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The 24-hour serum profiles of bone markers in healthy older men and women.

van der Spoel E, Oei N, Cachucho R, Roelfsema F, Berbée JFP, Blauw GJ, Pijl H, Appelman-Dijkstra NM, van Heemst D.

Bone. 2018 Oct 4;120:61-69. doi: 10.1016/j.bone.2018.10.002. [Epub ahead of print]


Repeat length variations in polyglutamine disease-associated genes affect body mass index.

Gardiner SL, de Mutsert R, Trompet S, Boogaard MW, van Dijk KW, Jukema PJW, Slagboom PE, Roos RAC, Pijl H, Rosendaal FR, Aziz NA.

Int J Obes (Lond). 2018 Aug 17. doi: 10.1038/s41366-018-0161-7. [Epub ahead of print]


Effects of low-carbohydrate- compared with low-fat-diet interventions on metabolic control in people with type 2 diabetes: a systematic review including GRADE assessments.

van Zuuren EJ, Fedorowicz Z, Kuijpers T, Pijl H.

Am J Clin Nutr. 2018 Aug 1;108(2):300-331. doi: 10.1093/ajcn/nqy096.


High Diabetes Distress Among Ethnic Minorities Is Not Explained by Metabolic, Cardiovascular, or Lifestyle Factors: Findings From the Dutch Diabetes Pearl Cohort.

Özcan B, Rutters F, Snoek FJ, Roosendaal M, Sijbrands EJ, Elders PJM, Holleman F, Pijl H, Tack CJ, Abbink EJ, de Valk HW, Wolffenbuttel BHR, Stehouwer CDA, Schaper NC, Dekker JM, Schram MT; Diabetes Pearl from the Parelsnoer Initiative.

Diabetes Care. 2018 Sep;41(9):1854-1861. doi: 10.2337/dc17-2181. Epub 2018 Jun 26.


Brain activity and connectivity changes in response to glucose ingestion.

van Opstal AM, Hafkemeijer A, van den Berg-Huysmans AA, Hoeksma M, Blonk C, Pijl H, Rombouts SARB, van der Grond J.

Nutr Neurosci. 2018 May 27:1-8. doi: 10.1080/1028415X.2018.1477538. [Epub ahead of print]


From Diabetes Care to Diabetes Cure-The Integration of Systems Biology, eHealth, and Behavioral Change.

van Ommen B, Wopereis S, van Empelen P, van Keulen HM, Otten W, Kasteleyn M, Molema JJW, de Hoogh IM, Chavannes NH, Numans ME, Evers AWM, Pijl H.

Front Endocrinol (Lausanne). 2018 Jan 22;8:381. doi: 10.3389/fendo.2017.00381. eCollection 2017. Review.


The effect of consumption temperature on the homeostatic and hedonic responses to glucose ingestion in the hypothalamus and the reward system.

van Opstal AM, van den Berg-Huysmans AA, Hoeksma M, Blonk C, Pijl H, Rombouts SARB, van der Grond J.

Am J Clin Nutr. 2018 Jan 1;107(1):20-25. doi: 10.1093/ajcn/nqx023.


Effects of intranasal insulin application on the hypothalamic BOLD response to glucose ingestion.

Opstal AMV, Akintola AA, Elst MV, Westendorp RG, Pijl H, Heemst DV, Grond JV.

Sci Rep. 2017 Oct 17;7(1):13327. doi: 10.1038/s41598-017-13818-x.


Individual and partner's level of occupation and the association with HbA1c levels in people with Type 2 diabetes mellitus: the Dutch Diabetes Pearl cohort.

Rutte A, Rauh SP, Schram MT, Nijpels G, DeVries JH, Holleman F, Pijl H, Dekkers OM, Özcan B, Sijbrands EJG, Tack CJ, Abbink EJ, de Valk HW, Silvius B, Wolffenbuttel BHR, Stehouwer CDA, Schaper NC, Dekker JM, Beulens JW, Elders PJM, Rutters F; Diabetes Pearl from the Parelsnoer Initiative.

Diabet Med. 2017 Nov;34(11):1623-1628. doi: 10.1111/dme.13422. Epub 2017 Aug 3.


Serum levels of IGF-1 and IGF-BP3 are associated with event-free survival in adult Ewing sarcoma patients treated with chemotherapy.

de Groot S, Gelderblom H, Fiocco M, Bovée JV, van der Hoeven JJ, Pijl H, Kroep JR.

