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Items: 1 to 50 of 78

1.

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease.

Prakash V, Carson BB, Feenstra JM, Dass RA, Sekyrova P, Hoshino A, Petersen J, Guo Y, Parks MM, Kurylo CM, Batchelder JE, Haller K, Hashimoto A, Rundqivst H, Condeelis JS, Allis CD, Drygin D, Nieto MA, Andäng M, Percipalle P, Bergh J, Adameyko I, Farrants AÖ, Hartman J, Lyden D, Pietras K, Blanchard SC, Vincent CT.

Nat Commun. 2019 May 8;10(1):2110. doi: 10.1038/s41467-019-10100-8.

2.

Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ.

Strell C, Paulsson J, Jin SB, Tobin NP, Mezheyeuski A, Roswall P, Mutgan C, Mitsios N, Johansson H, Wickberg SM, Svedlund J, Nilsson M, Hall P, Mulder J, Radisky DC, Pietras K, Bergh J, Lendahl U, Wärnberg F, Östman A.

J Natl Cancer Inst. 2019 Feb 28. pii: djy234. doi: 10.1093/jnci/djy234. [Epub ahead of print]

PMID:
30816935
3.

Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling.

Papadakos KS, Bartoschek M, Rodriguez C, Gialeli C, Jin SB, Lendahl U, Pietras K, Blom AM.

Matrix Biol. 2018 Nov 28. pii: S0945-053X(18)30391-3. doi: 10.1016/j.matbio.2018.11.007. [Epub ahead of print]

PMID:
30502484
4.

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing.

Bartoschek M, Oskolkov N, Bocci M, Lövrot J, Larsson C, Sommarin M, Madsen CD, Lindgren D, Pekar G, Karlsson G, Ringnér M, Bergh J, Björklund Å, Pietras K.

Nat Commun. 2018 Dec 4;9(1):5150. doi: 10.1038/s41467-018-07582-3.

5.

Activin receptor-like kinase 1 is associated with immune cell infiltration and regulates CLEC14A transcription in cancer.

Bocci M, Sjölund J, Kurzejamska E, Lindgren D, Marzouka NA, Bartoschek M, Höglund M, Pietras K.

Angiogenesis. 2019 Feb;22(1):117-131. doi: 10.1007/s10456-018-9642-5. Epub 2018 Aug 21.

6.

PDGF family function and prognostic value in tumor biology.

Bartoschek M, Pietras K.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):984-990. doi: 10.1016/j.bbrc.2018.06.106. Epub 2018 Jun 23.

7.

Consensus guidelines for the use and interpretation of angiogenesis assays.

Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW.

Angiogenesis. 2018 Aug;21(3):425-532. doi: 10.1007/s10456-018-9613-x. Review.

8.

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.

Roswall P, Bocci M, Bartoschek M, Li H, Kristiansen G, Jansson S, Lehn S, Sjölund J, Reid S, Larsson C, Eriksson P, Anderberg C, Cortez E, Saal LH, Orsmark-Pietras C, Cordero E, Haller BK, Häkkinen J, Burvenich IJG, Lim E, Orimo A, Höglund M, Rydén L, Moch H, Scott AM, Eriksson U, Pietras K.

Nat Med. 2018 May;24(4):463-473. doi: 10.1038/nm.4494. Epub 2018 Mar 12.

9.

The PDGF pathway in breast cancer is linked to tumour aggressiveness, triple-negative subtype and early recurrence.

Jansson S, Aaltonen K, Bendahl PO, Falck AK, Karlsson M, Pietras K, Rydén L.

Breast Cancer Res Treat. 2018 Jun;169(2):231-241. doi: 10.1007/s10549-018-4664-7. Epub 2018 Jan 29.

10.

Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer.

Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirström K, Pietras K, Blom AM.

Oncogene. 2016 Oct 27;35(43):5585-5596. doi: 10.1038/onc.2016.98. Epub 2016 Apr 11.

PMID:
27065333
11.

Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer.

Escudero-Esparza A, Bartoschek M, Gialeli C, Okroj M, Owen S, Jirström K, Orimo A, Jiang WG, Pietras K, Blom AM.

Oncotarget. 2016 Nov 22;7(47):76920-76933. doi: 10.18632/oncotarget.12729.

12.

Compound genetically engineered mouse models of cancer reveal dual targeting of ALK1 and endoglin as a synergistic opportunity to impinge on angiogenic TGF-β signaling.

Eleftheriou NM, Sjölund J, Bocci M, Cortez E, Lee SJ, Cunha SI, Pietras K.

Oncotarget. 2016 Dec 20;7(51):84314-84325. doi: 10.18632/oncotarget.12604.

