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Items: 30


Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice.

Christofidou-Solomidou M, Pietrofesa RA, Park K, Albelda SM, Serve KM, Keil DE, Pfau JC.

Toxicol Appl Pharmacol. 2019 Jul 15;375:81-93. doi: 10.1016/j.taap.2019.04.018. Epub 2019 Apr 23.


LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks.

Chatterjee S, Pietrofesa RA, Park K, Tao JQ, Carabe-Fernandez A, Berman AT, Koumenis C, Sielecki T, Christofidou-Solomidou M.

Int J Mol Sci. 2019 Jan 5;20(1). pii: E176. doi: 10.3390/ijms20010176.


Applications of Out of Body Lung Perfusion.

Zhu B, Suzuki Y, DiSanto T, Rubin S, Penfil Z, Pietrofesa RA, Chatterjee S, Christofidou-Solomidou M, Cantu E.

Acad Radiol. 2019 Mar;26(3):404-411. doi: 10.1016/j.acra.2018.05.022. Epub 2018 Jul 24.


Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits myeloperoxidase activity in inflammatory cells.

Mishra OP, Popov AV, Pietrofesa RA, Nakamaru-Ogiso E, Andrake M, Christofidou-Solomidou M.

Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1364-1375. doi: 10.1016/j.bbagen.2018.03.003. Epub 2018 Mar 7.


Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner.

Pietrofesa RA, Chatterjee S, Park K, Arguiri E, Albelda SM, Christofidou-Solomidou M.

Antioxidants (Basel). 2018 Mar 2;7(3). pii: E38. doi: 10.3390/antiox7030038.


Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage.

Velalopoulou A, Chatterjee S, Pietrofesa RA, Koziol-White C, Panettieri RA, Lin L, Tuttle S, Berman A, Koumenis C, Christofidou-Solomidou M.

Int J Mol Sci. 2017 Nov 25;18(12). pii: E2525. doi: 10.3390/ijms18122525.


The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages.

Pietrofesa RA, Woodruff P, Hwang WT, Patel P, Chatterjee S, Albelda SM, Christofidou-Solomidou M.

Oxid Med Cell Longev. 2017;2017:7395238. doi: 10.1155/2017/7395238. Epub 2017 Sep 13.


Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice.

Chikara S, Mamidi S, Sreedasyam A, Chittem K, Pietrofesa R, Zuppa A, Moorthy G, Dyer N, Christofidou-Solomidou M, Reindl KM.

Cancer Prev Res (Phila). 2018 Jan;11(1):27-37. doi: 10.1158/1940-6207.CAPR-17-0119. Epub 2017 Oct 26.


Radiation Mitigating Properties of Intranasally Administered KL4 Surfactant in a Murine Model of Radiation-Induced Lung Damage.

Christofidou-Solomidou M, Pietrofesa RA, Arguiri E, Koumenis C, Segal R.

Radiat Res. 2017 Nov;188(5):491-504. doi: 10.1667/RR14686.1. Epub 2017 Sep 6.


Siderophore-mediated iron removal from chrysotile: Implications for asbestos toxicity reduction and bioremediation.

Mohanty SK, Gonneau C, Salamatipour A, Pietrofesa RA, Casper B, Christofidou-Solomidou M, Willenbring JK.

J Hazard Mater. 2018 Jan 5;341:290-296. doi: 10.1016/j.jhazmat.2017.07.033. Epub 2017 Jul 22.


Asbestos Fiber Preparation Methods Affect Fiber Toxicity.

Salamatipour A, Mohanty SK, Pietrofesa RA, Vann DR, Christofidou-Solomidou M, Willenbring JK.

Environ Sci Technol Lett. 2016 Jul 12;3(7):270-274. Epub 2016 Jun 14.


Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel.

Pietrofesa RA, Velalopoulou A, Lehman SL, Arguiri E, Solomides P, Koch CJ, Mishra OP, Koumenis C, Goodwin TJ, Christofidou-Solomidou M.

Int J Mol Sci. 2016 Jun 16;17(6). pii: E953. doi: 10.3390/ijms17060953.


Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection.

Mishra OP, Popov AV, Pietrofesa RA, Christofidou-Solomidou M.

Biochim Biophys Acta. 2016 Sep;1860(9):1884-97. doi: 10.1016/j.bbagen.2016.05.037. Epub 2016 May 31.


Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605).

Pietrofesa RA, Velalopoulou A, Albelda SM, Christofidou-Solomidou M.

Int J Mol Sci. 2016 Mar 1;17(3):322. doi: 10.3390/ijms17030322.


Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma.

Kadariya Y, Menges CW, Talarchek J, Cai KQ, Klein-Szanto AJ, Pietrofesa RA, Christofidou-Solomidou M, Cheung M, Mossman BT, Shukla A, Testa JR.

