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Items: 1 to 50 of 468

1.

Mild, Modular and Convergent Synthesis of Helical Naphtho[2,1-c]chromenes via a Multistep Cyclization/aromatization Cascade Sequence.

Hinkle RJ, Speer DJ, Carnell BB, Kanter BL, Pike RD.

J Org Chem. 2019 Nov 5. doi: 10.1021/acs.joc.9b02058. [Epub ahead of print]

PMID:
31684728
2.

Protease-associated import systems are widespread in Gram-negative bacteria.

Grinter R, Leung PM, Wijeyewickrema LC, Littler D, Beckham S, Pike RN, Walker D, Greening C, Lithgow T.

PLoS Genet. 2019 Oct 15;15(10):e1008435. doi: 10.1371/journal.pgen.1008435. eCollection 2019 Oct.

3.

Hybrid Resistance and Virulence Plasmids in "High-Risk" Clones of Klebsiella pneumoniae, Including Those Carrying blaNDM-5.

Turton J, Davies F, Turton J, Perry C, Payne Z, Pike R.

Microorganisms. 2019 Sep 6;7(9). pii: E326. doi: 10.3390/microorganisms7090326.

4.

Alkyl Pyridinium Iodocuprate(I) Clusters: Structural Types and Charge Transfer Behavior.

Wheaton AM, Streep ME, Ohlhaver CM, Nicholas AD, Barnes FH, Patterson HH, Pike RD.

ACS Omega. 2018 Nov 12;3(11):15281-15292. doi: 10.1021/acsomega.8b01986. eCollection 2018 Nov 30.

5.

OSSOS XV: PROBING THE DISTANT SOLAR SYSTEM WITH OBSERVED SCATTERING TNOS.

Kaib NA, Pike R, Lawler S, Kovalik M, Brown C, Alexandersen M, Bannister MT, Gladman BJ, Petit JM.

Astron J. 2019 Jul;158(1). pii: 43. doi: 10.3847/1538-3881/ab2383. Epub 2019 Jul 2.

PMID:
31379385
6.

TNFR1 membrane reorganization promotes distinct modes of TNFα signaling.

Morton PE, Perrin C, Levitt J, Matthews DR, Marsh RJ, Pike R, McMillan D, Maloney A, Poland S, Ameer-Beg S, Parsons M.

Sci Signal. 2019 Jul 30;12(592). pii: eaaw2418. doi: 10.1126/scisignal.aaw2418.

PMID:
31363067
7.

Determination of the crystal structure and substrate specificity of ananain.

Yongqing T, Wilmann PG, Pan J, West ML, Brown TJ, Mynott T, Pike RN, Wijeyewickrema LC.

Biochimie. 2019 Nov;166:194-202. doi: 10.1016/j.biochi.2019.07.011. Epub 2019 Jul 12.

PMID:
31306685
8.

Investigation of a Pandoraea apista cluster common to adult and paediatric cystic fibrosis patients attending two hospitals in the same city.

Kenna DTD, Coward A, Perry C, Pike R, Schaefer U, Turton J, Green H, Jones AM, Bright-Thomas RJ, Burns P, Narayan O, Wilkinson S, Turton JF.

J Med Microbiol. 2019 Jul;68(7):1081-1095. doi: 10.1099/jmm.0.001010. Epub 2019 Jun 18.

PMID:
31210630
9.

Synthesis and Luminescence of Optical Memory Active Tetramethylammonium Cyanocuprate(I) 3D Networks.

Nicholas AD, Bullard RM, Wheaton AM, Streep M, Nicholas VA, Pike RD, Patterson HH.

Materials (Basel). 2019 Apr 12;12(8). pii: E1211. doi: 10.3390/ma12081211.

10.

Innovative 2-Step Management Strategy Utilizing EXIT Procedure for a Fetus With Hypoplastic Left Heart Syndrome and Intact Atrial Septum.

Said SM, Qureshi MY, Taggart NW, Anderson HN, O'Leary PW, Cetta F, Alrahmani L, Cofer SA, Segura LG, Pike RB, Sharpe EE, Derleth DP, Nemergut ME, Van Dorn CS, Gleich SJ, Rose CH, Collura CA, Ruano R.

