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Items: 1 to 50 of 161

1.

Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver.

Kinast V, Leber SL, Brown RJP, Vieyres G, Behrendt P, Eßbach C, Strnad P, Vondran FWR, Cornberg M, Wex C, Pietschmann T, Haybaeck J, Todt D, Steinmann E.

Cells. 2019 Jun 18;8(6). pii: E610. doi: 10.3390/cells8060610.

2.

Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood.

Gottschick C, Raupach-Rosin H, Langer S, Hassan L, Horn J, Dorendorf E, Caputo M, Bittner M, Beier L, Rübsamen N, Schlinkmann K, Zoch B, Guzman CA, Hansen G, Heselich V, Holzapfel E, Hübner J, Pietschmann T, Pieper DH, Pletz M, Riese P, Schmidt-Pokrzywniak A, Hartwig S, von Kaisenberg C, Aydogdu M, Buhles M, Dressler F, Eberl W, Haase R, von Koch FE, Feidicker S, Frambach T, Franz HGB, Guthmann F, Koch HG, Seeger S, Oberhoff C, Pauker W, Petry KU, Schild RL, Tchirikov M, Röhrig E, Karch A, Mikolajczyk R.

Int J Epidemiol. 2019 Apr 1. pii: dyz069. doi: 10.1093/ije/dyz069. [Epub ahead of print] No abstract available.

PMID:
30938437
3.

Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors.

Zapatero-Belinchón FJ, Dietzel E, Dolnik O, Döhner K, Costa R, Hertel B, Veselkova B, Kirui J, Klintworth A, Manns MP, Pöhlmann S, Pietschmann T, Krey T, Ciesek S, Gerold G, Sodeik B, Becker S, von Hahn T.

Viruses. 2019 Mar 19;11(3). pii: E275. doi: 10.3390/v11030275.

4.

HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit.

Vieyres G, Pietschmann T.

Cells. 2019 Mar 12;8(3). pii: E233. doi: 10.3390/cells8030233. Review.

5.

Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood.

Gottschick C, Raupach-Rosin H, Langer S, Hassan L, Horn J, Dorendorf E, Caputo M, Bittner M, Beier L, Rübsamen N, Schlinkmann K, Zoch B, Guzman CA, Hansen G, Heselich V, Holzapfel E, Hübner J, Pietschmann T, Pieper DH, Pletz M, Riese P, Schmidt-Pokrzywniak A, Hartwig S, von Kaisenberg C, Aydogdu M, Buhles M, Dressler F, Eberl W, Haase R, Edler von Koch F, Feidicker S, Frambach T, Franz HGB, Guthmann F, Koch HG, Seeger S, Oberhoff C, Pauker W, Petry KU, Schild RL, Tchirikov M, Röhrig E, Mikolajczyk R.

Int J Epidemiol. 2019 Feb 27. pii: dyz001. doi: 10.1093/ije/dyz001. [Epub ahead of print] No abstract available.

PMID:
30815674
6.

A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors.

Banda DH, Perin PM, Brown RJP, Todt D, Solodenko W, Hoffmeyer P, Kumar Sahu K, Houghton M, Meuleman P, Müller R, Kirschning A, Pietschmann T.

J Hepatol. 2019 Jun;70(6):1082-1092. doi: 10.1016/j.jhep.2019.01.033. Epub 2019 Feb 13.

PMID:
30769006
7.

Hepatitis C Virus.

Pietschmann T, Brown RJP.

Trends Microbiol. 2019 Apr;27(4):379-380. doi: 10.1016/j.tim.2019.01.001. Epub 2019 Jan 29.

PMID:
30709707
8.

Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants.

Khera T, Behrendt P, Bankwitz D, Brown RJP, Todt D, Doepke M, Khan AG, Schulze K, Law J, Logan M, Hockman D, Wong JAJ, Dold L, Gonzalez-Motos V, Spengler U, Viejo-Borbolla A, Ströh LJ, Krey T, Tarr AW, Steinmann E, Manns MP, Klein F, Guzman CA, Marcotrigiano J, Houghton M, Pietschmann T.

