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Items: 49

1.

Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.

Wang Q, Corey RA, Hedger G, Aryal P, Grieben M, Nasrallah C, Baronina A, Pike ACW, Shi J, Carpenter EP, Sansom MSP.

Structure. 2019 Nov 27. pii: S0969-2126(19)30389-2. doi: 10.1016/j.str.2019.11.005. [Epub ahead of print]

2.

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP.

Nat Commun. 2019 Sep 2;10(1):3956. doi: 10.1038/s41467-019-11753-1.

3.

The translational neural circuitry of anxiety.

Robinson OJ, Pike AC, Cornwell B, Grillon C.

J Neurol Neurosurg Psychiatry. 2019 Dec;90(12):1353-1360. doi: 10.1136/jnnp-2019-321400. Epub 2019 Jun 29. Review.

PMID:
31256001
4.

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.

Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T.

Science. 2019 Feb 22;363(6429):875-880. doi: 10.1126/science.aav0569.

PMID:
30792303
5.

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.

Dong YY, Wang H, Pike ACW, Cochrane SA, Hamedzadeh S, Wyszyński FJ, Bushell SR, Royer SF, Widdick DA, Sajid A, Boshoff HI, Park Y, Lucas R, Liu WM, Lee SS, Machida T, Minall L, Mehmood S, Belaya K, Liu WW, Chu A, Shrestha L, Mukhopadhyay SMM, Strain-Damerell C, Chalk R, Burgess-Brown NA, Bibb MJ, Barry Iii CE, Robinson CV, Beeson D, Davis BG, Carpenter EP.

Cell. 2018 Nov 1;175(4):1045-1058.e16. doi: 10.1016/j.cell.2018.10.037.

6.

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike ACW, Carpenter EP, Baukrowitz T, Sansom MSP, Tucker SJ.

Structure. 2017 May 2;25(5):708-718.e2. doi: 10.1016/j.str.2017.03.006. Epub 2017 Apr 6.

7.

Deep Brain Stimulation in Anorexia Nervosa: Hope for the Hopeless or Exploitation of the Vulnerable? The Oxford Neuroethics Gold Standard Framework.

Park RJ, Singh I, Pike AC, Tan JO.

Front Psychiatry. 2017 Mar 20;8:44. doi: 10.3389/fpsyt.2017.00044. eCollection 2017.

8.

Hibernation reduces cellular damage caused by warm hepatic ischemia-reperfusion in ground squirrels.

Otis JP, Pike AC, Torrealba JR, Carey HV.

J Comp Physiol B. 2017 May;187(4):639-648. doi: 10.1007/s00360-017-1056-y. Epub 2017 Jan 31.

PMID:
28144740
9.

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2.

Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S, Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kühlbrandt W, Witzgall R, Ziegler C.

Nat Struct Mol Biol. 2017 Feb;24(2):123-130. doi: 10.1038/nsmb.3357. Epub 2017 Jan 16.

PMID:
28092368
10.

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).

Grieben M, Pike AC, Shintre CA, Venturi E, El-Ajouz S, Tessitore A, Shrestha L, Mukhopadhyay S, Mahajan P, Chalk R, Burgess-Brown NA, Sitsapesan R, Huiskonen JT, Carpenter EP.

Nat Struct Mol Biol. 2017 Feb;24(2):114-122. doi: 10.1038/nsmb.3343. Epub 2016 Dec 19.

PMID:
27991905
11.

An overview of heavy-atom derivatization of protein crystals.

Pike AC, Garman EF, Krojer T, von Delft F, Carpenter EP.

Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):303-18. doi: 10.1107/S2059798316000401. Epub 2016 Mar 1. Review.

12.

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures.

Pike AC, Gomathinayagam S, Swuec P, Berti M, Zhang Y, Schnecke C, Marino F, von Delft F, Renault L, Costa A, Gileadi O, Vindigni A.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4286-91. doi: 10.1073/pnas.1417594112. Epub 2015 Mar 23.

13.

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.

Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP.

Science. 2015 Mar 13;347(6227):1256-9. doi: 10.1126/science.1261512.

14.

Squeezing the most from every crystal: the fine details of data collection.

Krojer T, Pike AC, von Delft F.

