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B cell signaling in context.

Kwak K, Akkaya M, Pierce SK.

Nat Immunol. 2019 Aug;20(8):963-969. doi: 10.1038/s41590-019-0427-9. Epub 2019 Jul 8. Review.


The Differentiation in vitro of Human Tonsil B Cells With the Phenotypic and Functional Characteristics of T-bet+ Atypical Memory B Cells in Malaria.

Ambegaonkar AA, Nagata S, Pierce SK, Sohn H.

Front Immunol. 2019 Apr 24;10:852. doi: 10.3389/fimmu.2019.00852. eCollection 2019.


Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria.

Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO.

J Exp Med. 2019 Jun 3;216(6):1280-1290. doi: 10.1084/jem.20181681. Epub 2019 Apr 12.


Algal Sources of Sequestered Chloroplasts in the Sacoglossan Sea Slug Elysia crispata Vary by Location and Ecotype.

Middlebrooks ML, Curtis NE, Pierce SK.

Biol Bull. 2019 Apr;236(2):88-96. doi: 10.1086/701732. Epub 2019 Feb 13.


A draft genome assembly of the solar-powered sea slug Elysia chlorotica.

Cai H, Li Q, Fang X, Li J, Curtis NE, Altenburger A, Shibata T, Feng M, Maeda T, Schwartz JA, Shigenobu S, Lundholm N, Nishiyama T, Yang H, Hasebe M, Li S, Pierce SK, Wang J.

Sci Data. 2019 Feb 19;6:190022. doi: 10.1038/sdata.2019.22.


Intrinsic properties of human germinal center B cells set antigen affinity thresholds.

Kwak K, Quizon N, Sohn H, Saniee A, Manzella-Lapeira J, Holla P, Brzostowski J, Lu J, Xie H, Xu C, Spillane KM, Tolar P, Pierce SK.

Sci Immunol. 2018 Nov 30;3(29). pii: eaau6598. doi: 10.1126/sciimmunol.aau6598.


MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.

Riggle BA, Sinharay S, Schreiber-Stainthorp W, Munasinghe JP, Maric D, Prchalova E, Slusher BS, Powell JD, Miller LH, Pierce SK, Hammoud DA.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033. doi: 10.1073/pnas.1812909115. Epub 2018 Dec 4.


Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4+ T Cell Activation.

Akkaya B, Roesler AS, Miozzo P, Theall BP, Al Souz J, Smelkinson MG, Kabat J, Traba J, Sack MN, Brzostowski JA, Pena M, Dorward DW, Pierce SK, Akkaya M.

J Immunol. 2018 Dec 1;201(11):3294-3306. doi: 10.4049/jimmunol.1800753. Epub 2018 Oct 29.


From zero to sixty and back to zero again: the metabolic life of B cells.

Akkaya M, Pierce SK.

Curr Opin Immunol. 2019 Apr;57:1-7. doi: 10.1016/j.coi.2018.09.019. Epub 2018 Oct 9. Review.


IgG3 regulates tissue-like memory B cells in HIV-infected individuals.

Kardava L, Sohn H, Youn C, Austin JW, Wang W, Buckner CM, Justement JS, Melson VA, Roth GE, Hand MA, Gittens KR, Kwan RW, Sneller MC, Li Y, Chun TW, Sun PD, Pierce SK, Moir S.

Nat Immunol. 2018 Sep;19(9):1001-1012. doi: 10.1038/s41590-018-0180-5. Epub 2018 Aug 13.


Second signals rescue B cells from activation-induced mitochondrial dysfunction and death.

Akkaya M, Traba J, Roesler AS, Miozzo P, Akkaya B, Theall BP, Sohn H, Pena M, Smelkinson M, Kabat J, Dahlstrom E, Dorward DW, Skinner J, Sack MN, Pierce SK.

Nat Immunol. 2018 Aug;19(8):871-884. doi: 10.1038/s41590-018-0156-5. Epub 2018 Jul 9.


NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity.

Arora G, Hart GT, Manzella-Lapeira J, Doritchamou JY, Narum DL, Thomas LM, Brzostowski J, Rajagopalan S, Doumbo OK, Traore B, Miller LH, Pierce SK, Duffy PE, Crompton PD, Desai SA, Long EO.

Elife. 2018 Jun 26;7. pii: e36806. doi: 10.7554/eLife.36806.


