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A Noncanonical Role for Plasminogen Activator Inhibitor Type 1 in Obesity-Induced Diabetes.

Coudriet GM, Stoops J, Orr AV, Bhushan B, Koral K, Lee S, Previte DM, Dong HH, Michalopoulos GK, Mars WM, Piganelli JD.

Am J Pathol. 2019 Jul;189(7):1413-1422. doi: 10.1016/j.ajpath.2019.04.004. Epub 2019 May 2.


Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells.

Previte DM, Martins CP, O'Connor EC, Marre ML, Coudriet GM, Beck NW, Menk AV, Wright RH, Tse HM, Delgoffe GM, Piganelli JD.

Cell Rep. 2019 Apr 2;27(1):129-141.e4. doi: 10.1016/j.celrep.2019.03.004.


Protecting functional β cells with a therapeutic peptide.

Marré ML, Piganelli JD, James EA.

Ann Transl Med. 2018 Sep;6(18):372. doi: 10.21037/atm.2018.07.26. No abstract available.


Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes.

Buitinga M, Callebaut A, Marques Câmara Sodré F, Crèvecoeur I, Blahnik-Fagan G, Yang ML, Bugliani M, Arribas-Layton D, Marré M, Cook DP, Waelkens E, Mallone R, Piganelli JD, Marchetti P, Mamula MJ, Derua R, James EA, Mathieu C, Overbergh L.

Diabetes. 2018 Nov;67(11):2337-2348. doi: 10.2337/db18-0295.


T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis.

Ferguson ID, Griffin P, Michel JJ, Yano H, Gaffen SL, Mueller RG, Dvergsten JA, Piganelli JD, Rosenkranz ME, Kietz DA, Vallejo AN.

Front Immunol. 2018 Aug 6;9:1802. doi: 10.3389/fimmu.2018.01802. eCollection 2018.


Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.

Cunningham KE, Novak EA, Vincent G, Siow VS, Griffith BD, Ranganathan S, Rosengart MR, Piganelli JD, Mollen KP.

FASEB J. 2019 Jan;33(1):1330-1346. doi: 10.1096/fj.201800535R. Epub 2018 Aug 16.


Dietary Cellulose Supplementation Modulates the Immune Response in a Murine Endotoxemia Model.

Di Caro V, Cummings JL, Alcamo AM, Piganelli JD, Clark RSB, Morowitz MJ, Aneja RK.

Shock. 2019 Apr;51(4):526-534. doi: 10.1097/SHK.0000000000001180.


Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.

Marre ML, McGinty JW, Chow IT, DeNicola ME, Beck NW, Kent SC, Powers AC, Bottino R, Harlan DM, Greenbaum CJ, Kwok WW, Piganelli JD, James EA.

Diabetes. 2018 Jul;67(7):1356-1368. doi: 10.2337/db17-1166. Epub 2018 Apr 13.


BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model.

Bruni A, Pepper AR, Pawlick RL, Gala-Lopez B, Gamble A, Kin T, Malcolm AJ, Jones C, Piganelli JD, Crapo JD, Shapiro AMJ.

Am J Transplant. 2018 Aug;18(8):1879-1889. doi: 10.1111/ajt.14705. Epub 2018 Mar 31.


Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.

Xiao X, Guo P, Shiota C, Zhang T, Coudriet GM, Fischbach S, Prasadan K, Fusco J, Ramachandran S, Witkowski P, Piganelli JD, Gittes GK.

Cell Stem Cell. 2018 Jan 4;22(1):78-90.e4. doi: 10.1016/j.stem.2017.11.020.


Treatment with a Catalytic Superoxide Dismutase (SOD) Mimetic Improves Liver Steatosis, Insulin Sensitivity, and Inflammation in Obesity-Induced Type 2 Diabetes.

Coudriet GM, Delmastro-Greenwood MM, Previte DM, Marré ML, O'Connor EC, Novak EA, Vincent G, Mollen KP, Lee S, Dong HH, Piganelli JD.

Antioxidants (Basel). 2017 Nov 1;6(4). pii: E85. doi: 10.3390/antiox6040085.


