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Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics.

Jin M, Li Y, O'Laughlin R, Bittihn P, Pillus L, Tsimring LS, Hasty J, Hao N.

Cell Syst. 2019 Mar 27;8(3):242-253.e3. doi: 10.1016/j.cels.2019.02.002. Epub 2019 Mar 6.


Connecting GCN5's centromeric SAGA to the mitotic tension-sensing checkpoint.

Petty EL, Evpak M, Pillus L.

Mol Biol Cell. 2018 Sep 1;29(18):2201-2212. doi: 10.1091/mbc.E17-12-0701. Epub 2018 Jul 11.


Multigenerational silencing dynamics control cell aging.

Li Y, Jin M, O'Laughlin R, Bittihn P, Tsimring LS, Pillus L, Hasty J, Hao N.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11253-11258. doi: 10.1073/pnas.1703379114. Epub 2017 Oct 3.


Critical genomic regulation mediated by Enhancer of Polycomb.

Searle NE, Pillus L.

Curr Genet. 2018 Feb;64(1):147-154. doi: 10.1007/s00294-017-0742-3. Epub 2017 Sep 7. Review.


Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation.

Marquez-Lona EM, Torres-Machorro AL, Gonzales FR, Pillus L, Patrick GN.

PLoS One. 2017 Jun 29;12(6):e0179893. doi: 10.1371/journal.pone.0179893. eCollection 2017.


The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast.

Mason AG, Garza RM, McCormick MA, Patel B, Kennedy BK, Pillus L, La Spada AR.

Aging Cell. 2017 Aug;16(4):785-796. doi: 10.1111/acel.12611. Epub 2017 May 31.


Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1.

Searle NE, Torres-Machorro AL, Pillus L.

Genetics. 2017 Mar;205(3):1125-1137. doi: 10.1534/genetics.116.197830. Epub 2017 Jan 20.


Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae.

Petty EL, Lafon A, Tomlinson SL, Mendelsohn BA, Pillus L.

Genetics. 2016 Aug;203(4):1693-707. doi: 10.1534/genetics.116.189506. Epub 2016 Jun 17.


Functions for diverse metabolic activities in heterochromatin.

Su XB, Pillus L.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1526-35. doi: 10.1073/pnas.1518707113. Epub 2016 Mar 2.


The Set3 Complex Antagonizes the MYST Acetyltransferase Esa1 in the DNA Damage Response.

Torres-Machorro AL, Clark LG, Chang CS, Pillus L.

Mol Cell Biol. 2015 Nov;35(21):3714-25. doi: 10.1128/MCB.00298-15. Epub 2015 Aug 24.


A moonlighting metabolic protein influences repair at DNA double-stranded breaks.

Torres-Machorro AL, Aris JP, Pillus L.

Nucleic Acids Res. 2015 Feb 18;43(3):1646-58. doi: 10.1093/nar/gku1405. Epub 2015 Jan 27.


Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation.

Basnet H, Su XB, Tan Y, Meisenhelder J, Merkurjev D, Ohgi KA, Hunter T, Pillus L, Rosenfeld MG.

Nature. 2014 Dec 11;516(7530):267-71. doi: 10.1038/nature13736. Epub 2014 Sep 24.


The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.

McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK.

Cell Rep. 2014 Jul 24;8(2):477-86. doi: 10.1016/j.celrep.2014.06.037. Epub 2014 Jul 18.


Bypassing the requirement for an essential MYST acetyltransferase.

Torres-Machorro AL, Pillus L.

Genetics. 2014 Jul;197(3):851-63. doi: 10.1534/genetics.114.165894. Epub 2014 May 15.


Unexpected function of the glucanosyltransferase Gas1 in the DNA damage response linked to histone H3 acetyltransferases in Saccharomyces cerevisiae.

Eustice M, Pillus L.

Genetics. 2014 Apr;196(4):1029-39. doi: 10.1534/genetics.113.158824. Epub 2014 Feb 13.


Balancing chromatin remodeling and histone modifications in transcription.

Petty E, Pillus L.

Trends Genet. 2013 Nov;29(11):621-9. doi: 10.1016/j.tig.2013.06.006. Epub 2013 Jul 16. Review.


Decoupling epigenetic and genetic effects through systematic analysis of gene position.

Chen M, Licon K, Otsuka R, Pillus L, Ideker T.

Cell Rep. 2013 Jan 31;3(1):128-37. doi: 10.1016/j.celrep.2012.12.003. Epub 2013 Jan 3.


STUbLs in chromatin and genome stability.

Garza R, Pillus L.

Biopolymers. 2013 Feb;99(2):146-54. doi: 10.1002/bip.22125. Review.


Functional antagonism between Sas3 and Gcn5 acetyltransferases and ISWI chromatin remodelers.

Lafon A, Petty E, Pillus L.

PLoS Genet. 2012;8(10):e1002994. doi: 10.1371/journal.pgen.1002994. Epub 2012 Oct 4.


Suppression analysis of esa1 mutants in Saccharomyces cerevisiae links NAB3 to transcriptional silencing and nucleolar functions.

Chang CS, Clarke A, Pillus L.

G3 (Bethesda). 2012 Oct;2(10):1223-32. doi: 10.1534/g3.112.003558. Epub 2012 Oct 1.


Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage.

Scott EM, Pillus L.

