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APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice.

Stephen TL, Cacciottolo M, Balu D, Morgan TE, LaDu MJ, Finch CE, Pike CJ.

Acta Neuropathol Commun. 2019 May 21;7(1):82. doi: 10.1186/s40478-019-0729-z.


APOE genotype affects metabolic and Alzheimer-related outcomes induced by Western diet in female EFAD mice.

Christensen A, Pike CJ.

FASEB J. 2019 Mar;33(3):4054-4066. doi: 10.1096/fj.201801756R. Epub 2018 Dec 3.


TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity.

Moser VA, Uchoa MF, Pike CJ.

J Neuroinflammation. 2018 Nov 5;15(1):306. doi: 10.1186/s12974-018-1340-0.


Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats.

Moser VA, Christensen A, Liu J, Zhou A, Yagi S, Beam CR, Galea L, Pike CJ.

Neurobiol Aging. 2019 Jan;73:145-160. doi: 10.1016/j.neurobiolaging.2018.09.016. Epub 2018 Sep 22.


Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.

Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P.

Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7.


TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice.

Christensen A, Pike CJ.

Neurosci Lett. 2018 Sep 14;683:7-12. doi: 10.1016/j.neulet.2018.06.029. Epub 2018 Jun 18.


The Oxygen Paradox, the French Paradox, and age-related diseases.

Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA.

Geroscience. 2017 Dec;39(5-6):499-550. doi: 10.1007/s11357-017-0002-y. Epub 2017 Dec 21. Review.


Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice.

Moser VA, Pike CJ.

eNeuro. 2017 Jun 13;4(3). pii: ENEURO.0077-17.2017. doi: 10.1523/ENEURO.0077-17.2017. eCollection 2017 May-Jun.


Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice.

Christensen A, Pike CJ.

PLoS One. 2017 Jun 2;12(6):e0178490. doi: 10.1371/journal.pone.0178490. eCollection 2017.


Sex and the development of Alzheimer's disease.

Pike CJ.

J Neurosci Res. 2017 Jan 2;95(1-2):671-680. doi: 10.1002/jnr.23827. Review.


Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors.

Uchoa MF, Moser VA, Pike CJ.

Front Neuroendocrinol. 2016 Oct;43:60-82. doi: 10.1016/j.yfrne.2016.09.001. Epub 2016 Sep 17. Review.


Obesity and sex interact in the regulation of Alzheimer's disease.

Moser VA, Pike CJ.

Neurosci Biobehav Rev. 2016 Aug;67:102-18. doi: 10.1016/j.neubiorev.2015.08.021. Epub 2015 Dec 18. Review.


The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice.

Cacciottolo M, Christensen A, Moser A, Liu J, Pike CJ, Smith C, LaDu MJ, Sullivan PM, Morgan TE, Dolzhenko E, Charidimou A, Wahlund LO, Wiberg MK, Shams S, Chiang GC; Alzheimer's Disease Neuroimaging Initiative, Finch CE.

Neurobiol Aging. 2016 Jan;37:47-57. doi: 10.1016/j.neurobiolaging.2015.10.010. Epub 2015 Oct 19.


Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease.

Christensen A, Pike CJ.

Front Aging Neurosci. 2015 Jul 7;7:130. doi: 10.3389/fnagi.2015.00130. eCollection 2015. Review.


The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity.

Yin F, Yao J, Sancheti H, Feng T, Melcangi RC, Morgan TE, Finch CE, Pike CJ, Mack WJ, Cadenas E, Brinton RD.

Neurobiol Aging. 2015 Jul;36(7):2282-2295. doi: 10.1016/j.neurobiolaging.2015.03.013. Epub 2015 Apr 1.


Impact of continuous versus discontinuous progesterone on estradiol regulation of neuron viability and sprouting after entorhinal cortex lesion in female rats.

Barron AM, Brown MA, Morgan TE, Pike CJ.