Mayo Clin Proc. 2019 Feb;94(2):356-361. doi: 10.1016/j.mayocp.2018.08.004.

PMID:
30711131
11.

Further description of bovine tuberculosis trends in the United Kingdom and the Republic of Ireland, 2003-2015.

More SJ, Houtsma E, Doyle L, McGrath G, Clegg TA, de la Rua-Domenech R, Duignan A, Blissitt MJ, Dunlop M, Schroeder PG, Pike R, Upton P.

Vet Rec. 2018 Dec 15;183(23):717. doi: 10.1136/vr.104718. Epub 2018 Nov 28.

12.

Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods.

Li F, Wang Y, Li C, Marquez-Lago TT, Leier A, Rawlings ND, Haffari G, Revote J, Akutsu T, Chou KC, Purcell AW, Pike RN, Webb GI, Ian Smith A, Lithgow T, Daly RJ, Whisstock JC, Song J.

Brief Bioinform. 2018 Aug 29. doi: 10.1093/bib/bby077. [Epub ahead of print]

PMID:
30184176
13.

Synthesis of Spirocyclic Diphosphite-Supported Gold Metallomacrocycles via a Protodeauration/Cyclization Strategy: Mechanistic and Binding Studies.

Schafer LJ, Garcia KJ, Baggett AW, Lord TM, Findeis PM, Pike RD, Stockland RA Jr.

Inorg Chem. 2018 Sep 17;57(18):11662-11672. doi: 10.1021/acs.inorgchem.8b01805. Epub 2018 Sep 4.

PMID:
30178991
14.

Keratinocyte-specific ablation of protease-activated receptor 2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease.

Francis N, Ayodele BA, O'Brien-Simpson NM, Birchmeier W, Pike RN, Pagel CN, Mackie EJ.

Cell Microbiol. 2018 Nov;20(11):e12891. doi: 10.1111/cmi.12891. Epub 2018 Jul 31.

PMID:
30009515
15.

Molecular basis for the folding of β-helical autotransporter passenger domains.

Yuan X, Johnson MD, Zhang J, Lo AW, Schembri MA, Wijeyewickrema LC, Pike RN, Huysmans GHM, Henderson IR, Leyton DL.

Nat Commun. 2018 Apr 11;9(1):1395. doi: 10.1038/s41467-018-03593-2.

16.

Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells.

Casado P, Wilkes EH, Miraki-Moud F, Hadi MM, Rio-Machin A, Rajeeve V, Pike R, Iqbal S, Marfa S, Lea N, Best S, Gribben J, Fitzgibbon J, Cutillas PR.

Leukemia. 2018 Aug;32(8):1818-1822. doi: 10.1038/s41375-018-0032-1. Epub 2018 Apr 7. No abstract available.

17.

Pseudomonas aeruginosa sequence type 357 with VEB extended-spectrum β-lactamases in the UK: relatedness and resistance.

Greenwood B, Meunier D, Hopkins KL, Pike R, Ivanov Z, Turton JF, Hill R, Woodford N, Livermore DM.

Int J Antimicrob Agents. 2018 Aug;52(2):301-302. doi: 10.1016/j.ijantimicag.2018.03.013. Epub 2018 Mar 23. No abstract available.

PMID:
29580931
18.

KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation.

Pike R, Ortiz-Zapater E, Lumicisi B, Santis G, Parsons M.

Sci Signal. 2018 Jan 30;11(515). pii: eaaq1060. doi: 10.1126/scisignal.aaq1060.

19.

Activity of ceftazidime/avibactam against problem Enterobacteriaceae and Pseudomonas aeruginosa in the UK, 2015-16.

Livermore DM, Meunier D, Hopkins KL, Doumith M, Hill R, Pike R, Staves P, Woodford N.

J Antimicrob Chemother. 2018 Mar 1;73(3):648-657. doi: 10.1093/jac/dkx438.

PMID:
29228202
20.

Simultaneous flow cytometric immunophenotyping of necroptosis, apoptosis and RIP1-dependent apoptosis.

Lee HL, Pike R, Chong MHA, Vossenkamper A, Warnes G.

