, Peters GJ, Kathmann I, Teshale H, Noordhuis P, Comijn EM, Pinedo HM, Jansen G.

Cancer Chemother Pharmacol. 2008 Nov;62(6):937-48. doi: 10.1007/s00280-008-0683-0. Epub 2008 Feb 19.


[Osteoporosis in patients under treatment for cancer and the possibilities for prevention and treatment].

Eekhoff EM, Pinedo HM, Lips P.

Ned Tijdschr Geneeskd. 2007 Jun 23;151(25):1388-93. Review. Dutch.


Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition.

Verheul HM, Pinedo HM.

Nat Rev Cancer. 2007 Jun;7(6):475-85. doi: 10.1038/nrc2152. Review.


The 18 kDa isoform of basic fibroblast growth factor is sufficient to stimulate human melanoma growth and angiogenesis.

Fontijn D, Duyndam MC, Beliën JA, Gallegoz Ruiz MI, Pinedo HM, Boven E.

Melanoma Res. 2007 Jun;17(3):155-68.


Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor I activity in human ovarian cancer cells.

Duyndam MC, van Berkel MP, Dorsman JC, Rockx DA, Pinedo HM, Boven E.

Biochem Pharmacol. 2007 Jul 15;74(2):191-201. Epub 2007 Apr 6.


Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.

Giovannetti E, Backus HH, Wouters D, Ferreira CG, van Houten VM, Brakenhoff RH, Poupon MF, Azzarello A, Pinedo HM, Peters GJ.

Br J Cancer. 2007 Mar 12;96(5):769-75.


Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer.

Mauritz R, van Groeningen CJ, Smid K, Jansen G, Pinedo HM, Peters GJ.

Int J Cancer. 2007 Jun 15;120(12):2609-12.


Active specific immunotherapy with autologous tumor cell vaccines for stage II colon cancer: logistics, efficacy, safety and immunological Pharmacodynamics.

Hanna MG Jr, Hoover HC Jr, Pinedo HM, Finer M.

Hum Vaccin. 2006 Jul-Aug;2(4):185-91. Epub 2006 Jul 6.


A CD34(+) human cell line model of myeloid dendritic cell differentiation: evidence for a CD14(+)CD11b(+) Langerhans cell precursor.

Santegoets SJ, Masterson AJ, van der Sluis PC, Lougheed SM, Fluitsma DM, van den Eertwegh AJ, Pinedo HM, Scheper RJ, de Gruijl TD.

J Leukoc Biol. 2006 Dec;80(6):1337-44. Epub 2006 Sep 7.


A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance.

de Gruijl TD, Sombroek CC, Lougheed SM, Oosterhoff D, Buter J, van den Eertwegh AJ, Scheper RJ, Pinedo HM.

J Immunol. 2006 Jun 15;176(12):7232-42.


On our way to targeted therapy for cachexia in cancer?

Boddaert MS, Gerritsen WR, Pinedo HM.

Curr Opin Oncol. 2006 Jul;18(4):335-40. Review.


CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells.

Fontijn D, Duyndam MC, van Berkel MP, Yuana Y, Shapiro LH, Pinedo HM, Broxterman HJ, Boven E.

Br J Cancer. 2006 Jun 5;94(11):1627-36.


Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer.

Kroep JR, Smit EF, Giaccone G, Van der Born K, Beijnen JH, Van Groeningen CJ, Van der Vijgh WJ, Postmus PE, Pinedo HM, Peters GJ.

Cancer Chemother Pharmacol. 2006 Oct;58(4):509-16. Epub 2006 Mar 7.


Effects of gemcitabine on cis-platinum-DNA adduct formation and repair in a panel of gemcitabine and cisplatin-sensitive or -resistant human ovarian cancer cell lines.

Peters GJ, Van Moorsel CJ, Lakerveld B, Smid K, Noordhuis P, Comijn EC, Weaver D, Willey JC, Voorn D, Van der Vijgh WJ, Pinedo HM.

Int J Oncol. 2006 Jan;28(1):237-44.


Angiogenesis inhibitors: what is the clinical future?

Verheul HM, Pinedo HM.

Prog Drug Res. 2005;63:67-91. Review. No abstract available.


Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase.

Smorenburg CH, Peters GJ, van Groeningen CJ, Noordhuis P, Smid K, van Riel AM, Dercksen W, Pinedo HM, Giaccone G.

Ann Oncol. 2006 Jan;17(1):35-42. Epub 2005 Oct 26.


