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Items: 35


Ubiquinone Biosynthesis over the Entire O2 Range: Characterization of a Conserved O2-Independent Pathway.

Pelosi L, Vo CD, Abby SS, Loiseau L, Rascalou B, Hajj Chehade M, Faivre B, Goussé M, Chenal C, Touati N, Binet L, Cornu D, Fyfe CD, Fontecave M, Barras F, Lombard M, Pierrel F.

MBio. 2019 Jul 9;10(4). pii: e01319-19. doi: 10.1128/mBio.01319-19.


Vitamin K2 cannot substitute Coenzyme Q10 as electron carrier in the mitochondrial respiratory chain of mammalian cells.

Cerqua C, Casarin A, Pierrel F, Vazquez Fonseca L, Viola G, Salviati L, Trevisson E.

Sci Rep. 2019 Apr 25;9(1):6553. doi: 10.1038/s41598-019-43014-y.


A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone.

Hajj Chehade M, Pelosi L, Fyfe CD, Loiseau L, Rascalou B, Brugière S, Kazemzadeh K, Vo CD, Ciccone L, Aussel L, Couté Y, Fontecave M, Barras F, Lombard M, Pierrel F.

Cell Chem Biol. 2019 Apr 18;26(4):482-492.e7. doi: 10.1016/j.chembiol.2018.12.001. Epub 2019 Jan 24.


Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency.

Pierrel F.

Front Physiol. 2017 Jun 22;8:436. doi: 10.3389/fphys.2017.00436. eCollection 2017. Review.


The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ.

Loiseau L, Fyfe C, Aussel L, Hajj Chehade M, Hernández SB, Faivre B, Hamdane D, Mellot-Draznieks C, Rascalou B, Pelosi L, Velours C, Cornu D, Lombard M, Casadesús J, Pierrel F, Fontecave M, Barras F.

J Biol Chem. 2017 Jul 14;292(28):11937-11950. doi: 10.1074/jbc.M117.789164. Epub 2017 May 30.


Evolution of Ubiquinone Biosynthesis: Multiple Proteobacterial Enzymes with Various Regioselectivities To Catalyze Three Contiguous Aromatic Hydroxylation Reactions.

Pelosi L, Ducluzeau AL, Loiseau L, Barras F, Schneider D, Junier I, Pierrel F.

mSystems. 2016 Aug 30;1(4). pii: e00091-16. eCollection 2016 Jul-Aug.


Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast.

Payet LA, Leroux M, Willison JC, Kihara A, Pelosi L, Pierrel F.

Cell Chem Biol. 2016 Oct 20;23(10):1241-1250. doi: 10.1016/j.chembiol.2016.08.008. Epub 2016 Sep 29.


Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.

Stefely JA, Licitra F, Laredj L, Reidenbach AG, Kemmerer ZA, Grangeray A, Jaeg-Ehret T, Minogue CE, Ulbrich A, Hutchins PD, Wilkerson EM, Ruan Z, Aydin D, Hebert AS, Guo X, Freiberger EC, Reutenauer L, Jochem A, Chergova M, Johnson IE, Lohman DC, Rush MJP, Kwiecien NW, Singh PK, Schlagowski AI, Floyd BJ, Forsman U, Sindelar PJ, Westphall MS, Pierrel F, Zoll J, Dal Peraro M, Kannan N, Bingman CA, Coon JJ, Isope P, Puccio H, Pagliarini DJ.

Mol Cell. 2016 Aug 18;63(4):608-620. doi: 10.1016/j.molcel.2016.06.030. Epub 2016 Aug 4.


The COQ2 genotype predicts the severity of coenzyme Q10 deficiency.

Desbats MA, Morbidoni V, Silic-Benussi M, Doimo M, Ciminale V, Cassina M, Sacconi S, Hirano M, Basso G, Pierrel F, Navas P, Salviati L, Trevisson E.

Hum Mol Genet. 2016 Oct 1;25(19):4256-4265. doi: 10.1093/hmg/ddw257. Epub 2016 Aug 4.


Coenzyme Q Biosynthesis: Evidence for a Substrate Access Channel in the FAD-Dependent Monooxygenase Coq6.