Methods. 2018 Feb 1;134-135:56-66. doi: 10.1016/j.ymeth.2017.10.013. Epub 2017 Nov 24.

PMID:
29175336
21.

Improving Results of Surgery for Ebstein Anomaly: Where Are We After 235 Cone Repairs?

Holst KA, Dearani JA, Said S, Pike RB, Connolly HM, Cannon BC, Sessions KL, O'Byrne MM, O'Leary PW.

Ann Thorac Surg. 2018 Jan;105(1):160-168. doi: 10.1016/j.athoracsur.2017.09.058. Epub 2017 Nov 24.

PMID:
29174783
22.

rpoB gene sequencing highlights the prevalence of an E. miricola cluster over other Elizabethkingia species among UK cystic fibrosis patients.

Kenna DTD, Fuller A, Martin K, Perry C, Pike R, Burns PJ, Narayan O, Wilkinson S, Hill R, Woodford N, Logan JMJ, Turton JF.

Diagn Microbiol Infect Dis. 2018 Feb;90(2):109-114. doi: 10.1016/j.diagmicrobio.2017.10.014. Epub 2017 Oct 26.

PMID:
29174734
23.

Further Investigation of the Intermolecular Diels-Alder Cycloaddition for the Synthesis of Bicyclo[2.2.2]diazaoctane Alkaloids.

Perkins JC, Wang X, Pike RD, Scheerer JR.

J Org Chem. 2017 Dec 15;82(24):13656-13662. doi: 10.1021/acs.joc.7b02403. Epub 2017 Nov 27.

24.

Arterial Stiffness Is Associated With QTc Interval Prolongation in Patients With Heart Failure.

Al-Zaiti S, Saba S, Pike R, Williams J, Khraim F.

Biol Res Nurs. 2018 May;20(3):255-263. doi: 10.1177/1099800417737835. Epub 2017 Oct 26.

PMID:
29073767
25.

PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy.

Song J, Li F, Leier A, Marquez-Lago TT, Akutsu T, Haffari G, Chou KC, Webb GI, Pike RN, Hancock J.

Bioinformatics. 2018 Feb 15;34(4):684-687. doi: 10.1093/bioinformatics/btx670.

26.

The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.

Pang SS, Wijeyewickrema LC, Hor L, Tan S, Lameignere E, Conway EM, Blom AM, Mohlin FC, Liu X, Payne RJ, Whisstock JC, Pike RN.

J Immunol. 2017 Dec 1;199(11):3883-3891. doi: 10.4049/jimmunol.1700158. Epub 2017 Oct 23.

27.

Metal Substitution and Solvomorphism in Alkylthiolate-Bridged Zn3 and HgZn2 Metal Clusters.

Hallinger MR, Gerhard AC, Ritz MD, Sacks JS, Poutsma JC, Pike RD, Wojtas L, Bebout DC.

ACS Omega. 2017 Oct 5;2(10):6391-6404. doi: 10.1021/acsomega.7b01087. eCollection 2017 Oct 31.

28.

A T cell-specific knockout reveals an important role for protease-activated receptor 2 in lymphocyte development.

Francis N, Every AL, Ayodele BA, Pike RN, Mackie EJ, Pagel CN.

Int J Biochem Cell Biol. 2017 Nov;92:95-103. doi: 10.1016/j.biocel.2017.09.015. Epub 2017 Sep 22.

PMID:
28951199
29.

Electrophilic Cyclization of Phenylalkynediols to Naphthyl(aryl)iodonium Triflates with Chelating Hydroxyls: Preparation and X-ray Analyses.

Hinkle RJ, Bredenkamp SE, Pike RD, Cheon SI.

J Org Chem. 2017 Nov 17;82(22):11781-11786. doi: 10.1021/acs.joc.7b01619. Epub 2017 Sep 11.

PMID:
28817776
30.

First outbreak of colonization by linezolid- and glycopeptide-resistant Enterococcus faecium harbouring the cfr gene in a UK nephrology unit.

Inkster T, Coia J, Meunier D, Doumith M, Martin K, Pike R, Imrie L, Kane H, Hay M, Wiuff C, Wilson J, Deighan C, Hopkins KL, Woodford N, Hill R.

