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Items: 1 to 50 of 320

1.

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP.

Nat Commun. 2019 Sep 2;10(1):3956. doi: 10.1038/s41467-019-11753-1.

2.

Idarubicin, cytarabine, and nivolumab in patients with newly diagnosed acute myeloid leukaemia or high-risk myelodysplastic syndrome: a single-arm, phase 2 study.

Ravandi F, Assi R, Daver N, Benton CB, Kadia T, Thompson PA, Borthakur G, Alvarado Y, Jabbour EJ, Konopleva M, Takahashi K, Kornblau S, DiNardo CD, Estrov Z, Flores W, Basu S, Allison J, Sharma P, Pierce S, Pike A, Cortes JE, Garcia-Manero G, Kantarjian HM.

Lancet Haematol. 2019 Sep;6(9):e480-e488. doi: 10.1016/S2352-3026(19)30114-0. Epub 2019 Aug 7.

PMID:
31400961
3.

Helping parents to help children overcome fear: The influence of a short video tutorial.

Ewing D, Pike A, Dash S, Hughes Z, Thompson EJ, Hazell C, Ang CM, Kucuk N, Laine A, Cartwright-Hatton S.

Br J Clin Psychol. 2019 Aug 7. doi: 10.1111/bjc.12233. [Epub ahead of print]

PMID:
31390073
4.

TIN2 functions with TPP1/POT1 to stimulate telomerase processivity.

Pike AM, Strong MA, Ouyang JPT, Greider CW.

Mol Cell Biol. 2019 Aug 5. pii: MCB.00593-18. doi: 10.1128/MCB.00593-18. [Epub ahead of print]

5.

Identifying Indicators of National Council Licensure Examination for Registered Nurses (NCLEX-RN) Success in Nursing Graduates in Newfoundland & Labrador.

Pike AD, Lukewich J, Wells J, Kirkland MC, Manuel M, Watkins K.

Int J Nurs Educ Scholarsh. 2019 Aug 6;16(1). pii: /j/ijnes.2019.16.issue-1/ijnes-2018-0060/ijnes-2018-0060.xml. doi: 10.1515/ijnes-2018-0060.

PMID:
31377739
6.

Stop the Bleed: Is Mass Education the Best Approach?

Motameni AT, Pike AI, Denzik KR, Arnold LF, Muradov JM, McKinley WI, Benns MV, Harbrecht BG.

Am Surg. 2019 Jun 1;85(6):601-605.

PMID:
31267900
7.

The translational neural circuitry of anxiety.

Robinson OJ, Pike AC, Cornwell B, Grillon C.

J Neurol Neurosurg Psychiatry. 2019 Jun 29. pii: jnnp-2019-321400. doi: 10.1136/jnnp-2019-321400. [Epub ahead of print] Review.

PMID:
31256001
8.

Corrections and connection to the community: A diagnostic and service program for incarcerated adult men with FASD.

Brintnell ES, Sawhney AS, Bailey PG, Nelson M, Pike AD, Wielandt P.

Int J Law Psychiatry. 2019 May - Jun;64:8-17. doi: 10.1016/j.ijlp.2018.12.005. Epub 2019 Jan 7.

PMID:
31122643
9.

Spirituality and Moral Injury Among Military Personnel: A Mini-Review.

Brémault-Phillips S, Pike A, Scarcella F, Cherwick T.

Front Psychiatry. 2019 Apr 29;10:276. doi: 10.3389/fpsyt.2019.00276. eCollection 2019. Review.

10.

Physician-reported barriers to using evidence-based recommendations for low back pain in clinical practice: a systematic review and synthesis of qualitative studies using the Theoretical Domains Framework.

Hall AM, Scurrey SR, Pike AE, Albury C, Richmond HL, Matthews J, Toomey E, Hayden JA, Etchegary H.

Implement Sci. 2019 May 7;14(1):49. doi: 10.1186/s13012-019-0884-4.

12.