Ismail A, Leroux V, Smadja M, Gonzalez L, Lombard M, Pierrel F, Mellot-Draznieks C, Fontecave M.

PLoS Comput Biol. 2016 Jan 25;12(1):e1004690. doi: 10.1371/journal.pcbi.1004690. eCollection 2016 Jan.


Coq6 is responsible for the C4-deamination reaction in coenzyme Q biosynthesis in Saccharomyces cerevisiae.

Ozeir M, Pelosi L, Ismail A, Mellot-Draznieks C, Fontecave M, Pierrel F.

J Biol Chem. 2015 Oct 2;290(40):24140-51. doi: 10.1074/jbc.M115.675744. Epub 2015 Aug 10.


Demethylmenaquinol is a substrate of Escherichia coli nitrate reductase A (NarGHI) and forms a stable semiquinone intermediate at the NarGHI quinol oxidation site.

Rendon J, Pilet E, Fahs Z, Seduk F, Sylvi L, Hajj Chehade M, Pierrel F, Guigliarelli B, Magalon A, Grimaldi S.

Biochim Biophys Acta. 2015 Aug;1847(8):739-47. doi: 10.1016/j.bbabio.2015.05.001. Epub 2015 May 12.


Three conserved histidine residues contribute to mitochondrial iron transport through mitoferrins.

Brazzolotto X, Pierrel F, Pelosi L.

Biochem J. 2014 May 15;460(1):79-89. doi: 10.1042/BJ20140107.


Biosynthesis and physiology of coenzyme Q in bacteria.

Aussel L, Pierrel F, Loiseau L, Lombard M, Fontecave M, Barras F.

Biochim Biophys Acta. 2014 Jul;1837(7):1004-11. doi: 10.1016/j.bbabio.2014.01.015. Epub 2014 Jan 28. Review.


ubiJ, a new gene required for aerobic growth and proliferation in macrophage, is involved in coenzyme Q biosynthesis in Escherichia coli and Salmonella enterica serovar Typhimurium.

Aussel L, Loiseau L, Hajj Chehade M, Pocachard B, Fontecave M, Pierrel F, Barras F.

J Bacteriol. 2014 Jan;196(1):70-9. doi: 10.1128/JB.01065-13. Epub 2013 Oct 18.


Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency.

Doimo M, Trevisson E, Airik R, Bergdoll M, Santos-Ocaña C, Hildebrandt F, Navas P, Pierrel F, Salviati L.

Biochim Biophys Acta. 2014 Jan;1842(1):1-6. doi: 10.1016/j.bbadis.2013.10.007. Epub 2013 Oct 18.


ubiI, a new gene in Escherichia coli coenzyme Q biosynthesis, is involved in aerobic C5-hydroxylation.

Hajj Chehade M, Loiseau L, Lombard M, Pecqueur L, Ismail A, Smadja M, Golinelli-Pimpaneau B, Mellot-Draznieks C, Hamelin O, Aussel L, Kieffer-Jaquinod S, Labessan N, Barras F, Fontecave M, Pierrel F.

J Biol Chem. 2013 Jul 5;288(27):20085-92. doi: 10.1074/jbc.M113.480368. Epub 2013 May 24.


Overexpression of the Coq8 kinase in Saccharomyces cerevisiae coq null mutants allows for accumulation of diagnostic intermediates of the coenzyme Q6 biosynthetic pathway.

Xie LX, Ozeir M, Tang JY, Chen JY, Jaquinod SK, Fontecave M, Clarke CF, Pierrel F.

J Biol Chem. 2012 Jul 6;287(28):23571-81. doi: 10.1074/jbc.M112.360354. Epub 2012 May 16.


Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency.

Ozeir M, Mühlenhoff U, Webert H, Lill R, Fontecave M, Pierrel F.

Chem Biol. 2011 Sep 23;18(9):1134-42. doi: 10.1016/j.chembiol.2011.07.008.


Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster.

Mühlenhoff U, Molik S, Godoy JR, Uzarska MA, Richter N, Seubert A, Zhang Y, Stubbe J, Pierrel F, Herrero E, Lillig CH, Lill R.

