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Engineering allosteric regulation in protein kinases.

Pincus D, Pandey JP, Feder ZA, Creixell P, Resnekov O, Reynolds KA.

Sci Signal. 2018 Nov 6;11(555). pii: eaar3250. doi: 10.1126/scisignal.aar3250.


Genetic and epigenetic determinants establish a continuum of Hsf1 occupancy and activity across the yeast genome.

Pincus D, Anandhakumar J, Thiru P, Guertin MJ, Erkine AM, Gross DS.

Mol Biol Cell. 2018 Oct 17:mbcE18060353. doi: 10.1091/mbc.E18-06-0353. [Epub ahead of print]


Working From Home: An Initial Pilot Examination of Videoconferencing-Based Cognitive Behavioral Therapy for Anxious Youth Delivered to the Home Setting.

Carpenter AL, Pincus DB, Furr JM, Comer JS.

Behav Ther. 2018 Nov;49(6):917-930. doi: 10.1016/j.beth.2018.01.007. Epub 2018 Mar 5.


Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.

Creixell P, Pandey JP, Palmeri A, Bhattacharyya M, Creixell M, Ranganathan R, Pincus D, Yaffe MB.

Cell Syst. 2018 Oct 24;7(4):371-383.e4. doi: 10.1016/j.cels.2018.08.008. Epub 2018 Sep 19.


Medical Costs of Delayed Hip Fracture Surgery.

Pincus D, Wasserstein D, Ravi B, Huang A, Paterson JM, Jenkinson RJ, Kreder HJ, Nathens AB, Wodchis WP.

J Bone Joint Surg Am. 2018 Aug 15;100(16):1387-1396. doi: 10.2106/JBJS.17.01147.


N-methyl-D-aspartate Partial Agonist Enhanced Intensive Cognitive-Behavioral Therapy of Panic Disorder in Adolescents.

Leyfer O, Carpenter A, Pincus D.

Child Psychiatry Hum Dev. 2018 Aug 4. doi: 10.1007/s10578-018-0837-1. [Epub ahead of print]


Reporting and evaluating wait times for urgent hip fracture surgery in Ontario, Canada.

Pincus D, Wasserstein D, Ravi B, Byrne JP, Huang A, Paterson JM, Nathens AB, Kreder HJ, Jenkinson RJ, Wodchis WP.

CMAJ. 2018 Jun 11;190(23):E702-E709. doi: 10.1503/cmaj.170830.


Wait Time for Hip Fracture Surgery and Mortality-Reply.

Pincus D, Ravi B, Wodchis WP.

JAMA. 2018 Jun 5;319(21):2234-2235. doi: 10.1001/jama.2018.4426. No abstract available.


Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides.

Truttmann MC, Pincus D, Ploegh HL.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5008-E5017. doi: 10.1073/pnas.1801989115. Epub 2018 May 14.


Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity.

Zheng X, Beyzavi A, Krakowiak J, Patel N, Khalil AS, Pincus D.

Cell Rep. 2018 Mar 20;22(12):3099-3106. doi: 10.1016/j.celrep.2018.02.083.


Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.

Kayatekin C, Amasino A, Gaglia G, Flannick J, Bonner JM, Fanning S, Narayan P, Barrasa MI, Pincus D, Landgraf D, Nelson J, Hesse WR, Costanzo M; AMP T2D-GENES Consortium, Myers CL, Boone C, Florez JC, Lindquist S.

Cell. 2018 Mar 22;173(1):62-73.e9. doi: 10.1016/j.cell.2018.02.026. Epub 2018 Mar 8.


Identification and Characterization of Clostridium difficile Sequence Type 37 Genotype by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.

Li R, Xiao D, Yang J, Sun S, Kaplan S, Li Z, Niu Y, Qiang C, Zhai Y, Wang X, Zhao X, Zhao B, Welker M, Pincus DH, Jin D, Kamboj M, Zheng G, Zhang G, Zhang J, Tang YW, Zhao J.

J Clin Microbiol. 2018 Apr 25;56(5). pii: e01990-17. doi: 10.1128/JCM.01990-17. Print 2018 May.


Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.

Solís EJ, Pandey JP, Zheng X, Jin DX, Gupta PB, Airoldi EM, Pincus D, Denic V.

Mol Cell. 2018 Feb 1;69(3):534. doi: 10.1016/j.molcel.2018.01.021. No abstract available.


Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response.

Krakowiak J, Zheng X, Patel N, Feder ZA, Anandhakumar J, Valerius K, Gross DS, Khalil AS, Pincus D.

Elife. 2018 Feb 2;7. pii: e31668. doi: 10.7554/eLife.31668.


Virtual Reality As a Training Tool to Treat Physical Inactivity in Children.

Kiefer AW, Pincus D, Richardson MJ, Myer GD.

Front Public Health. 2017 Dec 20;5:349. doi: 10.3389/fpubh.2017.00349. eCollection 2017.


A Preliminary Examination of the Link Between Maternal Experiential Avoidance and Parental Accommodation in Anxious and Non-anxious Children.

Feinberg L, Kerns C, Pincus DB, Comer JS.

Child Psychiatry Hum Dev. 2018 Aug;49(4):652-658. doi: 10.1007/s10578-018-0781-0.


The utility and safety of flexible bronchoscopy in critically ill acute leukemia patients: a retrospective cohort study.

Deotare U, Merman E, Pincus D, Kraguljac AP, Croucher D, Kumar V, Ibrahimova N, Minden MD, Lee C, Mehta S.

Can J Anaesth. 2018 Mar;65(3):272-279. doi: 10.1007/s12630-017-1041-7. Epub 2017 Dec 18.


The Link Between Anxiety Severity and Irritability Among Anxious Youth: Evaluating the Mediating Role of Sleep Problems.

Poznanski B, Cornacchio D, Coxe S, Pincus DB, McMakin DL, Comer JS.

Child Psychiatry Hum Dev. 2018 Jun;49(3):352-359. doi: 10.1007/s10578-017-0769-1.


Association of Overlapping Surgery With Increased Risk for Complications Following Hip Surgery: A Population-Based, Matched Cohort Study.

Ravi B, Pincus D, Wasserstein D, Govindarajan A, Huang A, Austin PC, Jenkinson R, Henry PDG, Paterson JM, Kreder HJ.

JAMA Intern Med. 2018 Jan 1;178(1):75-83. doi: 10.1001/jamainternmed.2017.6835.


The dynamics of stress and fatigue across menopause: attractors, coupling, and resilience.

Taylor-Swanson L, Wong AE, Pincus D, Butner JE, Hahn-Holbrook J, Koithan M, Wann K, Woods NF.

Menopause. 2018 Apr;25(4):380-390. doi: 10.1097/GME.0000000000001025.


Association Between Wait Time and 30-Day Mortality in Adults Undergoing Hip Fracture Surgery.

Pincus D, Ravi B, Wasserstein D, Huang A, Paterson JM, Nathens AB, Kreder HJ, Jenkinson RJ, Wodchis WP.

JAMA. 2017 Nov 28;318(20):1994-2003. doi: 10.1001/jama.2017.17606.


Direct medical costs of motorcycle crashes in Ontario.

Pincus D, Wasserstein D, Nathens AB, Bai YQ, Redelmeier DA, Wodchis WP.

CMAJ. 2017 Nov 20;189(46):E1410-E1415. doi: 10.1503/cmaj.170337.


Transient neonatal zinc deficiency in exclusively breastfed preterm infants.

Watson L, Cartwright D, Jardine LA, Pincus D, Koorts P, Kury S, Bezieau S, George S, Moloney S, Holt J, Coman D.

J Paediatr Child Health. 2018 Mar;54(3):319-322. doi: 10.1111/jpc.13780. Epub 2017 Nov 16. No abstract available.


Serial Immunoprecipitation of 3xFLAG/V5-tagged Yeast Proteins to Identify Specific Interactions with Chaperone Proteins.

Zheng X, Pincus D.

Bio Protoc. 2017 Jun 20;7(12). pii: e2348. doi: 10.21769/BioProtoc.2348.


Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry in Clinical Microbiology: What Are the Current Issues?

van Belkum A, Welker M, Pincus D, Charrier JP, Girard V.

Ann Lab Med. 2017 Nov;37(6):475-483. doi: 10.3343/alm.2017.37.6.475. Review.


Factor structure of the intolerance of uncertainty scale for children.

Cornacchio D, Sanchez AL, Coxe S, Roy A, Pincus DB, Read KL, Holaway RM, Kendall PC, Comer JS.

J Anxiety Disord. 2018 Jan;53:100-107. doi: 10.1016/j.janxdis.2017.07.003. Epub 2017 Jul 31.


Brainstem angiocentric glioma: report of 2 cases.

Weaver KJ, Crawford LM, Bennett JA, Rivera-Zengotita ML, Pincus DW.

J Neurosurg Pediatr. 2017 Oct;20(4):347-351. doi: 10.3171/2017.5.PEDS16402. Epub 2017 Jul 28.


Timing of femoral shaft fracture fixation following major trauma: A retrospective cohort study of United States trauma centers.

Byrne JP, Nathens AB, Gomez D, Pincus D, Jenkinson RJ.

PLoS Med. 2017 Jul 5;14(7):e1002336. doi: 10.1371/journal.pmed.1002336. eCollection 2017 Jul.


Informal regionalization of pediatric fracture care in the Greater Toronto Area: a retrospective cross-sectional study.

Pincus D, Morrison S, Gargan MF, Camp MW.

CMAJ Open. 2017 Jun 14;5(2):E468-E475. doi: 10.9778/cmajo.20160156.


Rate of and Risk Factors for Intermediate-Term Reoperation After Ankle Fracture Fixation: A Population-Based Cohort Study.

Pincus D, Veljkovic A, Zochowski T, Mahomed N, Ogilivie-Harris D, Wasserstein D.

J Orthop Trauma. 2017 Oct;31(10):e315-e320. doi: 10.1097/BOT.0000000000000920.


Outcomes of After-Hours Hip Fracture Surgery.

Pincus D, Desai SJ, Wasserstein D, Ravi B, Paterson JM, Henry P, Kreder HJ, Jenkinson R.

J Bone Joint Surg Am. 2017 Jun 7;99(11):914-922. doi: 10.2106/JBJS.16.00788.


Maternal emotion regulation during child distress, child anxiety accommodation, and links between maternal and child anxiety.

Kerns CE, Pincus DB, McLaughlin KA, Comer JS.

J Anxiety Disord. 2017 Aug;50:52-59. doi: 10.1016/j.janxdis.2017.05.002. Epub 2017 May 10.


Psychotherapy Is Chaotic-(Not Only) in a Computational World.

Schiepek GK, Viol K, Aichhorn W, Hütt MT, Sungler K, Pincus D, Schöller HJ.

Front Psychol. 2017 Apr 24;8:379. doi: 10.3389/fpsyg.2017.00379. eCollection 2017.


A Systematic Review and Appraisal of Clinical Practice Guidelines for Musculoskeletal Soft Tissue Injuries and Conditions.

Pincus D, Kuhn JE, Sheth U, Rizzone K, Colbenson K, Dwyer T, Karpinos A, Marks PH, Wasserstein D.

Am J Sports Med. 2017 May;45(6):1458-1464. doi: 10.1177/0363546516667903. Epub 2016 Oct 17. Review.


An evolution-based strategy for engineering allosteric regulation.

Pincus D, Resnekov O, Reynolds KA.

Phys Biol. 2017 Apr 28;14(2):025002. doi: 10.1088/1478-3975/aa64a4.


Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response.

Truttmann MC, Zheng X, Hanke L, Damon JR, Grootveld M, Krakowiak J, Pincus D, Ploegh HL.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E152-E160. doi: 10.1073/pnas.1619234114. Epub 2016 Dec 28.


Development of a scale to evaluate young children's responses to uncertainty and low environmental structure.

Sanchez AL, Cornacchio D, Chou T, Leyfer O, Coxe S, Pincus D, Comer JS.

