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Items: 1 to 50 of 230

1.

Exploring the roles of MACIT and multiplexin collagens in stem cells and cancer.

Izzi V, Heljasvaara R, Heikkinen A, Karppinen SM, Koivunen J, Pihlajaniemi T.

Semin Cancer Biol. 2019 Aug 31. pii: S1044-579X(19)30193-2. doi: 10.1016/j.semcancer.2019.08.033. [Epub ahead of print] Review.

PMID:
31479735
2.

Stromal integrin α11 regulates PDGFR-β signaling and promotes breast cancer progression.

Primac I, Maquoi E, Blacher S, Heljasvaara R, Van Deun J, Smeland HY, Canale A, Louis T, Stuhr L, Sounni NE, Cataldo D, Pihlajaniemi T, Pequeux C, De Wever O, Gullberg D, Noel A.

J Clin Invest. 2019 Jul 9;130:4609-4628. doi: 10.1172/JCI125890.

3.

Toward understanding scarless skin wound healing and pathological scarring.

Karppinen SM, Heljasvaara R, Gullberg D, Tasanen K, Pihlajaniemi T.

F1000Res. 2019 Jun 5;8. pii: F1000 Faculty Rev-787. doi: 10.12688/f1000research.18293.1. eCollection 2019. Review.

4.

Collagen XIII-derived ectodomain regulates bone angiogenesis and intracortical remodeling.

Koivunen J, Kemppainen AV, Finnilä MA, Keski-Filppula R, Härönen H, Tu H, Pellikka H, Heikkinen A, Kylmäoja E, Sormunen R, Miinalainen I, Saarakkala S, Izzi V, Pihlajaniemi T.

Matrix Biol. 2019 Jun 17. pii: S0945-053X(19)30159-3. doi: 10.1016/j.matbio.2019.06.005. [Epub ahead of print]

PMID:
31220558
5.

Collagen XVIII Deposition in the Basement Membrane Zone beneath the Newly Forming Epidermis during Wound Healing in Mice.

Maeba T, Yonezawa T, Ono M, Tomono Y, Heljasvaara R, Pihlajaniemi T, Inagawa K, Oohashi T.

Acta Med Okayama. 2019 Apr;73(2):135-146. doi: 10.18926/AMO/56649.

6.

Collagen XIII and Other ECM Components in the Assembly and Disease of the Neuromuscular Junction.

Heikkinen A, Härönen H, Norman O, Pihlajaniemi T.

Anat Rec (Hoboken). 2019 Feb 15. doi: 10.1002/ar.24092. [Epub ahead of print]

PMID:
30768864
7.

Correct expression and localization of collagen XIII are crucial for the normal formation and function of the neuromuscular system.

Härönen H, Zainul Z, Naumenko N, Sormunen R, Miinalainen I, Shakirzyanova A, Santoleri S, Kemppainen AV, Giniatullin R, Pihlajaniemi T, Heikkinen A.

Eur J Neurosci. 2019 Jun;49(11):1491-1511. doi: 10.1111/ejn.14346. Epub 2019 Feb 8.

PMID:
30667565
8.

The N-terminal domain of unknown function (DUF959) in collagen XVIII is intrinsically disordered and highly O-glycosylated.

Kaur I, Ruskamo S, Koivunen J, Heljasvaara R, Lackman JJ, Izzi V, Petäjä-Repo UE, Kursula P, Pihlajaniemi T.

Biochem J. 2018 Nov 20;475(22):3577-3593. doi: 10.1042/BCJ20180405.

PMID:
30327321
9.

Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance.

Zhang H, Fredericks T, Xiong G, Qi Y, Rychahou PG, Li JD, Pihlajaniemi T, Xu W, Xu R.

Breast Cancer Res. 2018 Oct 1;20(1):116. doi: 10.1186/s13058-018-1030-y.

10.

Collagen XIII Is Required for Neuromuscular Synapse Regeneration and Functional Recovery after Peripheral Nerve Injury.