Acta Crystallogr D Biol Crystallogr. 2013 Jul;69(Pt 7):1303-13. doi: 10.1107/S0907444913013280. Epub 2013 Jun 18.

15.

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.

Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9710-5. doi: 10.1073/pnas.1217042110. Epub 2013 May 28.

16.

The structural basis of ZMPSTE24-dependent laminopathies.

Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP.

Science. 2013 Mar 29;339(6127):1604-7. doi: 10.1126/science.1231513.

PMID:
23539603
17.

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

Canning P, Cooper CD, Krojer T, Murray JW, Pike AC, Chaikuad A, Keates T, Thangaratnarajah C, Hojzan V, Ayinampudi V, Marsden BD, Gileadi O, Knapp S, von Delft F, Bullock AN.

J Biol Chem. 2013 Mar 15;288(11):7803-14. doi: 10.1074/jbc.M112.437996. Epub 2013 Jan 24. Erratum in: J Biol Chem. 2013 Sep 27;388(39):28304. Ayinampudi, Vikram [added].

18.

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.

Adams CJ, Pike AC, Maniam S, Sharpe TD, Coutts AS, Knapp S, La Thangue NB, Bullock AN.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3778-83. doi: 10.1073/pnas.1113731109. Epub 2012 Feb 23.

19.

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

Lucic B, Zhang Y, King O, Mendoza-Maldonado R, Berti M, Niesen FH, Burgess-Brown NA, Pike AC, Cooper CD, Gileadi O, Vindigni A.

Nucleic Acids Res. 2011 Mar;39(5):1703-17. doi: 10.1093/nar/gkq1031. Epub 2010 Nov 8.

20.

Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.

Zadjali F, Pike AC, Vesterlund M, Sun J, Wu C, Li SS, Rönnstrand L, Knapp S, Bullock AN, Flores-Morales A.

J Biol Chem. 2011 Jan 7;286(1):480-90. doi: 10.1074/jbc.M110.173526. Epub 2010 Oct 28.

21.

Structural comparison of human mammalian ste20-like kinases.

Record CJ, Chaikuad A, Rellos P, Das S, Pike AC, Fedorov O, Marsden BD, Knapp S, Lee WH.

PLoS One. 2010 Aug 6;5(8):e11905. doi: 10.1371/journal.pone.0011905.

22.

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.

Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S.

PLoS Biol. 2010 Jul 27;8(7):e1000426. doi: 10.1371/journal.pbio.1000426.

23.

Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3.

Porté S, Valencia E, Yakovtseva EA, Borràs E, Shafqat N, Debreczeny JE, Pike AC, Oppermann U, Farrés J, Fita I, Parés X.

J Biol Chem. 2009 Jun 19;284(25):17194-205. doi: 10.1074/jbc.M109.001800. Epub 2009 Apr 5.

24.

Structure of dystrophia myotonica protein kinase.

Elkins JM, Amos A, Niesen FH, Pike AC, Fedorov O, Knapp S.

Protein Sci. 2009 Apr;18(4):782-91. doi: 10.1002/pro.82.

25.

Structure of the human RECQ1 helicase reveals a putative strand-separation pin.

Pike AC, Shrestha B, Popuri V, Burgess-Brown N, Muzzolini L, Costantini S, Vindigni A, Gileadi O.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1039-44. doi: 10.1073/pnas.0806908106. Epub 2009 Jan 16.

26.

X-ray crystallography of agonist/antagonist-bound receptors.

Pike AC.

Methods Mol Biol. 2009;505:51-66. doi: 10.1007/978-1-60327-575-0_4.

PMID:
19117139
27.

Accurate whole human genome sequencing using reversible terminator chemistry.

