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Items: 26

1.

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.

Kanwal A, Pillai VB, Samant S, Gupta M, Gupta MP.

FASEB J. 2019 Oct;33(10):10872-10888. doi: 10.1096/fj.201900767R. Epub 2019 Jul 12.

PMID:
31318577
2.

Cellular mechanisms promoting cachexia and how they are opposed by sirtuins 1.

Samant SA, Pillai VB, Gupta MP.

Can J Physiol Pharmacol. 2019 Apr;97(4):235-245. doi: 10.1139/cjpp-2018-0479.

PMID:
30407871
3.

The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy.

Samant SA, Kanwal A, Pillai VB, Bao R, Gupta MP.

Sci Rep. 2017 Sep 19;7(1):11877. doi: 10.1038/s41598-017-10838-5.

4.

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.

Pillai VB, Kanwal A, Fang YH, Sharp WW, Samant S, Arbiser J, Gupta MP.

Oncotarget. 2017 May 23;8(21):34082-34098. doi: 10.18632/oncotarget.16133.

5.

SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.

Bindu S, Pillai VB, Kanwal A, Samant S, Mutlu GM, Verdin E, Dulin N, Gupta MP.

Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L68-L78. doi: 10.1152/ajplung.00188.2016. Epub 2016 Nov 4.

6.

Role of Sirtuins in Regulating Pathophysiology of the Heart.

Bindu S, Pillai VB, Gupta MP.

Trends Endocrinol Metab. 2016 Aug;27(8):563-573. doi: 10.1016/j.tem.2016.04.015. Epub 2016 May 19. Review.

PMID:
27210897
7.

Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice.

Pillai VB, Bindu S, Sharp W, Fang YH, Kim G, Gupta M, Samant S, Gupta MP.

Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H962-72. doi: 10.1152/ajpheart.00832.2015. Epub 2016 Feb 12.

8.

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β.

Sundaresan NR, Bindu S, Pillai VB, Samant S, Pan Y, Huang JY, Gupta M, Nagalingam RS, Wolfgeher D, Verdin E, Gupta MP.

Mol Cell Biol. 2015 Dec 14;36(5):678-92. doi: 10.1128/MCB.00586-15.

9.

Histone Deacetylase 3 (HDAC3)-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity.

Samant SA, Pillai VB, Sundaresan NR, Shroff SG, Gupta MP.

J Biol Chem. 2015 Jun 19;290(25):15559-69. doi: 10.1074/jbc.M115.653048. Epub 2015 Apr 24.

10.

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.

Pillai VB, Samant S, Sundaresan NR, Raghuraman H, Kim G, Bonner MY, Arbiser JL, Walker DI, Jones DP, Gius D, Gupta MP.

Nat Commun. 2015 Apr 14;6:6656. doi: 10.1038/ncomms7656.

11.

CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus SIV239 vaccine enhances SIV-specific humoral and cellular immunity and improves protection against a heterologous SIVE660 mucosal challenge.

Kwa S, Lai L, Gangadhara S, Siddiqui M, Pillai VB, Labranche C, Yu T, Moss B, Montefiori DC, Robinson HL, Kozlowski PA, Amara RR.

J Virol. 2014 Sep 1;88(17):9579-89. doi: 10.1128/JVI.00975-14. Epub 2014 Jun 11.

12.

Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging.

Pillai VB, Sundaresan NR, Gupta MP.

Circ Res. 2014 Jan 17;114(2):368-78. doi: 10.1161/CIRCRESAHA.113.300536. Review.

13.

SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress.

Samant SA, Zhang HJ, Hong Z, Pillai VB, Sundaresan NR, Wolfgeher D, Archer SL, Chan DC, Gupta MP.

Mol Cell Biol. 2014 Mar;34(5):807-19. doi: 10.1128/MCB.01483-13. Epub 2013 Dec 16.

14.

Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling.