Toll-like receptor 9 antagonizes antibody affinity maturation.

Akkaya M, Akkaya B, Kim AS, Miozzo P, Sohn H, Pena M, Roesler AS, Theall BP, Henke T, Kabat J, Lu J, Dorward DW, Dahlstrom E, Skinner J, Miller LH, Pierce SK.

Nat Immunol. 2018 Mar;19(3):255-266. doi: 10.1038/s41590-018-0052-z. Epub 2018 Feb 23.


Do we know enough to find an adjunctive therapy for cerebral malaria in African children?

Riggle BA, Miller LH, Pierce SK.

F1000Res. 2017 Nov 22;6:2039. doi: 10.12688/f1000research.12401.1. eCollection 2017. Review.


Malaria-induced interferon-γ drives the expansion of Tbethi atypical memory B cells.

Obeng-Adjei N, Portugal S, Holla P, Li S, Sohn H, Ambegaonkar A, Skinner J, Bowyer G, Doumbo OK, Traore B, Pierce SK, Crompton PD.

PLoS Pathog. 2017 Sep 27;13(9):e1006576. doi: 10.1371/journal.ppat.1006576. eCollection 2017 Sep.


A Streamlined Approach to Antibody Novel Germline Allele Prediction and Validation.

Wendel BS, He C, Crompton PD, Pierce SK, Jiang N.

Front Immunol. 2017 Sep 4;8:1072. doi: 10.3389/fimmu.2017.01072. eCollection 2017.


Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children.

Wendel BS, He C, Qu M, Wu D, Hernandez SM, Ma KY, Liu EW, Xiao J, Crompton PD, Pierce SK, Ren P, Chen K, Jiang N.

Nat Commun. 2017 Sep 14;8(1):531. doi: 10.1038/s41467-017-00645-x.


A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection.

Srinivasan P, Baldeviano GC, Miura K, Diouf A, Ventocilla JA, Leiva KP, Lugo-Roman L, Lucas C, Orr-Gonzalez S, Zhu D, Villasante E, Soisson L, Narum DL, Pierce SK, Long CA, Diggs C, Duffy PE, Lescano AG, Miller LH.

NPJ Vaccines. 2017;2. pii: 14. doi: 10.1038/s41541-017-0015-7. Epub 2017 May 22.


T cell-dependent antigen adjuvanted with DOTAP-CpG-B but not DOTAP-CpG-A induces robust germinal center responses and high affinity antibodies in mice.

Akkaya M, Akkaya B, Sheehan PW, Miozzo P, Pena M, Qi CF, Manzella-Lapeira J, Bolland S, Pierce SK.

Eur J Immunol. 2017 Nov;47(11):1890-1899. doi: 10.1002/eji.201747113. Epub 2017 Aug 21.


Atypical memory B cells in human chronic infectious diseases: An interim report.

Portugal S, Obeng-Adjei N, Moir S, Crompton PD, Pierce SK.

Cell Immunol. 2017 Nov;321:18-25. doi: 10.1016/j.cellimm.2017.07.003. Epub 2017 Jul 11. Review.


B Cells Produce Type 1 IFNs in Response to the TLR9 Agonist CpG-A Conjugated to Cationic Lipids.

Akkaya M, Akkaya B, Miozzo P, Rawat M, Pena M, Sheehan PW, Kim AS, Kamenyeva O, Kabat J, Bolland S, Chaturvedi A, Pierce SK.

J Immunol. 2017 Aug 1;199(3):931-940. doi: 10.4049/jimmunol.1700348. Epub 2017 Jun 26.


A Preliminary Molecular and Phylogenetic Analysis of the Genome of a Novel Endogenous Retrovirus in the Sea Slug Elysia chlorotica.

Pierce SK, Mahadevan P, Massey SE, Middlebrooks ML.

Biol Bull. 2016 Dec;231(3):236-244. doi: 10.1086/691071.


The nanoscale spatial organization of B-cell receptors on immunoglobulin M- and G-expressing human B-cells.

Lee J, Sengupta P, Brzostowski J, Lippincott-Schwartz J, Pierce SK.

Mol Biol Cell. 2017 Feb 15;28(4):511-523. doi: 10.1091/mbc.E16-06-0452. Epub 2016 Dec 14.


An Optimized Protocol to Analyze Glycolysis and Mitochondrial Respiration in Lymphocytes.

Traba J, Miozzo P, Akkaya B, Pierce SK, Akkaya M.

