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Antibody recognition of bacterial surfaces and extracellular polysaccharides.

Soliman C, Pier GB, Ramsland PA.

Curr Opin Struct Biol. 2019 Dec 21;62:48-55. doi: 10.1016/ [Epub ahead of print] Review.


A Conserved Streptococcal Virulence Regulator Controls the Expression of a Distinct Class of M-Like Proteins.

D'Gama JD, Ma Z, Zhang H, Liu X, Fan H, Morris ERA, Cohen ND, Cywes-Bentley C, Pier GB, Waldor MK.

mBio. 2019 Oct 22;10(5). pii: e02500-19. doi: 10.1128/mBio.02500-19.


Immunization against poly-N-acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity.

Hülsdünker J, Thomas OS, Haring E, Unger S, Gonzalo Núñez N, Tugues S, Gao Z, Duquesne S, Cywes-Bentley C, Oyardi O, Kirschnek S, Schmitt-Graeff A, Pabst O, Koenecke C, Duyster J, Apostolova P, Blaser MJ, Becher B, Pier GB, Häcker G, Zeiser R.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20700-20706. doi: 10.1073/pnas.1908549116. Epub 2019 Sep 16.


In vitro evaluation of complement deposition and opsonophagocytic killing of Rhodococcus equi mediated by poly-N-acetyl glucosamine hyperimmune plasma compared to commercial plasma products.

Folmar CN, Cywes-Bentley C, Bordin AI, Rocha JN, Bray JM, Kahn SK, Schuckert AE, Pier GB, Cohen ND.

J Vet Intern Med. 2019 May;33(3):1493-1499. doi: 10.1111/jvim.15511. Epub 2019 Apr 29.


PolyGlcNAc-containing exopolymers enable surface penetration by non-motile Enterococcus faecalis.

Ramos Y, Rocha J, Hael AL, van Gestel J, Vlamakis H, Cywes-Bentley C, Cubillos-Ruiz JR, Pier GB, Gilmore MS, Kolter R, Morales DK.

PLoS Pathog. 2019 Feb 11;15(2):e1007571. doi: 10.1371/journal.ppat.1007571. eCollection 2019 Feb.


PNAG-specific equine IgG1 mediates significantly greater opsonization and killing of Prescottella equi (formerly Rhodococcus equi) than does IgG4/7.

Rocha JN, Dangott LJ, Mwangi W, Alaniz RC, Bordin AI, Cywes-Bentley C, Lawhon SD, Pillai SD, Bray JM, Pier GB, Cohen ND.

Vaccine. 2019 Feb 21;37(9):1142-1150. doi: 10.1016/j.vaccine.2019.01.028. Epub 2019 Jan 26.


Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia.

Liang X, Gupta K, Quintero JR, Cernadas M, Kobzik L, Christou H, Pier GB, Owen CA, Çataltepe S.

FASEB J. 2019 Mar;33(3):3562-3574. doi: 10.1096/fj.201802002R. Epub 2018 Nov 21.


Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi.

Cywes-Bentley C, Rocha JN, Bordin AI, Vinacur M, Rehman S, Zaidi TS, Meyer M, Anthony S, Lambert M, Vlock DR, Giguère S, Cohen ND, Pier GB.

PLoS Pathog. 2018 Jul 19;14(7):e1007160. doi: 10.1371/journal.ppat.1007160. eCollection 2018 Jul.


Production of poly-β-1,6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by Streptomyces.

van Dissel D, Willemse J, Zacchetti B, Claessen D, Pier GB, van Wezel GP.

Microb Cell. 2018 Feb 12;5(6):269-279. doi: 10.15698/mic2018.06.635.


Antibodies to Conserved Surface Polysaccharides Protect Mice Against Bacterial Conjunctivitis.

Zaidi TS, Zaidi T, Pier GB.

Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2512-2519. doi: 10.1167/iovs.18-23795.


PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms.

Little DJ, Pfoh R, Le Mauff F, Bamford NC, Notte C, Baker P, Guragain M, Robinson H, Pier GB, Nitz M, Deora R, Sheppard DC, Howell PL.

PLoS Pathog. 2018 Apr 23;14(4):e1006998. doi: 10.1371/journal.ppat.1006998. eCollection 2018 Apr.


Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly antimicrobial antibodies.

Stevenson TC, Cywes-Bentley C, Moeller TD, Weyant KB, Putnam D, Chang YF, Jones BD, Pier GB, DeLisa MP.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3106-E3115. doi: 10.1073/pnas.1718341115. Epub 2018 Mar 19.


Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine.

