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Items: 1 to 50 of 150

1.

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.

Schmidt AF, Holmes MV, Preiss D, Swerdlow DI, Denaxas S, Fatemifar G, Faraway R, Finan C, Valentine D, Fairhurst-Hunter Z, Hartwig FP, Horta BL, Hypponen E, Power C, Moldovan M, van Iperen E, Hovingh K, Demuth I, Norman K, Steinhagen-Thiessen E, Demuth J, Bertram L, Lill CM, Coassin S, Willeit J, Kiechl S, Willeit K, Mason D, Wright J, Morris R, Wanamethee G, Whincup P, Ben-Shlomo Y, McLachlan S, Price JF, Kivimaki M, Welch C, Sanchez-Galvez A, Marques-Vidal P, Nicolaides A, Panayiotou AG, Onland-Moret NC, van der Schouw YT, Matullo G, Fiorito G, Guarrera S, Sacerdote C, Wareham NJ, Langenberg C, Scott RA, Luan J, Bobak M, Malyutina S, Pająk A, Kubinova R, Tamosiunas A, Pikhart H, Grarup N, Pedersen O, Hansen T, Linneberg A, Jess T, Cooper J, Humphries SE, Brilliant M, Kitchner T, Hakonarson H, Carrell DS, McCarty CA, Lester KH, Larson EB, Crosslin DR, de Andrade M, Roden DM, Denny JC, Carty C, Hancock S, Attia J, Holliday E, Scott R, Schofield P, O'Donnell M, Yusuf S, Chong M, Pare G, van der Harst P, Said MA, Eppinga RN, Verweij N, Snieder H; Lifelines Cohort authors, Christen T, Mook-Kanamori DO; ICBP Consortium, Gustafsson S, Lind L, Ingelsson E, Pazoki R, Franco O, Hofman A, Uitterlinden A, Dehghan A, Teumer A, Baumeister S, Dörr M, Lerch MM, Völker U, Völzke H, Ward J, Pell JP, Meade T, Christophersen IE, Maitland-van der Zee AH, Baranova EV, Young R, Ford I, Campbell A, Padmanabhan S, Bots ML, Grobbee DE, Froguel P, Thuillier D, Roussel R, Bonnefond A, Cariou B, Smart M, Bao Y, Kumari M, Mahajan A, Hopewell JC, Seshadri S; METASTROKE Consortium of the ISGC, Dale C, Costa RPE, Ridker PM, Chasman DI, Reiner AP, Ritchie MD, Lange LA, Cornish AJ, Dobbins SE, Hemminki K, Kinnersley B, Sanson M, Labreche K, Simon M, Bondy M, Law P, Speedy H, Allan J, Li N, Went M, Weinhold N, Morgan G, Sonneveld P, Nilsson B, Goldschmidt H, Sud A, Engert A, Hansson M, Hemingway H, Asselbergs FW, Patel RS, Keating BJ, Sattar N, Houlston R, Casas JP, Hingorani AD.

BMC Cardiovasc Disord. 2019 Oct 29;19(1):240. doi: 10.1186/s12872-019-1187-z.

2.

Association between soft drink, fruit juice consumption and obesity in Eastern Europe: cross-sectional and longitudinal analysis of the HAPIEE study.

Garduño-Alanís A, Malyutina S, Pajak A, Stepaniak U, Kubinova R, Denisova D, Pikhart H, Peasey A, Bobak M, Stefler D.

J Hum Nutr Diet. 2019 Sep 1. doi: 10.1111/jhn.12696. [Epub ahead of print]

PMID:
31475413
3.

The association between the FTO gene variant and alcohol consumption and binge and problem drinking in different gene-environment background: The HAPIEE study.

Hubacek JA, Pikhart H, Peasey A, Malyutina S, Pajak A, Tamosiunas A, Voevoda M, Holmes MV, Bobak M.

Gene. 2019 Jul 30;707:30-35. doi: 10.1016/j.gene.2019.05.002. Epub 2019 May 2.

PMID:
31055022
4.

Alcohol Screening and Brief Advice in NHS General Dental Practices: A Cluster Randomized Controlled Feasibility Trial.