Pillai VB, Sundaresan NR, Kim G, Samant S, Moreno-Vinasco L, Garcia JG, Gupta MP.

Am J Physiol Heart Circ Physiol. 2013 Feb 1;304(3):H415-26. doi: 10.1152/ajpheart.00468.2012. Epub 2012 Nov 30.

15.

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.

Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MP.

Nat Med. 2012 Nov;18(11):1643-50. doi: 10.1038/nm.2961. Epub 2012 Oct 21.

16.

The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.

Sundaresan NR, Pillai VB, Wolfgeher D, Samant S, Vasudevan P, Parekh V, Raghuraman H, Cunningham JM, Gupta M, Gupta MP.

Sci Signal. 2011 Jul 19;4(182):ra46. doi: 10.1126/scisignal.2001465.

17.

Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes.

Pillai VB, Sundaresan NR, Samant SA, Wolfgeher D, Trivedi CM, Gupta MP.

Mol Cell Biol. 2011 Jun;31(11):2349-63. doi: 10.1128/MCB.01205-10. Epub 2011 Mar 28.

18.

Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy.

Sundaresan NR, Pillai VB, Gupta MP.

J Mol Cell Cardiol. 2011 Oct;51(4):614-8. doi: 10.1016/j.yjmcc.2011.01.008. Epub 2011 Jan 27. Review.

19.

HDAC3-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activity.

Samant SA, Courson DS, Sundaresan NR, Pillai VB, Tan M, Zhao Y, Shroff SG, Rock RS, Gupta MP.

J Biol Chem. 2011 Feb 18;286(7):5567-77. doi: 10.1074/jbc.M110.163865. Epub 2010 Dec 21. Retraction in: J Biol Chem. 2015 Mar 6;290(10):6009.

20.

Mitochondrial SIRT3 and heart disease.

Pillai VB, Sundaresan NR, Jeevanandam V, Gupta MP.

Cardiovasc Res. 2010 Nov 1;88(2):250-6. doi: 10.1093/cvr/cvq250. Epub 2010 Aug 4. Review.

21.

Adjuvantive effects of anti-4-1BB agonist Ab and 4-1BBL DNA for a HIV-1 Gag DNA vaccine: different effects on cellular and humoral immunity.

Ganguly S, Liu J, Pillai VB, Mittler RS, Amara RR.

Vaccine. 2010 Feb 3;28(5):1300-9. doi: 10.1016/j.vaccine.2009.11.020. Epub 2009 Nov 26.

22.

Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway.

Pillai VB, Sundaresan NR, Kim G, Gupta M, Rajamohan SB, Pillai JB, Samant S, Ravindra PV, Isbatan A, Gupta MP.

J Biol Chem. 2010 Jan 29;285(5):3133-44. doi: 10.1074/jbc.M109.077271. Epub 2009 Nov 24.

23.

SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1.

Rajamohan SB, Pillai VB, Gupta M, Sundaresan NR, Birukov KG, Samant S, Hottiger MO, Gupta MP.

Mol Cell Biol. 2009 Aug;29(15):4116-29. doi: 10.1128/MCB.00121-09. Epub 2009 May 26.

24.

SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.

Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP.

Mol Cell Biol. 2008 Oct;28(20):6384-401. doi: 10.1128/MCB.00426-08. Epub 2008 Aug 18.

25.

Comparative studies on in vitro expression and in vivo immunogenicity of supercoiled and open circular forms of plasmid DNA vaccines.

Pillai VB, Hellerstein M, Yu T, Amara RR, Robinson HL.

Vaccine. 2008 Feb 20;26(8):1136-41. doi: 10.1016/j.vaccine.2007.10.023. Epub 2007 Oct 30.

26.

Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression.

Pillai JB, Chen M, Rajamohan SB, Samant S, Pillai VB, Gupta M, Gupta MP.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1388-97. doi: 10.1152/ajpheart.01339.2007. Epub 2008 Jan 11.

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