Genes Dev. 2010 Sep 1;24(17):1903-13. doi: 10.1101/gad.1935910.


Structural basis for L-lysine feedback inhibition of homocitrate synthase.

Bulfer SL, Scott EM, Pillus L, Trievel RC.

J Biol Chem. 2010 Apr 2;285(14):10446-53. doi: 10.1074/jbc.M109.094383. Epub 2010 Jan 19.


Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.

Bulfer SL, Scott EM, Couture JF, Pillus L, Trievel RC.

J Biol Chem. 2009 Dec 18;284(51):35769-80. doi: 10.1074/jbc.M109.046821.


The SAGA subunit Ada2 functions in transcriptional silencing.

Jacobson S, Pillus L.

Mol Cell Biol. 2009 Nov;29(22):6033-45. doi: 10.1128/MCB.00542-09. Epub 2009 Sep 8.


The glucanosyltransferase Gas1 functions in transcriptional silencing.

Koch MR, Pillus L.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11224-9. doi: 10.1073/pnas.0900809106. Epub 2009 Jun 16.


Dynamic reprogramming of transcription factors to and from the subtelomere.

Mak HC, Pillus L, Ideker T.

Genome Res. 2009 Jun;19(6):1014-25. doi: 10.1101/gr.084178.108. Epub 2009 Apr 16.


Identifying critical non-catalytic residues that modulate protein kinase A activity.

Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G.

PLoS One. 2009;4(3):e4746. doi: 10.1371/journal.pone.0004746. Epub 2009 Mar 9.


MYSTs mark chromatin for chromosomal functions.

Pillus L.

Curr Opin Cell Biol. 2008 Jun;20(3):326-33. doi: 10.1016/ Epub 2008 May 27. Review.


Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2.

Darst RP, Garcia SN, Koch MR, Pillus L.

Mol Cell Biol. 2008 Feb;28(4):1361-72. Epub 2007 Dec 17. Erratum in: Mol Cell Biol. 2008 Dec;28(24):7532.


New nomenclature for chromatin-modifying enzymes.

Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y.

Cell. 2007 Nov 16;131(4):633-6. No abstract available.


Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2.

Kennedy EJ, Ghosh G, Pillus L.

J Biol Chem. 2008 Jan 11;283(2):1084-93. Epub 2007 Oct 30.


MYST opportunities for growth control: yeast genes illuminate human cancer gene functions.

Lafon A, Chang CS, Scott EM, Jacobson SJ, Pillus L.

Oncogene. 2007 Aug 13;26(37):5373-84. Review.


Nuclear export modulates the cytoplasmic Sir2 homologue Hst2.

Wilson JM, Le VQ, Zimmerman C, Marmorstein R, Pillus L.

EMBO Rep. 2006 Dec;7(12):1247-51. Epub 2006 Nov 17.


Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing.

Clarke AS, Samal E, Pillus L.

Mol Biol Cell. 2006 Apr;17(4):1744-57. Epub 2006 Jan 25.


SIR1 and the origin of epigenetic states in Saccharomyces cerevisiae.

Pillus L, Rine J.

Cold Spring Harb Symp Quant Biol. 2004;69:259-65. Review. No abstract available.


Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast.

Wirén M, Silverstein RA, Sinha I, Walfridsson J, Lee HM, Laurenson P, Pillus L, Robyr D, Grunstein M, Ekwall K.

EMBO J. 2005 Aug 17;24(16):2906-18. Epub 2005 Aug 4.


Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms.

Lo WS, Gamache ER, Henry KW, Yang D, Pillus L, Berger SL.

EMBO J. 2005 Mar 9;24(5):997-1008. Epub 2005 Feb 17.


Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+.

Freeman-Cook LL, Gómez EB, Spedale EJ, Marlett J, Forsburg SL, Pillus L, Laurenson P.

Genetics. 2005 Mar;169(3):1243-60. Epub 2004 Nov 15.


Functional analyses of chromatin modifications in yeast.

Jacobson SJ, Laurenson PM, Pillus L.

Methods Enzymol. 2004;377:3-55. Review. No abstract available.


The Sir4 C-terminal coiled coil is required for telomeric and mating type silencing in Saccharomyces cerevisiae.

Murphy GA, Spedale EJ, Powell ST, Pillus L, Schultz SC, Chen L.

J Mol Biol. 2003 Dec 5;334(4):769-80.


Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.

Henry KW, Wyce A, Lo WS, Duggan LJ, Emre NC, Kao CF, Pillus L, Shilatifard A, Osley MA, Berger SL.

Genes Dev. 2003 Nov 1;17(21):2648-63. Epub 2003 Oct 16.


Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase.

Clements A, Poux AN, Lo WS, Pillus L, Berger SL, Marmorstein R.

Mol Cell. 2003 Aug;12(2):461-73.


Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiae.

Lowell JE, Roughton AI, Lundblad V, Pillus L.

Genetics. 2003 Jul;164(3):909-21.


Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex.

Parsons XH, Garcia SN, Pillus L, Kadonaga JT.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1609-14. Epub 2003 Feb 5.


Histone H3 specific acetyltransferases are essential for cell cycle progression.

Howe L, Auston D, Grant P, John S, Cook RG, Workman JL, Pillus L.

Genes Dev. 2001 Dec 1;15(23):3144-54.

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