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Items: 7


Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition.

Winfield HJ, Cahill MM, O'Shea KD, Pierce LT, Robert T, Ruchaud S, Bach S, Marchand P, McCarthy FO.

Bioorg Med Chem. 2018 Aug 7;26(14):4209-4224. doi: 10.1016/j.bmc.2018.07.012. Epub 2018 Jul 9.


Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates.

Cahill MM, O'Shea KD, Pierce LT, Winfield HJ, Eccles KS, Lawrence SE, McCarthy FO.

Pharmaceuticals (Basel). 2017 Jul 5;10(3). pii: E62. doi: 10.3390/ph10030062.


A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.

Johansen LM, DeWald LE, Shoemaker CJ, Hoffstrom BG, Lear-Rooney CM, Stossel A, Nelson E, Delos SE, Simmons JA, Grenier JM, Pierce LT, Pajouhesh H, Lehár J, Hensley LE, Glass PJ, White JM, Olinger GG.

Sci Transl Med. 2015 Jun 3;7(290):290ra89. doi: 10.1126/scitranslmed.aaa5597.


Improving the Efficiency of Free Energy Calculations in the Amber Molecular Dynamics Package.

Kaus JW, Pierce LT, Walker RC, McCammont JA.

J Chem Theory Comput. 2013 Sep 10;9(9). doi: 10.1021/ct400340s.


Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents.

Pierce LT, Cahill MM, Winfield HJ, McCarthy FO.

Eur J Med Chem. 2012 Oct;56:292-300. doi: 10.1016/j.ejmech.2012.08.002. Epub 2012 Aug 10.


Adenosine A2A and beta-2 adrenergic receptor agonists: novel selective and synergistic multiple myeloma targets discovered through systematic combination screening.

Rickles RJ, Tam WF, Giordano TP 3rd, Pierce LT, Farwell M, McMillin DW, Necheva A, Crowe D, Chen M, Avery W, Kansra V, Nawrocki ST, Carew JS, Giles FJ, Mitsiades CS, Borisy AA, Anderson KC, Lee MS.

Mol Cancer Ther. 2012 Jul;11(7):1432-42. doi: 10.1158/1535-7163.MCT-11-0925. Epub 2012 Apr 3.


Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies.

Rickles RJ, Pierce LT, Giordano TP 3rd, Tam WF, McMillin DW, Delmore J, Laubach JP, Borisy AA, Richardson PG, Lee MS.

Blood. 2010 Jul 29;116(4):593-602. doi: 10.1182/blood-2009-11-252668. Epub 2010 Apr 9.


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