Analysis of States' Barriers to and Progress Toward Implementation of Health and Safety Policies for Secondary School Athletics.

Pike AM, Adams WM, Huggins RA, Mazerolle SM, Casa DJ.

J Athl Train. 2019 Apr;54(4):361-373. doi: 10.4085/1062-6050-28-18. Epub 2019 Apr 24.

PMID:
31017807
13.

Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865).

Owen RM, Blakemore D, Cao L, Flanagan N, Fish R, Gibson KR, Gurrell R, Huh CW, Kammonen J, Mortimer-Cassen E, Nickolls SA, Omoto K, Owen D, Pike A, Pryde DC, Reynolds DS, Roeloffs R, Rose C, Stead C, Takeuchi M, Warmus JS, Watson C.

J Med Chem. 2019 Jun 27;62(12):5773-5796. doi: 10.1021/acs.jmedchem.9b00322. Epub 2019 Apr 26.

PMID:
30964988
14.

Antibodies to Peptides in Semiconserved Domains of RIFINs and STEVORs Correlate with Malaria Exposure.

Zhou AE, Berry AA, Bailey JA, Pike A, Dara A, Agrawal S, Stucke EM, Ouattara A, Coulibaly D, Lyke KE, Laurens MB, Adams M, Takala-Harrison S, Pablo J, Jasinskas A, Nakajima R, Niangaly A, Kouriba B, Kone AK, Rowe JA, Doumbo OK, Thera MA, Patel JJ, Tan JC, Felgner PL, Plowe CV, Travassos MA.

mSphere. 2019 Mar 20;4(2). pii: e00097-19. doi: 10.1128/mSphere.00097-19.

15.

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.

Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T.

Science. 2019 Feb 22;363(6429):875-880. doi: 10.1126/science.aav0569.

PMID:
30792303
16.

Recent Canadian efforts to develop population-level pregnancy intervention studies to mitigate effects of natural disasters and other tragedies.

Olson DM, Brémault-Phillips S, King S, Metz GAS, Montesanti S, Olson JK, Hyde A, Pike A, Hoover T, Linder R, Joggerst B, Watts R.

J Dev Orig Health Dis. 2019 Feb;10(1):108-114. doi: 10.1017/S2040174418001113. Epub 2019 Jan 10.

PMID:
30626455
17.

Leprosy at the edge of Europe-Biomolecular, isotopic and osteoarchaeological findings from medieval Ireland.

Taylor GM, Murphy EM, Mendum TA, Pike AWG, Linscott B, Wu H, O'Grady J, Richardson H, O'Donovan E, Troy C, Stewart GR.

PLoS One. 2018 Dec 26;13(12):e0209495. doi: 10.1371/journal.pone.0209495. eCollection 2018.

18.

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.

Dong YY, Wang H, Pike ACW, Cochrane SA, Hamedzadeh S, Wyszyński FJ, Bushell SR, Royer SF, Widdick DA, Sajid A, Boshoff HI, Park Y, Lucas R, Liu WM, Lee SS, Machida T, Minall L, Mehmood S, Belaya K, Liu WW, Chu A, Shrestha L, Mukhopadhyay SMM, Strain-Damerell C, Chalk R, Burgess-Brown NA, Bibb MJ, Barry Iii CE, Robinson CV, Beeson D, Davis BG, Carpenter EP.

Cell. 2018 Nov 1;175(4):1045-1058.e16. doi: 10.1016/j.cell.2018.10.037.

19.

Meniscal and Chondral Pathology Associated With Anterior Cruciate Ligament Injuries.

Pike AN, Patzkowski JC, Bottoni CR.

J Am Acad Orthop Surg. 2019 Feb 1;27(3):75-84. doi: 10.5435/JAAOS-D-17-00670. Review.

PMID:
30320730
20.

Health and health service use of very elderly Newfoundlanders.

Hurd J, Pike A, Knight J, Tarrant G, Aubrey-Bassler K, Asghari S, Godwin M.

