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Items: 1 to 50 of 53


Effects of vaccines in protecting against Ebola virus disease: protocol for a systematic review.

Mathebula L, Ndwandwe DE, Pienaar E, Wiysonge CS.

BMJ Open. 2019 Jul 3;9(7):e029617. doi: 10.1136/bmjopen-2019-029617.


The Cochrane 2018 Review on Brief Interventions in Primary Care for Hazardous and Harmful Alcohol Consumption: A Distillation for Clinicians and Policy Makers.

Beyer FR, Campbell F, Bertholet N, Daeppen JB, Saunders JB, Pienaar ED, Muirhead CR, Kaner EFS.

Alcohol Alcohol. 2019 Jul 1;54(4):417-427. doi: 10.1093/alcalc/agz035.


In Vitro Granuloma Models of Tuberculosis: Potential and Challenges.

Elkington P, Lerm M, Kapoor N, Mahon R, Pienaar E, Huh D, Kaushal D, Schlesinger LS.

J Infect Dis. 2019 May 24;219(12):1858-1866. doi: 10.1093/infdis/jiz020.


Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations.

Sarathy J, Blanc L, Alvarez-Cabrera N, O'Brien P, Dias-Freedman I, Mina M, Zimmerman M, Kaya F, Ho Liang HP, Prideaux B, Dietzold J, Salgame P, Savic RM, Linderman J, Kirschner D, Pienaar E, Dartois V.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02516-18. doi: 10.1128/AAC.02516-18. Print 2019 May.


Prosthetic use by persons with unilateral transfemoral amputation in a South African setting.

Pienaar E, Visagie S.

Prosthet Orthot Int. 2019 Jun;43(3):276-283. doi: 10.1177/0309364619825891. Epub 2019 Feb 7.


Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes.

Joslyn LR, Pienaar E, DiFazio RM, Suliman S, Kagina BM, Flynn JL, Scriba TJ, Linderman JJ, Kirschner DE.

Front Microbiol. 2018 Aug 17;9:1734. doi: 10.3389/fmicb.2018.01734. eCollection 2018.


Multifidelity Analysis for Predicting Rare Events in Stochastic Computational Models of Complex Biological Systems.

Pienaar E.

Biomed Eng Comput Biol. 2018 Aug 3;9:1179597218790253. doi: 10.1177/1179597218790253. eCollection 2018.


Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas.

Pienaar E, Linderman JJ, Kirschner DE.

PLoS One. 2018 May 10;13(5):e0196322. doi: 10.1371/journal.pone.0196322. eCollection 2018.


A systematic review of strategies for reducing missed opportunities for vaccination.

Jaca A, Mathebula L, Iweze A, Pienaar E, Wiysonge CS.

Vaccine. 2018 May 17;36(21):2921-2927. doi: 10.1016/j.vaccine.2018.04.028. Epub 2018 Apr 19. Review.


Effectiveness of brief alcohol interventions in primary care populations.

Kaner EF, Beyer FR, Muirhead C, Campbell F, Pienaar ED, Bertholet N, Daeppen JB, Saunders JB, Burnand B.

Cochrane Database Syst Rev. 2018 Feb 24;2:CD004148. doi: 10.1002/14651858.CD004148.pub4. Review.


Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model.

Warsinske HC, Pienaar E, Linderman JJ, Mattila JT, Kirschner DE.

Front Immunol. 2017 Dec 20;8:1843. doi: 10.3389/fimmu.2017.01843. eCollection 2017.


Applying optimization algorithms to tuberculosis antibiotic treatment regimens.

Cicchese JM, Pienaar E, Kirschner DE, Linderman JJ.

Cell Mol Bioeng. 2017 Dec;10(6):523-535. doi: 10.1007/s12195-017-0507-6. Epub 2017 Aug 30.


Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach.

Pienaar E, Sarathy J, Prideaux B, Dietzold J, Dartois V, Kirschner DE, Linderman JJ.

PLoS Comput Biol. 2017 Aug 17;13(8):e1005650. doi: 10.1371/journal.pcbi.1005650. eCollection 2017 Aug.


A review of computational and mathematical modeling contributions to our understanding of Mycobacterium tuberculosis within-host infection and treatment.

Kirschner D, Pienaar E, Marino S, Linderman JJ.

Curr Opin Syst Biol. 2017 Jun;3:170-185. doi: 10.1016/j.coisb.2017.05.014. Epub 2017 May 22.


Molecular characterisation of acute intermittent porphyria in a cohort of South African patients and kinetic analysis of two expressed mutants.

Fortgens P, Pienaar E, Corrigall A, Sonderup M, Spearman CW, Meissner P.

J Clin Pathol. 2017 Jun;70(6):515-520. doi: 10.1136/jclinpath-2016-203907. Epub 2016 Nov 14.


Multiscale Model of Mycobacterium tuberculosis Infection Maps Metabolite and Gene Perturbations to Granuloma Sterilization Predictions.

Pienaar E, Matern WM, Linderman JJ, Bader JS, Kirschner DE.

Infect Immun. 2016 Apr 22;84(5):1650-1669. doi: 10.1128/IAI.01438-15. Print 2016 May.


