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Items: 38

1.

pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry.

Jones GN, Rooney C, Griffin N, Roudier M, Young LA, Garcia-Trinidad A, Hughes GD, Whiteaker JR, Wilson Z, Odedra R, Zhao L, Ivey RG, Howat WJ, Harrington EA, Barrett JC, Ramos-Montoya A, Lau A, Paulovich AG, Cadogan EB, Pierce AJ.

Br J Cancer. 2018 Nov;119(10):1233-1243. doi: 10.1038/s41416-018-0286-4. Epub 2018 Nov 2.

PMID:
30385821
2.

Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition.

Zhong H, Chen C, Tammali R, Breen S, Zhang J, Fazenbaker C, Kennedy M, Conway J, Higgs BW, Holoweckyj N, Raja R, Harper J, Pierce AJ, Herbst R, Tice DA.

Mol Cancer Ther. 2019 Jan;18(1):89-99. doi: 10.1158/1535-7163.MCT-18-0314. Epub 2018 Oct 23.

PMID:
30352801
3.

Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein.

Oberst MD, Augé C, Morris C, Kentner S, Mulgrew K, McGlinchey K, Hair J, Hanabuchi S, Du Q, Damschroder M, Feng H, Eck S, Buss N, de Haan L, Pierce AJ, Park H, Sylwester A, Axthelm MK, Picker L, Morris NP, Weinberg A, Hammond SA.

Mol Cancer Ther. 2018 May;17(5):1024-1038. doi: 10.1158/1535-7163.MCT-17-0200. Epub 2018 Mar 15.

4.

Draft Whole-Genome Sequence of Deinococcus sp. UR1, a Putative Novel Species Isolated from an External Stainless Steel Surface in the Canadian Prairies.

Suchan DM, Steve JJ, Pierce AJ, Olshefsky SC, Kirzinger MWB, Perry BJ, Cameron ADS, Yost CK.

Genome Announc. 2018 Jan 11;6(2). pii: e01407-17. doi: 10.1128/genomeA.01407-17.

5.

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.

Morgado-Palacin I, Day A, Murga M, Lafarga V, Anton ME, Tubbs A, Chen HT, Ergan A, Anderson R, Bhandoola A, Pike KG, Barlaam B, Cadogan E, Wang X, Pierce AJ, Hubbard C, Armstrong SA, Nussenzweig A, Fernandez-Capetillo O.

Sci Signal. 2016 Sep 13;9(445):ra91. doi: 10.1126/scisignal.aad8243.

6.

ATM protein is deficient in over 40% of lung adenocarcinomas.

Villaruz LC, Jones H, Dacic S, Abberbock S, Kurland BF, Stabile LP, Siegfried JM, Conrads TP, Smith NR, O'Connor MJ, Pierce AJ, Bakkenist CJ.

Oncotarget. 2016 Sep 6;7(36):57714-57725. doi: 10.18632/oncotarget.9757.

7.

A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways.

Rios-Doria J, Sabol D, Chesebrough J, Stewart D, Xu L, Tammali R, Cheng L, Du Q, Schifferli K, Rothstein R, Leow CC, Heidbrink-Thompson J, Jin X, Gao C, Friedman J, Wilkinson B, Damschroder M, Pierce AJ, Hollingsworth RE, Tice DA, Michelotti EF.

Mol Cancer Ther. 2015 Jul;14(7):1637-49. doi: 10.1158/1535-7163.MCT-14-1040. Epub 2015 May 6.

8.

Clinical evaluation of pazopanib eye drops versus ranibizumab intravitreal injections in subjects with neovascular age-related macular degeneration.

Csaky KG, Dugel PU, Pierce AJ, Fries MA, Kelly DS, Danis RP, Wurzelmann JI, Xu CF, Hossain M, Trivedi T.

Ophthalmology. 2015 Mar;122(3):579-88. doi: 10.1016/j.ophtha.2014.09.036. Epub 2014 Nov 26.

PMID:
25432081
9.

Measuring recombination proficiency in mouse embryonic stem cells.

Pierce AJ, Jasin M.

Methods Mol Biol. 2014;1105:481-95. doi: 10.1007/978-1-62703-739-6_34.

PMID:
24623248
10.

The gene cluster instability (GCI) assay for recombination.

Killen MW, Stults DM, Pierce AJ.

Methods Mol Biol. 2014;1105:457-79. doi: 10.1007/978-1-62703-739-6_33.

PMID:
24623247
11.

The sister chromatid exchange (SCE) assay.

Stults DM, Killen MW, Pierce AJ.

Methods Mol Biol. 2014;1105:439-55. doi: 10.1007/978-1-62703-739-6_32.

PMID:
24623246
12.

Escherichia coli RecG functionally suppresses human Bloom syndrome phenotypes.

Killen MW, Stults DM, Wilson WA, Pierce AJ.

BMC Mol Biol. 2012 Oct 30;13:33. doi: 10.1186/1471-2199-13-33.

13.

Plant-frugivore interactions in an intact tropical forest in north-east Thailand.

Sankamethawee W, Pierce AJ, Gale GA, Hardesty BD.

Integr Zool. 2011 Sep;6(3):195-212. doi: 10.1111/j.1749-4877.2011.00244.x.

PMID:
21910839
14.

Configuration and rearrangement of the human GAGE gene clusters.

Killen MW, Taylor TL, Stults DM, Jin W, Wang LL, Moscow JA, Pierce AJ.

Am J Transl Res. 2011 May 15;3(3):234-42. Epub 2011 May 8.