Environmental Factors Contribute to β Cell Endoplasmic Reticulum Stress and Neo-Antigen Formation in Type 1 Diabetes.

Marré ML, Piganelli JD.

Front Endocrinol (Lausanne). 2017 Sep 29;8:262. doi: 10.3389/fendo.2017.00262. eCollection 2017.


Reactive Oxygen Species and Their Implications on CD4+ T Cells in Type 1 Diabetes.

Previte DM, Piganelli JD.

Antioxid Redox Signal. 2018 Nov 10;29(14):1399-1414. doi: 10.1089/ars.2017.7357. Epub 2017 Nov 28. Review.


Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation.

Previte DM, O'Connor EC, Novak EA, Martins CP, Mollen KP, Piganelli JD.

PLoS One. 2017 Apr 20;12(4):e0175549. doi: 10.1371/journal.pone.0175549. eCollection 2017.


A novel redox-active metalloporphyrin reduces reactive oxygen species and inflammatory markers but does not improve marginal mass engraftment in a murine donation after circulatory death islet transplantation model.

Bruni A, Pepper AR, Gala-Lopez B, Pawlick R, Abualhassan N, Crapo JD, Piganelli JD, Shapiro AM.

Islets. 2016 Jul 3;8(4):e1190058. doi: 10.1080/19382014.2016.1190058.


Inherent ER stress in pancreatic islet β cells causes self-recognition by autoreactive T cells in type 1 diabetes.

Marré ML, Profozich JL, Coneybeer JT, Geng X, Bertera S, Ford MJ, Trucco M, Piganelli JD.

J Autoimmun. 2016 Aug;72:33-46. doi: 10.1016/j.jaut.2016.04.009. Epub 2016 May 9.


Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected β cells.

Schulte BM, Kers-Rebel ED, Bottino R, Piganelli JD, Galama JM, Engelse MA, de Koning EJ, Adema GJ.

Clin Exp Immunol. 2016 Jun;184(3):293-307. doi: 10.1111/cei.12779. Epub 2016 Mar 23.


Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigs.

Tanaka T, Fujita M, Bottino R, Piganelli JD, McGrath K, Li J, Lee W, Iwase H, Wijkstrom M, Bertera S, Long C, Landsittel D, Haruma K, Cooper DK, Hara H.

Islets. 2016;8(1):1-12. doi: 10.1080/19382014.2016.1149283. Epub 2016 Feb 8.


β cell ER stress and the implications for immunogenicity in type 1 diabetes.

Marré ML, James EA, Piganelli JD.

Front Cell Dev Biol. 2015 Oct 27;3:67. doi: 10.3389/fcell.2015.00067. eCollection 2015. Review.


T cell epitopes and post-translationally modified epitopes in type 1 diabetes.

McGinty JW, Marré ML, Bajzik V, Piganelli JD, James EA.

Curr Diab Rep. 2015 Nov;15(11):90. doi: 10.1007/s11892-015-0657-7. Review.


Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes.

Padgett LE, Anderson B, Liu C, Ganini D, Mason RP, Piganelli JD, Mathews CE, Tse HM.

Diabetes. 2015 Dec;64(12):4171-83. doi: 10.2337/db15-0546. Epub 2015 Aug 12.


Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice.

Calabuig-Navarro V, Yamauchi J, Lee S, Zhang T, Liu YZ, Sadlek K, Coudriet GM, Piganelli JD, Jiang CL, Miller R, Lowe M, Harashima H, Dong HH.

J Biol Chem. 2015 Jun 19;290(25):15581-94. doi: 10.1074/jbc.M115.650994. Epub 2015 May 5.


Activated macrophages create lineage-specific microenvironments for pancreatic acinar- and β-cell regeneration in mice.

Criscimanna A, Coudriet GM, Gittes GK, Piganelli JD, Esni F.

Gastroenterology. 2014 Nov;147(5):1106-18.e11. doi: 10.1053/j.gastro.2014.08.008. Epub 2014 Aug 14.


Changing the energy of an immune response.

Delmastro-Greenwood MM, Piganelli JD.

Am J Clin Exp Immunol. 2013 Feb 27;2(1):30-54. Print 2013.


Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells.

Delmastro-Greenwood MM, Votyakova T, Goetzman E, Marre ML, Previte DM, Tovmasyan A, Batinic-Haberle I, Trucco MM, Piganelli JD.

Antioxid Redox Signal. 2013 Dec 1;19(16):1902-15. doi: 10.1089/ars.2012.5167. Epub 2013 Jul 5.


Effects of metalloporphyrins on reducing inflammation and autoimmunity.

Delmastro-Greenwood MM, Tse HM, Piganelli JD.

Antioxid Redox Signal. 2014 May 20;20(15):2465-77. doi: 10.1089/ars.2013.5257. Epub 2013 Apr 19. Review.


Administration of a negative vaccination induces hyporesponsiveness to islet allografts.

Sklavos MM, Coudriet GM, Delmastro M, Bertera S, Coneybeer JT, He J, Trucco M, Piganelli JD.

Cell Transplant. 2013;22(7):1147-55. doi: 10.3727/096368912X657233. Epub 2012 Oct 1.


Human-scale whole-organ bioengineering for liver transplantation: a regenerative medicine approach.

Yagi H, Fukumitsu K, Fukuda K, Kitago M, Shinoda M, Obara H, Itano O, Kawachi S, Tanabe M, Coudriet GM, Piganelli JD, Gilbert TW, Soto-Gutierrez A, Kitagawa Y.

Cell Transplant. 2013;22(2):231-42. doi: 10.3727/096368912X654939. Epub 2012 Aug 27.


Cytokine and chemokine production by human pancreatic islets upon enterovirus infection.

Schulte BM, Lanke KH, Piganelli JD, Kers-Rebel ED, Bottino R, Trucco M, Huijbens RJ, Radstake TR, Engelse MA, de Koning EJ, Galama JM, Adema GJ, van Kuppeveld FJ.

Diabetes. 2012 Aug;61(8):2030-6. doi: 10.2337/db11-1547. Epub 2012 May 17.


Modulation of redox balance leaves murine diabetogenic TH1 T cells "LAG-3-ing" behind.

Delmastro MM, Styche AJ, Trucco MM, Workman CJ, Vignali DA, Piganelli JD.

Diabetes. 2012 Jul;61(7):1760-8. doi: 10.2337/db11-1591. Epub 2012 May 14.


Leukocyte-derived extracellular superoxide dismutase does not contribute to airspace EC-SOD after interstitial pulmonary injury.

Manni ML, Epperly MW, Han W, Blackwell TS, Duncan SR, Piganelli JD, Oury TD.

Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L160-6. doi: 10.1152/ajplung.00360.2010. Epub 2011 Oct 14.


A multivalent vaccine for type 1 diabetes skews T cell subsets to Th2 phenotype in NOD mice.

Lin MS, Tse HM, Delmastro MM, Bertera S, Wong CT, Lakomy R, He J, Sklavos MM, Coudriet GM, Pietropaolo M, Trucco MM, Piganelli JD.

Immunol Res. 2011 Aug;50(2-3):213-20. doi: 10.1007/s12026-011-8215-0.


Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.

Thayer TC, Delano M, Liu C, Chen J, Padgett LE, Tse HM, Annamali M, Piganelli JD, Moldawer LL, Mathews CE.

Diabetes. 2011 Aug;60(8):2144-51. doi: 10.2337/db10-1222. Epub 2011 Jun 29.


Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage.

Sheng H, Spasojevic I, Tse HM, Jung JY, Hong J, Zhang Z, Piganelli JD, Batinic-Haberle I, Warner DS.

J Pharmacol Exp Ther. 2011 Sep;338(3):906-16. doi: 10.1124/jpet.110.176701. Epub 2011 Jun 7.


Oxidative stress and redox modulation potential in type 1 diabetes.

Delmastro MM, Piganelli JD.

Clin Dev Immunol. 2011;2011:593863. doi: 10.1155/2011/593863. Epub 2011 May 18.


Extracellular superoxide dismutase in macrophages augments bacterial killing by promoting phagocytosis.