J Hosp Infect. 2017 Dec;97(4):397-402. doi: 10.1016/j.jhin.2017.07.003. Epub 2017 Jul 8.

PMID:
28698020
31.

FRI-2 carbapenemase-producing Enterobacter cloacae complex in the UK.

Meunier D, Findlay J, Doumith M, Godoy D, Perry C, Pike R, Gronthoud F, Shryane T, Poirel L, Welfare W, Woodford N, Hopkins KL.

J Antimicrob Chemother. 2017 Sep 1;72(9):2478-2482. doi: 10.1093/jac/dkx173.

PMID:
28605515
32.

Activity of ceftolozane/tazobactam against surveillance and 'problem' Enterobacteriaceae, Pseudomonas aeruginosa and non-fermenters from the British Isles.

Livermore DM, Mushtaq S, Meunier D, Hopkins KL, Hill R, Adkin R, Chaudhry A, Pike R, Staves P, Woodford N; BSAC Resistance Surveillance Standing Committee.

J Antimicrob Chemother. 2017 Aug 1;72(8):2278-2289. doi: 10.1093/jac/dkx136.

33.

Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites.

Kennedy AT, Wijeyewickrema LC, Huglo A, Lin C, Pike R, Cowman AF, Tham WH.

J Immunol. 2017 Jun 15;198(12):4728-4737. doi: 10.4049/jimmunol.1700067. Epub 2017 May 8.

34.

Prevalence of Burkholderia species, including members of Burkholderia cepacia complex, among UK cystic and non-cystic fibrosis patients.

Kenna DTD, Lilley D, Coward A, Martin K, Perry C, Pike R, Hill R, Turton JF.

J Med Microbiol. 2017 Apr;66(4):490-501. doi: 10.1099/jmm.0.000458.

PMID:
28463663
35.

IMI-2 carbapenemase in a clinical Klebsiella variicola isolated in the UK.

Hopkins KL, Findlay J, Doumith M, Mather B, Meunier D, D'Arcy S, Pike R, Mustafa N, Howe R, Wootton M, Woodford N.

J Antimicrob Chemother. 2017 Jul 1;72(7):2129-2131. doi: 10.1093/jac/dkx103. No abstract available.

PMID:
28379381
36.

OXA-48-like carbapenemases in the UK: an analysis of isolates and cases from 2007 to 2014.

Findlay J, Hopkins KL, Loy R, Doumith M, Meunier D, Hill R, Pike R, Mustafa N, Livermore DM, Woodford N.

J Antimicrob Chemother. 2017 May 1;72(5):1340-1349. doi: 10.1093/jac/dkx012.

PMID:
28199647
37.

Serratia marcescens producing SME carbapenemases: an emerging resistance problem in the UK?

Hopkins KL, Findlay J, Meunier D, Cummins M, Curtis S, Kustos I, Mustafa N, Perry C, Pike R, Woodford N.

J Antimicrob Chemother. 2017 May 1;72(5):1535-1537. doi: 10.1093/jac/dkw567. No abstract available.

PMID:
28108680
38.

Characterization of carbapenemase-producing Enterobacteriaceae in the West Midlands region of England: 2007-14.

Findlay J, Hopkins KL, Alvarez-Buylla A, Meunier D, Mustafa N, Hill R, Pike R, McCrae LX, Hawkey PM, Woodford N.

J Antimicrob Chemother. 2017 Apr 1;72(4):1054-1062. doi: 10.1093/jac/dkw560.

PMID:
28073969
39.

Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014.

Sheppard C, Fry NK, Mushtaq S, Woodford N, Reynolds R, Janes R, Pike R, Hill R, Kimuli M, Staves P, Doumith M, Harrison T, Livermore DM.

Euro Surveill. 2016 Dec 15;21(50). pii: 30423. doi: 10.2807/1560-7917.ES.2016.21.50.30423.

40.

Effects of dry needling to the symptomatic versus control shoulder in patients with unilateral subacromial pain syndrome.

Koppenhaver S, Embry R, Ciccarello J, Waltrip J, Pike R, Walker M, Fernández-de-Las-Peñas C, Croy T, Flynn T.

