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Items: 10

1.

Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system.

Chanda PK, Gao Y, Mark L, Btesh J, Strassle BW, Lu P, Piesla MJ, Zhang MY, Bingham B, Uveges A, Kowal D, Garbe D, Kouranova EV, Ring RH, Bates B, Pangalos MN, Kennedy JD, Whiteside GT, Samad TA.

Mol Pharmacol. 2010 Dec;78(6):996-1003. doi: 10.1124/mol.110.068304. Epub 2010 Sep 20.

PMID:
20855465
2.

Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease.

Strassle BW, Mark L, Leventhal L, Piesla MJ, Jian Li X, Kennedy JD, Glasson SS, Whiteside GT.

Osteoarthritis Cartilage. 2010 Oct;18(10):1319-28. doi: 10.1016/j.joca.2010.06.007. Epub 2010 Jul 13.

3.

WAY-318068: a novel, potent and selective noradrenaline re-uptake inhibitor with activity in rodent models of pain and depression.

Whiteside GT, Dwyer JM, Harrison JE, Beyer CE, Cummons T, Manzino L, Mark L, Johnston GH, Strassle BW, Adedoyin A, Lu P, Piesla MJ, Pulicicchio CM, Erve JC, Platt BJ, Hughes ZA, Rogers KE, Deecher DC, Trybulski EJ, Kennedy JD, Zhang P, Leventhal L.

Br J Pharmacol. 2010 Jul;160(5):1105-18. doi: 10.1111/j.1476-5381.2010.00690.x.

4.

Depression-like phenotype following chronic CB1 receptor antagonism.

Beyer CE, Dwyer JM, Piesla MJ, Platt BJ, Shen R, Rahman Z, Chan K, Manners MT, Samad TA, Kennedy JD, Bingham B, Whiteside GT.

Neurobiol Dis. 2010 Aug;39(2):148-55. doi: 10.1016/j.nbd.2010.03.020. Epub 2010 Apr 8.

PMID:
20381618
5.

Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice.

Gao Y, Vasilyev DV, Goncalves MB, Howell FV, Hobbs C, Reisenberg M, Shen R, Zhang MY, Strassle BW, Lu P, Mark L, Piesla MJ, Deng K, Kouranova EV, Ring RH, Whiteside GT, Bates B, Walsh FS, Williams G, Pangalos MN, Samad TA, Doherty P.

J Neurosci. 2010 Feb 10;30(6):2017-24. doi: 10.1523/JNEUROSCI.5693-09.2010.

6.

Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.

Piesla MJ, Leventhal L, Strassle BW, Harrison JE, Cummons TA, Lu P, Whiteside GT.

Brain Res. 2009 Oct 27;1295:89-98. doi: 10.1016/j.brainres.2009.07.091. Epub 2009 Aug 3.

PMID:
19651113
7.

Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain.

Sullivan NR, Leventhal L, Harrison J, Smith VA, Cummons TA, Spangler TB, Sun SC, Lu P, Uveges AJ, Strassle BW, Piesla MJ, Ramdass R, Barry A, Schantz J, Adams W, Whiteside GT, Adedoyin A, Jones PG.

J Pharmacol Exp Ther. 2007 Sep;322(3):1294-304. Epub 2007 Jun 22.

PMID:
17586724
8.

Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers.

Bingham B, Jones PG, Uveges AJ, Kotnis S, Lu P, Smith VA, Sun SC, Resnick L, Chlenov M, He Y, Strassle BW, Cummons TA, Piesla MJ, Harrison JE, Whiteside GT, Kennedy JD.

Br J Pharmacol. 2007 Aug;151(7):1061-70. Epub 2007 Jun 4. Erratum in: Br J Pharmacol. 2007 Aug;151(7):1137.

9.

An estrogen receptor-beta agonist is active in models of inflammatory and chemical-induced pain.

Leventhal L, Brandt MR, Cummons TA, Piesla MJ, Rogers KE, Harris HA.

Eur J Pharmacol. 2006 Dec 28;553(1-3):146-8. Epub 2006 Sep 26.

PMID:
17056036
10.

WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activity.

Marquis KL, Sabb AL, Logue SF, Brennan JA, Piesla MJ, Comery TA, Grauer SM, Ashby CR Jr, Nguyen HQ, Dawson LA, Barrett JE, Stack G, Meltzer HY, Harrison BL, Rosenzweig-Lipson S.

J Pharmacol Exp Ther. 2007 Jan;320(1):486-96. Epub 2006 Oct 12.

PMID:
17038512

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