Dose-finding study of the multitargeted tyrosine kinase inhibitor SU6668 in patients with advanced malignancies.

Kuenen BC, Giaccone G, Ruijter R, Kok A, Schalkwijk C, Hoekman K, Pinedo HM.

Clin Cancer Res. 2005 Sep 1;11(17):6240-6.


Pharmacokinetics of bolus 5-fluorouracil: relationship between dose, plasma concentrations, area-under-the-curve and toxicity.

Codacci-Pisanelli G, Pinedo HM, Lankelma J, Van Groeningen CJ, Van Kuilenburg AB, Van Gennip AH, Peters GJ.

J Chemother. 2005 Jun;17(3):315-20.


Melanoma-specific tumor-infiltrating lymphocytes but not circulating melanoma-specific T cells may predict survival in resected advanced-stage melanoma patients.

Haanen JB, Baars A, Gomez R, Weder P, Smits M, de Gruijl TD, von Blomberg BM, Bloemena E, Scheper RJ, van Ham SM, Pinedo HM, van den Eertwegh AJ.

Cancer Immunol Immunother. 2006 Apr;55(4):451-8. Epub 2005 Jul 21.


Recombinant human endostatin administered as a 28-day continuous intravenous infusion, followed by daily subcutaneous injections: a phase I and pharmacokinetic study in patients with advanced cancer.

Hansma AH, Broxterman HJ, van der Horst I, Yuana Y, Boven E, Giaccone G, Pinedo HM, Hoekman K.

Ann Oncol. 2005 Oct;16(10):1695-701. Epub 2005 Jul 12.


Inhibition of angiogenesis in cancer patients.

Verheul HM, Pinedo HM.

Expert Opin Emerg Drugs. 2005 May;10(2):403-12. Review.


Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11.

Oosterhoff D, Overmeer RM, de Graaf M, van der Meulen IH, Giaccone G, van Beusechem VW, Haisma HJ, Pinedo HM, Gerritsen WR.

Br J Cancer. 2005 Mar 14;92(5):882-7.


Induction of p53 up-regulated modulator of apoptosis messenger RNA by chemotherapeutic treatment of locally advanced breast cancer.

Middelburg R, de Haas RR, Dekker H, Kerkhoven RM, Pohlmann PR, Fuentes-Alburo A, Mohar A, Pinedo HM, Lankelma J.

Clin Cancer Res. 2005 Mar 1;11(5):1863-9.


Immunotherapy with autologous tumor cell-BCG vaccine in patients with colon cancer: a prospective study of medical and economic benefits.

Uyl-de Groot CA, Vermorken JB, Hanna MG Jr, Verboom P, Groot MT, Bonsel GJ, Meijer CJ, Pinedo HM.

Vaccine. 2005 Mar 18;23(17-18):2379-87.


Gene-directed enzyme prodrug therapy with carboxylesterase enhances the anticancer efficacy of the conditionally replicating adenovirus AdDelta24.

Oosterhoff D, Pinedo HM, Witlox MA, Carette JE, Gerritsen WR, van Beusechem VW.

Gene Ther. 2005 Jun;12(12):1011-8.


Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate.

de Bruin M, van Capel T, Smid K, van der Born K, Fukushima M, Hoekman K, Pinedo HM, Peters GJ.

Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1485-90.


Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients.

Mauritz R, Beumer IJ, Marsh S, McLeod HL, Smid K, van Groeningen CJ, Pinedo HM, Peters GJ.

Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1381-4.


Upregulation of platelet derived endothelial cell growth factor/thymidine phosphorylase by interferon alpha.

de Bruin M, Smid K, van der Ent MA, Fukushima M, Pinedo HM, Peters GJ.

Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1367-70.


A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy.

de Graaf M, Nevalainen TJ, Scheeren HW, Pinedo HM, Haisma HJ, Boven E.

Biochem Pharmacol. 2004 Dec 1;68(11):2273-81.


Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells.

de Bruin M, Peters GJ, Oerlemans R, Assaraf YG, Masterson AJ, Adema AD, Dijkmans BA, Pinedo HM, Jansen G.

Mol Pharmacol. 2004 Oct;66(4):1054-60. Epub 2004 Jul 21.


Angiogenesis: a potential target for therapy of soft tissue sarcomas.

Hoekman K, Pinedo HM.

Cancer Treat Res. 2004;120:169-80. Review. No abstract available.


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