Can Fam Physician. 2018 Oct;64(10):e453-e461.

21.

Response to Comment on "U-Th dating of carbonate crusts reveals Neandertal origin of Iberian cave art".

Hoffmann DL, Standish CD, García-Diez M, Pettitt PB, Milton JA, Zilhão J, Alcolea-González JJ, Cantalejo-Duarte P, Collado H, de Balbín R, Lorblanchet M, Ramos-Muñoz J, Weniger GC, Pike AWG.

Science. 2018 Oct 12;362(6411). pii: eaau1736. doi: 10.1126/science.aau1736.

PMID:
30309914
22.

The role of organic anion-transporting polypeptides and formulation in the clearance and distribution of a novel Nav 1.7 channel blocker.

Pike A, Flanagan NJ, Storer RI, Swain NA, Tseng E.

Biopharm Drug Dispos. 2018 Sep;39(8):388-393. doi: 10.1002/bdd.2156.

PMID:
30175851
23.

Facilitating implementation of the Decision-Making Capacity Assessment (DMCA) Model: senior leadership perspectives on the use of the National Implementation Research Network (NIRN) Model and frameworks.

Brémault-Phillips S, Pike A, Charles L, Roduta-Roberts M, Mitra A, Friesen S, Moulton L, Parmar J.

BMC Res Notes. 2018 Aug 23;11(1):607. doi: 10.1186/s13104-018-3714-x.

24.

Dates for Neanderthal art and symbolic behaviour are reliable.

Hoffmann DL, Standish CD, Pike AWG, García-Diez M, Pettitt PB, Angelucci DE, Villaverde V, Zapata J, Milton JA, Alcolea-González J, Cantalejo-Duarte P, Collado H, de Balbín R, Lorblanchet M, Ramos-Muñoz J, Weniger GC, Zilhão J.

Nat Ecol Evol. 2018 Jul;2(7):1044-1045. doi: 10.1038/s41559-018-0598-z. No abstract available.

PMID:
29942018
25.

Self-Priming Enzymatic Fabrication of Multiply Modified DNA.

Whitfield CJ, Little RC, Khan K, Ijiro K, Connolly BA, Tuite EM, Pike AR.

Chemistry. 2018 Oct 12;24(57):15267-15274. doi: 10.1002/chem.201801976. Epub 2018 Sep 14.

PMID:
29931815
26.

The Synthesis of Designer DNA.

Little RC, Whitfield CJ, Tuite EM, Pike AR.

Methods Mol Biol. 2018;1811:11-21. doi: 10.1007/978-1-4939-8582-1_2.

PMID:
29926443
27.

Physiology of Hyperuricemia and Urate-Lowering Treatments.

Benn CL, Dua P, Gurrell R, Loudon P, Pike A, Storer RI, Vangjeli C.

Front Med (Lausanne). 2018 May 31;5:160. doi: 10.3389/fmed.2018.00160. eCollection 2018. Review.

28.

Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface antigen subsets.

Travassos MA, Niangaly A, Bailey JA, Ouattara A, Coulibaly D, Lyke KE, Laurens MB, Pablo J, Jasinskas A, Nakajima R, Berry AA, Adams M, Jacob CG, Pike A, Takala-Harrison S, Liang L, Kouriba B, Kone AK, Rowe JA, Moulds J, Diallo DA, Doumbo OK, Thera MA, Felgner PL, Plowe CV.

Sci Rep. 2018 Apr 19;8(1):6281. doi: 10.1038/s41598-018-24462-4.

29.
31.

Duplex Healing of Selectively Thiolated Guanosine Mismatches through a Cd2+ Chemical Stimulus.

Lunn SML, Hribesh S, Whitfield CJ, Hall MJ, Houlton A, Bronowska AK, Tuite EM, Pike AR.

Chembiochem. 2018 Mar 25. doi: 10.1002/cbic.201800100. [Epub ahead of print]

PMID:
29575493
32.

