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A control region near the fibroblast growth factor 23 gene mediates response to phosphate, 1,25(OH)2D3 and LPS in vivo.

Lee SM, Carlson AH, Onal M, Benkusky NA, Meyer MB, Pike JW.

Endocrinology. 2019 Oct 10. pii: en.2019-00622. doi: 10.1210/en.2019-00622. [Epub ahead of print]


A chromatin-based mechanism controls differential regulation of the cytochrome P450 gene Cyp24a1 in renal and non-renal tissues.

Meyer MB, Lee SM, Carlson AH, Benkusky NA, Kaufmann M, Jones G, Pike JW.

J Biol Chem. 2019 Sep 27;294(39):14467-14481. doi: 10.1074/jbc.RA119.010173. Epub 2019 Aug 22.


Targeted genomic deletions identify diverse enhancer functions and generate a kidney-specific, endocrine-deficient Cyp27b1 pseudo-null mouse.

Meyer MB, Benkusky NA, Kaufmann M, Lee SM, Redfield RR, Jones G, Pike JW.

J Biol Chem. 2019 Jun 14;294(24):9518-9535. doi: 10.1074/jbc.RA119.008760. Epub 2019 May 3.


The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2.

Helzer KT, Szatkowski Ozers M, Meyer MB, Benkusky NA, Solodin N, Reese RM, Warren CL, Pike JW, Alarid ET.

Mol Cell Biol. 2019 Jan 16;39(3). pii: e00417-18. doi: 10.1128/MCB.00417-18. Print 2019 Feb 1.


Evaluation of the pulmonary embolism rule out criteria (PERC rule) in children evaluated for suspected pulmonary embolism.

Kline JA, Ellison AM, Kanis J, Pike JW, Hall CL.

Thromb Res. 2018 Aug;168:1-4. doi: 10.1016/j.thromres.2018.05.026. Epub 2018 May 24.


A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse Fgf23 Gene.

Onal M, Carlson AH, Thostenson JD, Benkusky NA, Meyer MB, Lee SM, Pike JW.

JBMR Plus. 2018 Jan;2(1):32-47. doi: 10.1002/jbm4.10023. Epub 2017 Nov 21.


Biology and Mechanisms of Action of the Vitamin D Hormone.

Pike JW, Christakos S.

Endocrinol Metab Clin North Am. 2017 Dec;46(4):815-843. doi: 10.1016/j.ecl.2017.07.001. Epub 2017 Sep 29. Review.


A kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene Cyp27b1 essential for vitamin D3 activation.

Meyer MB, Benkusky NA, Kaufmann M, Lee SM, Onal M, Jones G, Pike JW.

J Biol Chem. 2017 Oct 20;292(42):17541-17558. doi: 10.1074/jbc.M117.806901. Epub 2017 Aug 14.


The impact of VDR expression and regulation in vivo.

Lee SM, Meyer MB, Benkusky NA, O'Brien CA, Pike JW.

J Steroid Biochem Mol Biol. 2018 Mar;177:36-45. doi: 10.1016/j.jsbmb.2017.06.002. Epub 2017 Jun 9.


Deletion of a Distal RANKL Gene Enhancer Delays Progression of Atherosclerotic Plaque Calcification in Hypercholesterolemic Mice.

Shamsuzzaman S, Onal M, St John HC, Pike JW.

J Cell Biochem. 2017 Dec;118(12):4240-4253. doi: 10.1002/jcb.26074. Epub 2017 May 30.


The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights.

Pike JW, Meyer MB, Lee SM, Onal M, Benkusky NA.

J Clin Invest. 2017 Apr 3;127(4):1146-1154. doi: 10.1172/JCI88887. Epub 2017 Feb 27. Review.


Class 3 semaphorins are transcriptionally regulated by 1,25(OH)2D3 in osteoblasts.

Ryynänen J, Kriebitzsch C, Meyer MB, Janssens I, Pike JW, Verlinden L, Verstuyf A.

J Steroid Biochem Mol Biol. 2017 Oct;173:185-193. doi: 10.1016/j.jsbmb.2017.02.005. Epub 2017 Feb 9.


Progesterone potentiates the growth inhibitory effects of calcitriol in endometrial cancer via suppression of CYP24A1.

Bokhari AA, Lee LR, Raboteau D, Turbov J, Rodriguez IV, Pike JW, Hamilton CA, Maxwell GL, Rodriguez GC, Syed V.

Oncotarget. 2016 Nov 22;7(47):77576-77590. doi: 10.18632/oncotarget.12725.


Absence of the Vitamin D Receptor Inhibits Atherosclerotic Plaque Calcification in Female Hypercholesterolemic Mice.

Shamsuzzaman S, Onal M, St John HC, Jeffery JJ, Pike JW.

J Cell Biochem. 2017 May;118(5):1050-1064. doi: 10.1002/jcb.25679. Epub 2017 Jan 5.


CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis.

Wang L, Zhao Z, Meyer MB, Saha S, Yu M, Guo A, Wisinski KB, Huang W, Cai W, Pike JW, Yuan M, Ahlquist P, Xu W.

