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Human megakaryocytes possess intrinsic anti-viral immunity through regulated induction of IFITM3.

Campbell RA, Schwertz H, Hottz ED, Rowley JW, Manne BK, Washington AV, Hunter-Mellado R, Tolley ND, Christensen M, Eustes AS, Montenont E, Bhatlekar S, Ventrone CH, Kirkpatrick BD, Pierce KK, Whitehead SS, Diehl SA, Bray PF, Zimmerman GA, Kosaka Y, Bozza PT, Bozza FA, Weyrich AS, Rondina MT.

Blood. 2019 Feb 5. pii: blood-2018-09-873984. doi: 10.1182/blood-2018-09-873984. [Epub ahead of print]


Whole Transcriptome Analysis of Renal Intercalated Cells Predicts Lipopolysaccharide Mediated Inhibition of Retinoid X Receptor alpha Function.

Saxena V, Fitch J, Ketz J, White P, Wetzel A, Chanley MA, Spencer JD, Becknell B, Pierce KR, Arregui SW, Nelson RD, Schwartz GJ, Velazquez V, Walker LA, Chen X, Yan P, Hains DS, Schwaderer AL.

Sci Rep. 2019 Jan 24;9(1):545. doi: 10.1038/s41598-018-36921-z.


Effect of dietary n-3 polyunsaturated fatty acid supplementation and post-insemination plane of nutrition on systemic concentrations of metabolic analytes, progesterone, hepatic gene expression and embryo development and survival in beef heifers.

Doyle DN, Lonergan P, Diskin MG, Pierce KM, Kelly AK, Stanton C, Waters SM, Parr MH, Kenny DA.

Theriogenology. 2019 Mar 15;127:102-113. doi: 10.1016/j.theriogenology.2018.12.037. Epub 2018 Dec 26.


Alcoholism as a predictor for pseudarthrosis in primary spine fusion: An analysis of risk factors and 30-day outcomes for 52,402 patients from 2005 to 2013.

Passias PG, Bortz C, Alas H, Segreto FA, Horn SR, Ihejirika YU, Vasquez-Montes D, Pierce KE, Brown AE, Shenoy K, DelSole EM, Johnson B, Oh C, Zhou PL, Deflorimonte C, Dhillon ES, Jankowski PP, Diebo BG, Lafage V, Lafage R, Vira SN, Bendo JA, Goldstein JA, Schwab FJ, Gerling MC.

J Orthop. 2018 Dec 20;16(1):36-40. doi: 10.1016/j.jor.2018.12.011. eCollection 2019 Jan-Feb.


Milk production of Holstein-Friesian cows of divergent Economic Breeding Index evaluated under seasonal pasture-based management.

O'Sullivan M, Horan B, Pierce KM, McParland S, O'Sullivan K, Buckley F.

J Dairy Sci. 2019 Mar;102(3):2560-2577. doi: 10.3168/jds.2018-15559. Epub 2019 Jan 3.


Comprehensive cross-disorder analyses of CNTNAP2 suggest it is unlikely to be a primary risk gene for psychiatric disorders.

Toma C, Pierce KD, Shaw AD, Heath A, Mitchell PB, Schofield PR, Fullerton JM.

PLoS Genet. 2018 Dec 26;14(12):e1007535. doi: 10.1371/journal.pgen.1007535. eCollection 2018 Dec.


The effect of by-product inclusion and concentrate feeding rate on milk production and composition, pasture dry matter intake, and nitrogen excretion of mid-late lactation spring-calving cows grazing a perennial ryegrass-based pasture.

Condren SA, Kelly AK, Lynch MB, Boland TM, Whelan SJ, Grace C, Rajauria G, Pierce KM.

J Dairy Sci. 2019 Feb;102(2):1247-1256. doi: 10.3168/jds.2018-14970. Epub 2018 Dec 20.


Gut microbiome structure and metabolic activity in inflammatory bowel disease.

Franzosa EA, Sirota-Madi A, Avila-Pacheco J, Fornelos N, Haiser HJ, Reinker S, Vatanen T, Hall AB, Mallick H, McIver LJ, Sauk JS, Wilson RG, Stevens BW, Scott JM, Pierce K, Deik AA, Bullock K, Imhann F, Porter JA, Zhernakova A, Fu J, Weersma RK, Wijmenga C, Clish CB, Vlamakis H, Huttenhower C, Xavier RJ.