Bentley DR, Balasubramanian S, Swerdlow HP, Smith GP, Milton J, Brown CG, Hall KP, Evers DJ, Barnes CL, Bignell HR, Boutell JM, Bryant J, Carter RJ, Keira Cheetham R, Cox AJ, Ellis DJ, Flatbush MR, Gormley NA, Humphray SJ, Irving LJ, Karbelashvili MS, Kirk SM, Li H, Liu X, Maisinger KS, Murray LJ, Obradovic B, Ost T, Parkinson ML, Pratt MR, Rasolonjatovo IM, Reed MT, Rigatti R, Rodighiero C, Ross MT, Sabot A, Sankar SV, Scally A, Schroth GP, Smith ME, Smith VP, Spiridou A, Torrance PE, Tzonev SS, Vermaas EH, Walter K, Wu X, Zhang L, Alam MD, Anastasi C, Aniebo IC, Bailey DM, Bancarz IR, Banerjee S, Barbour SG, Baybayan PA, Benoit VA, Benson KF, Bevis C, Black PJ, Boodhun A, Brennan JS, Bridgham JA, Brown RC, Brown AA, Buermann DH, Bundu AA, Burrows JC, Carter NP, Castillo N, Chiara E Catenazzi M, Chang S, Neil Cooley R, Crake NR, Dada OO, Diakoumakos KD, Dominguez-Fernandez B, Earnshaw DJ, Egbujor UC, Elmore DW, Etchin SS, Ewan MR, Fedurco M, Fraser LJ, Fuentes Fajardo KV, Scott Furey W, George D, Gietzen KJ, Goddard CP, Golda GS, Granieri PA, Green DE, Gustafson DL, Hansen NF, Harnish K, Haudenschild CD, Heyer NI, Hims MM, Ho JT, Horgan AM, Hoschler K, Hurwitz S, Ivanov DV, Johnson MQ, James T, Huw Jones TA, Kang GD, Kerelska TH, Kersey AD, Khrebtukova I, Kindwall AP, Kingsbury Z, Kokko-Gonzales PI, Kumar A, Laurent MA, Lawley CT, Lee SE, Lee X, Liao AK, Loch JA, Lok M, Luo S, Mammen RM, Martin JW, McCauley PG, McNitt P, Mehta P, Moon KW, Mullens JW, Newington T, Ning Z, Ling Ng B, Novo SM, O'Neill MJ, Osborne MA, Osnowski A, Ostadan O, Paraschos LL, Pickering L, Pike AC, Pike AC, Chris Pinkard D, Pliskin DP, Podhasky J, Quijano VJ, Raczy C, Rae VH, Rawlings SR, Chiva Rodriguez A, Roe PM, Rogers J, Rogert Bacigalupo MC, Romanov N, Romieu A, Roth RK, Rourke NJ, Ruediger ST, Rusman E, Sanches-Kuiper RM, Schenker MR, Seoane JM, Shaw RJ, Shiver MK, Short SW, Sizto NL, Sluis JP, Smith MA, Ernest Sohna Sohna J, Spence EJ, Stevens K, Sutton N, Szajkowski L, Tregidgo CL, Turcatti G, Vandevondele S, Verhovsky Y, Virk SM, Wakelin S, Walcott GC, Wang J, Worsley GJ, Yan J, Yau L, Zuerlein M, Rogers J, Mullikin JC, Hurles ME, McCooke NJ, West JS, Oaks FL, Lundberg PL, Klenerman D, Durbin R, Smith AJ.

Nature. 2008 Nov 6;456(7218):53-9. doi: 10.1038/nature07517.

28.

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.

Pike AC, Rellos P, Niesen FH, Turnbull A, Oliver AW, Parker SA, Turk BE, Pearl LH, Knapp S.

EMBO J. 2008 Feb 20;27(4):704-14. doi: 10.1038/emboj.2008.8. Epub 2008 Jan 31.

29.

Structural insights into corepressor recognition by antagonist-bound estrogen receptors.

Heldring N, Pawson T, McDonnell D, Treuter E, Gustafsson JA, Pike AC.

J Biol Chem. 2007 Apr 6;282(14):10449-55. Epub 2007 Feb 5.

30.

Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain.

van de Wijngaart DJ, van Royen ME, Hersmus R, Pike AC, Houtsmuller AB, Jenster G, Trapman J, Dubbink HJ.

J Biol Chem. 2006 Jul 14;281(28):19407-16. Epub 2006 May 11.

31.

Androgen receptor ligand-binding domain interaction and nuclear receptor specificity of FXXLF and LXXLL motifs as determined by L/F swapping.

Dubbink HJ, Hersmus R, Pike AC, Molier M, Brinkmann AO, Jenster G, Trapman J.

