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Items: 1 to 50 of 209

1.

Positive airway pressure for sleep-disordered breathing in acute quadriplegia: a randomised controlled trial.

Berlowitz DJ, Schembri R, Graco M, Ross JM, Ayas N, Gordon I, Lee B, Graham A, Cross SV, McClelland M, Kennedy P, Thumbikat P, Bennett C, Townson A, Geraghty TJ, Pieri-Davies S, Singhal R, Marshall K, Short D, Nunn A, Mortimer D, Brown D, Pierce RJ, Cistulli PA; COSAQ Collaborative.

Thorax. 2019 Mar;74(3):282-290. doi: 10.1136/thoraxjnl-2018-212319. Epub 2018 Dec 11.

2.

Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism.

Pereira ASA, Amaral MS, Vasconcelos EJR, Pires DS, Asif H, daSilva LF, Morales-Vicente DA, Carneiro VC, Angeli CB, Palmisano G, Fantappie MR, Pierce RJ, Setubal JC, Verjovski-Almeida S.

PLoS Negl Trop Dis. 2018 Oct 26;12(10):e0006873. doi: 10.1371/journal.pntd.0006873. eCollection 2018 Oct.

3.

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.

Marek M, Shaik TB, Heimburg T, Chakrabarti A, Lancelot J, Ramos-Morales E, Da Veiga C, Kalinin D, Melesina J, Robaa D, Schmidtkunz K, Suzuki T, Holl R, Ennifar E, Pierce RJ, Jung M, Sippl W, Romier C.

J Med Chem. 2018 Nov 21;61(22):10000-10016. doi: 10.1021/acs.jmedchem.8b01087. Epub 2018 Nov 8.

PMID:
30347148
4.

Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis.

Bayer T, Chakrabarti A, Lancelot J, Shaik TB, Hausmann K, Melesina J, Schmidtkunz K, Marek M, Erdmann F, Schmidt M, Robaa D, Romier C, Pierce RJ, Jung M, Sippl W.

ChemMedChem. 2018 Aug 10;13(15):1517-1529. doi: 10.1002/cmdc.201800238. Epub 2018 Jul 4.

PMID:
29806110
5.

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.

Simoben CV, Robaa D, Chakrabarti A, Schmidtkunz K, Marek M, Lancelot J, Kannan S, Melesina J, Shaik TB, Pierce RJ, Romier C, Jung M, Sippl W.

Molecules. 2018 Mar 2;23(3). pii: E566. doi: 10.3390/molecules23030566.

6.

Analysis of the interactome of Schistosoma mansoni histone deacetylase 8.

Caby S, Pagliazzo L, Lancelot J, Saliou JM, Bertheaume N, Pierce RJ, Roger E.

PLoS Negl Trop Dis. 2017 Nov 20;11(11):e0006089. doi: 10.1371/journal.pntd.0006089. eCollection 2017 Nov.

7.

Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.

Stenzel K, Chakrabarti A, Melesina J, Hansen FK, Lancelot J, Herkenhöhner S, Lungerich B, Marek M, Romier C, Pierce RJ, Sippl W, Jung M, Kurz T.

Arch Pharm (Weinheim). 2017 Aug;350(8). doi: 10.1002/ardp.201700096. Epub 2017 Jun 22.

PMID:
28639720
8.

The Future of Drug Development for Neglected Tropical Diseases: How the European Commission Can Continue to Make a Difference.

Pierce RJ, MacDougall J, Leurs R, Costi MP.

Trends Parasitol. 2017 Aug;33(8):581-583. doi: 10.1016/j.pt.2017.04.007. Epub 2017 May 18.

PMID:
28529130
9.

Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases.

Scholte LLS, Mourão MM, Pais FS, Melesina J, Robaa D, Volpini AC, Sippl W, Pierce RJ, Oliveira G, Nahum LA.

Infect Genet Evol. 2017 Sep;53:175-188. doi: 10.1016/j.meegid.2017.05.011. Epub 2017 May 13.

10.

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth.

Chua MJ, Arnold MS, Xu W, Lancelot J, Lamotte S, Späth GF, Prina E, Pierce RJ, Fairlie DP, Skinner-Adams TS, Andrews KT.

Int J Parasitol Drugs Drug Resist. 2017 Apr;7(1):42-50. doi: 10.1016/j.ijpddr.2016.12.005. Epub 2016 Dec 23.

11.

Sensory detection of threshold intensity resistive loads in severe obstructive sleep apnoea.

Ruehland WR, Rochford PD, Pierce RJ, Webster KE, Trinder JA, Jordan AS, O'Donoghue FJ.