Onco Targets Ther. 2017 Jun 13;10:2963-2970. doi: 10.2147/OTT.S123726. eCollection 2017.


Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals.

van den Berg R, Noordam R, Kooijman S, Jansen SWM, Akintola AA, Slagboom PE, Pijl H, Rensen PCN, Biermasz NR, van Heemst D.

Aging Cell. 2017 Apr;16(2):237-243. doi: 10.1111/acel.12547. Epub 2016 Nov 19.


Diabetes incidence and glucose intolerance prevalence increase with higher outdoor temperature.

Blauw LL, Aziz NA, Tannemaat MR, Blauw CA, de Craen AJ, Pijl H, Rensen PC.

BMJ Open Diabetes Res Care. 2017 Feb 20;5(1):e000317. doi: 10.1136/bmjdrc-2016-000317. eCollection 2017.


Effect of diet-induced weight loss on lipoprotein(a) levels in obese individuals with and without type 2 diabetes.

Berk KA, Yahya R, Verhoeven AJM, Touw J, Leijten FP, van Rossum EF, Wester VL, Lips MA, Pijl H, Timman R, Erhart G, Kronenberg F, Roeters van Lennep JE, Sijbrands EJG, Mulder MT.

Diabetologia. 2017 Jun;60(6):989-997. doi: 10.1007/s00125-017-4246-y. Epub 2017 Apr 6.


Familial Longevity Is Not Associated with Major Differences in the Hypothalamic-Pituitary-Gonadal Axis in Healthy Middle-Aged Men.

van der Spoel E, Roelfsema F, Jansen SW, Akintola AA, Ballieux BE, Cobbaert CM, Blauw GJ, Slagboom PE, Westendorp RG, Pijl H, van Heemst D.

Front Endocrinol (Lausanne). 2016 Nov 9;7:143. eCollection 2016.


Weight loss induced by very low calorie diet is associated with a more beneficial systemic inflammatory profile than by Roux-en-Y gastric bypass.

Lips MA, van Klinken JB, Pijl H, Janssen I, Willems van Dijk K, Koning F, van Harmelen V.

Metabolism. 2016 Nov;65(11):1614-1620. doi: 10.1016/j.metabol.2016.07.013. Epub 2016 Aug 16.


Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity.

van der Spoel E, Jansen SW, Akintola AA, Ballieux BE, Cobbaert CM, Slagboom PE, Blauw GJ, Westendorp RGJ, Pijl H, Roelfsema F, van Heemst D.

Aging Cell. 2016 Dec;15(6):1126-1131. doi: 10.1111/acel.12519. Epub 2016 Sep 7.


Energy restriction and Roux-en-Y gastric bypass reduce postprandial α-dicarbonyl stress in obese women with type 2 diabetes.

Maessen DE, Hanssen NM, Lips MA, Scheijen JL, Willems van Dijk K, Pijl H, Stehouwer CD, Schalkwijk CG.

Diabetologia. 2016 Sep;59(9):2013-7. doi: 10.1007/s00125-016-4009-1. Epub 2016 Jun 16.


Insulin-like growth factor 1 receptor expression and IGF1R 3129G > T polymorphism are associated with response to neoadjuvant chemotherapy in breast cancer patients: results from the NEOZOTAC trial (BOOG 2010-01).

de Groot S, Charehbili A, van Laarhoven HW, Mooyaart AL, Dekker-Ensink NG, van de Ven S, Janssen LG, Swen JJ, Smit VT, Heijns JB, Kessels LW, van der Straaten T, Böhringer S, Gelderblom H, van der Hoeven JJ, Guchelaar HJ, Pijl H, Kroep JR; Dutch Breast Cancer Research Group.

Breast Cancer Res. 2016 Jan 6;18(1):3. doi: 10.1186/s13058-015-0663-3.


Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans.

Pal A, Potjer TP, Thomsen SK, Ng HJ, Barrett A, Scharfmann R, James TJ, Bishop DT, Karpe F, Godsland IF, Vasen HF, Newton-Bishop J, Pijl H, McCarthy MI, Gloyn AL.

Diabetes. 2016 Feb;65(2):527-33. doi: 10.2337/db15-0602. Epub 2015 Nov 5.


Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals.

