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Items: 23

1.

Sulfonamide inhibitors of α2β1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation.

Nissinen L, Ojala M, Langen B, Dost R, Pihlavisto M, Käpylä J, Marjamäki A, Heino J.

Pharmacol Res Perspect. 2015 Jun;3(3):e00146. doi: 10.1002/prp2.146. Epub 2015 May 15.

2.

Novel pyridazinone inhibitors for vascular adhesion protein-1 (VAP-1): old target-new inhibition mode.

Bligt-Lindén E, Pihlavisto M, Szatmári I, Otwinowski Z, Smith DJ, Lázár L, Fülöp F, Salminen TA.

J Med Chem. 2013 Dec 27;56(24):9837-48. doi: 10.1021/jm401372d. Epub 2013 Dec 13.

3.

Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.

Nissinen L, Koivunen J, Käpylä J, Salmela M, Nieminen J, Jokinen J, Sipilä K, Pihlavisto M, Pentikäinen OT, Marjamäki A, Heino J.

J Biol Chem. 2012 Dec 28;287(53):44694-702. doi: 10.1074/jbc.M111.309450. Epub 2012 Nov 6.

4.

Heparin-like polysaccharides reduce osteolytic bone destruction and tumor growth in a mouse model of breast cancer bone metastasis.

Pollari S, Käkönen RS, Mohammad KS, Rissanen JP, Halleen JM, Wärri A, Nissinen L, Pihlavisto M, Marjamäki A, Perälä M, Guise TA, Kallioniemi O, Käkönen SM.

Mol Cancer Res. 2012 May;10(5):597-604. doi: 10.1158/1541-7786.MCR-11-0482. Epub 2012 Apr 20.

5.

Fluorescent small molecule probe to modulate and explore α2β1 integrin function.

Koivunen JT, Nissinen L, Käpylä J, Jokinen J, Pihlavisto M, Marjamäki A, Heino J, Huuskonen J, Pentikäinen OT.

J Am Chem Soc. 2011 Sep 21;133(37):14558-61. doi: 10.1021/ja206086c. Epub 2011 Aug 30.

PMID:
21863823
6.

Identification of two imidazole binding sites and key residues for substrate specificity in human primary amine oxidase AOC3.

Elovaara H, Kidron H, Parkash V, Nymalm Y, Bligt E, Ollikka P, Smith DJ, Pihlavisto M, Salmi M, Jalkanen S, Salminen TA.

Biochemistry. 2011 Jun 21;50(24):5507-20. doi: 10.1021/bi200117z. Epub 2011 May 27.

PMID:
21585208
7.

Novel hydrazine molecules as tools to understand the flexibility of vascular adhesion protein-1 ligand-binding site: toward more selective inhibitors.

Nurminen EM, Pihlavisto M, Lázár L, Pentikäinen U, Fülöp F, Pentikäinen OT.

J Med Chem. 2011 Apr 14;54(7):2143-54. doi: 10.1021/jm200059p. Epub 2011 Mar 15.

PMID:
21405023
8.

Synthesis, in vitro activity, and three-dimensional quantitative structure-activity relationship of novel hydrazine inhibitors of human vascular adhesion protein-1.

Nurminen EM, Pihlavisto M, Lázár L, Szakonyi Z, Pentikäinen U, Fülöp F, Pentikäinen OT.

J Med Chem. 2010 Sep 9;53(17):6301-15. doi: 10.1021/jm100337z.

PMID:
20690686
9.

O-sulfated bacterial polysaccharides with low anticoagulant activity inhibit metastasis.

Borgenström M, Wärri A, Hiilesvuo K, Käkönen R, Käkönen S, Nissinen L, Pihlavisto M, Marjamäki A, Vlodavsky I, Naggi A, Torri G, Casu B, Veromaa T, Salmivirta M, Elenius K.

Semin Thromb Hemost. 2007 Jul;33(5):547-56.

PMID:
17629853
10.

Vascular amine oxidases are needed for leukocyte extravasation into inflamed joints in vivo.

Marttila-Ichihara F, Smith DJ, Stolen C, Yegutkin GG, Elima K, Mercier N, Kiviranta R, Pihlavisto M, Alaranta S, Pentikäinen U, Pentikäinen O, Fülöp F, Jalkanen S, Salmi M.

Arthritis Rheum. 2006 Sep;54(9):2852-62.