Respir Physiol Neurobiol. 2017 Feb;236:29-41. doi: 10.1016/j.resp.2016.10.014. Epub 2016 Nov 9.

PMID:
27836649
12.

Antiplasmodial Activity Is an Ancient and Conserved Feature of Tick Defensins.

Cabezas-Cruz A, Tonk M, Bouchut A, Pierrot C, Pierce RJ, Kotsyfakis M, Rahnamaeian M, Vilcinskas A, Khalife J, Valdés JJ.

Front Microbiol. 2016 Oct 24;7:1682. eCollection 2016.

13.

Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni.

Marek M, Shaik TB, Duclaud S, Pierce RJ, Romier C.

Methods Mol Biol. 2016;1436:109-18. doi: 10.1007/978-1-4939-3667-0_8.

PMID:
27246211
14.

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.

Heimburg T, Chakrabarti A, Lancelot J, Marek M, Melesina J, Hauser AT, Shaik TB, Duclaud S, Robaa D, Erdmann F, Schmidt M, Romier C, Pierce RJ, Jung M, Sippl W.

J Med Chem. 2016 Mar 24;59(6):2423-35. doi: 10.1021/acs.jmedchem.5b01478. Epub 2016 Mar 14.

PMID:
26937828
15.

Combattre les maladies négligées en ciblant sélectivement leurs enzymes épigénétiques : le cas de la désacétylase 8 (HDAC8) de Schistosoma mansoni.

Marek M, Shaik TB, Jung M, Sippl W, Pierce RJ, Romier C.

Biol Aujourdhui. 2016;210(4):311-320. doi: 10.1051/jbio/2017001. Epub 2017 Mar 22. French.

PMID:
28327287
16.

The utility of automated measures of ocular metrics for detecting driver drowsiness during extended wakefulness.

Jackson ML, Kennedy GA, Clarke C, Gullo M, Swann P, Downey LA, Hayley AC, Pierce RJ, Howard ME.

Accid Anal Prev. 2016 Feb;87:127-33. doi: 10.1016/j.aap.2015.11.033. Epub 2015 Dec 10.

PMID:
26687538
17.

Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors.

Melesina J, Robaa D, Pierce RJ, Romier C, Sippl W.

J Mol Graph Model. 2015 Nov;62:342-361. doi: 10.1016/j.jmgm.2015.10.006. Epub 2015 Oct 19.

PMID:
26595183
18.

Fast evolutionary rates associated with functional loss in class I glucose transporters of Schistosoma mansoni.

Cabezas-Cruz A, Valdés JJ, Lancelot J, Pierce RJ.

BMC Genomics. 2015 Nov 19;16:980. doi: 10.1186/s12864-015-2144-6.

19.

HDAC8: a multifaceted target for therapeutic interventions.

Chakrabarti A, Oehme I, Witt O, Oliveira G, Sippl W, Romier C, Pierce RJ, Jung M.

Trends Pharmacol Sci. 2015 Jul;36(7):481-92. doi: 10.1016/j.tips.2015.04.013. Epub 2015 May 23. Review.

20.

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.

Marek M, Oliveira G, Pierce RJ, Jung M, Sippl W, Romier C.

Future Med Chem. 2015;7(6):783-800. doi: 10.4155/fmc.15.25. Review.

21.

Schistosome sirtuins as drug targets.

Lancelot J, Cabezas-Cruz A, Caby S, Marek M, Schultz J, Romier C, Sippl W, Jung M, Pierce RJ.

Future Med Chem. 2015;7(6):765-82. doi: 10.4155/fmc.15.24. Review.

22.

How has the genomics era impacted schistosomiasis drug discovery?

Oliveira G, Pierce RJ.

Future Med Chem. 2015;7(6):685-7. doi: 10.4155/fmc.15.30. No abstract available.

23.

Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni.

Schiedel M, Marek M, Lancelot J, Karaman B, Almlöf I, Schultz J, Sippl W, Pierce RJ, Romier C, Jung M.

J Biomol Screen. 2015 Jan;20(1):112-21. doi: 10.1177/1087057114555307. Epub 2014 Oct 16.

PMID:
25325257
24.

Epigenetic control of gene function in schistosomes: a source of therapeutic targets?

Cabezas-Cruz A, Lancelot J, Caby S, Oliveira G, Pierce RJ.

Front Genet. 2014 Sep 10;5:317. doi: 10.3389/fgene.2014.00317. eCollection 2014. Review.

25.

Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation.

Kannan S, Melesina J, Hauser AT, Chakrabarti A, Heimburg T, Schmidtkunz K, Walter A, Marek M, Pierce RJ, Romier C, Jung M, Sippl W.