Soliman C, Walduck AK, Yuriev E, Richards JS, Cywes-Bentley C, Pier GB, Ramsland PA.

J Biol Chem. 2018 Apr 6;293(14):5079-5089. doi: 10.1074/jbc.RA117.001170. Epub 2018 Feb 15.


Complexity of Complement Resistance Factors Expressed by Acinetobacter baumannii Needed for Survival in Human Serum.

Sanchez-Larrayoz AF, Elhosseiny NM, Chevrette MG, Fu Y, Giunta P, Spallanzani RG, Ravi K, Pier GB, Lory S, Maira-Litrán T.

J Immunol. 2017 Oct 15;199(8):2803-2814. doi: 10.4049/jimmunol.1700877. Epub 2017 Aug 30.


Role of de-N-acetylase PgaB from Aggregatibacter actinomycetemcomitans in exopolysaccharide export in biofilm mode of growth.

Shanmugam M, Oyeniyi AO, Parthiban C, Gujjarlapudi SK, Pier GB, Ramasubbu N.

Mol Oral Microbiol. 2017 Dec;32(6):500-510. doi: 10.1111/omi.12188. Epub 2017 Jul 3.


A Novel Repressor of the ica Locus Discovered in Clinically Isolated Super-Biofilm-Elaborating Staphylococcus aureus.

Yu L, Hisatsune J, Hayashi I, Tatsukawa N, Sato'o Y, Mizumachi E, Kato F, Hirakawa H, Pier GB, Sugai M.

mBio. 2017 Jan 31;8(1). pii: e02282-16. doi: 10.1128/mBio.02282-16.


Active and Passive Immunization Against Staphylococcus aureus Periprosthetic Osteomyelitis in Rats.

Søe NH, Jensen NV, Jensen AL, Koch J, Poulsen SS, Pier GB, Johansen HK.

In Vivo. 2017 Jan 2;31(1):45-50.


Efficacy of Antibody to PNAG Against Keratitis Caused by Fungal Pathogens.

Zhao G, Zaidi TS, Bozkurt-Guzel C, Zaidi TH, Lederer JA, Priebe GP, Pier GB.

Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6797-6804. doi: 10.1167/iovs.16-20358.


Staphylococcus epidermidis Biofilm-Released Cells Induce a Prompt and More Marked In vivo Inflammatory-Type Response than Planktonic or Biofilm Cells.

França A, Pérez-Cabezas B, Correia A, Pier GB, Cerca N, Vilanova M.

Front Microbiol. 2016 Sep 27;7:1530. eCollection 2016.


Transcriptomic Analysis of Staphylococcus epidermidis Biofilm-Released Cells upon Interaction with Human Blood Circulating Immune Cells and Soluble Factors.

França A, Pier GB, Vilanova M, Cerca N.

Front Microbiol. 2016 Jul 21;7:1143. doi: 10.3389/fmicb.2016.01143. eCollection 2016. No abstract available.


Poly-N-Acetylglucosamine Production by Staphylococcus epidermidis Cells Increases Their In Vivo Proinflammatory Effect.

Ferreirinha P, Pérez-Cabezas B, Correia A, Miyazawa B, França A, Carvalhais V, Faustino A, Cordeiro-da-Silva A, Teixeira L, Pier GB, Cerca N, Vilanova M.

Infect Immun. 2016 Sep 19;84(10):2933-43. doi: 10.1128/IAI.00290-16. Print 2016 Oct.


Antibiotic resistance and virulence: Understanding the link and its consequences for prophylaxis and therapy.

Guillard T, Pons S, Roux D, Pier GB, Skurnik D.

Bioessays. 2016 Jul;38(7):682-93. doi: 10.1002/bies.201500180. Epub 2016 Jun 1. Review.


Distinct Mechanisms Underlie Boosted Polysaccharide-Specific IgG Responses Following Secondary Challenge with Intact Gram-Negative versus Gram-Positive Extracellular Bacteria.

Kar S, Arjunaraja S, Akkoyunlu M, Pier GB, Snapper CM.

J Immunol. 2016 Jun 1;196(11):4614-21. doi: 10.4049/jimmunol.1600082. Epub 2016 Apr 22.


Characterization of an in vitro fed-batch model to obtain cells released from S. epidermidis biofilms.

França A, Carvalhais V, Vilanova M, Pier GB, Cerca N.

AMB Express. 2016 Mar;6(1):23. doi: 10.1186/s13568-016-0197-9. Epub 2016 Mar 22.


Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi.

Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, Yarovinsky F.