Zainul Z, Heikkinen A, Koivisto H, Rautalahti I, Kallio M, Lin S, Härönen H, Norman O, Rüegg MA, Tanila H, Pihlajaniemi T.

J Neurosci. 2018 Apr 25;38(17):4243-4258. doi: 10.1523/JNEUROSCI.3119-17.2018. Epub 2018 Apr 6.

11.

2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.

Nkizinkiko Y, Desantis J, Koivunen J, Haikarainen T, Murthy S, Sancineto L, Massari S, Ianni F, Obaji E, Loza MI, Pihlajaniemi T, Brea J, Tabarrini O, Lehtiö L.

Sci Rep. 2018 Jan 26;8(1):1680. doi: 10.1038/s41598-018-19872-3.

12.

Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia.

Izzi V, Lakkala J, Devarajan R, Savolainen ER, Koistinen P, Heljasvaara R, Pihlajaniemi T.

Leuk Res Rep. 2017 Dec 13;9:9-13. doi: 10.1016/j.lrr.2017.12.001. eCollection 2018.

13.

Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways.

Ullah K, Rosendahl AH, Izzi V, Bergmann U, Pihlajaniemi T, Mäki JM, Myllyharju J.

Sci Rep. 2017 Dec 8;7(1):17220. doi: 10.1038/s41598-017-17376-0.

14.

Understanding the extracellular matrix in acute myeloid leukemia.

Izzi V, Heljasvaara R, Pihlajaniemi T.

Haematologica. 2017 Nov;102(11):1807-1809. doi: 10.3324/haematol.2017.174847. No abstract available.

15.

Vanin 1 (VNN1) levels predict poor outcome in acute myeloid leukemia.

Izzi V, Lakkala J, Devarajan R, Savolainen ER, Koistinen P, Heljasvaara R, Pihlajaniemi T.

Am J Hematol. 2018 Jan;93(1):E4-E7. doi: 10.1002/ajh.24925. Epub 2017 Oct 23. No abstract available.

16.

Autoimmune antibodies to collagen XIII in myasthenia gravis patients.

Tu H, Pirskanen-Matell R, Heikkinen A, Oikarainen T, Risteli J, Pihlajaniemi T.

Muscle Nerve. 2018 Mar;57(3):506-510. doi: 10.1002/mus.25969. Epub 2017 Nov 30.

PMID:
28885698
17.

An extracellular matrix signature in leukemia precursor cells and acute myeloid leukemia.

Izzi V, Lakkala J, Devarajan R, Ruotsalainen H, Savolainen ER, Koistinen P, Heljasvaara R, Pihlajaniemi T.

Haematologica. 2017 Jul;102(7):e245-e248. doi: 10.3324/haematol.2017.167304. Epub 2017 Apr 14. No abstract available.

18.

Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse.

Härönen H, Zainul Z, Tu H, Naumenko N, Sormunen R, Miinalainen I, Shakirzyanova A, Oikarainen T, Abdullin A, Martin P, Santoleri S, Koistinaho J, Silman I, Giniatullin R, Fox MA, Heikkinen A, Pihlajaniemi T.

Hum Mol Genet. 2017 Jun 1;26(11):2076-2090. doi: 10.1093/hmg/ddx101.

PMID:
28369367
19.

Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma.

Riihilä P, Nissinen L, Farshchian M, Kallajoki M, Kivisaari A, Meri S, Grénman R, Peltonen S, Peltonen J, Pihlajaniemi T, Heljasvaara R, Kähäri VM.

Am J Pathol. 2017 May;187(5):1186-1197. doi: 10.1016/j.ajpath.2017.01.006. Epub 2017 Mar 17.

20.

GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.

Géraud C, Koch PS, Zierow J, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin HG, Schledzewski K, Goerdt S.

J Clin Invest. 2017 Mar 1;127(3):1099-1114. doi: 10.1172/JCI90086. Epub 2017 Feb 20.

