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Items: 1 to 50 of 108

1.

Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2.

Malakar P, Stein I, Saragovi A, Winkler R, Stern-Ginossar N, Berger M, Pikarsky E, Karni R.

Cancer Res. 2019 May 15;79(10):2480-2493. doi: 10.1158/0008-5472.CAN-18-1432. Epub 2019 Mar 26.

PMID:
30914432
2.

VICKZ1 enhances tumor progression and metastasis in lung adenocarcinomas in mice.

Rosenfeld YB, Krumbein M, Yeffet A, Schiffmann N, Mishalian I, Pikarsky E, Oberman F, Fridlender Z, Yisraeli JK.

Oncogene. 2019 May;38(21):4169-4181. doi: 10.1038/s41388-019-0715-8. Epub 2019 Jan 30.

PMID:
30700831
3.

Author Correction: WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.

Abu-Remaileh M, Khalaileh A, Pikarsky E, Aqeilan RI.

Cell Death Dis. 2018 Nov 23;9(12):1159. doi: 10.1038/s41419-018-1158-9.

4.

Vav1 mutations identified in human cancers give rise to different oncogenic phenotypes.

Shalom B, Farago M, Pikarsky E, Katzav S.

Oncogenesis. 2018 Oct 8;7(10):80. doi: 10.1038/s41389-018-0091-1.

5.

Neighbourhood deaths cause a switch in cancer subtype.

Pikarsky E.

Nature. 2018 Oct;562(7725):45-46. doi: 10.1038/d41586-018-06217-3. No abstract available.

PMID:
30275548
6.

microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.

Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, Frank AK, Cardenas DV, Sonntag R, Luedde M, Trautwein C, Stein I, Pikarsky E, Loosen S, Tacke F, Ringelhan M, Avsaroglu SK, Goga A, Buendia MA, Vucur M, Heikenwalder M, Zucman-Rossi J, Zender L, Roderburg C, Luedde T.

Gastroenterology. 2018 Dec;155(6):1951-1966.e26. doi: 10.1053/j.gastro.2018.08.032. Epub 2018 Aug 27.

PMID:
30165047
7.

Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.

Minzel W, Venkatachalam A, Fink A, Hung E, Brachya G, Burstain I, Shaham M, Rivlin A, Omer I, Zinger A, Elias S, Winter E, Erdman PE, Sullivan RW, Fung L, Mercurio F, Li D, Vacca J, Kaushansky N, Shlush L, Oren M, Levine R, Pikarsky E, Snir-Alkalay I, Ben-Neriah Y.

Cell. 2018 Sep 20;175(1):171-185.e25. doi: 10.1016/j.cell.2018.07.045. Epub 2018 Aug 23.

PMID:
30146162
8.

Postnatal DNA demethylation and its role in tissue maturation.

Reizel Y, Sabag O, Skversky Y, Spiro A, Steinberg B, Bernstein D, Wang A, Kieckhaefer J, Li C, Pikarsky E, Levin-Klein R, Goren A, Rajewsky K, Kaestner KH, Cedar H.

Nat Commun. 2018 May 23;9(1):2040. doi: 10.1038/s41467-018-04456-6.

9.

WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.

Abu-Remaileh M, Khalaileh A, Pikarsky E, Aqeilan RI.

Cell Death Dis. 2018 May 1;9(5):511. doi: 10.1038/s41419-018-0510-4. Erratum in: Cell Death Dis. 2018 Nov 23;9(12):1159.

10.

Ev vivo organ culture as potential prioritization tool for breast cancer targeted therapy.

Grinshpun A, Gavert N, Granit RZ, Masuri H, Ben-Porath I, Breuer S, Zick A, Rosenberg S, Maoz M, Granit A, Pikarsky E, Strausmman R, Peretz T, Sonnenblick A.

Cancer Biol Ther. 2018 Aug 3;19(8):645-648. doi: 10.1080/15384047.2018.1450114. Epub 2018 Apr 13.

11.

SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors.

Roth L, Srivastava S, Lindzen M, Sas-Chen A, Sheffer M, Lauriola M, Enuka Y, Noronha A, Mancini M, Lavi S, Tarcic G, Pines G, Nevo N, Heyman O, Ziv T, Rueda OM, Gnocchi D, Pikarsky E, Admon A, Caldas C, Yarden Y.

Sci Signal. 2018 Jan 30;11(515). pii: eaan0949. doi: 10.1126/scisignal.aan0949.

PMID:
29382783
12.

The immunology of hepatocellular carcinoma.

Ringelhan M, Pfister D, O'Connor T, Pikarsky E, Heikenwalder M.

