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Items: 1 to 50 of 180

1.

Association of fatty liver index with risk of incident type 2 diabetes by metabolic syndrome status in an Eastern Finland male cohort: a prospective study.

Olubamwo OO, Virtanen JK, Pihlajamaki J, Tuomainen TP.

BMJ Open. 2019 Jul 4;9(7):e026949. doi: 10.1136/bmjopen-2018-026949.

2.

Association of fatty liver disease with mortality outcomes in an Eastern Finland male cohort.

Olubamwo OO, Virtanen JK, Pihlajamäki J, Tuomainen TP.

BMJ Open Gastroenterol. 2019 May 24;6(1):e000219. doi: 10.1136/bmjgast-2018-000219. eCollection 2019.

3.

Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression.

Männistö V, Kaminska D, Kärjä V, Tiainen M, de Mello VD, Hanhineva K, Soininen P, Ala-Korpela M, Pihlajamäki J.

Liver Int. 2019 Jun 14. doi: 10.1111/liv.14174. [Epub ahead of print]

PMID:
31199045
4.

Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study.

Keski-Rahkonen P, Kolehmainen M, Lappi J, Micard V, Jokkala J, Rosa-Sibakov N, Pihlajamäki J, Kirjavainen PV, Mykkänen H, Poutanen K, Gunter MJ, Scalbert A, Hanhineva K.

Am J Clin Nutr. 2019 Jun 1;109(6):1630-1639. doi: 10.1093/ajcn/nqy394.

PMID:
31136658
5.

Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome-A SYSDIET Sub-Study.

Myhrstad MCW, de Mello VD, Dahlman I, Kolehmainen M, Paananen J, Rundblad A, Carlberg C, Olstad OK, Pihlajamäki J, Holven KB, Hermansen K, Dragsted LO, Gunnarsdottir I, Cloetens L, Storm MU, Åkesson B, Rosqvist F, Hukkanen J, Herzig KH, Risérus U, Thorsdottir I, Poutanen KS, Savolainen MJ, Schwab U, Arner P, Uusitupa M, Ulven SM.

Mol Nutr Food Res. 2019 Apr 9:e1801405. doi: 10.1002/mnfr.201801405. [Epub ahead of print]

PMID:
30964598
6.

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients.

Dongiovanni P, Meroni M, Baselli G, Mancina RM, Ruscica M, Longo M, Rametta R, Cespiati A, Pelusi S, Ferri N, Ranzani V, Nobili V, Pihlajamaki J, Fracanzani AL, Badiali S, Petta S, Fargion S, Romeo S, Kozlitina J, Valenti L.

J Lipid Res. 2019 Jun;60(6):1144-1153. doi: 10.1194/jlr.P090449. Epub 2019 Mar 27.

PMID:
30918065
7.

Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates.

Puris E, Pasanen M, Ranta VP, Gynther M, Petsalo A, Käkelä P, Männistö V, Pihlajamäki J.

Basic Clin Pharmacol Toxicol. 2019 Aug;125(2):123-132. doi: 10.1111/bcpt.13234. Epub 2019 Apr 10.

PMID:
30916845
8.

Correction to: Liver DNA methylation of FADS2 associates with FADS2 genotype.

Walle P, Männistö V, de Mello VD, Vaittinen M, Perfilyev A, Hanhineva K, Ling C, Pihlajamäki J.

Clin Epigenetics. 2019 Mar 12;11(1):47. doi: 10.1186/s13148-019-0625-1.

9.

Digitally supported program for type 2 diabetes risk identification and risk reduction in real-world setting: protocol for the StopDia model and randomized controlled trial.

Pihlajamäki J, Männikkö R, Tilles-Tirkkonen T, Karhunen L, Kolehmainen M, Schwab U, Lintu N, Paananen J, Järvenpää R, Harjumaa M, Martikainen J, Kohl J, Poutanen K, Ermes M, Absetz P, Lindström J, Lakka TA; StopDia study group.

BMC Public Health. 2019 Mar 1;19(1):255. doi: 10.1186/s12889-019-6574-y.

10.

Prevalence and Risk Factors of Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis.