Cancer Cell. 2016 Jul 11;30(1):179-180. doi: 10.1016/j.ccell.2016.06.013. Epub 2016 Jul 11. No abstract available.


Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-derived Mesenchymal Stem Cells.

Meyer MB, Benkusky NA, Sen B, Rubin J, Pike JW.

J Biol Chem. 2016 Aug 19;291(34):17829-47. doi: 10.1074/jbc.M116.736538. Epub 2016 Jul 11.


Progestins inhibit calcitriol-induced CYP24A1 and synergistically inhibit ovarian cancer cell viability: An opportunity for chemoprevention.

Rodriguez GC, Turbov J, Rosales R, Yoo J, Hunn J, Zappia KJ, Lund K, Barry CP, Rodriguez IV, Pike JW, Conrads TP, Darcy KM, Maxwell GL, Hamilton CA, Syed V, Thaete LG.

Gynecol Oncol. 2016 Oct;143(1):159-167. doi: 10.1016/j.ygyno.2016.04.022. Epub 2016 Jul 29.


Genomic Determinants of Vitamin D-Regulated Gene Expression.

Pike JW, Meyer MB, Benkusky NA, Lee SM, St John H, Carlson A, Onal M, Shamsuzzaman S.

Vitam Horm. 2016;100:21-44. doi: 10.1016/bs.vh.2015.10.011. Epub 2015 Nov 27. Review.


Closing in on Vitamin D Action in Skeletal Muscle: Early Activity in Muscle Stem Cells?

Pike JW.

Endocrinology. 2016 Jan;157(1):48-51. doi: 10.1210/en.2015-2009. No abstract available.


Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-Induced Expression of RANKL.

Onal M, St John HC, Danielson AL, Markert JW, Riley EM, Pike JW.

Endocrinology. 2016 Feb;157(2):482-96. doi: 10.1210/en.2015-1788. Epub 2015 Dec 8.


Mechanisms of Enhancer-mediated Hormonal Control of Vitamin D Receptor Gene Expression in Target Cells.

Lee SM, Meyer MB, Benkusky NA, O'Brien CA, Pike JW.

J Biol Chem. 2015 Dec 18;290(51):30573-86. doi: 10.1074/jbc.M115.693614. Epub 2015 Oct 25.


Selective regulation of Mmp13 by 1,25(OH)2D3, PTH, and Osterix through distal enhancers.

Meyer MB, Benkusky NA, Onal M, Pike JW.

J Steroid Biochem Mol Biol. 2016 Nov;164:258-264. doi: 10.1016/j.jsbmb.2015.09.001. Epub 2015 Sep 5.


The vitamin D receptor functions as a transcription regulator in the absence of 1,25-dihydroxyvitamin D3.

Lee SM, Pike JW.

J Steroid Biochem Mol Biol. 2016 Nov;164:265-270. doi: 10.1016/j.jsbmb.2015.08.018. Epub 2015 Aug 29.


Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes.

Kraushar ML, Viljetic B, Wijeratne HR, Thompson K, Jiao X, Pike JW, Medvedeva V, Groszer M, Kiledjian M, Hart RP, Rasin MR.

J Neurosci. 2015 Aug 5;35(31):10911-26. doi: 10.1523/JNEUROSCI.0601-15.2015.


1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D.

Kaneko I, Sabir MS, Dussik CM, Whitfield GK, Karrys A, Hsieh JC, Haussler MR, Meyer MB, Pike JW, Jurutka PW.

FASEB J. 2015 Sep;29(9):4023-35. doi: 10.1096/fj.14-269811. Epub 2015 Jun 12.


1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium-regulating Components.

Lee SM, Riley EM, Meyer MB, Benkusky NA, Plum LA, DeLuca HF, Pike JW.

J Biol Chem. 2015 Jul 17;290(29):18199-215. doi: 10.1074/jbc.M115.665794. Epub 2015 Jun 3.


Epigenetic histone modifications and master regulators as determinants of context dependent nuclear receptor activity in bone cells.

Pike JW, Meyer MB, St John HC, Benkusky NA.

Bone. 2015 Dec;81:757-764. doi: 10.1016/j.bone.2015.03.012. Epub 2015 Mar 27. Review.


Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions.

Meyer MB, Benkusky NA, Pike JW.

J Biol Chem. 2015 Apr 24;290(17):11093-107. doi: 10.1074/jbc.M115.648394. Epub 2015 Mar 15.


The parathyroid hormone-regulated transcriptome in osteocytes: parallel actions with 1,25-dihydroxyvitamin D3 to oppose gene expression changes during differentiation and to promote mature cell function.

St John HC, Meyer MB, Benkusky NA, Carlson AH, Prideaux M, Bonewald LF, Pike JW.

Bone. 2015 Mar;72:81-91. doi: 10.1016/j.bone.2014.11.010. Epub 2014 Nov 22.


A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse.

Onal M, Bishop KA, St John HC, Danielson AL, Riley EM, Piemontese M, Xiong J, Goellner JJ, O'Brien CA, Pike JW.

J Bone Miner Res. 2015 May;30(5):855-68. doi: 10.1002/jbmr.2417.


