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Items: 1 to 50 of 139


Quantifying drug-induced bone marrow toxicity using a novel haematopoiesis systems pharmacology model.

Fornari C, O'Connor LO, Pin C, Smith A, Yates JWT, Amy Cheung SY, Jodrell DI, Mettetal JT, Collins TA.

CPT Pharmacometrics Syst Pharmacol. 2019 Sep 11. doi: 10.1002/psp4.12459. [Epub ahead of print]


Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet.

Luo Y, Yang Y, Liu M, Wang D, Wang F, Bi Y, Ji J, Li S, Liu Y, Chen R, Huang H, Wang X, Swidnicka-Siergiejko AK, Janowitz T, Beyaz S, Wang G, Xu S, Bialkowska AB, Luo CK, Pin CL, Liang G, Lu X, Wu M, Shroyer KR, Wolff RA, Plunkett W, Ji B, Li Z, Li E, Li X, Yang VW, Logsdon CD, Abbruzzese JL, Lu W.

Gastroenterology. 2019 Jul 25. pii: S0016-5085(19)41127-X. doi: 10.1053/j.gastro.2019.07.030. [Epub ahead of print]


18F-Labeled PET Probe Targeting Enhancer of Zeste Homologue 2 (EZH2) for Cancer Imaging.

Yu L, Despotovic N, Kovacs MS, Pin CL, Luyt LG.

ACS Med Chem Lett. 2019 Feb 27;10(3):334-340. doi: 10.1021/acsmedchemlett.8b00613. eCollection 2019 Mar 14.


Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation.

Parker A, Vaux L, Patterson AM, Modasia A, Muraro D, Fletcher AG, Byrne HM, Maini PK, Watson AJM, Pin C.

Cell Death Dis. 2019 Feb 6;10(2):108. doi: 10.1038/s41419-018-1275-5.


The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice.

Young CC, Baker RM, Howlett CJ, Hryciw T, Herman JE, Higgs D, Gibbons R, Crawford H, Brown A, Pin CL.

Cell Mol Gastroenterol Hepatol. 2018 Sep 14;7(1):93-113. doi: 10.1016/j.jcmgh.2018.09.004. eCollection 2019.


Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea.

Peters MF, Landry T, Pin C, Maratea K, Dick C, Wagoner MP, Choy AL, Barthlow H, Snow D, Stevens Z, Armento A, Scott CW, Ayehunie S.

Toxicol Sci. 2019 Mar 1;168(1):3-17. doi: 10.1093/toxsci/kfy268.


Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium.

Muraro D, Parker A, Vaux L, Filippi S, Almet AA, Fletcher AG, Watson AJM, Pin C, Maini PK, Byrne HM.

J R Soc Interface. 2018 Aug;15(145). pii: 20180037. doi: 10.1098/rsif.2018.0037.


Epigenetics of gastrointestinal diseases: notes from a workshop.

Marks DL, Olson RL, Urrutia R, Billadeau DD, Roy N, Calin GA, Fabbri M, Koutsioumpa M, Iliopoulos D, Ordog T, Huebert R, Sarmento O, Bamidele AO, Faubion W, Lomberk GL, Siveke J, Ahuja N, Iovanna J, Hlady RA, Robertson K, Kisiel J, Pin CL, Fernandez-Zapico ME.

Epigenetics. 2018;13(4):449-457. doi: 10.1080/15592294.2018.1464351. Epub 2018 Jul 30.


Optical tweezing using tunable optical lattices along a few-mode silicon waveguide.

Pin C, Jager JB, Tardif M, Picard E, Hadji E, de Fornel F, Cluzel B.

Lab Chip. 2018 Jun 12;18(12):1750-1757. doi: 10.1039/c8lc00298c.


Zinc and Metallothionein in the Development and Progression of Dental Caries.

Rahman MT, Hossain A, Pin CH, Yahya NA.

Biol Trace Elem Res. 2019 Jan;187(1):51-58. doi: 10.1007/s12011-018-1369-z. Epub 2018 May 9. Review.


Trapping and Deposition of Dye-Molecule Nanoparticles in the Nanogap of a Plasmonic Antenna.

Pin C, Ishida S, Takahashi G, Sudo K, Fukaminato T, Sasaki K.

ACS Omega. 2018 May 3;3(5):4878-4883. doi: 10.1021/acsomega.8b00282. eCollection 2018 May 31.