21.

Lack of collagen XV is protective after ischemic stroke in mice.

Dhungana H, Huuskonen MT, Pihlajaniemi T, Heljasvaara R, Vivien D, Kanninen KM, Malm T, Koistinaho J, Lemarchant S.

Cell Death Dis. 2017 Jan 12;8(1):e2541. doi: 10.1038/cddis.2016.456.

22.

Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity.

Nathubhai A, Haikarainen T, Koivunen J, Murthy S, Koumanov F, Lloyd MD, Holman GD, Pihlajaniemi T, Tosh D, Lehtiö L, Threadgill MD.

J Med Chem. 2017 Jan 26;60(2):814-820. doi: 10.1021/acs.jmedchem.6b01574. Epub 2017 Jan 9.

PMID:
27983846
23.

Collagen XVIII in tissue homeostasis and dysregulation - Lessons learned from model organisms and human patients.

Heljasvaara R, Aikio M, Ruotsalainen H, Pihlajaniemi T.

Matrix Biol. 2017 Jan;57-58:55-75. doi: 10.1016/j.matbio.2016.10.002. Epub 2016 Oct 13. Review.

PMID:
27746220
24.

Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage.

Venkannagari H, Verheugd P, Koivunen J, Haikarainen T, Obaji E, Ashok Y, Narwal M, Pihlajaniemi T, Lüscher B, Lehtiö L.

Cell Chem Biol. 2016 Oct 20;23(10):1251-1260. doi: 10.1016/j.chembiol.2016.08.012. Epub 2016 Sep 22.

25.

Editorial: Wound healing and fibrosis-two sides of the same coin.

Gullberg D, Kletsas D, Pihlajaniemi T.

Cell Tissue Res. 2016 Sep;365(3):449-51. doi: 10.1007/s00441-016-2478-7.

PMID:
27475651
26.

Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.

Honkanen HK, Izzi V, Petäistö T, Holopainen T, Harjunen V, Pihlajaniemi T, Alitalo K, Heljasvaara R.

Neoplasia. 2016 Jul;18(7):436-46. doi: 10.1016/j.neo.2016.05.002.

27.

Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney.

Lin CH, Chen J, Zhang Z, Johnson GV, Cooper AJ, Feola J, Bank A, Shein J, Ruotsalainen HJ, Pihlajaniemi TA, Goligorsky MS.

Kidney Int. 2016 Jun;89(6):1281-92. doi: 10.1016/j.kint.2016.01.030. Epub 2016 Apr 14.

28.

Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis.

Kivinen N, Felszeghy S, Kinnunen AI, Setälä N, Aikio M, Kinnunen K, Sironen R, Pihlajaniemi T, Kauppinen A, Kaarniranta K.

Biogerontology. 2016 Aug;17(4):749-61. doi: 10.1007/s10522-016-9647-7. Epub 2016 Apr 28.

PMID:
27125427
29.

Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study.

Pirhonen J, Arola J, Sädevirta S, Luukkonen P, Karppinen SM, Pihlajaniemi T, Isomäki A, Hukkanen M, Yki-Järvinen H, Ikonen E.

PLoS One. 2016 Jan 25;11(1):e0147804. doi: 10.1371/journal.pone.0147804. eCollection 2016.

30.

Membrane-associated collagens with interrupted triple-helices (MACITs): evolution from a bilaterian common ancestor and functional conservation in C. elegans.

Tu H, Huhtala P, Lee HM, Adams JC, Pihlajaniemi T.

BMC Evol Biol. 2015 Dec 14;15:281. doi: 10.1186/s12862-015-0554-3.

31.

Collagens XV and XVIII show different expression and localisation in cutaneous squamous cell carcinoma: type XV appears in tumor stroma, while XVIII becomes upregulated in tumor cells and lost from microvessels.