Endocrinology. 2015 Mar;156(3):1091-9. doi: 10.1210/en.2014-1216. Epub 2014 Dec 16.


Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function.

Jayaraman A, Lent-Schochet D, Pike CJ.

J Neuroinflammation. 2014 Sep 16;11:162. doi: 10.1186/s12974-014-0162-y.


Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions.

Jayaraman A, Pike CJ.

Curr Diab Rep. 2014 Apr;14(4):476. doi: 10.1007/s11892-014-0476-2. Review.


Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats.

Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ.

Endocrinology. 2014 Apr;155(4):1398-406. doi: 10.1210/en.2013-1725. Epub 2014 Jan 15.


Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons.

Jayaraman A, Pike CJ.

Mol Cell Endocrinol. 2014 Mar 25;384(1-2):52-60. doi: 10.1016/j.mce.2014.01.003. Epub 2014 Jan 11.


Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease.

Barron AM, Rosario ER, Elteriefi R, Pike CJ.

PLoS One. 2013 Oct 28;8(10):e78554. doi: 10.1371/journal.pone.0078554. eCollection 2013.


Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.

Barron AM, Garcia-Segura LM, Caruso D, Jayaraman A, Lee JW, Melcangi RC, Pike CJ.

J Neurosci. 2013 May 15;33(20):8891-7. doi: 10.1523/JNEUROSCI.1350-13.2013.


Age-related changes in neuroactive steroid levels in 3xTg-AD mice.

Caruso D, Barron AM, Brown MA, Abbiati F, Carrero P, Pike CJ, Garcia-Segura LM, Melcangi RC.

Neurobiol Aging. 2013 Apr;34(4):1080-9. doi: 10.1016/j.neurobiolaging.2012.10.007. Epub 2012 Nov 2.


17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain.

Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ.

Endocrinology. 2012 Nov;153(11):5467-79. doi: 10.1210/en.2012-1464. Epub 2012 Sep 7.


Evaluation of the effects of testosterone and luteinizing hormone on regulation of β-amyloid in male 3xTg-AD mice.

Rosario ER, Carroll JC, Pike CJ.

Brain Res. 2012 Jul 23;1466:137-45. doi: 10.1016/j.brainres.2012.05.011. Epub 2012 May 14.


Gender, sex steroid hormones, and Alzheimer's disease.

Vest RS, Pike CJ.

Horm Behav. 2013 Feb;63(2):301-7. doi: 10.1016/j.yhbeh.2012.04.006. Epub 2012 Apr 19. Review.


Caspase activation contributes to astrogliosis.

Aras R, Barron AM, Pike CJ.

Brain Res. 2012 Apr 23;1450:102-15. doi: 10.1016/j.brainres.2012.02.056. Epub 2012 Mar 1.


Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles.

Zhao L, Morgan TE, Mao Z, Lin S, Cadenas E, Finch CE, Pike CJ, Mack WJ, Brinton RD.

PLoS One. 2012;7(2):e31267. doi: 10.1371/journal.pone.0031267. Epub 2012 Feb 29.


Sex hormones, aging, and Alzheimer's disease.

Barron AM, Pike CJ.

Front Biosci (Elite Ed). 2012 Jan 1;4:976-97. Review.


Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure.

Carroll JC, Rosario ER, Kreimer S, Villamagna A, Gentzschein E, Stanczyk FZ, Pike CJ.

Brain Res. 2010 Dec 17;1366:233-45. doi: 10.1016/j.brainres.2010.10.009. Epub 2010 Oct 8.


Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.

Rosario ER, Carroll J, Pike CJ.

Brain Res. 2010 Nov 4;1359:281-90. doi: 10.1016/j.brainres.2010.08.068. Epub 2010 Aug 31.


Androgens selectively protect against apoptosis in hippocampal neurones.

Nguyen TV, Jayaraman A, Quaglino A, Pike CJ.