Ntouva A, Porter J, Crawford MJ, Britton A, Gratus C, Newton T, Tsakos G, Heilmann A, Pikhart H, Watt RG.

Alcohol Alcohol. 2019 May 1;54(3):235-242. doi: 10.1093/alcalc/agz017.

PMID:
30882135
5.

Fruit, vegetable intake and blood pressure trajectories in older age.

Stefler D, Malyutina S, Nikitin Y, Nikitenko T, Rodriguez-Artalejo F, Peasey A, Pikhart H, Sabia S, Bobak M.

J Hum Hypertens. 2019 Sep;33(9):671-678. doi: 10.1038/s41371-019-0189-8. Epub 2019 Mar 6.

6.

Early-life exposure to household chemicals and wheezing in children.

Mikeš O, Vrbová M, Klánová J, Čupr P, Švancara J, Pikhart H.

Sci Total Environ. 2019 May 1;663:418-425. doi: 10.1016/j.scitotenv.2019.01.254. Epub 2019 Jan 25.

PMID:
30716632
7.

Mortality in the Visegrad countries from the perspective of socioeconomic inequalities.

Bosakova L, Rosicova K, Filakovska Bobakova D, Rosic M, Dzurova D, Pikhart H, Lustigova M, Santana P.

Int J Public Health. 2019 Apr;64(3):365-376. doi: 10.1007/s00038-018-1183-6. Epub 2018 Dec 7.

PMID:
30535783
8.

The prospective relationship between social cohesion and depressive symptoms among older adults from Central and Eastern Europe.

Bertossi Urzua C, Ruiz MA, Pajak A, Kozela M, Kubinova R, Malyutina S, Peasey A, Pikhart H, Marmot M, Bobak M.

J Epidemiol Community Health. 2019 Feb;73(2):117-122. doi: 10.1136/jech-2018-211063. Epub 2018 Nov 1.

9.

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of exposure to long working hours and of the effect of exposure to long working hours on ischaemic heart disease.

Li J, Brisson C, Clays E, Ferrario MM, Ivanov ID, Landsbergis P, Leppink N, Pega F, Pikhart H, Prüss-Üstün A, Rugulies R, Schnall PL, Stevens G, Tsutsumi A, Ujita Y, Siegrist J.

Environ Int. 2018 Oct;119:558-569. doi: 10.1016/j.envint.2018.06.022. Epub 2018 Aug 17.

PMID:
30125833
10.

Sleeping habits of adolescents in relation to their physical activity and exercise output: results from the ELSPAC study.

Máchal J, Zlámal F, Kukla L, Švancara J, Pikhart H, Bienertová-Vašků J.

J Epidemiol Community Health. 2018 Dec;72(12):1141-1146. doi: 10.1136/jech-2018-210970. Epub 2018 Jul 30.

PMID:
30061097
11.

Mediterranean diet and physical functioning trajectories in Eastern Europe: Findings from the HAPIEE study.

Stefler D, Hu Y, Malyutina S, Pajak A, Kubinova R, Peasey A, Pikhart H, Rodriguez-Artalejo F, Bobak M.

PLoS One. 2018 Jul 12;13(7):e0200460. doi: 10.1371/journal.pone.0200460. eCollection 2018.

12.

Domains and Measurements of Healthy Aging in Epidemiological Studies: A Review.

Lu W, Pikhart H, Sacker A.

Gerontologist. 2019 Jul 16;59(4):e294-e310. doi: 10.1093/geront/gny029.

13.

Role of allostatic load and health behaviours in explaining socioeconomic disparities in mortality: a structural equation modelling approach.

Kim GR, Jee SH, Pikhart H.

J Epidemiol Community Health. 2018 Jun;72(6):545-551. doi: 10.1136/jech-2017-209131. Epub 2018 Feb 19.

PMID:
29459378
14.

Cardiovascular health among the Czech population at the beginning of the 21st century: a 12-year follow-up study.

Lustigova M, Dzurova D, Pikhart H, Kubinova R, Bobak M.

J Epidemiol Community Health. 2018 May;72(5):442-448. doi: 10.1136/jech-2017-209967. Epub 2018 Feb 8.

15.

Estimated dietary iodine intake as a predictor of placental size: evidence from the ELSPAC study.