Cell. 2016 Feb 25;164(5):827-8. doi: 10.1016/j.cell.2016.02.015. No abstract available.


The exceptionally broad-based potential of active and passive vaccination targeting the conserved microbial surface polysaccharide PNAG.

Skurnik D, Cywes-Bentley C, Pier GB.

Expert Rev Vaccines. 2016 Aug;15(8):1041-53. doi: 10.1586/14760584.2016.1159135. Epub 2016 Mar 16. Review.


Extended-spectrum antibodies protective against carbapenemase-producing Enterobacteriaceae.

Skurnik D, Roux D, Pons S, Guillard T, Lu X, Cywes-Bentley C, Pier GB.

J Antimicrob Chemother. 2016 Apr;71(4):927-35. doi: 10.1093/jac/dkv448. Epub 2016 Jan 7.


Novel vaccine antigen combinations elicit protective immune responses against Escherichia coli sepsis.

Mellata M, Mitchell NM, Schödel F, Curtiss R Rd, Pier GB.

Vaccine. 2016 Jan 27;34(5):656-662. doi: 10.1016/j.vaccine.2015.12.014. Epub 2015 Dec 18.


Impact of Drug Resistance on Virulence and Fitness of Bacterial Pathogens.

Roux D, Pons S, Guillard T, Ricard JD, Pier GB, Skurnik D.

Crit Care Med. 2016 Jan;44(1):e50. doi: 10.1097/CCM.0000000000001330. No abstract available.


Structural Relationship of the Lipid A Acyl Groups to Activation of Murine Toll-Like Receptor 4 by Lipopolysaccharides from Pathogenic Strains of Burkholderia mallei, Acinetobacter baumannii, and Pseudomonas aeruginosa.

Korneev KV, Arbatsky NP, Molinaro A, Palmigiano A, Shaikhutdinova RZ, Shneider MM, Pier GB, Kondakova AN, Sviriaeva EN, Sturiale L, Garozzo D, Kruglov AA, Nedospasov SA, Drutskaya MS, Knirel YA, Kuprash DV.

Front Immunol. 2015 Nov 23;6:595. doi: 10.3389/fimmu.2015.00595. eCollection 2015.


Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia.

Gauguet S, D'Ortona S, Ahnger-Pier K, Duan B, Surana NK, Lu R, Cywes-Bentley C, Gadjeva M, Shan Q, Priebe GP, Pier GB.

Infect Immun. 2015 Oct;83(10):4003-14. doi: 10.1128/IAI.00037-15. Epub 2015 Jul 27.


Fitness cost of antibiotic susceptibility during bacterial infection.

Roux D, Danilchanka O, Guillard T, Cattoir V, Aschard H, Fu Y, Angoulvant F, Messika J, Ricard JD, Mekalanos JJ, Lory S, Pier GB, Skurnik D.

Sci Transl Med. 2015 Jul 22;7(297):297ra114. doi: 10.1126/scitranslmed.aab1621.


Identification of Poly-N-acetylglucosamine as a Major Polysaccharide Component of the Bacillus subtilis Biofilm Matrix.

Roux D, Cywes-Bentley C, Zhang YF, Pons S, Konkol M, Kearns DB, Little DJ, Howell PL, Skurnik D, Pier GB.

J Biol Chem. 2015 Jul 31;290(31):19261-72. doi: 10.1074/jbc.M115.648709. Epub 2015 Jun 15.


Comparative proteomic and transcriptomic profile of Staphylococcus epidermidis biofilms grown in glucose-enriched medium.

Carvalhais V, França A, Pier GB, Vilanova M, Cerca N, Vitorino R.

Talanta. 2015 Jan;132:705-12. doi: 10.1016/j.talanta.2014.10.012. Epub 2014 Oct 19.


Microbiota-driven immune cellular maturation is essential for antibody-mediated adaptive immunity to Staphylococcus aureus infection in the eye.

Zaidi T, Zaidi T, Cywes-Bentley C, Lu R, Priebe GP, Pier GB.

Infect Immun. 2014 Aug;82(8):3483-91. doi: 10.1128/IAI.01951-14. Epub 2014 Jun 9.


A Poly-N-acetylglucosamine-Shiga toxin broad-spectrum conjugate vaccine for Shiga toxin-producing Escherichia coli.

Lu X, Skurnik D, Pozzi C, Roux D, Cywes-Bentley C, Ritchie JM, Munera D, Gening ML, Tsvetkov YE, Nifantiev NE, Waldor MK, Pier GB.

mBio. 2014 Mar 25;5(2):e00974-14. doi: 10.1128/mBio.00974-14.