An adaptable but threatened big cat: density, diet and prey selection of the Indochinese leopard (Panthera pardus delacouri) in eastern Cambodia.

Rostro-García S, Kamler JF, Crouthers R, Sopheak K, Prum S, In V, Pin C, Caragiulo A, Macdonald DW.

R Soc Open Sci. 2018 Feb 7;5(2):171187. doi: 10.1098/rsos.171187. eCollection 2018 Feb.


The correlation between renal transplantation and liver carcinoma: a meta-analysis.

Yongzhi H, Min X, Bo Y, Pin C, Xueqiang S.

Oncotarget. 2017 Jul 22;8(40):68928-68937. doi: 10.18632/oncotarget.19456. eCollection 2017 Sep 15.


Host-microbe interaction in the gastrointestinal tract.

Parker A, Lawson MAE, Vaux L, Pin C.

Environ Microbiol. 2018 Jul;20(7):2337-2353. doi: 10.1111/1462-2920.13926. Epub 2017 Nov 10. Review.


A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium.

Maclaren OJ, Parker A, Pin C, Carding SR, Watson AJM, Fletcher AG, Byrne HM, Maini PK.

PLoS Comput Biol. 2017 Jul 28;13(7):e1005688. doi: 10.1371/journal.pcbi.1005688. eCollection 2017 Jul.


Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice.

Fazio EN, Young CC, Toma J, Levy M, Berger KR, Johnson CL, Mehmood R, Swan P, Chu A, Cregan SP, Dilworth FJ, Howlett CJ, Pin CL.

Mol Biol Cell. 2017 Sep 1;28(18):2347-2359. doi: 10.1091/mbc.E17-04-0254. Epub 2017 Jul 12.


Lineage-dependent spatial and functional organization of the mammalian enteric nervous system.

Lasrado R, Boesmans W, Kleinjung J, Pin C, Bell D, Bhaw L, McCallum S, Zong H, Luo L, Clevers H, Vanden Berghe P, Pachnis V.

Science. 2017 May 19;356(6339):722-726. doi: 10.1126/science.aam7511.


Characterization of OATP1B3 and OATP2B1 transporter expression in the islet of the adult human pancreas.

Kim M, Deacon P, Tirona RG, Kim RB, Pin CL, Meyer Zu Schwabedissen HE, Wang R, Schwarz UI.

Histochem Cell Biol. 2017 Oct;148(4):345-357. doi: 10.1007/s00418-017-1580-6. Epub 2017 May 10.


Administration of Lactobacillus johnsonii FI9785 to chickens affects colonisation by Campylobacter jejuni and the intestinal microbiota.

Mañes-Lázaro R, Van Diemen PM, Pin C, Mayer MJ, Stevens MP, Narbad A.

Br Poult Sci. 2017 Aug;58(4):373-381. doi: 10.1080/00071668.2017.1307322. Epub 2017 May 12.


Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi.

Parker A, Maclaren OJ, Fletcher AG, Muraro D, Kreuzaler PA, Byrne HM, Maini PK, Watson AJ, Pin C.

FASEB J. 2017 Feb;31(2):636-649. doi: 10.1096/fj.201601002. Epub 2016 Oct 20.


Minimally Invasive Approach in Bilateral Chronic Subdural Hematomas: Surgical Selection and Outcome in 74 Cases.

Min X, Bo Y, Cunzu W, Xun Z, Xiaofeng L, Pin C, Hengzhu Z.

Turk Neurosurg. 2017;27(3):380-385. doi: 10.5137/1019-5149.JTN.16108-15.1.


Integrated plasmonic nanotweezers for nanoparticle manipulation.

Magno G, Ecarnot A, Pin C, Yam V, Gogol P, Mégy R, Cluzel B, Dagens B.

Opt Lett. 2016 Aug 15;41(16):3679-82. doi: 10.1364/OL.41.003679.


A Fibroblast Growth Factor 21-Pregnane X Receptor Pathway Downregulates Hepatic CYP3A4 in Nonalcoholic Fatty Liver Disease.

Woolsey SJ, Beaton MD, Mansell SE, Leon-Ponte M, Yu J, Pin CL, Adams PC, Kim RB, Tirona RG.

Mol Pharmacol. 2016 Oct;90(4):437-46. doi: 10.1124/mol.116.104687. Epub 2016 Aug 1.