Bienertová-Vašků J, Grulichová M, Mikeš O, Zlámal F, Pruša T, Pohořalá A, Andrýsková L, Pikhart H.

Nutr Metab (Lond). 2018 Jan 17;15:5. doi: 10.1186/s12986-018-0240-8. eCollection 2018.

16.

Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study.

Piler P, Švancara J, Kukla L, Pikhart H.

J Epidemiol Community Health. 2018 Apr;72(4):349-355. doi: 10.1136/jech-2017-209960. Epub 2018 Jan 25.

PMID:
29371328
17.

Does adiposity mediate the relationship between socioeconomic position and non-allergic asthma in childhood?

Lewis KM, Pikhart H, Morrison J.

J Epidemiol Community Health. 2018 May;72(5):390-396. doi: 10.1136/jech-2017-209722. Epub 2018 Jan 24.

18.

Psychosocial and socioeconomic determinants of cardiovascular mortality in Eastern Europe: A multicentre prospective cohort study.

Tillmann T, Pikhart H, Peasey A, Kubinova R, Pajak A, Tamosiunas A, Malyutina S, Steptoe A, Kivimäki M, Marmot M, Bobak M.

PLoS Med. 2017 Dec 6;14(12):e1002459. doi: 10.1371/journal.pmed.1002459. eCollection 2017 Dec.

19.

Association of Glutathione S-Transferase Polymorphisms with Dietary Composition but Not Anthropometry in Obese as Well as Nonobese Individuals.

Klánová B, Zlámal F, Pohořalá A, Slabý O, Pikhart H, Bienertová-Vašků J.

J Am Coll Nutr. 2018 Feb;37(2):87-92. doi: 10.1080/07315724.2017.1360807. Epub 2017 Oct 31.

PMID:
29087247
20.

Mother's education and offspring asthma risk in 10 European cohort studies.

Lewis KM, Ruiz M, Goldblatt P, Morrison J, Porta D, Forastiere F, Hryhorczuk D, Zvinchuk O, Saurel-Cubizolles MJ, Lioret S, Annesi-Maesano I, Vrijheid M, Torrent M, Iniguez C, Larranaga I, Harskamp-van Ginkel MW, Vrijkotte TGM, Klanova J, Svancara J, Barross H, Correia S, Jarvelin MR, Taanila A, Ludvigsson J, Faresjo T, Marmot M, Pikhart H.

Eur J Epidemiol. 2017 Sep;32(9):797-805. doi: 10.1007/s10654-017-0309-0. Epub 2017 Sep 19.

21.

Education and coronary heart disease: mendelian randomisation study.

Tillmann T, Vaucher J, Okbay A, Pikhart H, Peasey A, Kubinova R, Pajak A, Tamosiunas A, Malyutina S, Hartwig FP, Fischer K, Veronesi G, Palmer T, Bowden J, Davey Smith G, Bobak M, Holmes MV.

BMJ. 2017 Aug 30;358:j3542. doi: 10.1136/bmj.j3542.

22.

Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population.

Bienertová-Vašků J, Zlámal F, Pohořalá A, Mikeš O, Goldbergová-Pávková M, Novák J, Šplíchal Z, Pikhart H.

BMC Med Genet. 2017 Aug 22;18(1):90. doi: 10.1186/s12881-017-0454-z.

23.

Interventions to reduce inequalities in health and early child development in Europe from a qualitative perspective.

Morrison J, Pikhart H, Goldblatt P.

Int J Equity Health. 2017 May 25;16(1):87. doi: 10.1186/s12939-017-0584-0.

24.

Lifecourse transitions, gender and drinking in later life.

Holdsworth C, Frisher M, Mendonça M, DE Oliveiria C, Pikhart H, Shelton N.

Ageing Soc. 2017 Mar;37(3):462-494. doi: 10.1017/S0144686X15001178. Epub 2015 Oct 26.

25.

Impact of perceived control on all-cause and cardiovascular disease mortality in three urban populations of Central and Eastern Europe: the HAPIEE study.

Kozela M, Pająk A, Micek A, Besala A, Kubinova R, Malyutina S, Tamosiunas A, Pikhart H, Peasey A, Nikitin Y, Marmot M, Bobak M.