13.

Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function.

de Vinuesa AG, Bocci M, Pietras K, Ten Dijke P.

Biochem Soc Trans. 2016 Aug 15;44(4):1142-9. doi: 10.1042/BST20160093. Review.

PMID:
27528762
14.

Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I.

Dass RA, Sarshad AA, Carson BB, Feenstra JM, Kaur A, Obrdlik A, Parks MM, Prakash V, Love DK, Pietras K, Serra R, Blanchard SC, Percipalle P, Brown AM, Vincent CT.

PLoS Genet. 2016 Aug 8;12(8):e1006217. doi: 10.1371/journal.pgen.1006217. eCollection 2016 Aug.

15.

Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer.

Mezheyeuski A, Bradic Lindh M, Guren TK, Dragomir A, Pfeiffer P, Kure EH, Ikdahl T, Skovlund E, Corvigno S, Strell C, Pietras K, Ponten F, Mulder J, Qvortrup C, Portyanko A, Tveit KM, Glimelius B, Sorbye H, Östman A.

Oncotarget. 2016 Jul 5;7(27):41948-41958. doi: 10.18632/oncotarget.9632.

16.

Editorial: Novel Targets and Targeting Technologies to Modulate Tumor Microenvironment.

Prakash J, Pietras K.

Front Oncol. 2016 May 17;6:121. doi: 10.3389/fonc.2016.00121. eCollection 2016. No abstract available.

17.

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread.

Li X, Padhan N, Sjöström EO, Roche FP, Testini C, Honkura N, Sáinz-Jaspeado M, Gordon E, Bentley K, Philippides A, Tolmachev V, Dejana E, Stan RV, Vestweber D, Ballmer-Hofer K, Betsholtz C, Pietras K, Jansson L, Claesson-Welsh L.

Nat Commun. 2016 Mar 23;7:11017. doi: 10.1038/ncomms11017.

18.

Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML.

Lindblad O, Cordero E, Puissant A, Macaulay L, Ramos A, Kabir NN, Sun J, Vallon-Christersson J, Haraldsson K, Hemann MT, Borg Å, Levander F, Stegmaier K, Pietras K, Rönnstrand L, Kazi JU.

Oncogene. 2016 Sep 29;35(39):5119-31. doi: 10.1038/onc.2016.41. Epub 2016 Mar 21.

19.

Expression of GADS enhances FLT3-induced mitogenic signaling.

Chougule RA, Cordero E, Moharram SA, Pietras K, Rönnstrand L, Kazi JU.

Oncotarget. 2016 Mar 22;7(12):14112-24. doi: 10.18632/oncotarget.7415.

20.

Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD.

Cortez E, Gladh H, Braun S, Bocci M, Cordero E, Björkström NK, Miyazaki H, Michael IP, Eriksson U, Folestad E, Pietras K.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E864-73. doi: 10.1073/pnas.1509384113. Epub 2016 Feb 1.

21.

Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium.

Niaudet C, Hofmann JJ, Mäe MA, Jung B, Gaengel K, Vanlandewijck M, Ekvärn E, Salvado MD, Mehlem A, Al Sayegh S, He L, Lebouvier T, Castro-Freire M, Katayama K, Hultenby K, Moessinger C, Tannenberg P, Cunha S, Pietras K, Laviña B, Hong J, Berg T, Betsholtz C.

PLoS One. 2015 Sep 22;10(9):e0137949. doi: 10.1371/journal.pone.0137949. eCollection 2015.

22.

Decoding breast cancer tissue-stroma interactions using species-specific sequencing.

Chivukula IV, Ramsköld D, Storvall H, Anderberg C, Jin S, Mamaeva V, Sahlgren C, Pietras K, Sandberg R, Lendahl U.

Breast Cancer Res. 2015 Aug 13;17:109. doi: 10.1186/s13058-015-0616-x.

23.

Endothelial ALK1 Is a Therapeutic Target to Block Metastatic Dissemination of Breast Cancer.

Cunha SI, Bocci M, Lövrot J, Eleftheriou N, Roswall P, Cordero E, Lindström L, Bartoschek M, Haller BK, Pearsall RS, Mulivor AW, Kumar R, Larsson C, Bergh J, Pietras K.

Cancer Res. 2015 Jun 15;75(12):2445-56. doi: 10.1158/0008-5472.CAN-14-3706. Erratum in: Cancer Res. 2016 Oct 15;76(20):6131-6132.

24.

Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma.