J Hepatol. 2019 Apr;70(4):593-602. doi: 10.1016/j.jhep.2018.11.003. Epub 2018 Nov 13.

PMID:
30439392
9.

The Small-Compound Inhibitor K22 Displays Broad Antiviral Activity against Different Members of the Family Flaviviridae and Offers Potential as a Panviral Inhibitor.

García-Nicolás O, V'kovski P, Vielle NJ, Ebert N, Züst R, Portmann J, Stalder H, Gaschen V, Vieyres G, Stoffel M, Schweizer M, Summerfield A, Engler O, Pietschmann T, Todt D, Alves MP, Thiel V, Pfaender S.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01206-18. doi: 10.1128/AAC.01206-18. Print 2018 Nov.

10.

Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB.

Bruening J, Lasswitz L, Banse P, Kahl S, Marinach C, Vondran FW, Kaderali L, Silvie O, Pietschmann T, Meissner F, Gerold G.

PLoS Pathog. 2018 Jul 19;14(7):e1007111. doi: 10.1371/journal.ppat.1007111. eCollection 2018 Jul.

11.

CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells.

Banse P, Moeller R, Bruening J, Lasswitz L, Kahl S, Khan AG, Marcotrigiano J, Pietschmann T, Gerold G.

Viruses. 2018 Apr 20;10(4). pii: E207. doi: 10.3390/v10040207.

12.

Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies.

Bartenschlager R, Baumert TF, Bukh J, Houghton M, Lemon SM, Lindenbach BD, Lohmann V, Moradpour D, Pietschmann T, Rice CM, Thimme R, Wakita T.

Virus Res. 2018 Mar 15;248:53-62. doi: 10.1016/j.virusres.2018.02.016. Epub 2018 Mar 2. Review.

13.

Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease.

Baier C, Haid S, Beilken A, Behnert A, Wetzke M, Brown RJP, Schmitt C, Ebadi E, Hansen G, Schulz TF, Pietschmann T, Bange FC.

Antimicrob Resist Infect Control. 2018 Feb 13;7:21. doi: 10.1186/s13756-018-0316-2. eCollection 2018.

14.

Hepatitis E virus replication and interferon responses in human placental cells.

Knegendorf L, Drave SA, Dao Thi VL, Debing Y, Brown RJP, Vondran FWR, Resner K, Friesland M, Khera T, Engelmann M, Bremer B, Wedemeyer H, Behrendt P, Neyts J, Pietschmann T, Todt D, Steinmann E.

Hepatol Commun. 2018 Jan 8;2(2):173-187. doi: 10.1002/hep4.1138. eCollection 2018 Feb.

15.

Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry.

Behrendt P, Perin P, Menzel N, Banda D, Pfaender S, Alves MP, Thiel V, Meuleman P, Colpitts CC, Schang LM, Vondran FWR, Anggakusuma, Manns MP, Steinmann E, Pietschmann T.

Antiviral Res. 2017 Nov;147:19-28. doi: 10.1016/j.antiviral.2017.09.006. Epub 2017 Sep 18.

PMID:
28923507
16.

Hepatitis C Virus Strain-Dependent Usage of Apolipoprotein E Modulates Assembly Efficiency and Specific Infectivity of Secreted Virions.

Weller R, Hueging K, Brown RJP, Todt D, Joecks S, Vondran FWR, Pietschmann T.

J Virol. 2017 Aug 24;91(18). pii: e00422-17. doi: 10.1128/JVI.00422-17. Print 2017 Sep 15.

17.

[Personalized treatment of viral hepatitis of the present and the future : Hepatitis B, C, delta, and E].

Bartenschlager R, Cornberg M, Pietschmann T.

Internist (Berl). 2017 Jul;58(7):666-674. doi: 10.1007/s00108-017-0262-8. Review. German.

PMID:
28631044
18.

Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2.

Vasiliauskaite I, Owsianka A, England P, Khan AG, Cole S, Bankwitz D, Foung SKH, Pietschmann T, Marcotrigiano J, Rey FA, Patel AH, Krey T.