Pelusi S, Cespiati A, Rametta R, Pennisi G, Mannisto V, Rosso C, Baselli G, Dongiovanni P, Fracanzani AL, Badiali S, Maggioni M, Craxi A, Fargion S, Prati D, Nobili V, Bugianesi E, Romeo S, Pihlajamaki J, Petta S, Valenti L.

Clin Gastroenterol Hepatol. 2019 Jan 29. pii: S1542-3565(19)30074-6. doi: 10.1016/j.cgh.2019.01.027. [Epub ahead of print]

PMID:
30708111
11.

Liver DNA methylation of FADS2 associates with FADS2 genotype.

Walle P, Männistö V, de Mello VD, Vaittinen M, Perfilyev A, Hanhineva K, Ling C, Pihlajamäki J.

Clin Epigenetics. 2019 Jan 17;11(1):10. doi: 10.1186/s13148-019-0609-1. Erratum in: Clin Epigenetics. 2019 Mar 12;11(1):47.

12.

Inflammatory response to dietary linoleic acid depends on FADS1 genotype.

Lankinen MA, Fauland A, Shimizu BI, Ågren J, Wheelock CE, Laakso M, Schwab U, Pihlajamäki J.

Am J Clin Nutr. 2019 Jan 1;109(1):165-175. doi: 10.1093/ajcn/nqy287.

PMID:
30624587
13.

Measured energy content of frequently purchased restaurant meals: multi-country cross sectional study.

Roberts SB, Das SK, Suen VMM, Pihlajamäki J, Kuriyan R, Steiner-Asiedu M, Taetzsch A, Anderson AK, Silver RE, Barger K, Krauss A, Karhunen L, Zhang X, Hambly C, Schwab U, Triffoni-Melo AT, Taylor SF, Economos C, Kurpad AV, Speakman JR.

BMJ. 2018 Dec 12;363:k4864. doi: 10.1136/bmj.k4864.

14.

Small Intestinal Length Associates with Serum Triglycerides Before and After LRYGB.

Käkelä P, Männistö V, Vaittinen M, Venesmaa S, Kärjä V, Virtanen K, Paajanen H, Pihlajamäki J.

Obes Surg. 2018 Dec;28(12):3969-3975. doi: 10.1007/s11695-018-3447-x.

PMID:
30105660
15.

Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes.

Ihantola EL, Viisanen T, Gazali AM, Näntö-Salonen K, Juutilainen A, Moilanen L, Rintamäki R, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

J Immunol. 2018 Aug 15;201(4):1144-1153. doi: 10.4049/jimmunol.1701199. Epub 2018 Jul 13.

PMID:
30006377
16.

Association of fatty liver index with the risk of incident cardiovascular disease and acute myocardial infarction.

Olubamwo OO, Virtanen JK, Voutilainen A, Kauhanen J, Pihlajamäki J, Tuomainen TP.

Eur J Gastroenterol Hepatol. 2018 Sep;30(9):1047-1054. doi: 10.1097/MEG.0000000000001183.

PMID:
29912803
17.

Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease.

Dongiovanni P, Meroni M, Mancina RM, Baselli G, Rametta R, Pelusi S, Männistö V, Fracanzani AL, Badiali S, Miele L, Grimaudo S, Petta S, Bugianesi E, Soardo G, Fargion S, Pihlajamäki J, Romeo S, Valenti L.

Hepatol Commun. 2018 Apr 25;2(6):666-675. doi: 10.1002/hep4.1192. eCollection 2018 Jun.

18.

Sex Differences in the Methylome and Transcriptome of the Human Liver and Circulating HDL-Cholesterol Levels.

García-Calzón S, Perfilyev A, de Mello VD, Pihlajamäki J, Ling C.

J Clin Endocrinol Metab. 2018 Dec 1;103(12):4395-4408. doi: 10.1210/jc.2018-00423.

19.

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals.

Tuomainen M, Lindström J, Lehtonen M, Auriola S, Pihlajamäki J, Peltonen M, Tuomilehto J, Uusitupa M, de Mello VD, Hanhineva K.

Nutr Diabetes. 2018 May 25;8(1):35. doi: 10.1038/s41387-018-0046-9.

20.

Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD.