11.

Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications.

Airenne TT, Nymalm Y, Kidron H, Smith DJ, Pihlavisto M, Salmi M, Jalkanen S, Johnson MS, Salminen TA.

Protein Sci. 2005 Aug;14(8):1964-74.

12.

Granulocyte transmigration through the endothelium is regulated by the oxidase activity of vascular adhesion protein-1 (VAP-1).

Koskinen K, Vainio PJ, Smith DJ, Pihlavisto M, Ylä-Herttuala S, Jalkanen S, Salmi M.

Blood. 2004 May 1;103(9):3388-95. Epub 2004 Jan 15.

PMID:
14726375
13.

Molecular mechanisms of ligand-receptor interactions in transmembrane domain V of the alpha2A-adrenoceptor.

Peltonen JM, Nyrönen T, Wurster S, Pihlavisto M, Hoffrén AM, Marjamäki A, Xhaard H, Kanerva L, Savola JM, Johnson MS, Scheinin M.

Br J Pharmacol. 2003 Sep;140(2):347-58. Epub 2003 Aug 18.

14.

Crystallization and preliminary X-ray analysis of the human vascular adhesion protein-1.

Nymalm Y, Kidron H, Söderholm A, Viitanen L, Kaukonen K, Pihlavisto M, Smith D, Veromaa T, Airenne TT, Johnson MS, Salminen TA.

Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1288-90. Epub 2003 Jun 27.

PMID:
12832789
15.

Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine.

Nyrönen T, Pihlavisto M, Peltonen JM, Hoffrén AM, Varis M, Salminen T, Wurster S, Marjamäki A, Kanerva L, Katainen E, Laaksonen L, Savola JM, Scheinin M, Johnson MS.

Mol Pharmacol. 2001 May;59(5):1343-54.

PMID:
11306720
16.

Ligand recognition of serine-cysteine amino acid exchanges in transmembrane domain 5 of alpha2-adrenergic receptors by UK 14,304.

Cockcroft V, Frang H, Pihlavisto M, Marjamäki A, Scheinin M.

J Neurochem. 2000 Apr;74(4):1705-10.

17.

Functional assessment of recombinant human alpha(2)-adrenoceptor subtypes with cytosensor microphysiometry.

Pihlavisto M, Scheinin M.

Eur J Pharmacol. 1999 Dec 3;385(2-3):247-53.

PMID:
10607883
18.

Three-dimensional models of alpha(2A)-adrenergic receptor complexes provide a structural explanation for ligand binding.

Salminen T, Varis M, Nyrönen T, Pihlavisto M, Hoffrén AM, Lönnberg T, Marjamäki A, Frang H, Savola JM, Scheinin M, Johnson MS.

J Biol Chem. 1999 Aug 13;274(33):23405-13.

19.

Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human alpha(2A)-adrenergic receptor.

Marjamäki A, Frang H, Pihlavisto M, Hoffrén AM, Salminen T, Johnson MS, Kallio J, Javitch JA, Scheinin M.

J Biol Chem. 1999 Jul 30;274(31):21867-72.

20.

Modulation of agonist binding to recombinant human alpha2-adrenoceptors by sodium ions.

Pihlavisto M, Sjöholm B, Scheinin M, Wurster S.

Biochim Biophys Acta. 1998 Nov 19;1448(1):135-46.

21.

Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors.

Peltonen JM, Pihlavisto M, Scheinin M.

Eur J Pharmacol. 1998 Aug 21;355(2-3):275-9.

PMID:
9760042
22.

A series of 6-(omega-methanesulfonylthioalkoxy)-2-N-methyl- 1,2,3, 4-tetrahydroisoquinolines: cysteine-reactive molecular yardsticks for probing alpha2-adrenergic receptors.

Heinonen P, Koskua K, Pihlavisto M, Marjamäki A, Cockcroft V, Savola JM, Scheinin M, Lönnberg H.

Bioconjug Chem. 1998 May-Jun;9(3):358-64.

PMID:
9576810
23.

Chloroethylclonidine binds irreversibly to exposed cysteines in the fifth membrane-spanning domain of the human alpha2A-adrenergic receptor.

Marjamaki A, Pihlavisto M, Cockcroft V, Heinonen P, Savola JM, Scheinin M.

Mol Pharmacol. 1998 Mar;53(3):370-6.

PMID:
9495800

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