Cancer Prev Res (Phila). 2016 May;9(5):406-414. doi: 10.1158/1940-6207.CAPR-15-0347. Epub 2016 Mar 2.


The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage.

Velalopoulou A, Tyagi S, Pietrofesa RA, Arguiri E, Christofidou-Solomidou M.

Int J Mol Sci. 2015 Dec 22;17(1). pii: E7. doi: 10.3390/ijms17010007.


Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice.

Pietrofesa RA, Velalopoulou A, Arguiri E, Menges CW, Testa JR, Hwang WT, Albelda SM, Christofidou-Solomidou M.

Carcinogenesis. 2016 Feb;37(2):177-87. doi: 10.1093/carcin/bgv174. Epub 2015 Dec 17.


Metformin use and risk of colorectal adenoma after polypectomy in patients with type 2 diabetes mellitus.

Marks AR, Pietrofesa RA, Jensen CD, Zebrowski A, Corley DA, Doubeni CA.

Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1692-8. doi: 10.1158/1055-9965.EPI-15-0559. Epub 2015 Sep 16.


Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study.

Turowski JB, Pietrofesa RA, Lawson JA, Christofidou-Solomidou M, Hadjiliadis D.

BMC Complement Altern Med. 2015 May 13;15:148. doi: 10.1186/s12906-015-0651-2.


Space radiation-associated lung injury in a murine model.

Christofidou-Solomidou M, Pietrofesa RA, Arguiri E, Schweitzer KS, Berdyshev EV, McCarthy M, Corbitt A, Alwood JS, Yu Y, Globus RK, Solomides CC, Ullrich RL, Petrache I.

Am J Physiol Lung Cell Mol Physiol. 2015 Mar 1;308(5):L416-28. doi: 10.1152/ajplung.00260.2014. Epub 2014 Dec 19.


Novel synthetic (S,S) and (R,R)-secoisolariciresinol diglucosides (SDGs) protect naked plasmid and genomic DNA From gamma radiation damage.

Mishra OP, Pietrofesa R, Christofidou-Solomidou M.

Radiat Res. 2014 Jul;182(1):102-10. doi: 10.1667/RR13635.1. Epub 2014 Jun 19.


Dietary flaxseed modulates the miRNA profile in irradiated and non-irradiated murine lungs: a novel mechanism of tissue radioprotection by flaxseed.

Christofidou-Solomidou M, Pietrofesa R, Arguiri E, McAlexander MA, Witwer KW.

Cancer Biol Ther. 2014 Jul;15(7):930-7. doi: 10.4161/cbt.28905. Epub 2014 Apr 22.


Oxidative Lung Damage Resulting from Repeated Exposure to Radiation and Hyperoxia Associated with Space Exploration.

Pietrofesa RA, Turowski JB, Arguiri E, Milovanova TN, Solomides CC, Thom SR, Christofidou-Solomidou M.

J Pulm Respir Med. 2013 Sep 30;3(5). pii: 1000158.


Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs).

Mishra OP, Simmons N, Tyagi S, Pietrofesa R, Shuvaev VV, Valiulin RA, Heretsch P, Nicolaou KC, Christofidou-Solomidou M.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5325-8. doi: 10.1016/j.bmcl.2013.07.062. Epub 2013 Aug 2.


Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation.

Tan Q, Kerestes H, Percy MJ, Pietrofesa R, Chen L, Khurana TS, Christofidou-Solomidou M, Lappin TR, Lee FS.

J Biol Chem. 2013 Jun 14;288(24):17134-44. doi: 10.1074/jbc.M112.444059. Epub 2013 May 2.


Radiation mitigating properties of the lignan component in flaxseed.

Pietrofesa R, Turowski J, Tyagi S, Dukes F, Arguiri E, Busch TM, Gallagher-Colombo SM, Solomides CC, Cengel KA, Christofidou-Solomidou M.

BMC Cancer. 2013 Apr 4;13:179. doi: 10.1186/1471-2407-13-179.


Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG).

Christofidou-Solomidou M, Tyagi S, Pietrofesa R, Dukes F, Arguiri E, Turowski J, Grieshaber PA, Solomides CC, Cengel KA.

Radiat Res. 2012 Dec;178(6):568-80. doi: 10.1667/RR2980.1. Epub 2012 Oct 29.


Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes.

Dukes F, Kanterakis S, Lee J, Pietrofesa R, Andersen ES, Arguiri E, Tyagi S, Showe L, Amrani Y, Christofidou-Solomidou M.

BMC Complement Altern Med. 2012 Apr 20;12:47. doi: 10.1186/1472-6882-12-47.


Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice.

Christofidou-Solomidou M, Tyagi S, Tan KS, Hagan S, Pietrofesa R, Dukes F, Arguiri E, Heitjan DF, Solomides CC, Cengel KA.

BMC Cancer. 2011 Jun 24;11:269. doi: 10.1186/1471-2407-11-269.

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