Tauriainen MM, Männistö V, Kaminska D, Vaittinen M, Kärjä V, Käkelä P, Venesmaa S, Gylling H, Pihlajamäki J.

Biosci Rep. 2018 Apr 20;38(2). pii: BSR20171274. doi: 10.1042/BSR20171274. Print 2018 Apr 26.

21.

The effects of acceptance and commitment therapy on eating behavior and diet delivered through face-to-face contact and a mobile app: a randomized controlled trial.

Järvelä-Reijonen E, Karhunen L, Sairanen E, Muotka J, Lindroos S, Laitinen J, Puttonen S, Peuhkuri K, Hallikainen M, Pihlajamäki J, Korpela R, Ermes M, Lappalainen R, Kolehmainen M.

Int J Behav Nutr Phys Act. 2018 Feb 27;15(1):22. doi: 10.1186/s12966-018-0654-8.

22.

Brown adipose tissue lipid metabolism in morbid obesity: Effect of bariatric surgery-induced weight loss.

Dadson P, Hannukainen JC, Din MU, Lahesmaa M, Kalliokoski KK, Iozzo P, Pihlajamäki J, Karlsson HK, Parkkola R, Salminen P, Virtanen KA, Nuutila P.

Diabetes Obes Metab. 2018 May;20(5):1280-1288. doi: 10.1111/dom.13233. Epub 2018 Feb 22.

PMID:
29377423
23.

Incidence, Comorbidities, and Mortality in Idiopathic Normal Pressure Hydrocephalus.

Pyykkö OT, Nerg O, Niskasaari HM, Niskasaari T, Koivisto AM, Hiltunen M, Pihlajamäki J, Rauramaa T, Kojoukhova M, Alafuzoff I, Soininen H, Jääskeläinen JE, Leinonen V.

World Neurosurg. 2018 Apr;112:e624-e631. doi: 10.1016/j.wneu.2018.01.107. Epub 2018 Jan 31.

PMID:
29374607
24.

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver.

Dongiovanni P, Stender S, Pietrelli A, Mancina RM, Cespiati A, Petta S, Pelusi S, Pingitore P, Badiali S, Maggioni M, Mannisto V, Grimaudo S, Pipitone RM, Pihlajamaki J, Craxi A, Taube M, Carlsson LMS, Fargion S, Romeo S, Kozlitina J, Valenti L.

J Intern Med. 2018 Apr;283(4):356-370. doi: 10.1111/joim.12719. Epub 2017 Dec 27.

25.

Increased Liver Fatty Acid Uptake Is Partly Reversed and Liver Fat Content Normalized After Bariatric Surgery.

Immonen H, Hannukainen JC, Kudomi N, Pihlajamäki J, Saunavaara V, Laine J, Salminen P, Lehtimäki T, Pham T, Iozzo P, Nuutila P.

Diabetes Care. 2018 Feb;41(2):368-371. doi: 10.2337/dc17-0738. Epub 2017 Nov 20.

PMID:
29158250
26.

Evaluation of the Effect of Bariatric Surgery-Induced Weight Loss on Knee Gait and Cartilage Degeneration.

Liukkonen MK, Mononen ME, Vartiainen P, Kaukinen P, Bragge T, Suomalainen JS, Malo MKH, Venesmaa S, Käkelä P, Pihlajamäki J, Karjalainen PA, Arokoski JP, Korhonen RK.

J Biomech Eng. 2018 Apr 1;140(4). doi: 10.1115/1.4038330.

PMID:
29101403
27.

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects.

Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvärinen M, Itkonen MK, Holmberg MT, Kärjä V, Männistö VT, Neuvonen PJ, Pihlajamäki J, Backman JT, Niemi M.

Basic Clin Pharmacol Toxicol. 2018 Mar;122(3):341-345. doi: 10.1111/bcpt.12916. Epub 2017 Nov 17.

28.

Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver.

García-Calzón S, Perfilyev A, Männistö V, de Mello VD, Nilsson E, Pihlajamäki J, Ling C.

Clin Epigenetics. 2017 Sep 21;9:102. doi: 10.1186/s13148-017-0400-0. eCollection 2017.

29.

Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics.