Nat Immunol. 2018 Mar;19(3):222-232. doi: 10.1038/s41590-018-0044-z. Epub 2018 Jan 29. Review.

PMID:
29379119
13.

Learning the Roles of the Hepatic Adaptive Immune System in Hepatocellular Carcinoma-Nature's Guide for Successful Cancer Immunotherapy.

Heikenwälder M, Pikarsky E.

Semin Liver Dis. 2017 Aug;37(3):210-218. doi: 10.1055/s-0037-1606255. Epub 2017 Aug 28. Review. No abstract available.

PMID:
28847032
14.

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M.

Cancer Cell. 2017 Jun 12;31(6):771-789.e6. doi: 10.1016/j.ccell.2017.05.006.

15.

Treatment inferred from mutations identified using massive parallel sequencing leads to clinical benefit in some heavily pretreated cancer patients.

Zick A, Peretz T, Lotem M, Hubert A, Katz D, Temper M, Rottenberg Y, Uziely B, Nechushtan H, Meirovitz A, Sonnenblick A, Sapir E, Edelman D, Goldberg Y, Lossos A, Rosenberg S, Fried I, Finklstein R, Pikarsky E, Goldshmidt H.

Medicine (Baltimore). 2017 May;96(20):e6931. doi: 10.1097/MD.0000000000006931.

16.

miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression.

Hanin G, Yayon N, Tzur Y, Haviv R, Bennett ER, Udi S, Krishnamoorthy YR, Kotsiliti E, Zangen R, Efron B, Tam J, Pappo O, Shteyer E, Pikarsky E, Heikenwalder M, Greenberg DS, Soreq H.

Gut. 2018 Jun;67(6):1124-1134. doi: 10.1136/gutjnl-2016-312869. Epub 2017 Apr 5.

17.

Immune defects caused by mutations in the ubiquitin system.

Etzioni A, Ciechanover A, Pikarsky E.

J Allergy Clin Immunol. 2017 Mar;139(3):743-753. doi: 10.1016/j.jaci.2016.11.031. Review.

PMID:
28270366
18.

RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.

Tarcic O, Granit RZ, Pateras IS, Masury H, Maly B, Zwang Y, Yarden Y, Gorgoulis VG, Pikarsky E, Ben-Porath I, Oren M.

Cell Death Differ. 2017 Apr;24(4):694-704. doi: 10.1038/cdd.2016.126. Epub 2017 Feb 3.

19.

Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation.

Malakar P, Shilo A, Mogilevsky A, Stein I, Pikarsky E, Nevo Y, Benyamini H, Elgavish S, Zong X, Prasanth KV, Karni R.

Cancer Res. 2017 Mar 1;77(5):1155-1167. doi: 10.1158/0008-5472.CAN-16-1508. Epub 2016 Dec 19.

20.

Focal and Local: Ectopic Lymphoid Structures and Aggregates of Myeloid and Other Immune Cells in Liver.

Pikarsky E, Heikenwalder M.

Gastroenterology. 2016 Nov;151(5):780-783. doi: 10.1053/j.gastro.2016.09.029. Epub 2016 Sep 28. No abstract available.

PMID:
27693322
21.

Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters.

Darash-Yahana M, Pozniak Y, Lu M, Sohn YS, Karmi O, Tamir S, Bai F, Song L, Jennings PA, Pikarsky E, Geiger T, Onuchic JN, Mittler R, Nechushtai R.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10890-5. doi: 10.1073/pnas.1612736113. Epub 2016 Sep 12.

22.

SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan.

Roichman A, Kanfi Y, Glazz R, Naiman S, Amit U, Landa N, Tinman S, Stein I, Pikarsky E, Leor J, Cohen HY.

J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):603-615. doi: 10.1093/gerona/glw152.

PMID:
27519885
23.

Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc.

Abed J, Emgård JE, Zamir G, Faroja M, Almogy G, Grenov A, Sol A, Naor R, Pikarsky E, Atlan KA, Mellul A, Chaushu S, Manson AL, Earl AM, Ou N, Brennan CA, Garrett WS, Bachrach G.

Cell Host Microbe. 2016 Aug 10;20(2):215-25. doi: 10.1016/j.chom.2016.07.006.

24.

Widespread parainflammation in human cancer.

Aran D, Lasry A, Zinger A, Biton M, Pikarsky E, Hellman A, Butte AJ, Ben-Neriah Y.

Genome Biol. 2016 Jul 8;17(1):145. doi: 10.1186/s13059-016-0995-z.

25.

Hepatocellular carcinoma repression by TNFα-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization.