Akintola AA, Noordam R, Jansen SW, de Craen AJ, Ballieux BE, Cobbaert CM, Mooijaart SP, Pijl H, Westendorp RG, van Heemst D.

PLoS One. 2015 Oct 7;10(10):e0139973. doi: 10.1371/journal.pone.0139973. eCollection 2015.


The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study.

de Groot S, Vreeswijk MP, Welters MJ, Gravesteijn G, Boei JJ, Jochems A, Houtsma D, Putter H, van der Hoeven JJ, Nortier JW, Pijl H, Kroep JR.

BMC Cancer. 2015 Oct 5;15:652. doi: 10.1186/s12885-015-1663-5.


Increased PUFA Content and 5-Lipoxygenase Pathway Expression Are Associated with Subcutaneous Adipose Tissue Inflammation in Obese Women with Type 2 Diabetes.

Heemskerk MM, Giera M, Bouazzaoui FE, Lips MA, Pijl H, van Dijk KW, van Harmelen V.

Nutrients. 2015 Sep 11;7(9):7676-90. doi: 10.3390/nu7095362.


Exploratory analysis of candidate germline gene polymorphisms in breast cancer patients treated with neoadjuvant anthracycline-containing chemotherapy and associations with febrile neutropenia.

Charehbili A, de Groot S, van der Straaten T, Swen JJ, Pijl H, Gelderblom H, van de Velde CJ, Nortier JW, Guchelaar HJ, Kroep JR.

Pharmacogenomics. 2015;16(11):1267-76. doi: 10.2217/PGS.15.74. Epub 2015 Aug 20.


Paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis.

Manheimer EW, van Zuuren EJ, Fedorowicz Z, Pijl H.

Am J Clin Nutr. 2015 Oct;102(4):922-32. doi: 10.3945/ajcn.115.113613. Epub 2015 Aug 12. Review.


Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice.

Kooijman S, Wang Y, Parlevliet ET, Boon MR, Edelschaap D, Snaterse G, Pijl H, Romijn JA, Rensen PC.

Diabetologia. 2015 Nov;58(11):2637-46. doi: 10.1007/s00125-015-3727-0. Epub 2015 Aug 9.


Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship.

Jansen SW, Roelfsema F, van der Spoel E, Akintola AA, Postmus I, Ballieux BE, Slagboom PE, Cobbaert CM, van der Grond J, Westendorp RG, Pijl H, van Heemst D.

J Clin Endocrinol Metab. 2015 Oct;100(10):3806-13. doi: 10.1210/jc.2015-2624. Epub 2015 Jul 31.


Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions.

Jansen SW, Roelfsema F, Akintola AA, Oei NY, Cobbaert CM, Ballieux BE, van der Grond J, Westendorp RG, Pijl H, van Heemst D.

PLoS One. 2015 Jul 20;10(7):e0133119. doi: 10.1371/journal.pone.0133119. eCollection 2015.


Does midlife obesity really lower dementia risk?

van der Burg JM, Pijl H, Campman YJ, Roos RA, Aziz NA.

Lancet Diabetes Endocrinol. 2015 Jul;3(7):499-500. doi: 10.1016/S2213-8587(15)00217-X. No abstract available.


Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism.

Jansen SW, Akintola AA, Roelfsema F, van der Spoel E, Cobbaert CM, Ballieux BE, Egri P, Kvarta-Papp Z, Gereben B, Fekete C, Slagboom PE, van der Grond J, Demeneix BA, Pijl H, Westendorp RG, van Heemst D.

Sci Rep. 2015 Jun 19;5:11525. doi: 10.1038/srep11525.


The effects of sodium oxybate on core body and skin temperature regulation in narcolepsy.

van der Heide A, Donjacour CE, Pijl H, Reijntjes RH, Overeem S, Lammers GJ, Van Someren EJ, Fronczek R.

J Sleep Res. 2015 Oct;24(5):566-75. doi: 10.1111/jsr.12303. Epub 2015 Apr 24.


Obesity is marked by distinct functional connectivity in brain networks involved in food reward and salience.

Wijngaarden MA, Veer IM, Rombouts SA, van Buchem MA, Willems van Dijk K, Pijl H, van der Grond J.

Behav Brain Res. 2015;287:127-34. doi: 10.1016/j.bbr.2015.03.016. Epub 2015 Mar 14.