Evidence of metabolically active but non-culturable Listeria monocytogenes in long-term growth at 10 °C.

Gurresch A, Gerner W, Pin C, Wagner M, Hein I.

Res Microbiol. 2016 May;167(4):334-343. doi: 10.1016/j.resmic.2016.01.003. Epub 2016 Mar 31.


Atp2c2 Is Transcribed From a Unique Transcriptional Start Site in Mouse Pancreatic Acinar Cells.

Fenech MA, Sullivan CM, Ferreira LT, Mehmood R, MacDonald WA, Stathopulos PB, Pin CL.

J Cell Physiol. 2016 Dec;231(12):2768-78. doi: 10.1002/jcp.25391. Epub 2016 Apr 21.


Quantifying Lgr5-positive stem cell behaviour in the pyloric epithelium.

Leushacke M, Barker N, Pin C.

Sci Rep. 2016 Feb 26;6:21923. doi: 10.1038/srep21923.


A sudden cardiac asystole and cardiopulmonary resuscitation of trigeminocardiac reflex during retrosigmoid approach surgery.

Min X, Jixiang B, Pin C, Cunzu W.

Acta Neurol Belg. 2016 Sep;116(3):415-7. doi: 10.1007/s13760-015-0568-z. Epub 2015 Nov 25. No abstract available.


Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.

Moon PM, Penuela S, Barr K, Khan S, Pin CL, Welch I, Attur M, Abramson SB, Laird DW, Beier F.

J Mol Med (Berl). 2015 Aug;93(8):845-56. doi: 10.1007/s00109-015-1311-1. Epub 2015 Jul 4.


Acinar cell reprogramming: a clinically important target in pancreatic disease.

Pin CL, Ryan JF, Mehmood R.

Epigenomics. 2015;7(2):267-81. doi: 10.2217/epi.14.83. Review.


Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21.

Assini JM, Mulvihill EE, Burke AC, Sutherland BG, Telford DE, Chhoker SS, Sawyez CG, Drangova M, Adams AC, Kharitonenkov A, Pin CL, Huff MW.

Endocrinology. 2015 Jun;156(6):2087-102. doi: 10.1210/en.2014-2003. Epub 2015 Mar 16.


Interactions of Salmonella enterica subspecies enterica serovar Typhimurium with gut bacteria.

Avendaño-Pérez G, Nueno-Palop C, Narbad A, George SM, Baranyi J, Pin C.

Anaerobe. 2015 Jun;33:90-7. doi: 10.1016/j.anaerobe.2015.02.006. Epub 2015 Feb 26.


An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium.

Pin C, Parker A, Gunning AP, Ohta Y, Johnson IT, Carding SR, Sato T.

Integr Biol (Camb). 2015 Feb;7(2):213-28. doi: 10.1039/c4ib00236a.


Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver.

Zhang A, Sieglaff DH, York JP, Suh JH, Ayers SD, Winnier GE, Kharitonenkov A, Pin C, Zhang P, Webb P, Xia X.

J Endocrinol. 2015 Mar;224(3):289-301. doi: 10.1530/JOE-14-0440. Epub 2014 Dec 11.


Predicting the concentration of verotoxin-producing Escherichia coli bacteria during processing and storage of fermented raw-meat sausages.

Quinto EJ, Arinder P, Axelsson L, Heir E, Holck A, Lindqvist R, Lindblad M, Andreou P, Lauzon HL, Marteinsson VÞ, Pin C.

Appl Environ Microbiol. 2014 May;80(9):2715-27. doi: 10.1128/AEM.03791-13. Epub 2014 Feb 21.


Silencing of the Fibroblast growth factor 21 gene is an underlying cause of acinar cell injury in mice lacking MIST1.

Johnson CL, Mehmood R, Laing SW, Stepniak CV, Kharitonenkov A, Pin CL.

Am J Physiol Endocrinol Metab. 2014 Apr 15;306(8):E916-28. doi: 10.1152/ajpendo.00559.2013. Epub 2014 Feb 18.


γδ T-cell-deficient mice show alterations in mucin expression, glycosylation, and goblet cells but maintain an intact mucus layer.

Kober OI, Ahl D, Pin C, Holm L, Carding SR, Juge N.

Am J Physiol Gastrointest Liver Physiol. 2014 Apr 1;306(7):G582-93. doi: 10.1152/ajpgi.00218.2013. Epub 2014 Feb 6.