MBio. 2017 May 16;8(3). pii: e00382-17. doi: 10.1128/mBio.00382-17.

19.

Virucidal Activity of World Health Organization-Recommended Formulations Against Enveloped Viruses, Including Zika, Ebola, and Emerging Coronaviruses.

Siddharta A, Pfaender S, Vielle NJ, Dijkman R, Friesland M, Becker B, Yang J, Engelmann M, Todt D, Windisch MP, Brill FH, Steinmann J, Steinmann J, Becker S, Alves MP, Pietschmann T, Eickmann M, Thiel V, Steinmann E.

J Infect Dis. 2017 Mar 15;215(6):902-906. doi: 10.1093/infdis/jix046.

20.

Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.

Bankwitz D, Doepke M, Hueging K, Weller R, Bruening J, Behrendt P, Lee JY, Vondran FWR, Manns MP, Bartenschlager R, Pietschmann T.

J Hepatol. 2017 Sep;67(3):480-489. doi: 10.1016/j.jhep.2017.04.010. Epub 2017 Apr 22.

21.

Immune protection against reinfection with nonprimate hepacivirus.

Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJ, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgärtner W, Feige K, Pietschmann T, Cavalleri JM, Steinmann E.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2430-E2439. doi: 10.1073/pnas.1619380114. Epub 2017 Mar 8.

22.

Protein Interactions during the Flavivirus and Hepacivirus Life Cycle.

Gerold G, Bruening J, Weigel B, Pietschmann T.

Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S75-S91. doi: 10.1074/mcp.R116.065649. Epub 2017 Jan 11. Review.

23.

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy.

Khera T, Todt D, Vercauteren K, McClure CP, Verhoye L, Farhoudi A, Bhuju S, Geffers R, Baumert TF, Steinmann E, Meuleman P, Pietschmann T, Brown RJ.

Antiviral Res. 2017 Mar;139:129-137. doi: 10.1016/j.antiviral.2017.01.001. Epub 2017 Jan 3.

24.

Expanding the Host Range of Hepatitis C Virus through Viral Adaptation.

von Schaewen M, Dorner M, Hueging K, Foquet L, Gerges S, Hrebikova G, Heller B, Bitzegeio J, Doerrbecker J, Horwitz JA, Gerold G, Suerbaum S, Rice CM, Meuleman P, Pietschmann T, Ploss A.

MBio. 2016 Nov 8;7(6). pii: e01915-16. doi: 10.1128/mBio.01915-16.

25.

Clinically Approved Ion Channel Inhibitors Close Gates for Hepatitis C Virus and Open Doors for Drug Repurposing in Infectious Viral Diseases.

Pietschmann T.

J Virol. 2017 Jan 3;91(2). pii: e01914-16. doi: 10.1128/JVI.01914-16. Print 2017 Jan 15. Review.

26.

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites.

Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C.

Cell Host Microbe. 2016 Oct 12;20(4):443-457. doi: 10.1016/j.chom.2016.09.003.

27.

Hepacivirus NS3/4A Proteases Interfere with MAVS Signaling in both Their Cognate Animal Hosts and Humans: Implications for Zoonotic Transmission.

Anggakusuma, Brown RJP, Banda DH, Todt D, Vieyres G, Steinmann E, Pietschmann T.

J Virol. 2016 Nov 14;90(23):10670-10681. doi: 10.1128/JVI.01634-16. Print 2016 Dec 1.

28.

Erratum: Cell culture-derived HCV cannot infect synovial fibroblasts.

Abd-Elshafy DN, Pietschmann T, Müller-Ladner U, Neumann E, Anggakusuma, Bahgat MM, Pessler F, Behrendt P.

Sci Rep. 2016 Aug 26;6:21441. doi: 10.1038/srep21441. No abstract available.

29.

Apolipoprotein E polymorphisms and their protective effect on hepatitis E virus replication.

Weller R, Todt D, Engelmann M, Friesland M, Wedemeyer H, Pietschmann T, Steinmann E.