Cardiovascular flexibility in middle-aged overweight South Asians vs. white Caucasians: response to short-term caloric restriction.

Van Schinkel LD, Bakker LE, Jonker JT, De Roos A, Pijl H, Meinders AE, Jazet IM, Lamb HJ, Smit JW.

Nutr Metab Cardiovasc Dis. 2015 Apr;25(4):403-10. doi: 10.1016/j.numecd.2014.12.007. Epub 2014 Dec 30.


Thyroid function alters during neoadjuvant chemotherapy in breast cancer patients: results from the NEOZOTAC trial (BOOG 2010-01).

de Groot S, Janssen LG, Charehbili A, Dijkgraaf EM, Smit VT, Kessels LW, van Bochove A, van Laarhoven HW, Meershoek-Klein Kranenbarg E, van Leeuwen-Stok AE, van de Velde CJ, Putter H, Nortier JW, van der Hoeven JJ, Pijl H, Kroep JR.

Breast Cancer Res Treat. 2015 Jan;149(2):461-6. doi: 10.1007/s10549-014-3256-4. Epub 2015 Jan 4.


Middle-aged overweight South Asian men exhibit a different metabolic adaptation to short-term energy restriction compared with Europeans.

Bakker LE, Guigas B, van Schinkel LD, van der Zon GC, Streefland TC, van Klinken JB, Jonker JT, Lamb HJ, Smit JW, Pijl H, Meinders AE, Jazet IM.

Diabetologia. 2015 Jan;58(1):165-77. doi: 10.1007/s00125-014-3408-4. Epub 2014 Oct 15.


Roux-en-Y gastric bypass surgery, but not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes.

Lips MA, Van Klinken JB, van Harmelen V, Dharuri HK, 't Hoen PA, Laros JF, van Ommen GJ, Janssen IM, Van Ramshorst B, Van Wagensveld BA, Swank DJ, Van Dielen F, Dane A, Harms A, Vreeken R, Hankemeier T, Smit JW, Pijl H, Willems van Dijk K.

Diabetes Care. 2014 Dec;37(12):3150-6. doi: 10.2337/dc14-0195. Epub 2014 Oct 14.


Regulation of skeletal muscle energy/nutrient-sensing pathways during metabolic adaptation to fasting in healthy humans.

Wijngaarden MA, Bakker LE, van der Zon GC, 't Hoen PA, van Dijk KW, Jazet IM, Pijl H, Guigas B.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E885-95. doi: 10.1152/ajpendo.00215.2014. Epub 2014 Sep 23.


Downregulation of the acetyl-CoA metabolic network in adipose tissue of obese diabetic individuals and recovery after weight loss.

Dharuri H, 't Hoen PA, van Klinken JB, Henneman P, Laros JF, Lips MA, El Bouazzaoui F, van Ommen GJ, Janssen I, van Ramshorst B, van Wagensveld BA, Pijl H, Willems van Dijk K, van Harmelen V.

Diabetologia. 2014 Nov;57(11):2384-92. doi: 10.1007/s00125-014-3347-0. Epub 2014 Aug 7.


Resting-state functional connectivity of brain regions involved in cognitive control, motivation, and reward is enhanced in obese females.

Lips MA, Wijngaarden MA, van der Grond J, van Buchem MA, de Groot GH, Rombouts SA, Pijl H, Veer IM.

Am J Clin Nutr. 2014 Aug;100(2):524-31. doi: 10.3945/ajcn.113.080671. Epub 2014 Jun 25.


Glucose and fat metabolism in narcolepsy and the effect of sodium oxybate: a hyperinsulinemic-euglycemic clamp study.

Donjacour CE, Aziz NA, Overeem S, Kalsbeek A, Pijl H, Lammers GJ.

Sleep. 2014 Apr 1;37(4):795-801. doi: 10.5665/sleep.3592.


Selenium Supplementation for Hashimoto's Thyroiditis: Summary of a Cochrane Systematic Review.

van Zuuren EJ, Albusta AY, Fedorowicz Z, Carter B, Pijl H.

Eur Thyroid J. 2014 Mar;3(1):25-31. doi: 10.1159/000356040. Epub 2013 Nov 21. Review.


Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects.

Lips MA, de Groot GH, Berends FJ, Wiezer R, van Wagensveld BA, Swank DJ, Luijten A, van Dijk KW, Pijl H, Jansen PL, Schaap FG.

