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Protection of Cystinotic Mice by Kidney-Specific Megalin Ablation Supports an Endocytosis-Based Mechanism for Nephropathic Cystinosis Progression.

Janssens V, Gaide Chevronnay HP, Marie S, Vincent MF, Van Der Smissen P, Nevo N, Vainio S, Nielsen R, Christensen EI, Jouret F, Antignac C, Pierreux CE, Courtoy PJ.

J Am Soc Nephrol. 2019 Sep 23. pii: ASN.2019040371. doi: 10.1681/ASN.2019040371. [Epub ahead of print]


Pancreatic acinar differentiation is guided by differential laminin deposition.

Heymans C, Degosserie J, Spourquet C, Pierreux CE.

Sci Rep. 2019 Feb 25;9(1):2711. doi: 10.1038/s41598-019-39077-6.


Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency.

Grieco G, Janssens V, Gaide Chevronnay HP, N'Kuli F, Van Der Smissen P, Wang T, Shan J, Vainio S, Bilanges B, Jouret F, Vanhaesebroeck B, Pierreux CE, Courtoy PJ.

Sci Rep. 2018 Sep 20;8(1):14133. doi: 10.1038/s41598-018-32389-z.


Extracellular vesicles from endothelial progenitor cells promote thyroid follicle formation.

Degosserie J, Heymans C, Spourquet C, Halbout M, D'Auria L, Van Der Smissen P, Vertommen D, Courtoy PJ, Tyteca D, Pierreux CE.

J Extracell Vesicles. 2018 Jun 28;7(1):1487250. doi: 10.1080/20013078.2018.1487250. eCollection 2018.


Bioprinting of a functional vascularized mouse thyroid gland construct.

Bulanova EA, Koudan EV, Degosserie J, Heymans C, Pereira FD, Parfenov VA, Sun Y, Wang Q, Akhmedova SA, Sviridova IK, Sergeeva NS, Frank GA, Khesuani YD, Pierreux CE, Mironov VA.

Biofabrication. 2017 Aug 18;9(3):034105. doi: 10.1088/1758-5090/aa7fdd.


Highly Aggressive Metastatic Melanoma Cells Unable to Maintain Telomere Length.

Viceconte N, Dheur MS, Majerova E, Pierreux CE, Baurain JF, van Baren N, Decottignies A.

Cell Rep. 2017 Jun 20;19(12):2529-2543. doi: 10.1016/j.celrep.2017.05.046.


Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.

Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsée J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE.

Development. 2016 Jun 1;143(11):1958-70. doi: 10.1242/dev.134171. Epub 2016 Apr 11.


Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model.

Gaide Chevronnay HP, Janssens V, Van Der Smissen P, Rocca CJ, Liao XH, Refetoff S, Pierreux CE, Cherqui S, Courtoy PJ.

Endocrinology. 2016 Apr;157(4):1363-71. doi: 10.1210/en.2015-1762. Epub 2016 Jan 26.


Proliferation-Independent Initiation of Biliary Cysts in Polycystic Liver Diseases.

Beaudry JB, Cordi S, Demarez C, Lepreux S, Pierreux CE, Lemaigre FP.

PLoS One. 2015 Jun 30;10(6):e0132295. doi: 10.1371/journal.pone.0132295. eCollection 2015.


Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts.

Poncy A, Antoniou A, Cordi S, Pierreux CE, Jacquemin P, Lemaigre FP.

Dev Biol. 2015 Aug 15;404(2):136-48. doi: 10.1016/j.ydbio.2015.05.012. Epub 2015 May 29.


A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing.

Gaide Chevronnay HP, Janssens V, Van Der Smissen P, Liao XH, Abid Y, Nevo N, Antignac C, Refetoff S, Cherqui S, Pierreux CE, Courtoy PJ.

Endocrinology. 2015 Jun;156(6):2349-64. doi: 10.1210/en.2014-1672. Epub 2015 Mar 26.


Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition.