J Vis Exp. 2016 Nov 21;(117). doi: 10.3791/54918.


CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature.

Swanson PA 2nd, Hart GT, Russo MV, Nayak D, Yazew T, Peña M, Khan SM, Janse CJ, Pierce SK, McGavern DB.

PLoS Pathog. 2016 Dec 1;12(12):e1006022. doi: 10.1371/journal.ppat.1006022. eCollection 2016 Dec.


The Regulation of Inherently Autoreactive VH4-34-Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa.

Hart GT, Akkaya M, Chida AS, Wei C, Jenks SA, Tipton C, He C, Wendel BS, Skinner J, Arora G, Kayentao K, Ongoiba A, Doumbo O, Traore B, Narum DL, Jiang N, Crompton PD, Sanz I, Pierce SK.

J Immunol. 2016 Nov 15;197(10):3841-3849. Epub 2016 Oct 19.


PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria.

Crompton PD, Pierce SK.

Immunity. 2016 Aug 16;45(2):231-3. doi: 10.1016/j.immuni.2016.08.001.


A Simple, Versatile Antibody-Based Barcoding Method for Flow Cytometry.

Akkaya B, Miozzo P, Holstein AH, Shevach EM, Pierce SK, Akkaya M.

J Immunol. 2016 Sep 1;197(5):2027-38. doi: 10.4049/jimmunol.1600727. Epub 2016 Jul 20.


Targeting glutamine metabolism rescues mice from late-stage cerebral malaria.

Gordon EB, Hart GT, Tran TM, Waisberg M, Akkaya M, Kim AS, Hamilton SE, Pena M, Yazew T, Qi CF, Lee CF, Lo YC, Miller LH, Powell JD, Pierce SK.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13075-80. doi: 10.1073/pnas.1516544112. Epub 2015 Oct 5.


Inhibiting the Mammalian target of rapamycin blocks the development of experimental cerebral malaria.

Gordon EB, Hart GT, Tran TM, Waisberg M, Akkaya M, Skinner J, Zinöcker S, Pena M, Yazew T, Qi CF, Miller LH, Pierce SK.

MBio. 2015 Jun 2;6(3):e00725. doi: 10.1128/mBio.00725-15.


Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function.

Portugal S, Tipton CM, Sohn H, Kone Y, Wang J, Li S, Skinner J, Virtaneva K, Sturdevant DE, Porcella SF, Doumbo OK, Doumbo S, Kayentao K, Ongoiba A, Traore B, Sanz I, Pierce SK, Crompton PD.

Elife. 2015 May 8;4. doi: 10.7554/eLife.07218.


Ethnic differences in susceptibility to malaria: what have we learned from immuno-epidemiological studies in West Africa?

Arama C, Maiga B, Dolo A, Kouriba B, Traoré B, Crompton PD, Pierce SK, Troye-Blomberg M, Miller LH, Doumbo OK.

Acta Trop. 2015 Jun;146:152-6. doi: 10.1016/j.actatropica.2015.03.023. Epub 2015 Mar 27. Review.


Ups and downs in the search for a Herpes simplex virus vaccine.

Bolland S, Pierce SK.

Elife. 2015 Mar 10;4. doi: 10.7554/eLife.06883.


The V gene repertoires of classical and atypical memory B cells in malaria-susceptible West African children.

Zinöcker S, Schindler CE, Skinner J, Rogosch T, Waisberg M, Schickel JN, Meffre E, Kayentao K, Ongoïba A, Traoré B, Pierce SK.

J Immunol. 2015 Feb 1;194(3):929-39. doi: 10.4049/jimmunol.1402168. Epub 2015 Jan 2.


The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly.

Wang J, Sohn H, Sun G, Milner JD, Pierce SK.

Sci Signal. 2014 Sep 16;7(343):ra89. doi: 10.1126/scisignal.2005392.


Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis.

Waisberg M, Molina-Cruz A, Mizurini DM, Gera N, Sousa BC, Ma D, Leal AC, Gomes T, Kotsyfakis M, Ribeiro JM, Lukszo J, Reiter K, Porcella SF, Oliveira CJ, Monteiro RQ, Barillas-Mury C, Pierce SK, Francischetti IM.

PLoS Pathog. 2014 Sep 11;10(9):e1004338. doi: 10.1371/journal.ppat.1004338. eCollection 2014 Sep.