Cell Metab. 2010 Oct 6;12(4):373-385. doi: 10.1016/j.cmet.2010.08.001. Erratum in: Cell Metab. 2014 Oct 7;20(4):696.


Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis.

Pierrel F, Hamelin O, Douki T, Kieffer-Jaquinod S, Mühlenhoff U, Ozeir M, Lill R, Fontecave M.

Chem Biol. 2010 May 28;17(5):449-59. doi: 10.1016/j.chembiol.2010.03.014.


The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10.

Bestwick M, Khalimonchuk O, Pierrel F, Winge DR.

Mol Cell Biol. 2010 Jan;30(1):172-85. doi: 10.1128/MCB.00869-09.


Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1.

Pierrel F, Khalimonchuk O, Cobine PA, Bestwick M, Winge DR.

Mol Cell Biol. 2008 Aug;28(16):4927-39. doi: 10.1128/MCB.00057-08. Epub 2008 Jun 9.


Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae.

Khalimonchuk O, Rigby K, Bestwick M, Pierrel F, Cobine PA, Winge DR.

Eukaryot Cell. 2008 Aug;7(8):1427-31. doi: 10.1128/EC.00132-08. Epub 2008 May 23.


Isolated cytochrome c oxidase deficiency in G93A SOD1 mice overexpressing CCS protein.

Son M, Leary SC, Romain N, Pierrel F, Winge DR, Haller RG, Elliott JL.

J Biol Chem. 2008 May 2;283(18):12267-75. doi: 10.1074/jbc.M708523200. Epub 2008 Mar 11.


Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.

Pierrel F, Bestwick ML, Cobine PA, Khalimonchuk O, Cricco JA, Winge DR.

EMBO J. 2007 Oct 17;26(20):4335-46. Epub 2007 Sep 20.


tRNA-modifying MiaE protein from Salmonella typhimurium is a nonheme diiron monooxygenase.

Mathevon C, Pierrel F, Oddou JL, Garcia-Serres R, Blondin G, Latour JM, Ménage S, Gambarelli S, Fontecave M, Atta M.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13295-300. Epub 2007 Aug 6.


MiaB, a bifunctional radical-S-adenosylmethionine enzyme involved in the thiolation and methylation of tRNA, contains two essential [4Fe-4S] clusters.

Hernández HL, Pierrel F, Elleingand E, García-Serres R, Huynh BH, Johnson MK, Fontecave M, Atta M.

Biochemistry. 2007 May 1;46(17):5140-7. Epub 2007 Apr 4.


Metal Ion availability in mitochondria.

Pierrel F, Cobine PA, Winge DR.

Biometals. 2007 Jun;20(3-4):675-82. Epub 2007 Jan 16. Review.


Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase.

Cobine PA, Pierrel F, Bestwick ML, Winge DR.

J Biol Chem. 2006 Dec 1;281(48):36552-9. Epub 2006 Sep 28.


Copper trafficking to the mitochondrion and assembly of copper metalloenzymes.

Cobine PA, Pierrel F, Winge DR.

Biochim Biophys Acta. 2006 Jul;1763(7):759-72. Epub 2006 Mar 31. Review.


The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding.

Cobine PA, Pierrel F, Leary SC, Sasarman F, Horng YC, Shoubridge EA, Winge DR.

J Biol Chem. 2006 May 5;281(18):12270-6. Epub 2006 Mar 6.


MiaB protein is a bifunctional radical-S-adenosylmethionine enzyme involved in thiolation and methylation of tRNA.

Pierrel F, Douki T, Fontecave M, Atta M.

J Biol Chem. 2004 Nov 12;279(46):47555-63. Epub 2004 Aug 30.


MiaB protein from Thermotoga maritima. Characterization of an extremely thermophilic tRNA-methylthiotransferase.

Pierrel F, Hernandez HL, Johnson MK, Fontecave M, Atta M.

J Biol Chem. 2003 Aug 8;278(32):29515-24. Epub 2003 May 24.


Enzymatic modification of tRNAs: MiaB is an iron-sulfur protein.

Pierrel F, Björk GR, Fontecave M, Atta M.

J Biol Chem. 2002 Apr 19;277(16):13367-70. Epub 2002 Mar 6.

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