Dormancy within Staphylococcus epidermidis biofilms: a transcriptomic analysis by RNA-seq.

Carvalhais V, França A, Cerca F, Vitorino R, Pier GB, Vilanova M, Cerca N.

Appl Microbiol Biotechnol. 2014 Mar;98(6):2585-96. doi: 10.1007/s00253-014-5548-3. Epub 2014 Feb 7.


Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing.

Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, Pier GB.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20747-52. doi: 10.1073/pnas.1221552110. Epub 2013 Nov 18.


BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs.

Döring G, Bragonzi A, Paroni M, Aktürk FF, Cigana C, Schmidt A, Gilpin D, Heyder S, Born T, Smaczny C, Kohlhäufl M, Wagner TO, Loebinger MR, Bilton D, Tunney MM, Elborn JS, Pier GB, Konstan MW, Ulrich M.

J Cyst Fibros. 2014 Mar;13(2):156-63. doi: 10.1016/j.jcf.2013.10.007. Epub 2013 Oct 31.


A comprehensive analysis of in vitro and in vivo genetic fitness of Pseudomonas aeruginosa using high-throughput sequencing of transposon libraries.

Skurnik D, Roux D, Aschard H, Cattoir V, Yoder-Himes D, Lory S, Pier GB.

PLoS Pathog. 2013;9(9):e1003582. doi: 10.1371/journal.ppat.1003582. Epub 2013 Sep 5.


Will there ever be a universal Staphylococcus aureus vaccine?

Pier GB.

Hum Vaccin Immunother. 2013 Sep;9(9):1865-76. doi: 10.4161/hv.25182. Epub 2013 Jun 21. Review.


Monoclonal antibody raised against PNAG has variable effects on static S. epidermidis biofilm accumulation in vitro.

França A, Vilanova M, Cerca N, Pier GB.

Int J Biol Sci. 2013 May 25;9(5):518-20. doi: 10.7150/ijbs.6102. Print 2013. No abstract available.


Staphylococcus aureus corneal infections: effect of the Panton-Valentine leukocidin (PVL) and antibody to PVL on virulence and pathology.

Zaidi T, Zaidi T, Yoong P, Pier GB.

Invest Ophthalmol Vis Sci. 2013 Jul 1;54(7):4430-8. doi: 10.1167/iovs.13-11701.


Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens.

Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2209-18. doi: 10.1073/pnas.1303573110. Epub 2013 May 28.


Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity.

Py BF, Gonzalez SF, Long K, Kim MS, Kim YA, Zhu H, Yao J, Degauque N, Villet R, Ymele-Leki P, Gadjeva M, Pier GB, Carroll MC, Yuan J.

Immunity. 2013 May 23;38(5):1063-72. doi: 10.1016/j.immuni.2013.01.015. Epub 2013 May 16.


Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia.

Kamei A, Wu W, Traficante DC, Koh AY, Van Rooijen N, Pier GB, Priebe GP.

J Infect Dis. 2013 Jan 1;207(1):39-49. doi: 10.1093/infdis/jis657. Epub 2012 Oct 24.


Opsonic and protective properties of antibodies raised to conjugate vaccines targeting six Staphylococcus aureus antigens.

Pozzi C, Wilk K, Lee JC, Gening M, Nifantiev N, Pier GB.

PLoS One. 2012;7(10):e46648. doi: 10.1371/journal.pone.0046648. Epub 2012 Oct 15.


Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers.

Tamang DL, Pirzai W, Priebe GP, Traficante DC, Pier GB, Falck JR, Morisseau C, Hammock BD, McCormick BA, Gronert K, Hurley BP.

J Immunol. 2012 Nov 15;189(10):4960-9. doi: 10.4049/jimmunol.1201922. Epub 2012 Oct 8.


Synthesis and evaluation of a conjugate vaccine composed of Staphylococcus aureus poly-N-acetyl-glucosamine and clumping factor A.

Maira-Litrán T, Bentancor LV, Bozkurt-Guzel C, O'Malley JM, Cywes-Bentley C, Pier GB.

PLoS One. 2012;7(9):e43813. doi: 10.1371/journal.pone.0043813. Epub 2012 Sep 6.


Synthesis of pentasaccharides corresponding to the glycoform II of the outer core region of the Pseudomonas aeruginosa lipopolysaccharide.

Komarova BS, Tsvetkov YE, Pier GB, Nifantiev NE.

Carbohydr Res. 2012 Oct 1;360:56-68. doi: 10.1016/j.carres.2012.07.019. Epub 2012 Aug 7.


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