No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory.

Xu Y, Xu L, Zhao M, Xu C, Fan Y, Pierce SK, Liu W.

Cell Res. 2014 Jun;24(6):651-64. doi: 10.1038/cr.2014.65. Epub 2014 May 20. Review.


Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease.

Crompton PD, Moebius J, Portugal S, Waisberg M, Hart G, Garver LS, Miller LH, Barillas-Mury C, Pierce SK.

Annu Rev Immunol. 2014;32:157-87. doi: 10.1146/annurev-immunol-032713-120220. Review.


Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria.

Francischetti IM, Gordon E, Bizzarro B, Gera N, Andrade BB, Oliveira F, Ma D, Assumpção TC, Ribeiro JM, Pena M, Qi CF, Diouf A, Moretz SE, Long CA, Ackerman HC, Pierce SK, Sá-Nunes A, Waisberg M.

PLoS One. 2014 Feb 28;9(2):e87140. doi: 10.1371/journal.pone.0087140. eCollection 2014.


Encoding immunological memory in the initiation of B-cell receptor signaling.

Pierce SK, Liu W.

Cold Spring Harb Symp Quant Biol. 2013;78:231-7. doi: 10.1101/sqb.2013.78.020206. Epub 2013 Oct 7.


The impact of genetic susceptibility to systemic lupus erythematosus on placental malaria in mice.

Waisberg M, Lin CK, Huang CY, Pena M, Orandle M, Bolland S, Pierce SK.

PLoS One. 2013 May 10;8(5):e62820. doi: 10.1371/journal.pone.0062820. Print 2013.


Young lives lost as B cells falter: what we are learning about antibody responses in malaria.

Portugal S, Pierce SK, Crompton PD.

J Immunol. 2013 Apr 1;190(7):3039-46. doi: 10.4049/jimmunol.1203067. Review.


Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion.

Illingworth J, Butler NS, Roetynck S, Mwacharo J, Pierce SK, Bejon P, Crompton PD, Marsh K, Ndungu FM.

J Immunol. 2013 Feb 1;190(3):1038-47. doi: 10.4049/jimmunol.1202438. Epub 2012 Dec 21.


Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival.

Liu XQ, Stacey KJ, Horne-Debets JM, Cridland JA, Fischer K, Narum D, Mackay F, Pierce SK, Wykes MN.

Eur J Immunol. 2012 Dec;42(12):3291-301. doi: 10.1002/eji.201242689. Epub 2012 Oct 16.


The scaffolding protein synapse-associated protein 97 is required for enhanced signaling through isotype-switched IgG memory B cell receptors.

Liu W, Chen E, Zhao XW, Wan ZP, Gao YR, Davey A, Huang E, Zhang L, Crocetti J, Sandoval G, Joyce MG, Miceli C, Lukszo J, Aravind L, Swat W, Brzostowski J, Pierce SK.

Sci Signal. 2012 Jul 31;5(235):ra54. doi: 10.1126/scisignal.2002820.


Formation of BCR oligomers provides a mechanism for B cell affinity discrimination.

Tsourkas PK, Somkanya C D, Yu-Yang P, Liu W, Pierce SK, Raychaudhuri S.

J Theor Biol. 2012 Aug 21;307:174-82. doi: 10.1016/j.jtbi.2012.05.008. Epub 2012 May 19.


B cell analysis of ethnic groups in Mali with differential susceptibility to malaria.

Portugal S, Doumtabe D, Traore B, Miller LH, Troye-Blomberg M, Doumbo OK, Dolo A, Pierce SK, Crompton PD.

Malar J. 2012 May 11;11:162. doi: 10.1186/1475-2875-11-162.


Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P.

Waisberg M, Cerqueira GC, Yager SB, Francischetti IM, Lu J, Gera N, Srinivasan P, Miura K, Rada B, Lukszo J, Barbian KD, Leto TL, Porcella SF, Narum DL, El-Sayed N, Miller LH, Pierce SK.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5429-34. doi: 10.1073/pnas.1202689109. Epub 2012 Mar 19.


Intrinsic differences in the initiation of B cell receptor signaling favor responses of human IgG(+) memory B cells over IgM(+) naive B cells.

Davey AM, Pierce SK.

J Immunol. 2012 Apr 1;188(7):3332-41. doi: 10.4049/jimmunol.1102322. Epub 2012 Feb 29.

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