U-Th dating of carbonate crusts reveals Neandertal origin of Iberian cave art.

Hoffmann DL, Standish CD, García-Diez M, Pettitt PB, Milton JA, Zilhão J, Alcolea-González JJ, Cantalejo-Duarte P, Collado H, de Balbín R, Lorblanchet M, Ramos-Muñoz J, Weniger GC, Pike AWG.

Science. 2018 Feb 23;359(6378):912-915. doi: 10.1126/science.aap7778.

PMID:
29472483
33.

Inkjet printing and electrical characterisation of DNA-templated cadmium sulphide nanowires.

Nurdillayeva RN, Oshido AB, Bamford TA, El-Zubir O, Houlton A, Hedley J, Pike AR, Horrocks BR.

Nanotechnology. 2018 Feb 12;29(13):135704. doi: 10.1088/1361-6528/aaa92f. [Epub ahead of print]

PMID:
29432211
34.

Managing Canine Aggression in the Home.

Pike A.

Vet Clin North Am Small Anim Pract. 2018 May;48(3):387-402. doi: 10.1016/j.cvsm.2017.12.006. Epub 2018 Feb 9. Review.

PMID:
29429601
35.

Inkjet printing and electrical characterisation of DNA - templated cadmium sulfide nanowires.

Nurdillayeva R, Oshido A, Bamford T, El-Zubir O, Houlton A, Hedley J, Pike A, Horrocks B.

Nanotechnology. 2018 Jan 19. doi: 10.1088/1361-6528/aaa92f. [Epub ahead of print]

PMID:
29350628
36.

The Beginnings of Alpine Transhumance? Isotopic Insights into Neolithic Cattle Herding.

Gerling C, Doppler T, Pike AWG, Knipper C, Heyd V, Kuhn T, Lehmann MF, Schibler J.

Chimia (Aarau). 2017 Dec 1;71(12):860. doi: 10.2533/chimia.2017.860. No abstract available.

PMID:
29289249
37.

Mother-child positivity and negativity: Family-wide and child-specific main effects and interactions predict child adjustment.

Oliver BR, Pike A.

Dev Psychol. 2018 Apr;54(4):744-756. doi: 10.1037/dev0000467. Epub 2017 Dec 14.

PMID:
29239634
38.

Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865.

Nickolls SA, Gurrell R, van Amerongen G, Kammonen J, Cao L, Brown AR, Stead C, Mead A, Watson C, Hsu C, Owen RM, Pike A, Fish RL, Chen L, Qiu R, Morris ED, Feng G, Whitlock M, Gorman D, van Gerven J, Reynolds DS, Dua P, Butt RP.

Br J Pharmacol. 2018 Feb;175(4):708-725. doi: 10.1111/bph.14119. Epub 2018 Jan 18. Erratum in: Br J Pharmacol. 2019 Jan;176(1):127.

39.

Enhanced skills in global health and health equity: Guidelines for curriculum development.

Dawe R, Pike A, Kidd M, Janakiram P, Nicolle E, Allison J.

Can Med Educ J. 2017 Apr 20;8(2):e48-e60. eCollection 2017 Apr.

40.

The bacterium Wolbachia exploits host innate immunity to establish a symbiotic relationship with the dengue vector mosquito Aedes aegypti.

Pan X, Pike A, Joshi D, Bian G, McFadden MJ, Lu P, Liang X, Zhang F, Raikhel AS, Xi Z.

ISME J. 2018 Jan;12(1):277-288. doi: 10.1038/ismej.2017.174. Epub 2017 Nov 3.

41.

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.

Storer RI, Pike A, Swain NA, Alexandrou AJ, Bechle BM, Blakemore DC, Brown AD, Castle NA, Corbett MS, Flanagan NJ, Fengas D, Johnson MS, Jones LH, Marron BE, Payne CE, Printzenhoff D, Rawson DJ, Rose CR, Ryckmans T, Sun J, Theile JW, Torella R, Tseng E, Warmus JS.

