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Items: 1 to 50 of 76

1.

Advances in the structural studies of antibiotic potentiators against Escherichia coli.

Blankson GA, Parhi AK, Kaul M, Pilch DS, LaVoie EJ.

Bioorg Med Chem. 2019 Aug 1;27(15):3254-3278. doi: 10.1016/j.bmc.2019.06.003. Epub 2019 Jun 4. No abstract available.

PMID:
31235265
2.

Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli.

Blankson G, Parhi AK, Kaul M, Pilch DS, LaVoie EJ.

Eur J Med Chem. 2019 Sep 15;178:30-38. doi: 10.1016/j.ejmech.2019.05.075. Epub 2019 May 29.

PMID:
31173969
3.

╬▓-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus.

Ferrer-González E, Kaul M, Parhi AK, LaVoie EJ, Pilch DS.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00863-17. doi: 10.1128/AAC.00863-17. Print 2017 Sep.

4.

Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ.

Fujita J, Maeda Y, Mizohata E, Inoue T, Kaul M, Parhi AK, LaVoie EJ, Pilch DS, Matsumura H.

ACS Chem Biol. 2017 Jul 21;12(7):1947-1955. doi: 10.1021/acschembio.7b00323. Epub 2017 Jun 16.

5.

Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus.

Kaul M, Mark L, Parhi AK, LaVoie EJ, Pilch DS.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4290-6. doi: 10.1128/AAC.00613-16. Print 2016 Jul.

6.

Calorimetry of Nucleic Acids.

Rozners E, Pilch DS, Egli M.

Curr Protoc Nucleic Acid Chem. 2015 Dec 1;63:7.4.1-12. doi: 10.1002/0471142700.nc0704s63.

PMID:
26623974
7.

TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus.

Kaul M, Mark L, Zhang Y, Parhi AK, Lyu YL, Pawlak J, Saravolatz S, Saravolatz LD, Weinstein MP, LaVoie EJ, Pilch DS.

Antimicrob Agents Chemother. 2015 Aug;59(8):4845-55. doi: 10.1128/AAC.00708-15. Epub 2015 Jun 1.

8.

TXA497 as a topical antibacterial agent: comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin.

Dorrani M, Kaul M, Parhi A, LaVoie EJ, Pilch DS, Michniak-Kohn B.

Int J Pharm. 2014 Dec 10;476(1-2):199-204. doi: 10.1016/j.ijpharm.2014.09.033. Epub 2014 Sep 26.

PMID:
25263100
9.

Inhibition of RND-type efflux pumps confers the FtsZ-directed prodrug TXY436 with activity against Gram-negative bacteria.

Kaul M, Zhang Y, Parhi AK, Lavoie EJ, Pilch DS.

Biochem Pharmacol. 2014 Jun 1;89(3):321-8. doi: 10.1016/j.bcp.2014.03.002. Epub 2014 Mar 14.

PMID:
24637241
10.

Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723.

Kaul M, Mark L, Zhang Y, Parhi AK, LaVoie EJ, Pilch DS.

Biochem Pharmacol. 2013 Dec 15;86(12):1699-707. doi: 10.1016/j.bcp.2013.10.010. Epub 2013 Oct 20.

PMID:
24148278
11.

Macrocyclic pyridyl polyoxazoles: structure-activity studies of the aminoalkyl side-chain on G-quadruplex stabilization and cytotoxic activity.

Blankson G, Rzuczek SG, Bishop C, Pilch DS, Liu A, Liu L, Lavoie EJ, Rice JE.

Molecules. 2013 Sep 26;18(10):11938-63. doi: 10.3390/molecules181011938.

12.

An FtsZ-targeting prodrug with oral antistaphylococcal efficacy in vivo.

Kaul M, Mark L, Zhang Y, Parhi AK, Lavoie EJ, Pilch DS.

Antimicrob Agents Chemother. 2013 Dec;57(12):5860-9. doi: 10.1128/AAC.01016-13. Epub 2013 Sep 16.

13.

Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines.