Nat Microbiol. 2019 Feb;4(2):293-305. doi: 10.1038/s41564-018-0306-4. Epub 2018 Dec 10.


Software-Assisted Manual Review of Clinical Next-Generation Sequencing Data: An Alternative to Routine Sanger Sequencing Confirmation with Equivalent Results in >15,000 Germline DNA Screens.

Muzzey D, Kash S, Johnson JI, Melroy LM, Kaleta P, Pierce KA, Ready K, Kang HP, Haas KR.

J Mol Diagn. 2018 Dec 4. pii: S1525-1578(18)30175-2. doi: 10.1016/j.jmoldx.2018.10.002. [Epub ahead of print]


Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.

Lombardo MV, Pramparo T, Gazestani V, Warrier V, Bethlehem RAI, Carter Barnes C, Lopez L, Lewis NE, Eyler L, Pierce K, Courchesne E.

Nat Neurosci. 2018 Dec;21(12):1680-1688. doi: 10.1038/s41593-018-0281-3. Epub 2018 Nov 26.


Decreased rates of 30-day perioperative complications following ASD-corrective surgery: A modified Clavien analysis of 3300 patients from 2010 to 2014.

Passias PG, Bortz CA, Pierce KE, Segreto FA, Horn SR, Vasquez-Montes D, Lafage V, Brown AE, Ihejirika Y, Alas H, Varlotta C, Ge DH, Shepard N, Oh C, DelSole EM, Jankowski PP, Hockley A, Diebo BG, Vira SN, Sciubba DM, Raad M, Neuman BJ, Gerling MC.

J Clin Neurosci. 2019 Mar;61:147-152. doi: 10.1016/j.jocn.2018.10.104. Epub 2018 Nov 10.


Case 23-2018: A Man with Episodes of Confusion and Hypoglycemia.

Wexler DJ, Pierce KJ.

N Engl J Med. 2018 Nov 8;379(19):1882. doi: 10.1056/NEJMc1811310. No abstract available.


Cumulative and Differential Effects of Early Child Care and Middle Childhood Out-of-School Time on Adolescent Functioning.

Vandell DL, Lee KTH, Whitaker AA, Pierce KM.

Child Dev. 2018 Aug 28. doi: 10.1111/cdev.13136. [Epub ahead of print]


The circulating metabolome of human starvation.

Steinhauser ML, Olenchock BA, O'Keefe J, Lun M, Pierce KA, Lee H, Pantano L, Klibanski A, Shulman GI, Clish CB, Fazeli PK.

JCI Insight. 2018 Aug 23;3(16). pii: 121434. doi: 10.1172/jci.insight.121434. [Epub ahead of print]


Case 23-2018: A 36-Year-Old Man with Episodes of Confusion and Hypoglycemia.

Wexler DJ, Macias-Konstantopoulos W, Forcione DG, Xiong L, Cauley CE, Pierce KJ.

N Engl J Med. 2018 Jul 26;379(4):376-385. doi: 10.1056/NEJMcpc1802828. No abstract available.


Accumulation of succinate controls activation of adipose tissue thermogenesis.

Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET.

Nature. 2018 Aug;560(7716):102-106. doi: 10.1038/s41586-018-0353-2. Epub 2018 Jul 18.


The ASD Living Biology: from cell proliferation to clinical phenotype.

Courchesne E, Pramparo T, Gazestani VH, Lombardo MV, Pierce K, Lewis NE.

Mol Psychiatry. 2019 Jan;24(1):88-107. doi: 10.1038/s41380-018-0056-y. Epub 2018 Jun 22. Review.


Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma.

Gopal RK, Calvo SE, Shih AR, Chaves FL, McGuone D, Mick E, Pierce KA, Li Y, Garofalo A, Van Allen EM, Clish CB, Oliva E, Mootha VK.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6283-E6290. doi: 10.1073/pnas.1711888115. Epub 2018 Jun 18.


Social Support, Family Empowerment, Substance Use, and Perceived Parenting Competency during Pregnancy for Women with Substance Use Disorders.

Chou JL, Pierce KJ, Pennington LB, Seiler R, Michael J, Mc Namara D, Zand D.