J Chem Inf Model. 2014 Oct 27;54(10):3005-19. doi: 10.1021/ci5004653. Epub 2014 Oct 2.

PMID:
25243797
26.

Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis.

Carneiro VC, de Abreu da Silva IC, Torres EJ, Caby S, Lancelot J, Vanderstraete M, Furdas SD, Jung M, Pierce RJ, Fantappié MR.

PLoS Pathog. 2014 May 8;10(5):e1004116. doi: 10.1371/journal.ppat.1004116. eCollection 2014 May.

27.

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M.

J Mol Biol. 2014 Oct 9;426(20):3442-53. doi: 10.1016/j.jmb.2014.03.007. Epub 2014 Mar 20.

28.

Deterioration in driving performance during sleep deprivation is similar in professional and nonprofessional drivers.

Howard ME, Jackson ML, Swann P, Berlowitz DJ, Grunstein RR, Pierce RJ.

Traffic Inj Prev. 2014;15(2):132-7. doi: 10.1080/15389588.2013.800637.

PMID:
24345014
29.

Specific sleepiness symptoms are indicators of performance impairment during sleep deprivation.

Howard ME, Jackson ML, Berlowitz D, O'Donoghue F, Swann P, Westlake J, Wilkinson V, Pierce RJ.

Accid Anal Prev. 2014 Jan;62:1-8. doi: 10.1016/j.aap.2013.09.003. Epub 2013 Sep 13.

PMID:
24125802
30.

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.

Marek M, Kannan S, Hauser AT, Moraes Mourão M, Caby S, Cura V, Stolfa DA, Schmidtkunz K, Lancelot J, Andrade L, Renaud JP, Oliveira G, Sippl W, Jung M, Cavarelli J, Pierce RJ, Romier C.

PLoS Pathog. 2013;9(9):e1003645. doi: 10.1371/journal.ppat.1003645. Epub 2013 Sep 26.

31.

Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets.

Lancelot J, Caby S, Dubois-Abdesselem F, Vanderstraete M, Trolet J, Oliveira G, Bracher F, Jung M, Pierce RJ.

PLoS Negl Trop Dis. 2013 Sep 12;7(9):e2428. doi: 10.1371/journal.pntd.0002428. eCollection 2013.

32.

Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy.

Fréville A, Cailliau-Maggio K, Pierrot C, Tellier G, Kalamou H, Lafitte S, Martoriati A, Pierce RJ, Bodart JF, Khalife J.

BMC Biol. 2013 Jul 9;11:80. doi: 10.1186/1741-7007-11-80.

33.

Auto-titrating continuous positive airway pressure treatment for obstructive sleep apnoea after acute quadriplegia (COSAQ): study protocol for a randomized controlled trial.

Berlowitz DJ, Ayas N, Barnes M, Brown DJ, Cistulli PA, Geraghty T, Graham A, Lee BB, Morris M, O'Donoghue F, Rochford PD, Ross J, Singhal B, Spong J, Wadsworth B, Pierce RJ.

Trials. 2013 Jun 19;14:181. doi: 10.1186/1745-6215-14-181.

34.

Modeling the zing finger protein SmZF1 from Schistosoma mansoni: Insights into DNA binding and gene regulation.

Bitar M, Drummond MG, Costa MG, Lobo FP, Calzavara-Silva CE, Bisch PM, Machado CR, Macedo AM, Pierce RJ, Franco GR.

J Mol Graph Model. 2013 Feb;39:29-38. doi: 10.1016/j.jmgm.2012.10.004. Epub 2012 Oct 23.

PMID:
23220279
35.

Pilot study of remote telemonitoring in COPD.

Antoniades NC, Rochford PD, Pretto JJ, Pierce RJ, Gogler J, Steinkrug J, Sharpe K, McDonald CF.

Telemed J E Health. 2012 Oct;18(8):634-40. doi: 10.1089/tmj.2011.0231. Epub 2012 Sep 7.

PMID:
22957501
36.

Targeting schistosome histone modifying enzymes for drug development.

Pierce RJ, Dubois-Abdesselem F, Lancelot J, Andrade L, Oliveira G.

Curr Pharm Des. 2012;18(24):3567-78. Review.

PMID:
22607147
37.

Schistosoma mansoni histones: from transcription to chromatin regulation; an in silico analysis.

Anderson L, Pierce RJ, Verjovski-Almeida S.

Mol Biochem Parasitol. 2012 Jun;183(2):105-14. doi: 10.1016/j.molbiopara.2012.03.001. Epub 2012 Mar 10. Review.

PMID:
22414701
38.