J Anxiety Disord. 2017 Jan;45:17-23. doi: 10.1016/j.janxdis.2016.11.006. Epub 2016 Nov 21.


The Relationship Between Worry and Dimensions of Anxiety Symptoms in Children and Adolescents.

Rabner J, Mian ND, Langer DA, Comer JS, Pincus D.

Behav Cogn Psychother. 2017 Mar;45(2):124-138. doi: 10.1017/S1352465816000448. Epub 2016 Nov 17.


Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation.

Zheng X, Krakowiak J, Patel N, Beyzavi A, Ezike J, Khalil AS, Pincus D.

Elife. 2016 Nov 10;5. pii: e18638. doi: 10.7554/eLife.18638.


Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma.

Reinartz R, Wang S, Kebir S, Silver DJ, Wieland A, Zheng T, Küpper M, Rauschenbach L, Fimmers R, Shepherd TM, Trageser D, Till A, Schäfer N, Glas M, Hillmer AM, Cichon S, Smith AA, Pietsch T, Liu Y, Reynolds BA, Yachnis A, Pincus DW, Simon M, Brüstle O, Steindler DA, Scheffler B.

Clin Cancer Res. 2017 Jan 15;23(2):562-574. doi: 10.1158/1078-0432.CCR-15-2089. Epub 2016 Aug 12.


Size doesn't matter in the heat shock response.

Pincus D.

Curr Genet. 2017 May;63(2):175-178. doi: 10.1007/s00294-016-0638-7. Epub 2016 Aug 8. Review.


Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.

Solís EJ, Pandey JP, Zheng X, Jin DX, Gupta PB, Airoldi EM, Pincus D, Denic V.

Mol Cell. 2016 Jul 7;63(1):60-71. doi: 10.1016/j.molcel.2016.05.014. Epub 2016 Jun 16. Erratum in: Mol Cell. 2018 Feb 1;69(3):534.


Investigating the Impact of Flap Overdesign on Viability.

Aherrera AS, Pincus DJ, Vernadakis AJ.

Surg J (N Y). 2016 Jun 6;2(2):e37-e41. doi: 10.1055/s-0036-1584263. eCollection 2016 Apr.


Evaluation of the Vitek MS Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry System for Identification of Clinically Relevant Filamentous Fungi.

McMullen AR, Wallace MA, Pincus DH, Wilkey K, Burnham CA.

J Clin Microbiol. 2016 Aug;54(8):2068-73. doi: 10.1128/JCM.00825-16. Epub 2016 May 25.


FGFR1 N546K and H3F3A K27M mutations in a diffuse leptomeningeal tumour with glial and neuronal markers.

Dyson K, Rivera-Zengotita M, Kresak J, Weaver K, Stover B, Fort J, Rahman M, Pincus DW, Sayour EJ.

Histopathology. 2016 Oct;69(4):704-7. doi: 10.1111/his.12983. Epub 2016 Jul 4. No abstract available.


Moderators of intensive CBT for adolescent panic disorder: the of fear and avoidance.

Elkins RM, Gallo KP, Pincus DB, Comer JS.

Child Adolesc Ment Health. 2016 Feb 1;21(1):30-36. Epub 2015 Sep 8.


Late Effects After Radiotherapy for Childhood Low-grade Glioma.

Williams NL, Rotondo RL, Bradley JA, Pincus DW, Fort JA, Wynn T, Morris CG, Mendenhall NP, Indelicato DJ.

Am J Clin Oncol. 2018 Mar;41(3):307-312. doi: 10.1097/COC.0000000000000267.


The effects of cognitive-behavioral therapy for youth anxiety on sleep problems.

Peterman JS, Carper MM, Elkins RM, Comer JS, Pincus DB, Kendall PC.

J Anxiety Disord. 2016 Jan;37:78-88. doi: 10.1016/j.janxdis.2015.11.006. Epub 2015 Dec 18.


Parental Involvement in Intensive Treatment for Adolescent Panic Disorder and Its Impact on Depression.

Hardway CL, Pincus DB, Gallo KP, Comer JS.

J Child Fam Stud. 2015 Nov 1;24(11):3306-3317. Epub 2015 Jan 29.

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