Hirvensalo P, Tornio A, Neuvonen M, Tapaninen T, Paile-Hyvärinen M, Kärjä V, Männistö VT, Pihlajamäki J, Backman JT, Niemi M.

Clin Pharmacol Ther. 2018 Jul;104(1):158-168. doi: 10.1002/cpt.891. Epub 2017 Nov 6.

30.

Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling.

Walle P, Takkunen M, Männistö V, Vaittinen M, Käkelä P, Ågren J, Schwab U, Lindström J, Tuomilehto J, Uusitupa M, Pihlajamäki J.

Nutr Diabetes. 2017 Sep 4;7(9):e285. doi: 10.1038/nutd.2017.33.

31.

Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells.

López Rodríguez M, Kaminska D, Lappalainen K, Pihlajamäki J, Kaikkonen MU, Laakso M.

Genome Med. 2017 Jul 6;9(1):63. doi: 10.1186/s13073-017-0453-x.

32.

Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes.

de Mello VD, Lankinen MA, Lindström J, Puupponen-Pimiä R, Laaksonen DE, Pihlajamäki J, Lehtonen M, Uusitupa M, Tuomilehto J, Kolehmainen M, Törrönen R, Hanhineva K.

Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700019. Epub 2017 Jul 18.

PMID:
28556578
33.

Obstructive sleep apnea: the effect of bariatric surgery after 12 months. A prospective multicenter trial.

Peromaa-Haavisto P, Tuomilehto H, Kössi J, Virtanen J, Luostarinen M, Pihlajamäki J, Käkelä P, Victorzon M.

Sleep Med. 2017 Jul;35:85-90. doi: 10.1016/j.sleep.2016.12.017. Epub 2017 Jan 12.

PMID:
28549834
34.

Fatty acid uptake and blood flow in adipose tissue compartments of morbidly obese subjects with or without type 2 diabetes: effects of bariatric surgery.

Dadson P, Ferrannini E, Landini L, Hannukainen JC, Kalliokoski KK, Vaittinen M, Honka H, Karlsson HK, Tuulari JJ, Soinio M, Salminen P, Parkkola R, Pihlajamäki J, Iozzo P, Nuutila P.

Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E175-E182. doi: 10.1152/ajpendo.00044.2017. Epub 2017 Apr 11.

35.

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study.

de Mello VD, Paananen J, Lindström J, Lankinen MA, Shi L, Kuusisto J, Pihlajamäki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M.

Sci Rep. 2017 Apr 11;7:46337. doi: 10.1038/srep46337.

36.

Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action.

de Mello VD, Matte A, Perfilyev A, Männistö V, Rönn T, Nilsson E, Käkelä P, Ling C, Pihlajamäki J.

Epigenetics. 2017 Apr 3;12(4):287-295. doi: 10.1080/15592294.2017.1294305. Epub 2017 Feb 23.

37.

Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity.

Vaittinen M, Männistö V, Käkelä P, Ågren J, Tiainen M, Schwab U, Pihlajamäki J.

Obesity (Silver Spring). 2017 Mar;25(3):545-552. doi: 10.1002/oby.21753. Epub 2017 Feb 1.

38.

Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies.

Viisanen T, Ihantola EL, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

Diabetes. 2017 Feb;66(2):437-447. doi: 10.2337/db16-0714. Epub 2016 Oct 10.

39.

Hepatic DPP4 DNA Methylation Associates With Fatty Liver.

Baumeier C, Saussenthaler S, Kammel A, Jähnert M, Schlüter L, Hesse D, Canouil M, Lobbens S, Caiazzo R, Raverdy V, Pattou F, Nilsson E, Pihlajamäki J, Ling C, Froguel P, Schürmann A, Schwenk RW.

Diabetes. 2017 Jan;66(1):25-35. doi: 10.2337/db15-1716. Epub 2016 Oct 10.

40.

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention.

Walenbergh SM, Houben T, Rensen SS, Bieghs V, Hendrikx T, van Gorp PJ, Oligschlaeger Y, Jeurissen ML, Gijbels MJ, Buurman WA, Vreugdenhil AC, Greve JW, Plat J, Hofker MH, Kalhan S, Pihlajamäki J, Lindsey P, Koek GH, Shiri-Sverdlov R.