Subst Use Misuse. 2018 Nov 10;53(13):2250-2256. doi: 10.1080/10826084.2018.1467456. Epub 2018 May 14.


Naturalistic language sampling to characterize the language abilities of 3-year-olds with autism spectrum disorder.

Bacon EC, Osuna S, Courchesne E, Pierce K.

Autism. 2018 May 1:1362361318766241. doi: 10.1177/1362361318766241. [Epub ahead of print]


Paternally inherited cis-regulatory structural variants are associated with autism.

Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J.

Science. 2018 Apr 20;360(6386):327-331. doi: 10.1126/science.aan2261.


Implementing systems-based innovations to improve access to early screening, diagnosis, and treatment services for children with autism spectrum disorder: An Autism Spectrum Disorder Pediatric, Early Detection, Engagement, and Services network study.

Broder Fingert S, Carter A, Pierce K, Stone WL, Wetherby A, Scheldrick C, Smith C, Bacon E, James SN, Ibañez L, Feinberg E.

Autism. 2018 Apr 1:1362361318766238. doi: 10.1177/1362361318766238. [Epub ahead of print]


The geometric preference subtype in ASD: identifying a consistent, early-emerging phenomenon through eye tracking.

Moore A, Wozniak M, Yousef A, Barnes CC, Cha D, Courchesne E, Pierce K.

Mol Autism. 2018 Mar 21;9:19. doi: 10.1186/s13229-018-0202-z. eCollection 2018.


An examination of multiple classes of rare variants in extended families with bipolar disorder.

Toma C, Shaw AD, Allcock RJN, Heath A, Pierce KD, Mitchell PB, Schofield PR, Fullerton JM.

Transl Psychiatry. 2018 Mar 13;8(1):65. doi: 10.1038/s41398-018-0113-y.


Authors' Reply to Buckner et al.: 'Comment on: "The General Adaptation Syndrome: A Foundation for the Concept of Periodization".

Cunanan AJ, DeWeese BH, Wagle JP, Carroll KM, Sausaman R, Hornsby WG 3rd, Haff GG, Triplett NT, Pierce KC, Stone MH.

Sports Med. 2018 Jul;48(7):1755-1757. doi: 10.1007/s40279-018-0884-6. No abstract available.


Metabolic Predictors of Incident Coronary Heart Disease in Women.

Paynter NP, Balasubramanian R, Giulianini F, Wang DD, Tinker LF, Gopal S, Deik AA, Bullock K, Pierce KA, Scott J, Martínez-González MA, Estruch R, Manson JE, Cook NR, Albert CM, Clish CB, Rexrode KM.

Circulation. 2018 Feb 20;137(8):841-853. doi: 10.1161/CIRCULATIONAHA.117.029468.


Metabolomics signatures associated with an oral glucose challenge in pregnant women.

Gelaye B, Clish CB, Denis M, Larrabure G, Tadesse MG, Deik A, Pierce K, Bullock K, Dennis C, Enquobahrie DA, Williams MA.

Diabetes Metab. 2019 Jan;45(1):39-46. doi: 10.1016/j.diabet.2018.01.004. Epub 2018 Jan 11.


The General Adaptation Syndrome: A Foundation for the Concept of Periodization.

Cunanan AJ, DeWeese BH, Wagle JP, Carroll KM, Sausaman R, Hornsby WG 3rd, Haff GG, Triplett NT, Pierce KC, Stone MH.

Sports Med. 2018 Apr;48(4):787-797. doi: 10.1007/s40279-017-0855-3. Review.


Multi-year evaluation of stocking rate and animal genotype on milk production per hectare within intensive pasture-based production systems.

Coffey EL, Delaby L, Fleming C, Pierce KM, Horan B.

J Dairy Sci. 2018 Mar;101(3):2448-2462. doi: 10.3168/jds.2017-13632. Epub 2017 Dec 14.


A Pilot of a Brief Positive Parenting Program on Children Newly Diagnosed with Autism Spectrum Disorder.

Zand DH, Bultas MW, McMillin SE, Halloran D, White T, McNamara D, Pierce KJ.

Fam Process. 2018 Dec;57(4):901-914. doi: 10.1111/famp.12334. Epub 2017 Dec 14.