Johnson JR, Folestad E, Rowley JE, Noll EM, Walker SA, Lloyd CM, Rankin SM, Pietras K, Eriksson U, Fuxe J.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 1;308(7):L658-71. doi: 10.1152/ajplung.00286.2014. Epub 2015 Jan 30.

25.

Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer.

Femel J, Huijbers EJ, Saupe F, Cedervall J, Zhang L, Roswall P, Larsson E, Olofsson H, Pietras K, Dimberg A, Hellman L, Olsson AK.

Oncotarget. 2014 Dec 15;5(23):12418-27.

26.

Novel nano-sized MR contrast agent mediates strong tumor contrast enhancement in an oncogene-driven breast cancer model.

Eriksson PO, Aaltonen E, Petoral R Jr, Lauritzson P, Miyazaki H, Pietras K, Månsson S, Hansson L, Leander P, Axelsson O.

PLoS One. 2014 Oct 8;9(10):e107762. doi: 10.1371/journal.pone.0107762. eCollection 2014.

27.

Functional subsets of mesenchymal cell types in the tumor microenvironment.

Cortez E, Roswall P, Pietras K.

Semin Cancer Biol. 2014 Apr;25:3-9. doi: 10.1016/j.semcancer.2013.12.010. Epub 2014 Jan 7. Review.

PMID:
24412106
28.

Molecular biology of neuroendocrine tumors: from pathways to biomarkers and targets.

Capdevila J, Meeker A, García-Carbonero R, Pietras K, Astudillo A, Casanovas O, Scarpa A.

Cancer Metastasis Rev. 2014 Mar;33(1):345-51. doi: 10.1007/s10555-013-9468-y. Review.

PMID:
24375391
29.

Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression.

Yoshimatsu Y, Lee YG, Akatsu Y, Taguchi L, Suzuki HI, Cunha SI, Maruyama K, Suzuki Y, Yamazaki T, Katsura A, Oh SP, Zimmers TA, Lee SJ, Pietras K, Koh GY, Miyazono K, Watabe T.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18940-5. doi: 10.1073/pnas.1310479110. Epub 2013 Oct 16.

30.

MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer.

Johansson J, Berg T, Kurzejamska E, Pang MF, Tabor V, Jansson M, Roswall P, Pietras K, Sund M, Religa P, Fuxe J.

Oncogene. 2013 Dec 12;32(50):5614-24. doi: 10.1038/onc.2013.322. Epub 2013 Aug 19.

31.

Introduction to tumor-stroma interactions.

Ostman A, Pietras K.

Exp Cell Res. 2013 Jul 1;319(11):1595. doi: 10.1016/j.yexcr.2013.05.026. Epub 2013 Jun 25. No abstract available.

PMID:
25242505
32.

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination.

Anderberg C, Cunha SI, Zhai Z, Cortez E, Pardali E, Johnson JR, Franco M, Páez-Ribes M, Cordiner R, Fuxe J, Johansson BR, Goumans MJ, Casanovas O, ten Dijke P, Arthur HM, Pietras K.

J Exp Med. 2013 Mar 11;210(3):563-79. doi: 10.1084/jem.20120662. Epub 2013 Feb 11.

33.

Image-based 3D modeling study of the influence of vessel density and blood hemoglobin concentration on tumor oxygenation and response to irradiation.

Lagerlöf JH, Kindblom J, Cortez E, Pietras K, Bernhardt P.

Med Phys. 2013 Feb;40(2):024101. doi: 10.1118/1.4773886.

PMID:
23387780
34.

Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments.

Ehnman M, Missiaglia E, Folestad E, Selfe J, Strell C, Thway K, Brodin B, Pietras K, Shipley J, Östman A, Eriksson U.

Cancer Res. 2013 Apr 1;73(7):2139-49. doi: 10.1158/0008-5472.CAN-12-1646. Epub 2013 Jan 21.

35.

Fibroblasts as architects of cancer pathogenesis.

Marsh T, Pietras K, McAllister SS.

Biochim Biophys Acta. 2013 Jul;1832(7):1070-8. doi: 10.1016/j.bbadis.2012.10.013. Epub 2012 Oct 30. Review.

36.

miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma.

Põlajeva J, Swartling FJ, Jiang Y, Singh U, Pietras K, Uhrbom L, Westermark B, Roswall P.

BMC Cancer. 2012 Aug 29;12:378. doi: 10.1186/1471-2407-12-378.

37.

Fibroblast-dependent regulation of the stem cell properties of cancer cells.

Weiland A, Roswall P, Hatzihristidis TC, Pietras K, Ostman A, Strell C.

Neoplasma. 2012;59(6):719-27. doi: 10.4149/neo_2012_091. Review.