Li D, Fu J, Du M, Zhang H, Li L, Cen J, Li W, Chen X, Lin Y, Conway EM, Pikarsky E, Wang H, Pan G, Ji Y, Wang HY, Hui L.

Hepatology. 2016 Oct;64(4):1105-20. doi: 10.1002/hep.28637. Epub 2016 Jun 11.

26.

Hepatocellular carcinoma.

Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G.

Nat Rev Dis Primers. 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. Review.

27.

PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells.

Samarin J, Laketa V, Malz M, Roessler S, Stein I, Horwitz E, Singer S, Dimou E, Cigliano A, Bissinger M, Falk CS, Chen X, Dooley S, Pikarsky E, Calvisi DF, Schultz C, Schirmacher P, Breuhahn K.

Hepatology. 2016 Mar;63(3):813-26. doi: 10.1002/hep.28357. Epub 2016 Jan 14.

28.

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer.

Tarcic O, Pateras IS, Cooks T, Shema E, Kanterman J, Ashkenazi H, Boocholez H, Hubert A, Rotkopf R, Baniyash M, Pikarsky E, Gorgoulis VG, Oren M.

Cell Rep. 2016 Feb 16;14(6):1462-1476. doi: 10.1016/j.celrep.2016.01.020. Epub 2016 Feb 4.

29.

Type I Interferons Control Proliferation and Function of the Intestinal Epithelium.

Katlinskaya YV, Katlinski KV, Lasri A, Li N, Beiting DP, Durham AC, Yang T, Pikarsky E, Lengner CJ, Johnson FB, Ben-Neriah Y, Fuchs SY.

Mol Cell Biol. 2016 Jan 25;36(7):1124-35. doi: 10.1128/MCB.00988-15.

30.

Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells.

Holt SH, Darash-Yahana M, Sohn YS, Song L, Karmi O, Tamir S, Michaeli D, Luo Y, Paddock ML, Jennings PA, Onuchic JN, Azad RK, Pikarsky E, Cabantchik IZ, Nechushtai R, Mittler R.

J Cell Sci. 2016 Jan 1;129(1):155-65. doi: 10.1242/jcs.178293. Epub 2015 Nov 30.

31.

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.

Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E.

Nat Immunol. 2015 Dec;16(12):1235-44. doi: 10.1038/ni.3290. Epub 2015 Oct 26.

32.

Restoring inflammatory balance as a potential preventive strategy for inflammation induced cancer.

Hefetz-Sela S, Stein I, Pikarsky E.

Oncoimmunology. 2015 May 26;4(11):e1039764. eCollection 2015 Nov.

33.

Nonsyndromic Early-Onset Cone-Rod Dystrophy and Limb-Girdle Muscular Dystrophy in a Consanguineous Israeli Family are Caused by Two Independent yet Linked Mutations in ALMS1 and DYSF.

Lazar CH, Kimchi A, Namburi P, Mutsuddi M, Zelinger L, Beryozkin A, Ben-Simhon S, Obolensky A, Ben-Neriah Z, Argov Z, Pikarsky E, Fellig Y, Marks-Ohana D, Ratnapriya R, Banin E, Sharon D, Swaroop A.

Hum Mutat. 2015 Sep;36(9):836-41. doi: 10.1002/humu.22822. Epub 2015 Jul 14.

34.

High SEPT9_i1 protein expression is associated with high-grade prostate cancers.

Gilad R, Meir K, Stein I, German L, Pikarsky E, Mabjeesh NJ.

PLoS One. 2015 Apr 21;10(4):e0124251. doi: 10.1371/journal.pone.0124251. eCollection 2015.

35.

KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.

Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, Sommer T, Ziv T, Admon A, Naroditsky I, Jbara M, Brik A, Pikarsky E, Kwon YT, Doweck I, Ciechanover A.

Cell. 2015 Apr 9;161(2):333-47. doi: 10.1016/j.cell.2015.03.001.

36.

Chronic inflammation induces a novel epigenetic program that is conserved in intestinal adenomas and in colorectal cancer.

Abu-Remaileh M, Bender S, Raddatz G, Ansari I, Cohen D, Gutekunst J, Musch T, Linhart H, Breiling A, Pikarsky E, Bergman Y, Lyko F.

Cancer Res. 2015 May 15;75(10):2120-30. doi: 10.1158/0008-5472.CAN-14-3295. Epub 2015 Mar 25.

37.

The rejuvenating effect of pregnancy on muscle regeneration.

Falick Michaeli T, Laufer N, Sagiv JY, Dreazen A, Granot Z, Pikarsky E, Bergman Y, Gielchinsky Y.