Epigenetic reprogramming in Mist1(-/-) mice predicts the molecular response to cerulein-induced pancreatitis.

Mehmood R, Varga G, Mohanty SQ, Laing SW, Lu Y, Johnson CL, Kharitonenkov A, Pin CL.

PLoS One. 2014 Jan 21;9(1):e84182. doi: 10.1371/journal.pone.0084182. eCollection 2014.


Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium.

Rosenkrantz JT, Aarts H, Abee T, Rolfe MD, Knudsen GM, Nielsen MB, Thomsen LE, Zwietering MH, Olsen JE, Pin C.

BMC Microbiol. 2013 Dec 17;13:294. doi: 10.1186/1471-2180-13-294.


Comparison of the clonality of urothelial carcinoma developing in the upper urinary tract and those developing in the bladder.

Wang Y, Lang MR, Pin CL, Izawa JI.

Springerplus. 2013 Aug 28;2:412. doi: 10.1186/2193-1801-2-412. eCollection 2013.


Encapsulation of ammonium molybdophosphate and zirconium phosphate in alginate matrix for the sorption of rubidium(I).

Krys P, Testa F, Trochimczuk A, Pin C, Taulemesse JM, Vincent T, Guibal E.

J Colloid Interface Sci. 2013 Nov 1;409:141-50. doi: 10.1016/j.jcis.2013.07.046. Epub 2013 Jul 31.


Loss of culturability of Salmonella enterica subsp. enterica serovar Typhimurium upon cell-cell contact with human fecal bacteria.

Avendaño-Pérez G, Pin C.

Appl Environ Microbiol. 2013 May;79(10):3257-63. doi: 10.1128/AEM.00092-13. Epub 2013 Mar 15.


Mining the "glycocode"--exploring the spatial distribution of glycans in gastrointestinal mucin using force spectroscopy.

Gunning AP, Kirby AR, Fuell C, Pin C, Tailford LE, Juge N.

FASEB J. 2013 Jun;27(6):2342-54. doi: 10.1096/fj.12-221416. Epub 2013 Mar 14.


The transcriptional heat shock response of Salmonella typhimurium shows hysteresis and heated cells show increased resistance to heat and acid stress.

Pin C, Hansen T, Muñoz-Cuevas M, de Jonge R, Rosenkrantz JT, Löfström C, Aarts H, Olsen JE.

PLoS One. 2012;7(12):e51196. doi: 10.1371/journal.pone.0051196. Epub 2012 Dec 7.


Galectin 3-β-galactobiose interactions.

Gunning AP, Pin C, Morris VJ.

Carbohydr Polym. 2013 Jan 30;92(1):529-33. doi: 10.1016/j.carbpol.2012.08.104. Epub 2012 Sep 2.


Modelling the spatio-temporal cell dynamics reveals novel insights on cell differentiation and proliferation in the small intestinal crypt.

Pin C, Watson AJ, Carding SR.

PLoS One. 2012;7(5):e37115. doi: 10.1371/journal.pone.0037115. Epub 2012 May 18.


Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.

Johnson CL, Peat JM, Volante SN, Wang R, McLean CA, Pin CL.

J Pathol. 2012 Nov;228(3):351-65. doi: 10.1002/path.4015. Epub 2012 May 2.


The absence of MIST1 leads to increased ethanol sensitivity and decreased activity of the unfolded protein response in mouse pancreatic acinar cells.

Alahari S, Mehmood R, Johnson CL, Pin CL.

PLoS One. 2011;6(12):e28863. doi: 10.1371/journal.pone.0028863. Epub 2011 Dec 28.


Embryo collection induces transient activation of XBP1 arm of the ER stress response while embryo vitrification does not.

Abraham T, Pin CL, Watson AJ.

Mol Hum Reprod. 2012 May;18(5):229-42. doi: 10.1093/molehr/gar076. Epub 2011 Dec 7.


Lag phase is a distinct growth phase that prepares bacteria for exponential growth and involves transient metal accumulation.

Rolfe MD, Rice CJ, Lucchini S, Pin C, Thompson A, Cameron AD, Alston M, Stringer MF, Betts RP, Baranyi J, Peck MW, Hinton JC.

J Bacteriol. 2012 Feb;194(3):686-701. doi: 10.1128/JB.06112-11. Epub 2011 Dec 2.

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