Elucidation of Renal Scars in Children With Vesicoureteral Reflux Using Contrast-Enhanced Ultrasound: A Pilot Study.

Hains DS, Cohen HL, McCarville MB, Ellison EE, Huffman A, Glass S, Qureshi AH, Pierce KR, Cahill AL, Dixon A, Santos ND.

Kidney Int Rep. 2017 Jan 26;2(3):420-424. doi: 10.1016/j.ekir.2017.01.008. eCollection 2017 May.


Enhancing early psychosis treatment using smartphone technology: A longitudinal feasibility and validity study.

Niendam TA, Tully LM, Iosif AM, Kumar D, Nye KE, Denton JC, Zakskorn LN, Fedechko TL, Pierce KM.

J Psychiatr Res. 2018 Jan;96:239-246. doi: 10.1016/j.jpsychires.2017.10.017. Epub 2017 Oct 21.


A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer.

Wainberg ZA, Alsina M, Soares HP, Braña I, Britten CD, Del Conte G, Ezeh P, Houk B, Kern KA, Leong S, Pathan N, Pierce KJ, Siu LL, Vermette J, Tabernero J.

Target Oncol. 2017 Dec;12(6):775-785. doi: 10.1007/s11523-017-0530-5.


Rethinking the idea of late autism spectrum disorder onset.

Bacon EC, Courchesne E, Barnes CC, Cha D, Pence S, Schreibman L, Stahmer AC, Pierce K.

Dev Psychopathol. 2018 May;30(2):553-569. doi: 10.1017/S0954579417001067. Epub 2017 Aug 14.


Effect of stocking rate and animal genotype on dry matter intake, milk production, body weight, and body condition score in spring-calving, grass-fed dairy cows.

Coffey EL, Delaby L, Fitzgerald S, Galvin N, Pierce KM, Horan B.

J Dairy Sci. 2017 Sep;100(9):7556-7568. doi: 10.3168/jds.2017-12672. Epub 2017 Jun 28.


Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.

Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH; MEDIA Consortium; SIGMA T2D Consortium, Centeno-Cruz F, Zerrweck C, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES.

Cell. 2017 Jun 29;170(1):199-212.e20. doi: 10.1016/j.cell.2017.06.011.


Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains.

Geisheker MR, Heymann G, Wang T, Coe BP, Turner TN, Stessman HAF, Hoekzema K, Kvarnung M, Shaw M, Friend K, Liebelt J, Barnett C, Thompson EM, Haan E, Guo H, Anderlid BM, Nordgren A, Lindstrand A, Vandeweyer G, Alberti A, Avola E, Vinci M, Giusto S, Pramparo T, Pierce K, Nalabolu S, Michaelson JJ, Sedlacek Z, Santen GWE, Peeters H, Hakonarson H, Courchesne E, Romano C, Kooy RF, Bernier RA, Nordenskjöld M, Gecz J, Xia K, Zweifel LS, Eichler EE.

Nat Neurosci. 2017 Aug;20(8):1043-1051. doi: 10.1038/nn.4589. Epub 2017 Jun 19.


Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration.

Rowan S, Jiang S, Korem T, Szymanski J, Chang ML, Szelog J, Cassalman C, Dasuri K, McGuire C, Nagai R, Du XL, Brownlee M, Rabbani N, Thornalley PJ, Baleja JD, Deik AA, Pierce KA, Scott JM, Clish CB, Smith DE, Weinberger A, Avnit-Sagi T, Lotan-Pompan M, Segal E, Taylor A.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4472-E4481. doi: 10.1073/pnas.1702302114. Epub 2017 May 15.


In a randomized trial, the live attenuated tetravalent dengue vaccine TV003 is well-tolerated and highly immunogenic in subjects with flavivirus exposure prior to vaccination.

Whitehead SS, Durbin AP, Pierce KK, Elwood D, McElvany BD, Fraser EA, Carmolli MP, Tibery CM, Hynes NA, Jo M, Lovchik JM, Larsson CJ, Doty EA, Dickson DM, Luke CJ, Subbarao K, Diehl SA, Kirkpatrick BD.

PLoS Negl Trop Dis. 2017 May 8;11(5):e0005584. doi: 10.1371/journal.pntd.0005584. eCollection 2017 May.