Karppinen SM, Honkanen HK, Heljasvaara R, Riihilä P, Autio-Harmainen H, Sormunen R, Harjunen V, Väisänen MR, Väisänen T, Hurskainen T, Tasanen K, Kähäri VM, Pihlajaniemi T.

Exp Dermatol. 2016 May;25(5):348-54. doi: 10.1111/exd.12913.

PMID:
26660139
32.

Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences.

Richter K, Konzack A, Pihlajaniemi T, Heljasvaara R, Kietzmann T.

Redox Biol. 2015 Dec;6:344-352. doi: 10.1016/j.redox.2015.08.015. Epub 2015 Aug 28. Review.

33.

Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics.

Nkizinkiko Y, Suneel Kumar BV, Jeankumar VU, Haikarainen T, Koivunen J, Madhuri C, Yogeeswari P, Venkannagari H, Obaji E, Pihlajaniemi T, Sriram D, Lehtiö L.

Bioorg Med Chem. 2015 Aug 1;23(15):4139-49. doi: 10.1016/j.bmc.2015.06.063. Epub 2015 Jul 2.

PMID:
26183543
34.

Endostatin induces proliferation of oral carcinoma cells but its effect on invasion is modified by the tumor microenvironment.

Alahuhta I, Aikio M, Väyrynen O, Nurmenniemi S, Suojanen J, Teppo S, Pihlajaniemi T, Heljasvaara R, Salo T, Nyberg P.

Exp Cell Res. 2015 Aug 1;336(1):130-40. doi: 10.1016/j.yexcr.2015.06.012. Epub 2015 Jun 22.

PMID:
26112215
35.

EphB2 Promotes Progression of Cutaneous Squamous Cell Carcinoma.

Farshchian M, Nissinen L, Siljamäki E, Riihilä P, Toriseva M, Kivisaari A, Ala-Aho R, Kallajoki M, Veräjänkorva E, Honkanen HK, Heljasvaara R, Pihlajaniemi T, Grénman R, Peltonen J, Peltonen S, Kähäri VM.

J Invest Dermatol. 2015 Jul;135(7):1882-1892. doi: 10.1038/jid.2015.104. Epub 2015 Mar 19.

36.

Neural ECM and synaptogenesis.

Heikkinen A, Pihlajaniemi T, Faissner A, Yuzaki M.

Prog Brain Res. 2014;214:29-51. doi: 10.1016/B978-0-444-63486-3.00002-5.

PMID:
25410352
37.

Basement membrane zone collagens XV and XVIII/proteoglycans mediate leukocyte influx in renal ischemia/reperfusion.

Zaferani A, Talsma DT, Yazdani S, Celie JW, Aikio M, Heljasvaara R, Navis GJ, Pihlajaniemi T, van den Born J.

PLoS One. 2014 Sep 4;9(9):e106732. doi: 10.1371/journal.pone.0106732. eCollection 2014.

38.

Serum endostatin levels are elevated in colorectal cancer and correlate with invasion and systemic inflammatory markers.

Kantola T, Väyrynen JP, Klintrup K, Mäkelä J, Karppinen SM, Pihlajaniemi T, Autio-Harmainen H, Karttunen TJ, Mäkinen MJ, Tuomisto A.

Br J Cancer. 2014 Oct 14;111(8):1605-13. doi: 10.1038/bjc.2014.456. Epub 2014 Aug 19.

39.

Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition.

Aikio M, Elamaa H, Vicente D, Izzi V, Kaur I, Seppinen L, Speedy HE, Kaminska D, Kuusisto S, Sormunen R, Heljasvaara R, Jones EL, Muilu M, Jauhiainen M, Pihlajamäki J, Savolainen MJ, Shoulders CC, Pihlajaniemi T.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3043-52. doi: 10.1073/pnas.1405879111. Epub 2014 Jul 14.

40.

[Many dimensions of extracellular matrix research].

Pihlajaniemi T.

Duodecim. 2013;129(21):2262-72. Review. Finnish.