In silico evaluation and exploration of antibiotic tuberculosis treatment regimens.

Pienaar E, Dartois V, Linderman JJ, Kirschner DE.

BMC Syst Biol. 2015 Nov 14;9:79. doi: 10.1186/s12918-015-0221-8.


Systems Pharmacology Approach Toward the Design of Inhaled Formulations of Rifampicin and Isoniazid for Treatment of Tuberculosis.

Cilfone NA, Pienaar E, Thurber GM, Kirschner DE, Linderman JJ.

CPT Pharmacometrics Syst Pharmacol. 2015 Mar;4(3):e00022. doi: 10.1002/psp4.22. Epub 2015 Mar 11.


A multi-scale approach to designing therapeutics for tuberculosis.

Linderman JJ, Cilfone NA, Pienaar E, Gong C, Kirschner DE.

Integr Biol (Camb). 2015 May;7(5):591-609. doi: 10.1039/c4ib00295d. Epub 2015 Apr 30.


The importance of survey content: testing for the context dependency of the New Ecological Paradigm Scale.

Pienaar EF, Lew DK, Wallmo K.

Soc Sci Res. 2015 May;51:338-49. doi: 10.1016/j.ssresearch.2014.09.005. Epub 2014 Oct 5.


A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment.

Pienaar E, Cilfone NA, Lin PL, Dartois V, Mattila JT, Butler JR, Flynn JL, Kirschner DE, Linderman JJ.

J Theor Biol. 2015 Feb 21;367:166-179. doi: 10.1016/j.jtbi.2014.11.021. Epub 2014 Dec 9.


Replication rates of Mycobacterium tuberculosis in human macrophages do not correlate with mycobacterial antibiotic susceptibility.

Raffetseder J, Pienaar E, Blomgran R, Eklund D, Patcha Brodin V, Andersson H, Welin A, Lerm M.

PLoS One. 2014 Nov 11;9(11):e112426. doi: 10.1371/journal.pone.0112426. eCollection 2014.


Antimycobacterial activity of selected medicinal plants traditionally used in Sudan to treat infectious diseases.

Abuzeid N, Kalsum S, Koshy RJ, Larsson M, Glader M, Andersson H, Raffetseder J, Pienaar E, Eklund D, Alhassan MS, AlGadir HA, Koko WS, Schön T, Ahmed Mesaik M, Abdalla OM, Khalid A, Lerm M.

J Ethnopharmacol. 2014 Nov 18;157:134-9. doi: 10.1016/j.jep.2014.09.020. Epub 2014 Sep 28.


Task shifting from doctors to non-doctors for initiation and maintenance of antiretroviral therapy.

Kredo T, Adeniyi FB, Bateganya M, Pienaar ED.

Cochrane Database Syst Rev. 2014 Jul 1;(7):CD007331. doi: 10.1002/14651858.CD007331.pub3. Review.


A mathematical model of the initial interaction between Mycobacterium tuberculosis and macrophages.

Pienaar E, Lerm M.

J Theor Biol. 2014 Feb 7;342:23-32. doi: 10.1016/j.jtbi.2013.09.029. Epub 2013 Oct 7. Erratum in: J Theor Biol. 2014 May 21;349:172.


Are environmental attitudes influenced by survey context? An investigation of the context dependency of the New Ecological Paradigm (NEP) Scale.

Pienaar EF, Lew DK, Wallmo K.

Soc Sci Res. 2013 Nov;42(6):1542-54. doi: 10.1016/j.ssresearch.2013.07.001. Epub 2013 Jul 13.


Bibliometric and content analysis of the Cochrane Complementary Medicine Field specialized register of controlled trials.

Wieland LS, Manheimer E, Sampson M, Barnabas JP, Bouter LM, Cho K, Lee MS, Li X, Liu J, Moher D, Okabe T, Pienaar ED, Shin BC, Tharyan P, Tsutani K, van der Windt DA, Berman BM.

Syst Rev. 2013 Jul 4;2:51. doi: 10.1186/2046-4053-2-51.


A state-time epidemiology model of tuberculosis: importance of re-infection.

Viljoen S, Pienaar E, Viljoen HJ.

Comput Biol Chem. 2012 Feb;36:15-22. doi: 10.1016/j.compbiolchem.2011.11.003. Epub 2011 Nov 28.


Randomized controlled trials of HIV/AIDS prevention and treatment in Africa: results from the Cochrane HIV/AIDS Specialized Register.

Zani B, Pienaar ED, Oliver J, Siegfried N.

PLoS One. 2011;6(12):e28759. doi: 10.1371/journal.pone.0028759. Epub 2011 Dec 15.


Developing a geographic search filter to identify randomised controlled trials in Africa: finding the optimal balance between sensitivity and precision.

Pienaar E, Grobler L, Busgeeth K, Eisinga A, Siegfried N.

Health Info Libr J. 2011 Sep;28(3):210-5. doi: 10.1111/j.1471-1842.2011.00936.x. Epub 2011 Mar 30.


Experimental Validation of a Fundamental Model for PCR Efficiency.