Cell-specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct.

Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F812-F823. doi: 10.1152/ajprenal.00512.2016. Epub 2017 May 3.


Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging.

Salminen LE, Schofield PR, Pierce KD, Bruce SE, Griffin MG, Tate DF, Cabeen RP, Laidlaw DH, Conturo TE, Bolzenius JD, Paul RH.

Behav Brain Res. 2017 Jun 30;329:111-119. doi: 10.1016/j.bbr.2017.04.041. Epub 2017 Apr 27.


Association between Survival Time and Changes in NT-proBNP in Cats Treated for Congestive Heart Failure.

Pierce KV, Rush JE, Freeman LM, Cunningham SM, Yang VK.

J Vet Intern Med. 2017 May;31(3):678-684. doi: 10.1111/jvim.14690. Epub 2017 Mar 31.


Parenting self-efficacy and empowerment among expectant mothers with substance use disorders.

Zand DH, Chou JL, Pierce KJ, Pennington LB, Dickens RR, Michael J, McNamara D, White T.

Midwifery. 2017 May;48:32-38. doi: 10.1016/j.midw.2017.03.003. Epub 2017 Mar 7.


Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers.

Fingher N, Dinstein I, Ben-Shachar M, Haar S, Dale AM, Eyler L, Pierce K, Courchesne E.

Cortex. 2017 Dec;97:291-305. doi: 10.1016/j.cortex.2016.12.024. Epub 2017 Jan 23.


Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases.

Stessman HA, Xiong B, Coe BP, Wang T, Hoekzema K, Fenckova M, Kvarnung M, Gerdts J, Trinh S, Cosemans N, Vives L, Lin J, Turner TN, Santen G, Ruivenkamp C, Kriek M, van Haeringen A, Aten E, Friend K, Liebelt J, Barnett C, Haan E, Shaw M, Gecz J, Anderlid BM, Nordgren A, Lindstrand A, Schwartz C, Kooy RF, Vandeweyer G, Helsmoortel C, Romano C, Alberti A, Vinci M, Avola E, Giusto S, Courchesne E, Pramparo T, Pierce K, Nalabolu S, Amaral DG, Scheffer IE, Delatycki MB, Lockhart PJ, Hormozdiari F, Harich B, Castells-Nobau A, Xia K, Peeters H, Nordenskjöld M, Schenck A, Bernier RA, Eichler EE.

Nat Genet. 2017 Apr;49(4):515-526. doi: 10.1038/ng.3792. Epub 2017 Feb 13.


A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers.

Pierce KK, Whitehead SS, Kirkpatrick BD, Grier PL, Jarvis A, Kenney H, Carmolli MP, Reynolds C, Tibery CM, Lovchik J, Janiak A, Luke CJ, Durbin AP, Pletnev AG.

J Infect Dis. 2017 Jan 1;215(1):52-55. doi: 10.1093/infdis/jiw501. Epub 2016 Oct 25.


The effect of by-product inclusion level on milk production, nutrient digestibility and excretion, and rumen fermentation parameters in lactating dairy cows offered a pasture-based diet.

Whelan SJ, Carey W, Boland TM, Lynch MB, Kelly AK, Rajauria G, Pierce KM.

J Dairy Sci. 2017 Feb;100(2):1055-1062. doi: 10.3168/jds.2016-11600. Epub 2016 Dec 14.


The course of achalasia one to four decades after initial treatment.

Sawas T, Ravi K, Geno DM, Enders F, Pierce K, Wigle D, Katzka DA.

Aliment Pharmacol Ther. 2017 Feb;45(4):553-560. doi: 10.1111/apt.13888. Epub 2016 Dec 7.


Clinical Genotyping of Non-Small Cell Lung Cancers Using Targeted Next-Generation Sequencing: Utility of Identifying Rare and Co-mutations in Oncogenic Driver Genes.

Tafe LJ, Pierce KJ, Peterson JD, de Abreu F, Memoli VA, Black CC, Pettus JR, Marotti JD, Gutmann EJ, Liu X, Shirai K, Dragnev KH, Amos CI, Tsongalis GJ.

Neoplasia. 2016 Sep;18(9):577-83. doi: 10.1016/j.neo.2016.07.010.

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