J Epidemiol Community Health. 2017 Aug;71(8):771-778. doi: 10.1136/jech-2017-208992. Epub 2017 May 17.

26.

The Relationship between Body Mass Index and 10-Year Trajectories of Physical Functioning in Middle-Aged and Older Russians: Prospective Results of the Russian HAPIEE Study.

Hu Y, Malyutina S, Pikhart H, Peasey A, Holmes MV, Hubacek J, Denisova D, Nikitin Y, Bobak M.

J Nutr Health Aging. 2017;21(4):381-388. doi: 10.1007/s12603-016-0769-z.

PMID:
28346564
27.

Association of Adherence to a Healthy Diet with Cognitive Decline in European and American Older Adults: A Meta-Analysis within the CHANCES Consortium.

Berendsen AA, Kang JH, van de Rest O, Jankovic N, Kampman E, Kiefte-de Jong JC, Franco OH, Ikram MA, Pikhart H, Nilsson LM, Brenner H, Boffetta P, Rafnsson SB, Gustafson D, Kyrozis A, Trichopoulou A, Feskens EJ, Grodstein F, de Groot LC.

Dement Geriatr Cogn Disord. 2017;43(3-4):215-227. doi: 10.1159/000464269. Epub 2017 Mar 22.

28.

Parental heights and maternal education as predictors of length/height of children at birth, age 3 and 19 years, independently on diet: the ELSPAC study.

Bienertová-Vašků J, Zlámal F, Pruša T, Novák J, Mikeš O, Čupr P, Pohořalá A, Švancara J, Andrýsková L, Pikhart H.

Eur J Clin Nutr. 2017 Oct;71(10):1193-1199. doi: 10.1038/ejcn.2016.244. Epub 2017 Feb 8.

PMID:
28176773
29.

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.

Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, Hartwig FP, Horta BL, Hyppönen E, Power C, Moldovan M, van Iperen E, Hovingh GK, Demuth I, Norman K, Steinhagen-Thiessen E, Demuth J, Bertram L, Liu T, Coassin S, Willeit J, Kiechl S, Willeit K, Mason D, Wright J, Morris R, Wanamethee G, Whincup P, Ben-Shlomo Y, McLachlan S, Price JF, Kivimaki M, Welch C, Sanchez-Galvez A, Marques-Vidal P, Nicolaides A, Panayiotou AG, Onland-Moret NC, van der Schouw YT, Matullo G, Fiorito G, Guarrera S, Sacerdote C, Wareham NJ, Langenberg C, Scott R, Luan J, Bobak M, Malyutina S, Pająk A, Kubinova R, Tamosiunas A, Pikhart H, Husemoen LL, Grarup N, Pedersen O, Hansen T, Linneberg A, Simonsen KS, Cooper J, Humphries SE, Brilliant M, Kitchner T, Hakonarson H, Carrell DS, McCarty CA, Kirchner HL, Larson EB, Crosslin DR, de Andrade M, Roden DM, Denny JC, Carty C, Hancock S, Attia J, Holliday E, O'Donnell M, Yusuf S, Chong M, Pare G, van der Harst P, Said MA, Eppinga RN, Verweij N, Snieder H; LifeLines Cohort study group, Christen T, Mook-Kanamori DO, Gustafsson S, Lind L, Ingelsson E, Pazoki R, Franco O, Hofman A, Uitterlinden A, Dehghan A, Teumer A, Baumeister S, Dörr M, Lerch MM, Völker U, Völzke H, Ward J, Pell JP, Smith DJ, Meade T, Maitland-van der Zee AH, Baranova EV, Young R, Ford I, Campbell A, Padmanabhan S, Bots ML, Grobbee DE, Froguel P, Thuillier D, Balkau B, Bonnefond A, Cariou B, Smart M, Bao Y, Kumari M, Mahajan A, Ridker PM, Chasman DI, Reiner AP, Lange LA, Ritchie MD, Asselbergs FW, Casas JP, Keating BJ, Preiss D, Hingorani AD; UCLEB consortium, Sattar N.

Lancet Diabetes Endocrinol. 2017 Feb;5(2):97-105. doi: 10.1016/S2213-8587(16)30396-5. Epub 2016 Nov 29.