Mol Endocrinol. 2006 Aug;20(8):1742-55. Epub 2006 Apr 20.

PMID:
16627595
32.

Lessons learnt from structural studies of the oestrogen receptor.

Pike AC.

Best Pract Res Clin Endocrinol Metab. 2006 Mar;20(1):1-14. Review.

PMID:
16522516
33.

Delineation of a unique protein-protein interaction site on the surface of the estrogen receptor.

Kong EH, Heldring N, Gustafsson JA, Treuter E, Hubbard RE, Pike AC.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3593-8. Epub 2005 Feb 23. Erratum in: Proc Natl Acad Sci U S A. 2006 May 23;103(21):8298.

34.

Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor.

Dubbink HJ, Hersmus R, Verma CS, van der Korput HA, Berrevoets CA, van Tol J, Ziel-van der Made AC, Brinkmann AO, Pike AC, Trapman J.

Mol Endocrinol. 2004 Sep;18(9):2132-50. Epub 2004 Jun 3.

PMID:
15178743
35.

Structure and mechanism of the oestrogen receptor.

Kong EH, Pike AC, Hubbard RE.

Biochem Soc Trans. 2003 Feb;31(Pt 1):56-9. Review.

PMID:
12546653
36.

Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha.

Wärnmark A, Treuter E, Gustafsson JA, Hubbard RE, Brzozowski AM, Pike AC.

J Biol Chem. 2002 Jun 14;277(24):21862-8. Epub 2002 Apr 5.

37.

Haemorrhagic rash in infectious mononucleosis.

Ramanan AV, Pike AC, Robinson A.

Hosp Med. 2001 Jul;62(7):434-5. No abstract available.

PMID:
11480135
38.

Structural insights into the mode of action of a pure antiestrogen.

Pike AC, Brzozowski AM, Walton J, Hubbard RE, Thorsell AG, Li YL, Gustafsson JA, Carlquist M.

Structure. 2001 Feb 7;9(2):145-53.

39.

A structural biologist's view of the oestrogen receptor.

Pike AC, Brzozowski AM, Hubbard RE.

J Steroid Biochem Mol Biol. 2000 Nov 30;74(5):261-8. Review.

PMID:
11162934
40.

Structural insights into the mechanisms of agonism and antagonism in oestrogen receptor isoforms.

Hubbard RE, Pike AC, Brzozowski AM, Walton J, Bonn T, Gustafsson JA, Carlquist M.

Eur J Cancer. 2000 Sep;36 Suppl 4:S17-8.

PMID:
11056300
41.

Structural aspects of agonism and antagonism in the oestrogen receptor.

Pike AC, Brzozowski AM, Walton J, Hubbard RE, Bonn T, Gustafsson JA, Carlquist M.

Biochem Soc Trans. 2000;28(4):396-400. Review.

PMID:
10961927
42.

Structure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptor.

Wright LM, Brzozowski AM, Hubbard RE, Pike AC, Roberts SM, Skovgaard RN, Svendsen I, Vissing H, Bywater RP.

Acta Crystallogr D Biol Crystallogr. 2000 May;56(Pt 5):573-80.

PMID:
10771426
43.

Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist.

Pike AC, Brzozowski AM, Hubbard RE, Bonn T, Thorsell AG, Engström O, Ljunggren J, Gustafsson JA, Carlquist M.

EMBO J. 1999 Sep 1;18(17):4608-18.

44.

Structure of human factor VIIa and its implications for the triggering of blood coagulation.

Pike AC, Brzozowski AM, Roberts SM, Olsen OH, Persson E.

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8925-30.

45.

Velocardiofacial syndrome.

Pike AC, Super M.

Postgrad Med J. 1997 Dec;73(866):771-5. Review.

46.

Molecular basis of agonism and antagonism in the oestrogen receptor.

Brzozowski AM, Pike AC, Dauter Z, Hubbard RE, Bonn T, Engström O, Ohman L, Greene GL, Gustafsson JA, Carlquist M.

Nature. 1997 Oct 16;389(6652):753-8.

PMID:
9338790
48.

A structural basis for the interaction of urea with lysozyme.

Pike AC, Acharya KR.

Protein Sci. 1994 Apr;3(4):706-10.

49.

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