15.

Recombination phenotypes of the NCI-60 collection of human cancer cells.

Stults DM, Killen MW, Shelton BJ, Pierce AJ.

BMC Mol Biol. 2011 May 17;12:23. doi: 10.1186/1471-2199-12-23.

16.
17.

The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion.

Rajesh C, Baker DK, Pierce AJ, Pittman DL.

Nucleic Acids Res. 2011 Jan;39(1):132-45. doi: 10.1093/nar/gkq738. Epub 2010 Sep 2.

18.

MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.

Singh TR, Saro D, Ali AM, Zheng XF, Du CH, Killen MW, Sachpatzidis A, Wahengbam K, Pierce AJ, Xiong Y, Sung P, Meetei AR.

Mol Cell. 2010 Mar 26;37(6):879-86. doi: 10.1016/j.molcel.2010.01.036.

19.

Human rRNA gene clusters are recombinational hotspots in cancer.

Stults DM, Killen MW, Williamson EP, Hourigan JS, Vargas HD, Arnold SM, Moscow JA, Pierce AJ.

Cancer Res. 2009 Dec 1;69(23):9096-104. doi: 10.1158/0008-5472.CAN-09-2680. Epub 2009 Nov 17.

20.

Loss of Bloom syndrome protein destabilizes human gene cluster architecture.

Killen MW, Stults DM, Adachi N, Hanakahi L, Pierce AJ.

Hum Mol Genet. 2009 Sep 15;18(18):3417-28. doi: 10.1093/hmg/ddp282. Epub 2009 Jun 19.

PMID:
19542097
21.

Loss of 26S proteasome function leads to increased cell size and decreased cell number in Arabidopsis shoot organs.

Kurepa J, Wang S, Li Y, Zaitlin D, Pierce AJ, Smalle JA.

Plant Physiol. 2009 May;150(1):178-89. doi: 10.1104/pp.109.135970. Epub 2009 Mar 25.

22.

Genomic architecture and inheritance of human ribosomal RNA gene clusters.

Stults DM, Killen MW, Pierce HH, Pierce AJ.

Genome Res. 2008 Jan;18(1):13-8. Epub 2007 Nov 19.

23.

Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.

Bindra RS, Gibson SL, Meng A, Westermark U, Jasin M, Pierce AJ, Bristow RG, Classon MK, Glazer PM.

Cancer Res. 2005 Dec 15;65(24):11597-604.

24.

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.

Nakanishi K, Yang YG, Pierce AJ, Taniguchi T, Digweed M, D'Andrea AD, Wang ZQ, Jasin M.

Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1110-5. Epub 2005 Jan 13.

25.

Measuring recombination proficiency in mouse embryonic stem cells.

Pierce AJ, Jasin M.

Methods Mol Biol. 2005;291:373-84.

PMID:
15502236
26.

Genetic steps of mammalian homologous repair with distinct mutagenic consequences.

Stark JM, Pierce AJ, Oh J, Pastink A, Jasin M.

Mol Cell Biol. 2004 Nov;24(21):9305-16.

27.

Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks.

Araujo FD, Pierce AJ, Stark JM, Jasin M.

Oncogene. 2002 Jun 13;21(26):4176-80.

28.

ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair.

Stark JM, Hu P, Pierce AJ, Moynahan ME, Ellis N, Jasin M.

J Biol Chem. 2002 Jun 7;277(23):20185-94. Epub 2002 Mar 28.

29.

Gene conversion is strongly induced in human cells by double-strand breaks and is modulated by the expression of BCL-x(L).

Wiese C, Pierce AJ, Gauny SS, Jasin M, Kronenberg A.

Cancer Res. 2002 Mar 1;62(5):1279-83.

30.

NHEJ deficiency and disease.

Pierce AJ, Jasin M.

Mol Cell. 2001 Dec;8(6):1160-1.

31.

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells.

Pierce AJ, Hu P, Han M, Ellis N, Jasin M.

Genes Dev. 2001 Dec 15;15(24):3237-42.

32.

Double-strand breaks and tumorigenesis.

Pierce AJ, Stark JM, Araujo FD, Moynahan ME, Berwick M, Jasin M.

Trends Cell Biol. 2001 Nov;11(11):S52-9. Review.

PMID:
11684443
33.

BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.

Slupianek A, Schmutte C, Tombline G, Nieborowska-Skorska M, Hoser G, Nowicki MO, Pierce AJ, Fishel R, Skorski T.

Mol Cell. 2001 Oct;8(4):795-806.

34.

BRCA2 is required for homology-directed repair of chromosomal breaks.

Moynahan ME, Pierce AJ, Jasin M.

Mol Cell. 2001 Feb;7(2):263-72.

35.

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.

Pierce AJ, Johnson RD, Thompson LH, Jasin M.

Genes Dev. 1999 Oct 15;13(20):2633-8.

36.

DNA polymerase delta is required for human mismatch repair in vitro.

Longley MJ, Pierce AJ, Modrich P.

J Biol Chem. 1997 Apr 18;272(16):10917-21.

37.

Transcription from TATA-less promoters: dihydrofolate reductase as a model.

Azizkhan JC, Jensen DE, Pierce AJ, Wade M.

Crit Rev Eukaryot Gene Expr. 1993;3(4):229-54. Review.

PMID:
8286846
38.

A conserved DNA structural control element modulates transcription of a mammalian gene.

Pierce AJ, Jambou RC, Jensen DE, Azizkhan JC.

Nucleic Acids Res. 1992 Dec 25;20(24):6583-7.

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