Clin Endocrinol (Oxf). 2014 Dec;81(6):862-70. doi: 10.1111/cen.12496. Epub 2014 Jun 12.


Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

Guigas B, de Leeuw van Weenen JE, van Leeuwen N, Simonis-Bik AM, van Haeften TW, Nijpels G, Houwing-Duistermaat JJ, Beekman M, Deelen J, Havekes LM, Penninx BW, Vogelzangs N, van 't Riet E, Dehghan A, Hofman A, Witteman JC, Uitterlinden AG, Grarup N, Jørgensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Hottenga J, Romijn JA, Diamant M, Kramer MH, Heine RJ, Willemsen G, Dekker JM, Eekhoff EM, Pijl H, de Geus EJ, Slagboom PE, 't Hart LM.

Diabet Med. 2014 Aug;31(8):1001-8. doi: 10.1111/dme.12464. Epub 2014 May 2.


Increased systemic and adipose tissue inflammation differentiates obese women with T2DM from obese women with normal glucose tolerance.

van Beek L, Lips MA, Visser A, Pijl H, Ioan-Facsinay A, Toes R, Berends FJ, Willems van Dijk K, Koning F, van Harmelen V.

Metabolism. 2014 Apr;63(4):492-501. doi: 10.1016/j.metabol.2013.12.002. Epub 2013 Dec 10.


Effects of bariatric surgery on pericardial ectopic fat depositions and cardiovascular function.

van Schinkel LD, Sleddering MA, Lips MA, Jonker JT, de Roos A, Lamb HJ, Jazet IM, Pijl H, Smit JW.

Clin Endocrinol (Oxf). 2014 Nov;81(5):689-95. doi: 10.1111/cen.12402. Epub 2014 Feb 4.


A 5-day high-fat, high-calorie diet impairs insulin sensitivity in healthy, young South Asian men but not in Caucasian men.

Bakker LE, van Schinkel LD, Guigas B, Streefland TC, Jonker JT, van Klinken JB, van der Zon GC, Lamb HJ, Smit JW, Pijl H, Meinders AE, Jazet IM.

Diabetes. 2014 Jan;63(1):248-58. doi: 10.2337/db13-0696.


Thyrotropin secretion in healthy subjects is robust and independent of age and gender, and only weakly dependent on body mass index.

Roelfsema F, Pijl H, Kok P, Endert E, Fliers E, Biermasz NR, Pereira AM, Veldhuis JD.

J Clin Endocrinol Metab. 2014 Feb;99(2):570-8. doi: 10.1210/jc.2013-2858. Epub 2013 Nov 25.


Sustained cardiac remodeling after a short-term very low calorie diet in type 2 diabetes mellitus patients.

Jonker JT, Snel M, Hammer S, Jazet IM, van der Meer RW, Pijl H, Meinders AE, de Roos A, Smit JW, Romijn JA, Lamb HJ.

Int J Cardiovasc Imaging. 2014 Jan;30(1):121-7. doi: 10.1007/s10554-013-0302-y. Epub 2013 Oct 16.


Adipocyte telomere length associates negatively with adipocyte size, whereas adipose tissue telomere length associates negatively with the extent of fibrosis in severely obese women.

el Bouazzaoui F, Henneman P, Thijssen P, Visser A, Koning F, Lips MA, Janssen I, Pijl H, Willems van Dijk K, van Harmelen V.

Int J Obes (Lond). 2014 May;38(5):746-9. doi: 10.1038/ijo.2013.175. Epub 2013 Sep 12.


Functional and metabolic imaging of the cardiovascular system in young healthy South Asians and Caucasians unveils early differences.

van Schinkel LD, Bakker LE, Jonker JT, de Roos A, Pijl H, Meinders AE, Jazet IM, Smit JW, Lamb HJ.

Diabetes Care. 2013 Oct;36(10):e178-9. doi: 10.2337/dc13-0287. No abstract available.


The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system.

Coomans CP, Geerling JJ, van den Berg SA, van Diepen HC, Garcia-Tardón N, Thomas A, Schröder-van der Elst JP, Ouwens DM, Pijl H, Rensen PC, Havekes LM, Guigas B, Romijn JA.

Br J Pharmacol. 2013 Oct;170(4):908-18. doi: 10.1111/bph.12338.

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