30.

Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study.

Horvat P, Kubinova R, Pajak A, Tamosiunas A, Schöttker B, Pikhart H, Peasey A, Kozela M, Jansen E, Singh-Manoux A, Bobak M.

Dement Geriatr Cogn Disord. 2016;42(5-6):297-309. Epub 2016 Nov 2.

31.

The association of depressive symptoms with cardiovascular and all-cause mortality in Central and Eastern Europe: Prospective results of the HAPIEE study.

Kozela M, Bobak M, Besala A, Micek A, Kubinova R, Malyutina S, Denisova D, Richards M, Pikhart H, Peasey A, Marmot M, Pająk A.

Eur J Prev Cardiol. 2016 Nov;23(17):1839-1847. Epub 2016 May 6.

33.

Cohort Profile: The European Longitudinal Study of Pregnancy and Childhood (ELSPAC) in the Czech Republic.

Piler P, Kandrnal V, Kukla L, Andrýsková L, Švancara J, Jarkovský J, Dušek L, Pikhart H, Bobák M, Klánová J.

Int J Epidemiol. 2017 Oct 1;46(5):1379-1379f. doi: 10.1093/ije/dyw091. No abstract available.

34.

Lack of Association between NYD-SP18 Variant and Obesity. The Health Alcohol and Psychosocial Factors in Eastern Europe Study.

Hubacek JA, Pikhart H, Kubinova R, Peasey A, Malyutina S, Pajak A, Tamosiunas A, Bobak M.

Ann Nutr Metab. 2016;68(4):244-8. doi: 10.1159/000445982. Epub 2016 May 31.

35.

Education, material condition and physical functioning trajectories in middle-aged and older adults in Central and Eastern Europe: a cross-country comparison.

Hu Y, Pikhart H, Pająk A, Kubínová R, Malyutina S, Besala A, Peasey A, Marmot M, Bobak M.

J Epidemiol Community Health. 2016 Nov;70(11):1128-1135. doi: 10.1136/jech-2015-206548. Epub 2016 May 18.

36.

Impact of Low Maternal Education on Early Childhood Overweight and Obesity in Europe.

Ruiz M, Goldblatt P, Morrison J, Porta D, Forastiere F, Hryhorczuk D, Antipkin Y, Saurel-Cubizolles MJ, Lioret S, Vrijheid M, Torrent M, Iñiguez C, Larrañaga I, Bakoula C, Veltsista A, van Eijsden M, Vrijkotte TG, Andrýsková L, Dušek L, Barros H, Correia S, Järvelin MR, Taanila A, Ludvigsson J, Faresjö T, Marmot M, Pikhart H.

Paediatr Perinat Epidemiol. 2016 May;30(3):274-84. doi: 10.1111/ppe.12285. Epub 2016 Mar 4.

PMID:
26945670
37.

Effort-reward imbalance at work, over-commitment personality and diet quality in Central and Eastern European populations.

Chen SW, Peasey A, Stefler D, Malyutina S, Pajak A, Kubinova R, Chan JH, Bobak M, Pikhart H.

Br J Nutr. 2016 Apr 14;115(7):1254-64. doi: 10.1017/S0007114515005516. Epub 2016 Feb 12.

PMID:
26867471
38.

Serum folate, vitamin B-12 and cognitive function in middle and older age: The HAPIEE study.

Horvat P, Gardiner J, Kubinova R, Pajak A, Tamosiunas A, Schöttker B, Pikhart H, Peasey A, Jansen E, Bobak M.

Exp Gerontol. 2016 Apr;76:33-8. doi: 10.1016/j.exger.2016.01.011. Epub 2016 Jan 22.

39.

Is regular drinking in later life an indicator of good health? Evidence from the English Longitudinal Study of Ageing.

Holdsworth C, Mendonça M, Pikhart H, Frisher M, de Oliveira C, Shelton N.

J Epidemiol Community Health. 2016 Aug;70(8):764-70. doi: 10.1136/jech-2015-206949. Epub 2016 Jan 21.

40.

Alcohol Consumption and Longitudinal Trajectories of Physical Functioning in Central and Eastern Europe: A 10-Year Follow-up of HAPIEE Study.