Man Ther. 2016 Dec;26:62-69. doi: 10.1016/j.math.2016.07.009. Epub 2016 Jul 21.

PMID:
27497188
41.

Differences in systemic adaptive immunity contribute to the 'frequent exacerbator' COPD phenotype.

Geerdink JX, Simons SO, Pike R, Stauss HJ, Heijdra YF, Hurst JR.

Respir Res. 2016 Oct 28;17(1):140.

42.

Carbapenemase-producing Enterobacteriaceae in the UK: a national study (EuSCAPE-UK) on prevalence, incidence, laboratory detection methods and infection control measures.

Trepanier P, Mallard K, Meunier D, Pike R, Brown D, Ashby JP, Donaldson H, Awad-El-Kariem FM, Balakrishnan I, Cubbon M, Chadwick PR, Doughton M, Doughton R, Hardiman F, Harvey G, Horner C, Lee J, Lewis J, Loughrey A, Manuel R, Parsons H, Perry JD, Vanstone G, White G, Shetty N, Coia J, Wiuff C, Hopkins KL, Woodford N.

J Antimicrob Chemother. 2017 Feb;72(2):596-603. doi: 10.1093/jac/dkw414. Epub 2016 Sep 29.

PMID:
27687074
43.

Contrasting coordination behavior of Group 12 perchlorate salts with an acyclic N3O2 donor ligand by X-ray crystallography and (1)H NMR.

Tice DB, Pike RD, Bebout DC.

Dalton Trans. 2016 Aug 9;45(32):12871-83. doi: 10.1039/c6dt02322c.

PMID:
27472535
44.

Unifying physics and technology in light of Maxwell's equations.

Ellis J, Pike R, Zayats A.

Philos Trans A Math Phys Eng Sci. 2016 Aug 28;374(2075). pii: 20150264. doi: 10.1098/rsta.2015.0264. No abstract available.

45.

Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.

Wijeyewickrema LC, Lameignere E, Hor L, Duncan RC, Shiba T, Travers RJ, Kapopara PR, Lei V, Smith SA, Kim H, Morrissey JH, Pike RN, Conway EM.

Blood. 2016 Sep 29;128(13):1766-76. doi: 10.1182/blood-2016-02-699561. Epub 2016 Jun 23.

46.

TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers.

Morton PE, Hicks A, Ortiz-Zapater E, Raghavan S, Pike R, Noble A, Woodfin A, Jenkins G, Rayner E, Santis G, Parsons M.

Sci Rep. 2016 May 19;6:26321. doi: 10.1038/srep26321.

47.

PD1-Expressing T Cell Subsets Modify the Rejection Risk in Renal Transplant Patients.

Pike R, Thomas N, Workman S, Ambrose L, Guzman D, Sivakumaran S, Johnson M, Thorburn D, Harber M, Chain B, Stauss HJ.

Front Immunol. 2016 Apr 11;7:126. doi: 10.3389/fimmu.2016.00126. eCollection 2016.

48.

Novel Applications of Modified Ultrafiltration and Autologous Priming Techniques to Reduce Blood Product Exposure on ECMO.

Neal JR, Blau CL, Cornelius AM, Pike RB, Dearani JA, Mora BN.

J Extra Corpor Technol. 2016 Mar;48(1):23-6.

49.

SPM-1 metallo-β-lactamase-producing Pseudomonas aeruginosa ST277 in the UK.

Hopkins KL, Meunier D, Findlay J, Mustafa N, Parsons H, Pike R, Wright L, Woodford N.

J Med Microbiol. 2016 Jul;65(7):696-697. doi: 10.1099/jmm.0.000269. Epub 2016 Apr 27. No abstract available.

PMID:
27126265
50.

Evaluation of the K-SeT R.E.S.I.S.T. immunochromatographic assay for the rapid detection of KPC and OXA-48-like carbapenemases.

Meunier D, Vickers A, Pike R, Hill RL, Woodford N, Hopkins KL.

J Antimicrob Chemother. 2016 Aug;71(8):2357-9. doi: 10.1093/jac/dkw113. Epub 2016 Apr 26. No abstract available.

PMID:
27118775

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