Gohy ST, Hupin C, Fregimilicka C, Detry BR, Bouzin C, Gaide Chevronay H, Lecocq M, Weynand B, Ladjemi MZ, Pierreux CE, Birembaut P, Polette M, Pilette C.

Eur Respir J. 2015 May;45(5):1258-72. doi: 10.1183/09031936.00135814. Epub 2015 Mar 5.


An ex vivo culture system to study thyroid development.

Delmarcelle AS, Villacorte M, Hick AC, Pierreux CE.

J Vis Exp. 2014 Jun 6;(88). doi: 10.3791/51641.


Validation of housekeeping gene and impact on normalized gene expression in clear cell renal cell carcinoma: critical reassessment of YBX3/ZONAB/CSDA expression.

Dupasquier S, Delmarcelle AS, Marbaix E, Cosyns JP, Courtoy PJ, Pierreux CE.

BMC Mol Biol. 2014 May 16;15:9. doi: 10.1186/1471-2199-15-9.


MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival.

Steed E, Elbediwy A, Vacca B, Dupasquier S, Hemkemeyer SA, Suddason T, Costa AC, Beaudry JB, Zihni C, Gallagher E, Pierreux CE, Balda MS, Matter K.

J Cell Biol. 2014 Mar 3;204(5):821-38. doi: 10.1083/jcb.201304115. Epub 2014 Feb 24.


Time course of pathogenic and adaptation mechanisms in cystinotic mouse kidneys.

Gaide Chevronnay HP, Janssens V, Van Der Smissen P, N'Kuli F, Nevo N, Guiot Y, Levtchenko E, Marbaix E, Pierreux CE, Cherqui S, Antignac C, Courtoy PJ.

J Am Soc Nephrol. 2014 Jun;25(6):1256-69. doi: 10.1681/ASN.2013060598. Epub 2014 Feb 13.


Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.

Hick AC, Delmarcelle AS, Bouquet M, Klotz S, Copetti T, Forez C, Van Der Smissen P, Sonveaux P, Collet JF, Feron O, Courtoy PJ, Pierreux CE.

Dev Biol. 2013 Sep 1;381(1):227-40. doi: 10.1016/j.ydbio.2013.04.022. Epub 2013 May 21.


Class III phosphoinositide 3-kinase/VPS34 and dynamin are critical for apical endocytic recycling.

Carpentier S, N'Kuli F, Grieco G, Van Der Smissen P, Janssens V, Emonard H, Bilanges B, Vanhaesebroeck B, Gaide Chevronnay HP, Pierreux CE, Tyteca D, Courtoy PJ.

Traffic. 2013 Aug;14(8):933-48. doi: 10.1111/tra.12079. Epub 2013 Jun 3.


Deletion of the RNaseIII enzyme dicer in thyroid follicular cells causes hypothyroidism with signs of neoplastic alterations.

Rodriguez W, Jin L, Janssens V, Pierreux C, Hick AC, Urizar E, Costagliola S.

PLoS One. 2012;7(1):e29929. doi: 10.1371/journal.pone.0029929. Epub 2012 Jan 5.


A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation.

Laudadio I, Manfroid I, Achouri Y, Schmidt D, Wilson MD, Cordi S, Thorrez L, Knoops L, Jacquemin P, Schuit F, Pierreux CE, Odom DT, Peers B, Lemaigre FP.

Gastroenterology. 2012 Jan;142(1):119-29. doi: 10.1053/j.gastro.2011.09.001. Epub 2011 Sep 12.


A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis.

Raynaud P, Tate J, Callens C, Cordi S, Vandersmissen P, Carpentier R, Sempoux C, Devuyst O, Pierreux CE, Courtoy P, Dahan K, Delbecque K, Lepreux S, Pontoglio M, Guay-Woodford LM, Lemaigre FP.

Hepatology. 2011 Jun;53(6):1959-66. doi: 10.1002/hep.24292. Epub 2011 May 2.


Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas.