Hu Y, Pikhart H, Kubinova R, Malyutina S, Pajak A, Besala A, Bell S, Peasey A, Marmot M, Bobak M.

J Gerontol A Biol Sci Med Sci. 2016 Aug;71(8):1063-8. doi: 10.1093/gerona/glv233. Epub 2016 Jan 8.

41.
42.

Evidence for the free radical/oxidative stress theory of ageing from the CHANCES consortium: a meta-analysis of individual participant data.

Schöttker B, Brenner H, Jansen EH, Gardiner J, Peasey A, Kubínová R, Pająk A, Topor-Madry R, Tamosiunas A, Saum KU, Holleczek B, Pikhart H, Bobak M.

BMC Med. 2015 Dec 15;13:300. doi: 10.1186/s12916-015-0537-7.

43.

Mediterranean diet score and total and cardiovascular mortality in Eastern Europe: the HAPIEE study.

Stefler D, Malyutina S, Kubinova R, Pajak A, Peasey A, Pikhart H, Brunner EJ, Bobak M.

Eur J Nutr. 2017 Feb;56(1):421-429. doi: 10.1007/s00394-015-1092-x. Epub 2015 Nov 17.

44.

Alcohol, drinking pattern and all-cause, cardiovascular and alcohol-related mortality in Eastern Europe.

Bobak M, Malyutina S, Horvat P, Pajak A, Tamosiunas A, Kubinova R, Simonova G, Topor-Madry R, Peasey A, Pikhart H, Marmot MG.

Eur J Epidemiol. 2016 Jan;31(1):21-30. doi: 10.1007/s10654-015-0092-8. Epub 2015 Oct 14.

45.

Assessing the feasibility of screening and providing brief advice for alcohol misuse in general dental practice: a clustered randomised control trial protocol for the DART study.

Ntouva A, Porter J, Crawford MJ, Britton A, Gratus C, Newton T, Tsakos G, Heilmann A, Pikhart H, Watt RG.

BMJ Open. 2015 Oct 6;5(10):e008586. doi: 10.1136/bmjopen-2015-008586.

46.

Nobody Is Perfect: Comparison of the Accuracy of PCR-RFLP and KASP™ Method for Genotyping. ADH1B and FTO Polymorphisms as Examples.

Hubáček JA, Pikhart H, Peasey A, Kubínová R, Bobák M.

Folia Biol (Praha). 2015;61(4):156-60.

47.

FTO gene variant and risk of spontaneous abortion.

Hubacek JA, Kasparova D, Dlouha D, Pikhart H, Bobak M, Fait T.

Acta Obstet Gynecol Scand. 2016 Jan;95(1):118. doi: 10.1111/aogs.12777. Epub 2015 Oct 13. No abstract available.

PMID:
26399564
48.

WHO guidelines for a healthy diet and mortality from cardiovascular disease in European and American elderly: the CHANCES project.

Jankovic N, Geelen A, Streppel MT, de Groot LC, Kiefte-de Jong JC, Orfanos P, Bamia C, Trichopoulou A, Boffetta P, Bobak M, Pikhart H, Kee F, O'Doherty MG, Buckland G, Woodside J, Franco OH, Ikram MA, Struijk EA, Pajak A, Malyutina S, Kubinova R, Wennberg M, Park Y, Bueno-de-Mesquita HB, Kampman E, Feskens EJ.

Am J Clin Nutr. 2015 Oct;102(4):745-56. doi: 10.3945/ajcn.114.095117. Epub 2015 Sep 9.

49.

Do depressive symptoms predict cancer incidence?: 17-year follow-up of the Whitehall II study.

Archer G, Pikhart H, Head J.

J Psychosom Res. 2015 Dec;79(6):595-603. doi: 10.1016/j.jpsychores.2015.07.011. Epub 2015 Aug 8.

PMID:
26299450
50.

Is alcohol consumption in older adults associated with poor self-rated health? Cross-sectional and longitudinal analyses from the English Longitudinal Study of Ageing.

Frisher M, Mendonça M, Shelton N, Pikhart H, de Oliveira C, Holdsworth C.

BMC Public Health. 2015 Jul 24;15:703. doi: 10.1186/s12889-015-1993-x.

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