Aging Cell. 2015 Aug;14(4):698-700. doi: 10.1111/acel.12286. Epub 2015 Mar 13.

38.

Animal model studies indicate a candidate biomarker for sorafenib treatment of hepatocellular carcinoma.

Horwitz E, Stein I, Ben-Neriah Y, Pikarsky E.

Mol Cell Oncol. 2014 Oct 30;2(1):e968028. doi: 10.4161/23723548.2014.968028. eCollection 2015 Jan-Mar.

39.

Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation.

Hefetz-Sela S, Stein I, Klieger Y, Porat R, Sade-Feldman M, Zreik F, Nagler A, Pappo O, Quagliata L, Dazert E, Eferl R, Terracciano L, Wagner EF, Ben-Neriah Y, Baniyash M, Pikarsky E.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17582-7. doi: 10.1073/pnas.1409700111. Epub 2014 Nov 24.

40.

Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion.

Sebban S, Farago M, Rabinovich S, Lazer G, Idelchuck Y, Ilan L, Pikarsky E, Katzav S.

Oncotarget. 2014 Oct 15;5(19):9214-26.

41.

Long-chain fatty acid analogues suppress breast tumorigenesis and progression.

Gluschnaider U, Hertz R, Ohayon S, Smeir E, Smets M, Pikarsky E, Bar-Tana J.

Cancer Res. 2014 Dec 1;74(23):6991-7002. doi: 10.1158/0008-5472.CAN-14-0385. Epub 2014 Oct 10.

42.

Adult hepatocytes are generated by self-duplication rather than stem cell differentiation.

Yanger K, Knigin D, Zong Y, Maggs L, Gu G, Akiyama H, Pikarsky E, Stanger BZ.

Cell Stem Cell. 2014 Sep 4;15(3):340-349. doi: 10.1016/j.stem.2014.06.003. Epub 2014 Aug 14.

43.

Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment.

Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, Schweitzer N, Tornillo L, Kanarek N, Quagliata L, Zreik F, Porat RM, Finkelstein R, Reuter H, Koschny R, Ganten T, Mogler C, Shibolet O, Hess J, Breuhahn K, Grunewald M, Schirmacher P, Vogel A, Terracciano L, Angel P, Ben-Neriah Y, Pikarsky E.

Cancer Discov. 2014 Jun;4(6):730-43. doi: 10.1158/2159-8290.CD-13-0782. Epub 2014 Mar 31.

44.

Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development.

Shilo A, Ben Hur V, Denichenko P, Stein I, Pikarsky E, Rauch J, Kolch W, Zender L, Karni R.

RNA. 2014 Apr;20(4):505-15. doi: 10.1261/rna.042259.113. Epub 2014 Feb 26.

45.

Critical role for IL-1β in DNA damage-induced mucositis.

Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11. doi: 10.1073/pnas.1322691111. Epub 2014 Jan 27.

46.

A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.

Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, Stiewe T, Oren M, Alitalo K, Pikarsky E, Ben-Neriah Y.

Cancer Cell. 2013 Aug 12;24(2):242-56. doi: 10.1016/j.ccr.2013.06.005. Epub 2013 Jul 25. Erratum in: Cancer Cell. 2015 Jun 8;27(6):877-8.

47.

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.

Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M.

Cancer Cell. 2013 May 13;23(5):634-46. doi: 10.1016/j.ccr.2013.03.022. Erratum in: Cancer Cell. 2013 Aug 12;24(2):272. Rozenfeld, Nitzan [corrected to Rosenfeld, Nitzan].

48.

Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice.

Barashi N, Weiss ID, Wald O, Wald H, Beider K, Abraham M, Klein S, Goldenberg D, Axelrod J, Pikarsky E, Abramovitch R, Zeira E, Galun E, Peled A.

Hepatology. 2013 Sep;58(3):1021-30. doi: 10.1002/hep.26403. Epub 2013 Jul 12.

PMID:
23526353
49.

Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice.

Pusterla T, Nèmeth J, Stein I, Wiechert L, Knigin D, Marhenke S, Longerich T, Kumar V, Arnold B, Vogel A, Bierhaus A, Pikarsky E, Hess J, Angel P.

Hepatology. 2013 Jul;58(1):363-73. doi: 10.1002/hep.26395.

PMID:
23504974
50.

Vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancer.

Sebban S, Farago M, Gashai D, Ilan L, Pikarsky E, Ben-Porath I, Katzav S.

PLoS One. 2013;8(1):e54321. doi: 10.1371/journal.pone.0054321. Epub 2013 Jan 14.

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