Sci Rep. 2016 Dec 6;6:38278. doi: 10.1038/srep38278.

41.

Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver.

Bysani M, Perfilyev A, de Mello VD, Rönn T, Nilsson E, Pihlajamäki J, Ling C.

Epigenomics. 2017 Feb;9(2):105-122. doi: 10.2217/epi-2016-0087. Epub 2016 Dec 2.

42.

Serum Plant Sterols Associate with Gallstone Disease Independent of Weight Loss and Non-Alcoholic Fatty Liver Disease.

Käkelä P, Männistö V, Ilves I, Vaittinen M, Tauriainen MM, Eskelinen M, Gylling H, Paajanen H, Pihlajamäki J.

Obes Surg. 2017 May;27(5):1284-1291. doi: 10.1007/s11695-016-2446-z.

PMID:
27812789
43.

Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study.

Viitasalo A, Eloranta AM, Atalay M, Romeo S, Pihlajamäki J, Lakka TA.

Pediatr Res. 2016 Nov;80(5):651-655. doi: 10.1038/pr.2016.139. Epub 2016 Jul 13.

PMID:
27411039
44.

A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine.

Puris E, Pasanen M, Gynther M, Häkkinen MR, Pihlajamäki J, Keränen T, Honkakoski P, Raunio H, Petsalo A.

Anal Bioanal Chem. 2017 Jan;409(1):251-268. doi: 10.1007/s00216-016-9994-x. Epub 2016 Oct 12.

PMID:
27734142
45.

Regulation of alternative splicing in human obesity loci.

Kaminska D, Käkelä P, Nikkola E, Venesmaa S, Ilves I, Herzig KH, Kolehmainen M, Karhunen L, Kuusisto J, Gylling H, Pajukanta P, Laakso M, Pihlajamäki J.

Obesity (Silver Spring). 2016 Oct;24(10):2033-7. doi: 10.1002/oby.21587. Epub 2016 Aug 12.

46.

Molecular evaluation of vitamin D responsiveness of healthy young adults.

Seuter S, Virtanen JK, Nurmi T, Pihlajamäki J, Mursu J, Voutilainen S, Tuomainen TP, Neme A, Carlberg C.

J Steroid Biochem Mol Biol. 2017 Nov;174:314-321. doi: 10.1016/j.jsbmb.2016.06.003. Epub 2016 Jun 6.

PMID:
27282116
47.

Sleep of professional athletes: Underexploited potential to improve health and performance.

Tuomilehto H, Vuorinen VP, Penttilä E, Kivimäki M, Vuorenmaa M, Venojärvi M, Airaksinen O, Pihlajamäki J.

J Sports Sci. 2017 Apr;35(7):704-710. doi: 10.1080/02640414.2016.1184300. Epub 2016 May 13.

PMID:
27173843
48.

DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk.

Dayeh T, Tuomi T, Almgren P, Perfilyev A, Jansson PA, de Mello VD, Pihlajamäki J, Vaag A, Groop L, Nilsson E, Ling C.

Epigenetics. 2016 Jul 2;11(7):482-8. doi: 10.1080/15592294.2016.1178418. Epub 2016 May 5.

49.

High perceived stress is associated with unfavorable eating behavior in overweight and obese Finns of working age.

Järvelä-Reijonen E, Karhunen L, Sairanen E, Rantala S, Laitinen J, Puttonen S, Peuhkuri K, Hallikainen M, Juvonen K, Myllymäki T, Föhr T, Pihlajamäki J, Korpela R, Ermes M, Lappalainen R, Kolehmainen M.

Appetite. 2016 Aug 1;103:249-258. doi: 10.1016/j.appet.2016.04.023. Epub 2016 Apr 21.

PMID:
27108837
50.

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity.

Walle P, Takkunen M, Männistö V, Vaittinen M, Lankinen M, Kärjä V, Käkelä P, Ågren J, Tiainen M, Schwab U, Kuusisto J, Laakso M, Pihlajamäki J.

Metabolism. 2016 May;65(5):655-66. doi: 10.1016/j.metabol.2016.01.011. Epub 2016 Jan 23.

PMID:
27085774

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