Hepatology. 2016 Dec;64(6):2274-2276. doi: 10.1002/hep.28788. Epub 2016 Sep 30. No abstract available.

PMID:
27541341
30.

Hepatitis C virus plays hide and seek with neutralizing antibodies.

Bankwitz D, Pietschmann T.

Hepatology. 2016 Dec;64(6):1840-1842. doi: 10.1002/hep.28760. Epub 2016 Aug 25. No abstract available.

PMID:
27515101
31.

Hepatitis C Virus Stimulates Murine CD8α-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner.

Pfaender S, Grabski E, Detje CN, Riebesehl N, Lienenklaus S, Steinmann E, Kalinke U, Pietschmann T.

PLoS Pathog. 2016 Jul 6;12(7):e1005736. doi: 10.1371/journal.ppat.1005736. eCollection 2016 Jul.

32.

ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production.

Vieyres G, Welsch K, Gerold G, Gentzsch J, Kahl S, Vondran FW, Kaderali L, Pietschmann T.

PLoS Pathog. 2016 Apr 28;12(4):e1005568. doi: 10.1371/journal.ppat.1005568. eCollection 2016 Apr.

33.

Ion Channel Function and Cross-Species Determinants in Viral Assembly of Nonprimate Hepacivirus p7.

Walter S, Bollenbach A, Doerrbecker J, Pfaender S, Brown RJP, Vieyres G, Scott C, Foster R, Kumar A, Zitzmann N, Griffin S, Penin F, Pietschmann T, Steinmann E.

J Virol. 2016 Apr 29;90(10):5075-5089. doi: 10.1128/JVI.00132-16. Print 2016 May 15.

34.

Antiviral Activities of Different Interferon Types and Subtypes against Hepatitis E Virus Replication.

Todt D, François C, Anggakusuma, Behrendt P, Engelmann M, Knegendorf L, Vieyres G, Wedemeyer H, Hartmann R, Pietschmann T, Duverlie G, Steinmann E.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2132-9. doi: 10.1128/AAC.02427-15. Print 2016 Apr.

35.

Identification of a Human Respiratory Syncytial Virus Cell Entry Inhibitor by Using a Novel Lentiviral Pseudotype System.

Haid S, Grethe C, Bankwitz D, Grunwald T, Pietschmann T.

J Virol. 2015 Dec 30;90(6):3065-73. doi: 10.1128/JVI.03074-15.

36.

Distinct Escape Pathway by Hepatitis C Virus Genotype 1a from a Dominant CD8+ T Cell Response by Selection of Altered Epitope Processing.

Walker A, Skibbe K, Steinmann E, Pfaender S, Kuntzen T, Megger DA, Groten S, Sitek B, Lauer GM, Kim AY, Pietschmann T, Allen TM, Timm J.

J Virol. 2015 Oct 7;90(1):33-42. doi: 10.1128/JVI.01993-15. Print 2016 Jan 1.

37.

Decoding protein networks during virus entry by quantitative proteomics.

Gerold G, Bruening J, Pietschmann T.

Virus Res. 2016 Jun 15;218:25-39. doi: 10.1016/j.virusres.2015.09.006. Epub 2015 Sep 10. Review.

38.

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice.

Vercauteren K, Brown RJ, Mesalam AA, Doerrbecker J, Bhuju S, Geffers R, Van Den Eede N, McClure CP, Troise F, Verhoye L, Baumert T, Farhoudi A, Cortese R, Ball JK, Leroux-Roels G, Pietschmann T, Nicosia A, Meuleman P.

Gut. 2016 Dec;65(12):2029-2034. doi: 10.1136/gutjnl-2014-309045. Epub 2015 Aug 25.

PMID:
26306759
39.

A molecular tweezer antagonizes seminal amyloids and HIV infection.

Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Münch J.

Elife. 2015 Aug 18;4. pii: e05397. doi: 10.7554/eLife.05397.

40.

Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.

Perin PM, Haid S, Brown RJ, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash YM, Vondran FW, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Kirschning A, Müller R, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T.