PMID:
22862173
38.

Of mice and men: a comparative study of cancer-associated fibroblasts in mammary carcinoma.

Roswall P, Pietras K.

Ups J Med Sci. 2012 May;117(2):196-201. doi: 10.3109/03009734.2012.658973. Epub 2012 Mar 21.

39.

Use of a mouse model of pancreatic neuroendocrine tumors to find pericyte biomarkers of resistance to anti-angiogenic therapy.

Franco M, Pàez-Ribes M, Cortez E, Casanovas O, Pietras K.

Horm Metab Res. 2011 Nov;43(12):884-9. doi: 10.1055/s-0031-1284381. Epub 2011 Sep 29.

PMID:
21960459
40.

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression.

Franco M, Roswall P, Cortez E, Hanahan D, Pietras K.

Blood. 2011 Sep 8;118(10):2906-17. doi: 10.1182/blood-2011-01-331694. Epub 2011 Jul 21.

41.

Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B.

Falcon BL, Pietras K, Chou J, Chen D, Sennino B, Hanahan D, McDonald DM.

Am J Pathol. 2011 Jun;178(6):2920-30. doi: 10.1016/j.ajpath.2011.02.019.

42.

ALK1 as an emerging target for antiangiogenic therapy of cancer.

Cunha SI, Pietras K.

Blood. 2011 Jun 30;117(26):6999-7006. doi: 10.1182/blood-2011-01-330142. Epub 2011 Apr 5. Review.

43.

Engineered high-affinity affibody molecules targeting platelet-derived growth factor receptor β in vivo.

Lindborg M, Cortez E, Höidén-Guthenberg I, Gunneriusson E, von Hage E, Syud F, Morrison M, Abrahmsén L, Herne N, Pietras K, Frejd FY.

J Mol Biol. 2011 Mar 25;407(2):298-315. doi: 10.1016/j.jmb.2011.01.033. Epub 2011 Jan 28.

PMID:
21277312
44.

Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis.

Albrecht I, Kopfstein L, Strittmatter K, Schomber T, Falkevall A, Hagberg CE, Lorentz P, Jeltsch M, Alitalo K, Eriksson U, Christofori G, Pietras K.

PLoS One. 2010 Nov 24;5(11):e14109. doi: 10.1371/journal.pone.0014109.

45.

Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy.

Johansson A, Rudolfsson S, Hammarsten P, Halin S, Pietras K, Jones J, Stattin P, Egevad L, Granfors T, Wikström P, Bergh A.

Am J Pathol. 2010 Aug;177(2):1031-41. doi: 10.2353/ajpath.2010.100070. Epub 2010 Jul 8.

46.

Therapeutic efficacy of a DNA vaccine targeting the endothelial tip cell antigen delta-like ligand 4 in mammary carcinoma.

Haller BK, Bråve A, Wallgard E, Roswall P, Sunkari VG, Mattson U, Hallengärd D, Catrina SB, Hellström M, Pietras K.

Oncogene. 2010 Jul 29;29(30):4276-86. doi: 10.1038/onc.2010.176. Epub 2010 May 24.

PMID:
20498640
47.

Vascular endothelial growth factor B controls endothelial fatty acid uptake.

Hagberg CE, Falkevall A, Wang X, Larsson E, Huusko J, Nilsson I, van Meeteren LA, Samen E, Lu L, Vanwildemeersch M, Klar J, Genove G, Pietras K, Stone-Elander S, Claesson-Welsh L, Ylä-Herttuala S, Lindahl P, Eriksson U.

Nature. 2010 Apr 8;464(7290):917-21. doi: 10.1038/nature08945. Epub 2010 Mar 14.

PMID:
20228789
48.

Hallmarks of cancer: interactions with the tumor stroma.

Pietras K, Ostman A.

Exp Cell Res. 2010 May 1;316(8):1324-31. doi: 10.1016/j.yexcr.2010.02.045. Epub 2010 Mar 6. Review.

PMID:
20211171
49.

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis.

Cunha SI, Pardali E, Thorikay M, Anderberg C, Hawinkels L, Goumans MJ, Seehra J, Heldin CH, ten Dijke P, Pietras K.

J Exp Med. 2010 Jan 18;207(1):85-100. doi: 10.1084/jem.20091309. Epub 2010 Jan 11.

50.

Posterior fossa brain tissue injury: developmental, neuropsychological, and neurological consequences of brain tumors in children.

Larysz D, Blamek S, Larysz P, Pietras K, Mandera M.

Acta Neurochir Suppl. 2010;106:271-4. doi: 10.1007/978-3-211-98811-4_51.

PMID:
19812963

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