Pierreux CE, Cordi S, Hick AC, Achouri Y, Ruiz de Almodovar C, Prévot PP, Courtoy PJ, Carmeliet P, Lemaigre FP.

Dev Biol. 2010 Nov 1;347(1):216-27. doi: 10.1016/j.ydbio.2010.08.024. Epub 2010 Aug 31.


ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells.

Lima WR, Parreira KS, Devuyst O, Caplanusi A, N'kuli F, Marien B, Van Der Smissen P, Alves PM, Verroust P, Christensen EI, Terzi F, Matter K, Balda MS, Pierreux CE, Courtoy PJ.

J Am Soc Nephrol. 2010 Mar;21(3):478-88. doi: 10.1681/ASN.2009070698. Epub 2010 Feb 4.


[Personal contribution to the study of the formation of the tubular epithelial structures].

Pierreux Ch.

Bull Mem Acad R Med Belg. 2010;165(5-6):278-84. French.


Interaction between Hhex and SOX13 modulates Wnt/TCF activity.

Marfil V, Moya M, Pierreux CE, Castell JV, Lemaigre FP, Real FX, Bort R.

J Biol Chem. 2010 Feb 19;285(8):5726-37. doi: 10.1074/jbc.M109.046649. Epub 2009 Dec 22.


Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1.

Hick AC, van Eyll JM, Cordi S, Forez C, Passante L, Kohara H, Nagasawa T, Vanderhaeghen P, Courtoy PJ, Rousseau GG, Lemaigre FP, Pierreux CE.

BMC Dev Biol. 2009 Dec 14;9:66. doi: 10.1186/1471-213X-9-66.


Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.

Kang HS, Kim YS, ZeRuth G, Beak JY, Gerrish K, Kilic G, Sosa-Pineda B, Jensen J, Pierreux CE, Lemaigre FP, Foley J, Jetten AM.

Mol Cell Biol. 2009 Dec;29(24):6366-79. doi: 10.1128/MCB.01259-09. Epub 2009 Oct 5. Erratum in: Mol Cell Biol. 2010 Apr;30(7):1864. Pierreux, Christophe E [added]; Lemaigre, Frederic P [added].


Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9.

Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger BZ, Jacquemin P, Pierreux CE, Clotman F, Lemaigre FP.

Gastroenterology. 2009 Jun;136(7):2325-33. doi: 10.1053/j.gastro.2009.02.051. Epub 2009 Feb 21.


Effects of marginal iron overload on iron homeostasis and immune function in alveolar macrophages isolated from pregnant and normal rats.

Ward RJ, Wilmet S, Legssyer R, Leroy D, Toussaint L, Crichton RR, Pierreux C, Hue L, Piette J, Srai SK, Solanky N, Klein D, Summer K.

Biometals. 2009 Apr;22(2):211-23. doi: 10.1007/s10534-008-9155-6. Epub 2008 Aug 9.


Role of metalloproteinases at the onset of liver development.

Margagliotti S, Clotman F, Pierreux CE, Lemoine P, Rousseau GG, Henriet P, Lemaigre FP.

Dev Growth Differ. 2008 Jun;50(5):331-8. doi: 10.1111/j.1440-169X.2008.01031.x. Epub 2008 Apr 28.


The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration.

Margagliotti S, Clotman F, Pierreux CE, Beaudry JB, Jacquemin P, Rousseau GG, Lemaigre FP.

Dev Biol. 2007 Nov 15;311(2):579-89. Epub 2007 Sep 16.


Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development.

Beaudry JB, Pierreux CE, Hayhurst GP, Plumb-Rudewiez N, Weiss MC, Rousseau GG, Lemaigre FP.

Mol Cell Biol. 2006 Aug;26(16):6037-46.


The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.

Pierreux CE, Poll AV, Kemp CR, Clotman F, Maestro MA, Cordi S, Ferrer J, Leyns L, Rousseau GG, Lemaigre FP.

Gastroenterology. 2006 Feb;130(2):532-41.


Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.

van Eyll JM, Passante L, Pierreux CE, Lemaigre FP, Vanderhaeghen P, Rousseau GG.

Gene Expr Patterns. 2006 Apr;6(4):353-9. Epub 2006 Jan 30.


A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells.

Poll AV, Pierreux CE, Lokmane L, Haumaitre C, Achouri Y, Jacquemin P, Rousseau GG, Cereghini S, Lemaigre FP.

Diabetes. 2006 Jan;55(1):61-9.


Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors.

Clotman F, Jacquemin P, Plumb-Rudewiez N, Pierreux CE, Van der Smissen P, Dietz HC, Courtoy PJ, Rousseau GG, Lemaigre FP.

Genes Dev. 2005 Aug 15;19(16):1849-54.


Gene transfer into mouse prepancreatic endoderm by whole embryo electroporation.

Pierreux CE, Poll AV, Jacquemin P, Lemaigre FP, Rousseau GG.

JOP. 2005 Mar 10;6(2):128-35.


Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver.

Plumb-Rudewiez N, Clotman F, Strick-Marchand H, Pierreux CE, Weiss MC, Rousseau GG, Lemaigre FP.

Hepatology. 2004 Dec;40(6):1266-74.


The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm.

Pierreux CE, Vanhorenbeeck V, Jacquemin P, Lemaigre FP, Rousseau GG.

J Biol Chem. 2004 Dec 3;279(49):51298-304. Epub 2004 Sep 20.


Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin A.

van Eyll JM, Pierreux CE, Lemaigre FP, Rousseau GG.

J Cell Sci. 2004 Apr 15;117(Pt 10):2077-86. Epub 2004 Mar 30.


Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas.

Maestro MA, Boj SF, Luco RF, Pierreux CE, Cabedo J, Servitja JM, German MS, Rousseau GG, Lemaigre FP, Ferrer J.

Hum Mol Genet. 2003 Dec 15;12(24):3307-14. Epub 2003 Oct 21.


Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2.

Jacquemin P, Pierreux CE, Fierens S, van Eyll JM, Lemaigre FP, Rousseau GG.

Gene Expr Patterns. 2003 Oct;3(5):639-44.


Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6.

Lannoy VJ, Decaux JF, Pierreux CE, Lemaigre FP, Rousseau GG.

Diabetologia. 2002 Aug;45(8):1136-41. Epub 2002 Jun 6. Erratum in: Diabetologia. 2002 Dec;45(12):1744.


Plasticity of a transcriptional regulation network among alpha-proteobacteria is supported by the identification of CtrA targets in Brucella abortus.

Bellefontaine AF, Pierreux CE, Mertens P, Vandenhaute J, Letesson JJ, De Bolle X.

Mol Microbiol. 2002 Feb;43(4):945-60.


Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability.

Maurice D, Pierreux CE, Howell M, Wilentz RE, Owen MJ, Hill CS.

J Biol Chem. 2001 Nov 16;276(46):43175-81. Epub 2001 Sep 11.


Suboptimal enhancer sequences are required for efficient bovine leukemia virus propagation in vivo: implications for viral latency.

Merezak C, Pierreux C, Adam E, Lemaigre F, Rousseau GG, Calomme C, Van Lint C, Christophe D, Kerkhofs P, Burny A, Kettmann R, Willems L.

J Virol. 2001 Aug;75(15):6977-88.


Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

Pierreux CE, Nicolás FJ, Hill CS.

Mol Cell Biol. 2000 Dec;20(23):9041-54.


Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells.

Lehmann K, Janda E, Pierreux CE, Rytömaa M, Schulze A, McMahon M, Hill CS, Beug H, Downward J.

Genes Dev. 2000 Oct 15;14(20):2610-22.


Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes.

Howell M, Itoh F, Pierreux CE, Valgeirsdottir S, Itoh S, ten Dijke P, Hill CS.

Dev Biol. 1999 Oct 15;214(2):354-69.

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