Magnetic resonance spectroscopy and neurocognitive dysfunction in obstructive sleep apnea before and after CPAP treatment.

O'Donoghue FJ, Wellard RM, Rochford PD, Dawson A, Barnes M, Ruehland WR, Jackson ML, Howard ME, Pierce RJ, Jackson GD.

Sleep. 2012 Jan 1;35(1):41-8. doi: 10.5665/sleep.1582.

39.

Chromatin regulation in schistosomes and histone modifying enzymes as drug targets.

Pierce RJ, Dubois-Abdesselem F, Caby S, Trolet J, Lancelot J, Oger F, Bertheaume N, Roger E.

Mem Inst Oswaldo Cruz. 2011 Nov;106(7):794-801.

40.

Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection.

Pierrot C, dit Vampouille AA, Vandomme A, Lafitte S, Pierce RJ, Hot D, Khalife J.

Cell Microbiol. 2011 May;13(5):752-63. doi: 10.1111/j.1462-5822.2011.01574.x. Epub 2011 Feb 16.

PMID:
21323829
41.

The effect of sleep deprivation on BOLD activity elicited by a divided attention task.

Jackson ML, Hughes ME, Croft RJ, Howard ME, Crewther D, Kennedy GA, Owens K, Pierce RJ, O'Donoghue FJ, Johnston P.

Brain Imaging Behav. 2011 Jun;5(2):97-108. doi: 10.1007/s11682-011-9115-6.

PMID:
21271311
42.

Transcutaneous measurement of carbon dioxide tension during extended monitoring: evaluation of accuracy and stability, and an algorithm for correcting calibration drift.

Berlowitz DJ, Spong J, O'Donoghue FJ, Pierce RJ, Brown DJ, Campbell DA, Catcheside PG, Gordon I, Rochford PD.

Respir Care. 2011 Apr;56(4):442-8. doi: 10.4187/respcare.00454. Epub 2011 Jan 21.

43.

The 2007 AASM recommendations for EEG electrode placement in polysomnography: impact on sleep and cortical arousal scoring.

Ruehland WR, O'Donoghue FJ, Pierce RJ, Thornton AT, Singh P, Copland JM, Stevens B, Rochford PD.

Sleep. 2011 Jan 1;34(1):73-81.

44.

Vertebrate host protective immunity drives genetic diversity and antigenic polymorphism in Schistosoma mansoni.

Beltran S, Gourbal B, Boissier J, Duval D, Kieffer-Jaquinod S, Pierce RJ, Grunau C, Théron A, Mitta G.

J Evol Biol. 2011 Mar;24(3):554-72. doi: 10.1111/j.1420-9101.2010.02190.x. Epub 2010 Dec 16.

45.

Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni.

Baeza Garcia A, Pierce RJ, Gourbal B, Werkmeister E, Colinet D, Reichhart JM, Dissous C, Coustau C.

PLoS Pathog. 2010 Sep 23;6(9):e1001115. doi: 10.1371/journal.ppat.1001115.

46.

Changes in brain morphology in patients with obstructive sleep apnoea.

Morrell MJ, Jackson ML, Twigg GL, Ghiassi R, McRobbie DW, Quest RA, Pardoe H, Pell GS, Abbott DF, Rochford PD, Jackson GD, Pierce RJ, O'Donoghue FJ, Corfield DR.

Thorax. 2010 Oct;65(10):908-14. doi: 10.1136/thx.2009.126730.

47.

[Schistosome genomes: a key step in the war on the worm].

Pierce RJ, Mitta G, Roger E.

Med Sci (Paris). 2009 Aug-Sep;25(8-9):761-2. doi: 10.1051/medsci/2009258-9761. French. No abstract available.

48.

The genome of the blood fluke Schistosoma mansoni.

Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey CR, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM.

Nature. 2009 Jul 16;460(7253):352-8. doi: 10.1038/nature08160.

49.

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni.

Dubois F, Caby S, Oger F, Cosseau C, Capron M, Grunau C, Dissous C, Pierce RJ.

Mol Biochem Parasitol. 2009 Nov;168(1):7-15. doi: 10.1016/j.molbiopara.2009.06.001. Epub 2009 Jun 16.

PMID:
19538992
50.

The feasibility of using auto-titrating continuous positive airway pressure to treat obstructive sleep apnoea after acute tetraplegia.

Berlowitz DJ, Spong J, Pierce RJ, Ross J, Barnes M, Brown DJ.

Spinal Cord. 2009 Dec;47(12):868-73. doi: 10.1038/sc.2009.56. Epub 2009 Jun 2.

PMID:
19488050

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