Louw TM, Booth CS, Pienaar E, Termaat JR, Whitney SE, Viljoen HJ.

Chem Eng Sci. 2011 Apr 15;66(8):1783-1789.


Efficiency of the Polymerase Chain Reaction.

Booth CS, Pienaar E, Termaat JR, Whitney SE, Louw TM, Viljoen HJ.

Chem Eng Sci. 2010 Sep 1;65(17):4996-5006.


Self-reported outcomes of aural rehabilitation for adult hearing aid users in a South African context.

Pienaar E, Stearn N, Swanepoel de W.

S Afr J Commun Disord. 2010 Dec;57:4, 6, 8 passim.


Interventions for the prevention and management of oropharyngeal candidiasis associated with HIV infection in adults and children.

Pienaar ED, Young T, Holmes H.

Cochrane Database Syst Rev. 2010 Nov 10;(11):CD003940. doi: 10.1002/14651858.CD003940.pub3. Review.


A model of tuberculosis transmission and intervention strategies in an urban residential area.

Pienaar E, Fluitt AM, Whitney SE, Freifeld AG, Viljoen HJ.

Comput Biol Chem. 2010 Apr;34(2):86-96. doi: 10.1016/j.compbiolchem.2010.03.003. Epub 2010 Mar 9.


Gene synthesis by integrated polymerase chain assembly and PCR amplification using a high-speed thermocycler.

TerMaat JR, Pienaar E, Whitney SE, Mamedov TG, Subramanian A.

J Microbiol Methods. 2009 Dec;79(3):295-300. doi: 10.1016/j.mimet.2009.09.015. Epub 2009 Sep 29.


The effectiveness of brief alcohol interventions in primary care settings: a systematic review.

Kaner EF, Dickinson HO, Beyer F, Pienaar E, Schlesinger C, Campbell F, Saunders JB, Burnand B, Heather N.

Drug Alcohol Rev. 2009 May;28(3):301-23. doi: 10.1111/j.1465-3362.2009.00071.x.


A Kinetic Study of In Vitro Lysis of Mycobacterium smegmatis.

Valente W, Pienaar E, Fast A, Fluitt A, Whitney S, Fenton R, Barletta R, Chacon O, Viljoen H.

Chem Eng Sci. 2009 May 1;64(9):1944-1952.


A model of the complex response of Staphylococcus aureus to methicillin.

Pienaar E, Whitney SE, Viljoen HJ, van Rensburg NF.

J Theor Biol. 2009 Apr 7;257(3):438-45. doi: 10.1016/j.jtbi.2008.12.003. Epub 2008 Dec 11.


A fundamental study of the PCR amplification of GC-rich DNA templates.

Mamedov TG, Pienaar E, Whitney SE, TerMaat JR, Carvill G, Goliath R, Subramanian A, Viljoen HJ.

Comput Biol Chem. 2008 Dec;32(6):452-7. doi: 10.1016/j.compbiolchem.2008.07.021. Epub 2008 Jul 25.


The tri-frame model.

Pienaar E, Viljoen HJ.

J Theor Biol. 2008 Apr 21;251(4):616-27. doi: 10.1016/j.jtbi.2007.12.003. Epub 2007 Dec 14.


Ribosome kinetics and aa-tRNA competition determine rate and fidelity of peptide synthesis.

Fluitt A, Pienaar E, Viljoen H.

Comput Biol Chem. 2007 Oct;31(5-6):335-46. Epub 2007 Aug 15.


Effectiveness of brief alcohol interventions in primary care populations.

Kaner EF, Beyer F, Dickinson HO, Pienaar E, Campbell F, Schlesinger C, Heather N, Saunders J, Burnand B.

Cochrane Database Syst Rev. 2007 Apr 18;(2):CD004148. Review. Update in: Cochrane Database Syst Rev. 2018 Feb 24;2:CD004148.


A quantitative model of error accumulation during PCR amplification.

Pienaar E, Theron M, Nelson M, Viljoen HJ.

Comput Biol Chem. 2006 Apr;30(2):102-11. Epub 2006 Jan 10.


International collaboration, funding and association with burden of disease in randomized controlled trials in Africa.

Swingler GH, Pillay V, Pienaar ED, Ioannidis JP.

Bull World Health Organ. 2005 Jul;83(7):511-7.


Randomised trials in the South African Medical Journal, 1948-1997.

Pienaar ED, Volmink J, Zwarenstein M, Swingler GH.

S Afr Med J. 2002 Nov;92(11):901-3. Review.


Relation between burden of disease and randomised evidence in sub-Saharan Africa: survey of research.

Isaakidis P, Swingler GH, Pienaar E, Volmink J, Ioannidis JP.

BMJ. 2002 Mar 23;324(7339):702. Review.


Multicenter study on reproducibility of sperm morphology assessments.

Ombelet W, Bosmans E, Janssen M, Cox A, Maes M, Punjabi U, Blaton V, Gunst J, Haidl G, Wouters E, Spiessens C, Bornman MS, Pienaar E, Menkveld R, Lombard CJ.

Arch Androl. 1998 Sep-Oct;41(2):103-14.


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