Bioorg Med Chem Lett. 2017 Nov 1;27(21):4805-4811. doi: 10.1016/j.bmcl.2017.09.056. Epub 2017 Sep 28.

PMID:
29029933
42.

Changes in the microbiota cause genetically modified Anopheles to spread in a population.

Pike A, Dong Y, Dizaji NB, Gacita A, Mongodin EF, Dimopoulos G.

Science. 2017 Sep 29;357(6358):1396-1399. doi: 10.1126/science.aak9691. Epub 2017 Sep 28.

PMID:
28963254
43.

Gaining Access to Providing Medical Care to Male Sport Teams: The Female Athletic Trainer Perspective.

Pike A, Mazerolle SM, Barrett JL.

J Athl Train. 2017 Oct;52(10):946-954. doi: 10.4085/1062-6050-52.9.03. Epub 2017 Sep 22.

44.

Scaffolding under the microscope: Applying self-regulation and other-regulation perspectives to a scaffolded task.

Leith G, Yuill N, Pike A.

Br J Educ Psychol. 2018 Jun;88(2):174-191. doi: 10.1111/bjep.12178. Epub 2017 Aug 29.

PMID:
28856677
45.

BRD4 inhibitors block telomere elongation.

Wang S, Pike AM, Lee SS, Strong MA, Connelly CJ, Greider CW.

Nucleic Acids Res. 2017 Aug 21;45(14):8403-8410. doi: 10.1093/nar/gkx561.

46.

An early modern human presence in Sumatra 73,000-63,000 years ago.

Westaway KE, Louys J, Awe RD, Morwood MJ, Price GJ, Zhao JX, Aubert M, Joannes-Boyau R, Smith TM, Skinner MM, Compton T, Bailey RM, van den Bergh GD, de Vos J, Pike AWG, Stringer C, Saptomo EW, Rizal Y, Zaim J, Santoso WD, Trihascaryo A, Kinsley L, Sulistyanto B.

Nature. 2017 Aug 17;548(7667):322-325. doi: 10.1038/nature23452. Epub 2017 Aug 9.

PMID:
28792933
47.

High-resolution isotopic evidence of specialised cattle herding in the European Neolithic.

Gerling C, Doppler T, Heyd V, Knipper C, Kuhn T, Lehmann MF, Pike AWG, Schibler J.

PLoS One. 2017 Jul 26;12(7):e0180164. doi: 10.1371/journal.pone.0180164. eCollection 2017.

48.

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.

Swain NA, Batchelor D, Beaudoin S, Bechle BM, Bradley PA, Brown AD, Brown B, Butcher KJ, Butt RP, Chapman ML, Denton S, Ellis D, Galan SRG, Gaulier SM, Greener BS, de Groot MJ, Glossop MS, Gurrell IK, Hannam J, Johnson MS, Lin Z, Markworth CJ, Marron BE, Millan DS, Nakagawa S, Pike A, Printzenhoff D, Rawson DJ, Ransley SJ, Reister SM, Sasaki K, Storer RI, Stupple PA, West CW.

J Med Chem. 2017 Aug 24;60(16):7029-7042. doi: 10.1021/acs.jmedchem.7b00598. Epub 2017 Aug 10.

PMID:
28682065
49.

DNA Brush-Directed Vertical Alignment of Extensive Gold Nanorod Arrays with Controlled Density.

Nakamura S, Mitomo H, Aizawa M, Tani T, Matsuo Y, Niikura K, Pike A, Naya M, Shishido A, Ijiro K.

ACS Omega. 2017 May 19;2(5):2208-2213. doi: 10.1021/acsomega.7b00303. eCollection 2017 May 31.

50.

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike ACW, Carpenter EP, Baukrowitz T, Sansom MSP, Tucker SJ.

Structure. 2017 May 2;25(5):708-718.e2. doi: 10.1016/j.str.2017.03.006. Epub 2017 Apr 6.

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