Profiling histone modifications by chromatin immunoprecipitation coupled to deep sequencing in skeletal cells.

Meyer MB, Benkusky NA, Pike JW.

Methods Mol Biol. 2015;1226:61-70. doi: 10.1007/978-1-4939-1619-1_6.


Transcriptional regulation of the human TNFSF11 gene in T cells via a cell type-selective set of distal enhancers.

Bishop KA, Wang X, Coy HM, Meyer MB, Gumperz JE, Pike JW.

J Cell Biochem. 2015 Feb;116(2):320-30. doi: 10.1002/jcb.24974.


Expression of the vitamin D receptor in skeletal muscle: are we there yet?

Pike JW.

Endocrinology. 2014 Sep;155(9):3214-8. doi: 10.1210/en.2014-1624. No abstract available.


A humanized mouse model of hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia.

Lee SM, Goellner JJ, O'Brien CA, Pike JW.

Endocrinology. 2014 Nov;155(11):4137-48. doi: 10.1210/en.2014-1417. Epub 2014 Aug 22.


Identification of gene expression changes in postnatal rat foreskin after in utero anti-androgen exposure.

Pike JW, McDowell E, McCahan SM, Johnson KJ.

Reprod Toxicol. 2014 Aug;47:42-50. doi: 10.1016/j.reprotox.2014.05.011. Epub 2014 Jun 2.


Genomic determinants of gene regulation by 1,25-dihydroxyvitamin D3 during osteoblast-lineage cell differentiation.

Meyer MB, Benkusky NA, Lee CH, Pike JW.

J Biol Chem. 2014 Jul 11;289(28):19539-54. doi: 10.1074/jbc.M114.578104. Epub 2014 Jun 2.


The osteoblast to osteocyte transition: epigenetic changes and response to the vitamin D3 hormone.

St John HC, Bishop KA, Meyer MB, Benkusky NA, Leng N, Kendziorski C, Bonewald LF, Pike JW.

Mol Endocrinol. 2014 Jul;28(7):1150-65. doi: 10.1210/me.2014-1091. Epub 2014 May 30.


The RUNX2 cistrome in osteoblasts: characterization, down-regulation following differentiation, and relationship to gene expression.

Meyer MB, Benkusky NA, Pike JW.

J Biol Chem. 2014 Jun 6;289(23):16016-31. doi: 10.1074/jbc.M114.552216. Epub 2014 Apr 24.


Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype.

Lee SM, Bishop KA, Goellner JJ, O'Brien CA, Pike JW.

Endocrinology. 2014 Jun;155(6):2064-76. doi: 10.1210/en.2014-1107. Epub 2014 Apr 2.


Regulation of gene expression by 1,25-dihydroxyvitamin D3 in bone cells: exploiting new approaches and defining new mechanisms.

Pike JW, Lee SM, Meyer MB.

Bonekey Rep. 2014 Jan 8;3:482. doi: 10.1038/bonekey.2013.216. eCollection 2014 Jan 8. Review.


CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.

Wang L, Zhao Z, Meyer MB, Saha S, Yu M, Guo A, Wisinski KB, Huang W, Cai W, Pike JW, Yuan M, Ahlquist P, Xu W.

Cancer Cell. 2014 Jan 13;25(1):21-36. doi: 10.1016/j.ccr.2013.12.007. Erratum in: Cancer Cell. 2016 Jul 11;30(1):179-180.


Fundamentals of vitamin D hormone-regulated gene expression.

Pike JW, Meyer MB.

J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:5-11. doi: 10.1016/j.jsbmb.2013.11.004. Epub 2013 Nov 12. Review.


1,25-Dihydroxyvitamin D3 induced histone profiles guide discovery of VDR action sites.

Meyer MB, Benkusky NA, Pike JW.

J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:19-21. doi: 10.1016/j.jsbmb.2013.09.005. Epub 2013 Sep 13. Review.


Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells.

Obr AE, Grimm SL, Bishop KA, Pike JW, Lydon JP, Edwards DP.

Mol Endocrinol. 2013 Nov;27(11):1808-24. doi: 10.1210/me.2013-1077. Epub 2013 Sep 6.


Mechanical strain downregulates C/EBPβ in MSC and decreases endoplasmic reticulum stress.

Styner M, Meyer MB, Galior K, Case N, Xie Z, Sen B, Thompson WR, Pike JW, Rubin J.

PLoS One. 2012;7(12):e51613. doi: 10.1371/journal.pone.0051613. Epub 2012 Dec 12.


A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis.

McDowell EN, Kisielewski AE, Pike JW, Franco HL, Yao HH, Johnson KJ.

PLoS One. 2012;7(10):e47359. doi: 10.1371/journal.pone.0047359. Epub 2012 Oct 25.


1,25-Dihydroxyvitamin D3 and the aging-related forkhead box O and sestrin proteins in osteoblasts.

Eelen G, Verlinden L, Meyer MB, Gijsbers R, Pike JW, Bouillon R, Verstuyf A.

J Steroid Biochem Mol Biol. 2013 Jul;136:112-9. doi: 10.1016/j.jsbmb.2012.09.011. Epub 2012 Sep 16.


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