Parhi AK, Zhang Y, Saionz KW, Pradhan P, Kaul M, Trivedi K, Pilch DS, LaVoie EJ.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):4968-74. doi: 10.1016/j.bmcl.2013.06.048. Epub 2013 Jun 26.

14.

Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis.

Kaul M, Zhang Y, Parhi AK, Lavoie EJ, Tuske S, Arnold E, Kerrigan JE, Pilch DS.

Biochimie. 2013 Oct;95(10):1880-7. doi: 10.1016/j.biochi.2013.06.010. Epub 2013 Jun 25.

15.

Macrocyclic biphenyl tetraoxazoles: synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity.

Blankson GA, Pilch DS, Liu AA, Liu LF, Rice JE, LaVoie EJ.

Bioorg Med Chem. 2013 Aug 1;21(15):4511-20. doi: 10.1016/j.bmc.2013.05.033. Epub 2013 May 30.

16.

Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents.

Zhang Y, Giurleo D, Parhi A, Kaul M, Pilch DS, LaVoie EJ.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2001-6. doi: 10.1016/j.bmcl.2013.02.016. Epub 2013 Feb 13.

17.

Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes.

Kelley C, Lu S, Parhi A, Kaul M, Pilch DS, Lavoie EJ.

Eur J Med Chem. 2013 Feb;60:395-409. doi: 10.1016/j.ejmech.2012.12.027. Epub 2012 Dec 20.

18.

3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.

Kelley C, Zhang Y, Parhi A, Kaul M, Pilch DS, LaVoie EJ.

Bioorg Med Chem. 2012 Dec 15;20(24):7012-29. doi: 10.1016/j.bmc.2012.10.009. Epub 2012 Oct 17.

19.

Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives.

Parhi A, Kelley C, Kaul M, Pilch DS, LaVoie EJ.

Bioorg Med Chem Lett. 2012 Dec 1;22(23):7080-3. doi: 10.1016/j.bmcl.2012.09.097. Epub 2012 Oct 2.

20.

Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.

Parhi A, Lu S, Kelley C, Kaul M, Pilch DS, LaVoie EJ.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6962-6. doi: 10.1016/j.bmcl.2012.08.123. Epub 2012 Sep 20.

21.

A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.

Kaul M, Parhi AK, Zhang Y, LaVoie EJ, Tuske S, Arnold E, Kerrigan JE, Pilch DS.

J Med Chem. 2012 Nov 26;55(22):10160-76. doi: 10.1021/jm3012728. Epub 2012 Oct 26.

22.

Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity.

Satyanarayana M, Kim YA, Rzuczek SG, Pilch DS, Liu AA, Liu LF, Rice JE, LaVoie EJ.

Bioorg Med Chem Lett. 2010 May 15;20(10):3150-4. doi: 10.1016/j.bmcl.2010.03.086. Epub 2010 Mar 30.

PMID:
20409709
23.

Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents.

Rzuczek SG, Pilch DS, Liu A, Liu L, LaVoie EJ, Rice JE.

J Med Chem. 2010 May 13;53(9):3632-44. doi: 10.1021/jm1000612.

24.

A G-quadruplex stabilizer induces M-phase cell cycle arrest.

Tsai YC, Qi H, Lin CP, Lin RK, Kerrigan JE, Rzuczek SG, LaVoie EJ, Rice JE, Pilch DS, Lyu YL, Liu LF.

J Biol Chem. 2009 Aug 21;284(34):22535-43. doi: 10.1074/jbc.M109.020230. Epub 2009 Jun 16.

25.

Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.

Nudelman I, Rebibo-Sabbah A, Cherniavsky M, Belakhov V, Hainrichson M, Chen F, Schacht J, Pilch DS, Ben-Yosef T, Baasov T.

J Med Chem. 2009 May 14;52(9):2836-45. doi: 10.1021/jm801640k.

26.

Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency.

Satyanarayana M, Rzuczek SG, Lavoie EJ, Pilch DS, Liu A, Liu LF, Rice JE.