PMID:
24340677
41.

Image-based assessment of microvascular function and structure in collagen XV- and XVIII-deficient mice.

Rygh CB, Løkka G, Heljasvaara R, Taxt T, Pavlin T, Sormunen R, Pihlajaniemi T, Curry FR, Tenstad O, Reed RK.

J Physiol. 2014 Jan 15;592(2):325-36. doi: 10.1113/jphysiol.2013.263574. Epub 2013 Nov 11.

42.

Collagen XVIII short isoform is critical for retinal vascularization, and overexpression of the Tsp-1 domain affects eye growth and cataract formation.

Aikio M, Hurskainen M, Brideau G, Hägg P, Sormunen R, Heljasvaara R, Gould DB, Pihlajaniemi T.

Invest Ophthalmol Vis Sci. 2013 Nov 13;54(12):7450-62. doi: 10.1167/iovs.13-13039.

PMID:
24135756
43.

para-Substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors.

Haikarainen T, Koivunen J, Narwal M, Venkannagari H, Obaji E, Joensuu P, Pihlajaniemi T, Lehtiö L.

ChemMedChem. 2013 Dec;8(12):1978-85. doi: 10.1002/cmdc.201300337. Epub 2013 Oct 15.

PMID:
24130191
44.

Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.

Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala OE, Venkannagari H, Joensuu P, Pihlajaniemi T, Lehtiö L.

J Med Chem. 2013 Oct 24;56(20):7880-9. doi: 10.1021/jm401463y. Epub 2013 Oct 11.

PMID:
24116873
45.

Expression of VEGF and collagen XVIII in meningiomas: correlations with histopathological and MRI characteristics.

Salokorpi N, Yrjänä S, Tuominen H, Karttunen A, Heljasvaara R, Pihlajaniemi T, Heikkinen E, Koivukangas J.

Acta Neurochir (Wien). 2013 Jun;155(6):989-96; discussion 996. doi: 10.1007/s00701-013-1699-8. Epub 2013 Apr 20.

PMID:
23605255
46.

Arresten, a collagen-derived angiogenesis inhibitor, suppresses invasion of squamous cell carcinoma.

Aikio M, Alahuhta I, Nurmenniemi S, Suojanen J, Palovuori R, Teppo S, Sorsa T, López-Otín C, Pihlajaniemi T, Salo T, Heljasvaara R, Nyberg P.

PLoS One. 2012;7(12):e51044. doi: 10.1371/journal.pone.0051044. Epub 2012 Dec 5.

47.

Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis.

Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR.

Pediatr Cardiol. 2013 Feb;34(2):291-5. doi: 10.1007/s00246-012-0441-2. Epub 2012 Sep 8.

48.

Target-derived matricryptins organize cerebellar synapse formation through α3β1 integrins.

Su J, Stenbjorn RS, Gorse K, Su K, Hauser KF, Ricard-Blum S, Pihlajaniemi T, Fox MA.

Cell Rep. 2012 Aug 30;2(2):223-30. doi: 10.1016/j.celrep.2012.07.001. Epub 2012 Aug 9.

49.

Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.

Holopainen T, López-Alpuche V, Zheng W, Heljasvaara R, Jones D, He Y, Tvorogov D, D'Amico G, Wiener Z, Andersson LC, Pihlajaniemi T, Min W, Alitalo K.

Cancer Res. 2012 Jul 15;72(14):3512-21. doi: 10.1158/0008-5472.CAN-11-1070. Epub 2012 May 16. Erratum in: Cancer Res. 2012 Sep 15;72(18):4869.

50.

Collagen XIII: a type II transmembrane protein with relevance to musculoskeletal tissues, microvessels and inflammation.

Heikkinen A, Tu H, Pihlajaniemi T.

Int J Biochem Cell Biol. 2012 May;44(5):714-7. doi: 10.1016/j.biocel.2012.01.024. Epub 2012 Feb 8. Review.

PMID:
22342189

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