Manni ML, Tomai LP, Norris CA, Thomas LM, Kelley EE, Salter RD, Crapo JD, Chang LY, Watkins SC, Piganelli JD, Oury TD.

Am J Pathol. 2011 Jun;178(6):2752-9. doi: 10.1016/j.ajpath.2011.02.007.


Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS).

Hager EJ, Piganelli JD, Tse HM, Gibson KM.

J Inherit Metab Dis. 2012 Jan;35(1):159-68. doi: 10.1007/s10545-011-9349-x. Epub 2011 May 24.


Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases.

Coudriet GM, He J, Trucco M, Mars WM, Piganelli JD.

PLoS One. 2010 Nov 2;5(11):e15384. doi: 10.1371/journal.pone.0015384.


NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.

Tse HM, Thayer TC, Steele C, Cuda CM, Morel L, Piganelli JD, Mathews CE.

J Immunol. 2010 Nov 1;185(9):5247-58. doi: 10.4049/jimmunol.1001472. Epub 2010 Sep 29.


Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.

Batinic-Haberle I, Spasojevic I, Tse HM, Tovmasyan A, Rajic Z, St Clair DK, Vujaskovic Z, Dewhirst MW, Piganelli JD.

Amino Acids. 2012 Jan;42(1):95-113. doi: 10.1007/s00726-010-0603-6. Epub 2010 May 16. Review. Erratum in: Amino Acids. 2012 Jan;42(1):115-6.


Redox modulation protects islets from transplant-related injury.

Sklavos MM, Bertera S, Tse HM, Bottino R, He J, Beilke JN, Coulombe MG, Gill RG, Crapo JD, Trucco M, Piganelli JD.

Diabetes. 2010 Jul;59(7):1731-8. doi: 10.2337/db09-0588. Epub 2010 Apr 22.


Chromogranin A is an autoantigen in type 1 diabetes.

Stadinski BD, Delong T, Reisdorph N, Reisdorph R, Powell RL, Armstrong M, Piganelli JD, Barbour G, Bradley B, Crawford F, Marrack P, Mahata SK, Kappler JW, Haskins K.

Nat Immunol. 2010 Mar;11(3):225-31. doi: 10.1038/ni.1844. Epub 2010 Feb 7.


Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells.

Schulte BM, Kramer M, Ansems M, Lanke KH, van Doremalen N, Piganelli JD, Bottino R, Trucco M, Galama JM, Adema GJ, van Kuppeveld FJ.

Diabetes. 2010 May;59(5):1182-91. doi: 10.2337/db09-1071. Epub 2010 Jan 13.


Antioxidant levels represent a major determinant in the regenerative capacity of muscle stem cells.

Urish KL, Vella JB, Okada M, Deasy BM, Tobita K, Keller BB, Cao B, Piganelli JD, Huard J.

Mol Biol Cell. 2009 Jan;20(1):509-20. doi: 10.1091/mbc.E08-03-0274. Epub 2008 Nov 12.


Redox modulation inhibits CD8 T cell effector function.

Sklavos MM, Tse HM, Piganelli JD.

Free Radic Biol Med. 2008 Nov 15;45(10):1477-86. doi: 10.1016/j.freeradbiomed.2008.08.023. Epub 2008 Sep 9.


TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.

McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK.

J Immunol. 2008 Sep 15;181(6):4089-97.


TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol.

Zhao XJ, Dong Q, Bindas J, Piganelli JD, Magill A, Reiser J, Kolls JK.

J Immunol. 2008 Sep 1;181(5):3049-56.


Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome.

Hager EJ, Tse HM, Piganelli JD, Gupta M, Baetscher M, Tse TE, Pappu AS, Steiner RD, Hoffmann GF, Gibson KM.

J Inherit Metab Dis. 2007 Nov;30(6):888-95. Epub 2007 Nov 19.


Autoreactive T-cell responses: new technology in pursuit of an old nemesis.

Piganelli JD, Mathews CE.

Pediatr Diabetes. 2007 Oct;8(5):249-51. No abstract available.


Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness.

Tse HM, Milton MJ, Schreiner S, Profozich JL, Trucco M, Piganelli JD.

J Immunol. 2007 Jan 15;178(2):908-17.

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