J Neuroendocrinol. 2010 Sep;22(9):1013-22. doi: 10.1111/j.1365-2826.2010.02044.x. Epub 2010 Jun 16.


Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice.

Carroll JC, Rosario ER, Villamagna A, Pike CJ.

Endocrinology. 2010 Jun;151(6):2713-22. doi: 10.1210/en.2009-1487. Epub 2010 Apr 21.


Age-related changes in serum and brain levels of androgens in male Brown Norway rats.

Rosario ER, Chang L, Beckett TL, Carroll JC, Paul Murphy M, Stanczyk FZ, Pike CJ.

Neuroreport. 2009 Nov 25;20(17):1534-7. doi: 10.1097/WNR.0b013e328331f968.


Dihydrotestosterone activates CREB signaling in cultured hippocampal neurons.

Nguyen TV, Yao M, Pike CJ.

Brain Res. 2009 Nov 17;1298:1-12. doi: 10.1016/j.brainres.2009.08.066. Epub 2009 Aug 31.


Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease.

Rosario ER, Chang L, Head EH, Stanczyk FZ, Pike CJ.

Neurobiol Aging. 2011 Apr;32(4):604-13. doi: 10.1016/j.neurobiolaging.2009.04.008. Epub 2009 May 9.


Protective actions of sex steroid hormones in Alzheimer's disease.

Pike CJ, Carroll JC, Rosario ER, Barron AM.

Front Neuroendocrinol. 2009 Jul;30(2):239-58. doi: 10.1016/j.yfrne.2009.04.015. Epub 2009 May 7. Review.


Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones.

Jayaraman A, Pike CJ.

J Neuroendocrinol. 2009 Jan;21(1):77-81. doi: 10.1111/j.1365-2826.2008.01801.x.


Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats.

Carroll JC, Rosario ER, Pike CJ.

Neurosci Lett. 2008 Nov 21;445(3):229-32. doi: 10.1016/j.neulet.2008.09.010. Epub 2008 Sep 7.


Progesterone receptors: form and function in brain.

Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, Pike CJ, Mack WJ, Stanczyk FZ, Nilsen J.

Front Neuroendocrinol. 2008 May;29(2):313-39. doi: 10.1016/j.yfrne.2008.02.001. Epub 2008 Feb 23. Review.


Androgens regulate neprilysin expression: role in reducing beta-amyloid levels.

Yao M, Nguyen TV, Rosario ER, Ramsden M, Pike CJ.

J Neurochem. 2008 Jun 1;105(6):2477-88. doi: 10.1111/j.1471-4159.2008.05341.x.


Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice.

Carroll JC, Pike CJ.

Endocrinology. 2008 May;149(5):2607-11. doi: 10.1210/en.2007-1346. Epub 2008 Feb 14.


Androgen cell signaling pathways involved in neuroprotective actions.

Pike CJ, Nguyen TV, Ramsden M, Yao M, Murphy MP, Rosario ER.

Horm Behav. 2008 May;53(5):693-705. doi: 10.1016/j.yhbeh.2007.11.006. Epub 2007 Nov 22. Review.


Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.

Carroll JC, Rosario ER, Chang L, Stanczyk FZ, Oddo S, LaFerla FM, Pike CJ.

J Neurosci. 2007 Nov 28;27(48):13357-65.


Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease.

Rosario ER, Pike CJ.

Brain Res Rev. 2008 Mar;57(2):444-53. Epub 2007 Jul 7. Review.


Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection.

Nguyen TV, Yao M, Pike CJ.

Endocrinology. 2007 Jun;148(6):2936-43. Epub 2007 Mar 8.


Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease.

Rosario ER, Carroll JC, Oddo S, LaFerla FM, Pike CJ.

J Neurosci. 2006 Dec 20;26(51):13384-9.


Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons.

Chen MJ, Nguyen TV, Pike CJ, Russo-Neustadt AA.

Cell Signal. 2007 Jan;19(1):114-28. Epub 2006 Jun 7.


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