Hepatology. 2016 Jan;63(1):49-62. doi: 10.1002/hep.28111. Epub 2015 Oct 9.

41.

Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses.

Hueging K, Weller R, Doepke M, Vieyres G, Todt D, Wölk B, Vondran FW, Geffers R, Lauber C, Kaderali L, Penin F, Pietschmann T.

PLoS One. 2015 Jul 30;10(7):e0134529. doi: 10.1371/journal.pone.0134529. eCollection 2015.

42.

Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry.

Gerold G, Meissner F, Bruening J, Welsch K, Perin PM, Baumert TF, Vondran FW, Kaderali L, Marcotrigiano J, Khan AG, Mann M, Rice CM, Pietschmann T.

Cell Rep. 2015 Aug 4;12(5):864-78. doi: 10.1016/j.celrep.2015.06.063. Epub 2015 Jul 23.

43.

Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design.

Tarr AW, Khera T, Hueging K, Sheldon J, Steinmann E, Pietschmann T, Brown RJ.

Viruses. 2015 Jul 17;7(7):3995-4046. doi: 10.3390/v7072809. Review.

44.

Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity.

Koutsoudakis G, Romero-Brey I, Berger C, Pérez-Vilaró G, Monteiro Perin P, Vondran FW, Kalesse M, Harmrolfs K, Müller R, Martinez JP, Pietschmann T, Bartenschlager R, Brönstrup M, Meyerhans A, Díez J.

J Hepatol. 2015 Oct;63(4):813-21. doi: 10.1016/j.jhep.2015.06.002. Epub 2015 Jun 10.

PMID:
26070407
45.

Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells.

Lauber C, Vieyres G, Terczyńska-Dyla E, Anggakusuma, Dijkman R, Gad HH, Akhtar H, Geffers R, Vondran FW, Thiel V, Kaderali L, Pietschmann T, Hartmann R.

Genes Immun. 2015 Sep;16(6):414-21. doi: 10.1038/gene.2015.23. Epub 2015 Jun 11.

PMID:
26066369
46.

Assessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure.

Pfaender S, Walter S, Todt D, Behrendt P, Doerrbecker J, Wölk B, Engelmann M, Gravemann U, Seltsam A, Steinmann J, Burbelo PD, Klawonn F, Feige K, Pietschmann T, Cavalleri JM, Steinmann E.

J Gen Virol. 2015 Sep;96(9):2636-42. doi: 10.1099/vir.0.000208. Epub 2015 Jun 3.

47.

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.

Anggakusuma, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T, Steinmann E.

Hepatology. 2015 Sep;62(3):702-14. doi: 10.1002/hep.27913. Epub 2015 Jul 28.

PMID:
25999047
48.

Long-term follow-up of successful hepatitis C virus therapy: waning immune responses and disappearance of liver disease are consistent with cure.

Hedenstierna M, Weiland O, Brass A, Bankwitz D, Behrendt P, Uhnoo I, Aleman S, Cardell K, Fryden A, Norkrans G, Eilard A, Glaumann H, Pietschmann T, Sällberg M, Brenndörfer ED.

Aliment Pharmacol Ther. 2015 Mar;41(6):532-43. doi: 10.1111/apt.13096. Epub 2015 Jan 28.

49.

Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons.

Anggakusuma, Frentzen A, Gürlevik E, Yuan Q, Steinmann E, Ott M, Staeheli P, Schmid-Burgk J, Schmidt T, Hornung V, Kuehnel F, Pietschmann T.

J Virol. 2015 Apr;89(7):3833-45. doi: 10.1128/JVI.03129-14. Epub 2015 Jan 21.

50.

Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus-induced interferon alpha responses of plasmacytoid dendritic cells.

Grabski E, Wappler I, Pfaender S, Steinmann E, Haid S, Dzionek A, Pietschmann T, Kalinke U.

J Virol. 2015 Mar;89(6):3200-8. doi: 10.1128/JVI.03229-14. Epub 2014 Dec 31.

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