Bioorg Med Chem Lett. 2008 Jul 1;18(13):3802-4. doi: 10.1016/j.bmcl.2008.05.032. Epub 2008 May 15.

27.

Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds.

Pilch DS, Barbieri CM, Rzuczek SG, Lavoie EJ, Rice JE.

Biochimie. 2008 Aug;90(8):1233-49. doi: 10.1016/j.biochi.2008.03.011. Epub 2008 Apr 4.

28.
29.

Calorimetry of nucleic acids.

Pilch DS.

Curr Protoc Nucleic Acid Chem. 2001 May;Chapter 7:Unit 7.4. doi: 10.1002/0471142700.nc0704s00.

PMID:
18428872
30.

Lysinyl macrocyclic hexaoxazoles: synthesis and selective G-quadruplex stabilizing properties.

Rzuczek SG, Pilch DS, LaVoie EJ, Rice JE.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):913-7. doi: 10.1016/j.bmcl.2007.12.048. Epub 2008 Jan 14.

31.

Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites.

Kondo J, Hainrichson M, Nudelman I, Shallom-Shezifi D, Barbieri CM, Pilch DS, Westhof E, Baasov T.

Chembiochem. 2007 Sep 24;8(14):1700-9.

PMID:
17705310
32.

Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA.

Barbieri CM, Srinivasan AR, Rzuczek SG, Rice JE, LaVoie EJ, Pilch DS.

Nucleic Acids Res. 2007;35(10):3272-86. Epub 2007 Apr 22.

33.
34.

Defining the molecular forces that determine the impact of neomycin on bacterial protein synthesis: importance of the 2'-amino functionality.

Barbieri CM, Kaul M, Bozza-Hingos M, Zhao F, Tor Y, Hermann T, Pilch DS.

Antimicrob Agents Chemother. 2007 May;51(5):1760-9. Epub 2007 Mar 12.

35.

G-quadruplexes induce apoptosis in tumor cells.

Qi H, Lin CP, Fu X, Wood LM, Liu AA, Tsai YC, Chen Y, Barbieri CM, Pilch DS, Liu LF.

Cancer Res. 2006 Dec 15;66(24):11808-16.

36.
37.

Drug self-association modulates the cellular bioavailability of DNA minor groove-directed terbenzimidazoles.

Khan QA, Barbieri CM, Srinivasan AR, Wang YH, LaVoie EJ, Pilch DS.

J Med Chem. 2006 Aug 24;49(17):5245-51.

PMID:
16913713
38.

Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles.

Minhas GS, Pilch DS, Kerrigan JE, LaVoie EJ, Rice JE.

Bioorg Med Chem Lett. 2006 Aug 1;16(15):3891-5. Epub 2006 Jun 2.

PMID:
16735121
39.
41.
43.

Drug targeting of HIV-1 RNA.DNA hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication.

Li TK, Barbieri CM, Lin HC, Rabson AB, Yang G, Fan Y, Gaffney BL, Jones RA, Pilch DS.

Biochemistry. 2004 Aug 3;43(30):9732-42.

PMID:
15274628
45.
46.

Thermodynamics of aminoglycoside-rRNA recognition.

Pilch DS, Kaul M, Barbieri CM, Kerrigan JE.

Biopolymers. 2003 Sep;70(1):58-79. Review.

PMID:
12925993
47.

Aminoglycoside complexation with a DNA.RNA hybrid duplex: the thermodynamics of recognition and inhibition of RNA processing enzymes.

Barbieri CM, Li TK, Guo S, Wang G, Shallop AJ, Pan W, Yang G, Gaffney BL, Jones RA, Pilch DS.

J Am Chem Soc. 2003 May 28;125(21):6469-77.

PMID:
12785787
49.

Pentamidine inhibits catalytic activity of group I intron Ca.LSU by altering RNA folding.

Zhang Y, Li Z, Pilch DS, Leibowitz MJ.

Nucleic Acids Res. 2002 Jul 1;30(13):2961-71.

50.

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