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Items: 1 to 50 of 154

1.

Sharing Violent Thoughts on the Internet.

Abukamil R, Piel JL.

J Am Acad Psychiatry Law. 2019 Mar;47(1):82-90. doi: 10.29158/JAAPL.003826-19. Epub 2019 Feb 19.

PMID:
30782605
2.

Opening up the Single-Cell Toolbox for Microbial Natural Products Research.

Piel J, Cahn J.

Angew Chem Int Ed Engl. 2019 Feb 12. doi: 10.1002/anie.201900532. [Epub ahead of print]

PMID:
30748086
3.

In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids.

Schleyer G, Shahaf N, Ziv C, Dong Y, Meoded RA, Helfrich EJN, Schatz D, Rosenwasser S, Rogachev I, Aharoni A, Piel J, Vardi A.

Nat Microbiol. 2019 Mar;4(3):527-538. doi: 10.1038/s41564-018-0336-y. Epub 2019 Feb 4.

PMID:
30718847
4.

Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis.

Helf MJ, Freeman MF, Piel J.

J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):551-563. doi: 10.1007/s10295-018-02129-3. Epub 2019 Jan 9.

PMID:
30627933
5.

Introduction of d-Amino Acids in Minimalistic Peptide Substrates by an S-Adenosyl-l-Methionine Radical Epimerase.

Vagstad AL, Kuranaga T, Püntener S, Pattabiraman VR, Bode JW, Piel J.

Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2246-2250. doi: 10.1002/anie.201809508. Epub 2019 Jan 25.

PMID:
30521081
6.

Genome Mining-guided and MALDI Imaging-assisted Discovery of New Antibiotics.

Probst SI, Vogel C, Vorholt JA, Piel J.

Chimia (Aarau). 2018 Nov 30;72(11):816. doi: 10.2533/chimia.2018.816. No abstract available.

PMID:
30514426
7.

Aranazoles: Extensively Chlorinated Nonribosomal Peptide-Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339.

Moosmann P, Ueoka R, Gugger M, Piel J.

Org Lett. 2018 Sep 7;20(17):5238-5241. doi: 10.1021/acs.orglett.8b02193. Epub 2018 Aug 24.

PMID:
30141631
8.

Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome.

Helfrich EJN, Vogel CM, Ueoka R, Schäfer M, Ryffel F, Müller DB, Probst S, Kreuzer M, Piel J, Vorholt JA.

Nat Microbiol. 2018 Aug;3(8):909-919. doi: 10.1038/s41564-018-0200-0. Epub 2018 Jul 23.

PMID:
30038309
9.

Legislative Advocacy and Forensic Psychiatry Training.

Piel J.

J Am Acad Psychiatry Law. 2018 Jun;46(2):147-154. doi: 10.29158/JAAPL.003741-18.

PMID:
30026391
10.

Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source.

Ueoka R, Bhushan A, Probst SI, Bray WM, Lokey RS, Linington RG, Piel J.

Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14519-14523. doi: 10.1002/anie.201805673. Epub 2018 Aug 23.

PMID:
30025185
11.

Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis.

Byer AS, Yang H, McDaniel EC, Kathiresan V, Impano S, Pagnier A, Watts H, Denler C, Vagstad AL, Piel J, Duschene KS, Shepard EM, Shields TP, Scott LG, Lilla EA, Yokoyama K, Broderick WE, Hoffman BM, Broderick JB.

J Am Chem Soc. 2018 Jul 18;140(28):8634-8638. doi: 10.1021/jacs.8b04061. Epub 2018 Jul 6.

12.

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones.

Meoded RA, Ueoka R, Helfrich EJN, Jensen K, Magnus N, Piechulla B, Piel J.

Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11644-11648. doi: 10.1002/anie.201805363. Epub 2018 Jul 31.

13.

Biosynthetic Insights of Calyculin- and Misakinolide-Type Compounds in "Candidatus Entotheonella sp."

Uria AR, Piel J, Wakimoto T.

Methods Enzymol. 2018;604:287-330. doi: 10.1016/bs.mie.2018.02.017. Epub 2018 May 7.

PMID:
29779656
14.

Radical S-Adenosylmethionine Peptide Epimerases: Detection of Activity and Characterization of d-Amino Acid Products.

Morinaka BI, Vagstad AL, Piel J.

Methods Enzymol. 2018;604:237-257. doi: 10.1016/bs.mie.2018.01.033. Epub 2018 Apr 11.

PMID:
29779654
15.

Mental Condition Requirement in Competency to Stand Trial Assessments.

Reisner AD, Piel JL.

J Am Acad Psychiatry Law. 2018 Mar;46(1):86-92.

PMID:
29618540
16.

Lightweight, compact, and high-performance 3T MR system for imaging the brain and extremities.

Foo TKF, Laskaris E, Vermilyea M, Xu M, Thompson P, Conte G, Van Epps C, Immer C, Lee SK, Tan ET, Graziani D, Mathieu JB, Hardy CJ, Schenck JF, Fiveland E, Stautner W, Ricci J, Piel J, Park K, Hua Y, Bai Y, Kagan A, Stanley D, Weavers PT, Gray E, Shu Y, Frick MA, Campeau NG, Trzasko J, Huston J 3rd, Bernstein MA.

Magn Reson Med. 2018 Nov;80(5):2232-2245. doi: 10.1002/mrm.27175. Epub 2018 Mar 13.

PMID:
29536587
17.

Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.

Wagner DT, Zhang Z, Meoded RA, Cepeda AJ, Piel J, Keatinge-Clay AT.

ACS Chem Biol. 2018 Apr 20;13(4):975-983. doi: 10.1021/acschembio.8b00049. Epub 2018 Mar 1.

18.

Natural noncanonical protein splicing yields products with diverse β-amino acid residues.

Morinaka BI, Lakis E, Verest M, Helf MJ, Scalvenzi T, Vagstad AL, Sims J, Sunagawa S, Gugger M, Piel J.

Science. 2018 Feb 16;359(6377):779-782. doi: 10.1126/science.aao0157.

PMID:
29449488
19.

Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts.

Mori T, Cahn JKB, Wilson MC, Meoded RA, Wiebach V, Martinez AFC, Helfrich EJN, Albersmeier A, Wibberg D, Dätwyler S, Keren R, Lavy A, Rückert C, Ilan M, Kalinowski J, Matsunaga S, Takeyama H, Piel J.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1718-1723. doi: 10.1073/pnas.1715496115. Epub 2018 Feb 8.

20.

Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism.

Puri AW, Mevers E, Ramadhar TR, Petras D, Liu D, Piel J, Dorrestein PC, Greenberg EP, Lidstrom ME, Clardy J.

J Am Chem Soc. 2018 Feb 14;140(6):2002-2006. doi: 10.1021/jacs.7b12240. Epub 2018 Jan 30.

21.

Does Volk v DeMeerleer Conflict with the AMA Code of Medical Ethics on Breaching Patient Confidentiality to Protect Third Parties?

Piel JL, Opara R.

AMA J Ethics. 2018 Jan 1;20(1):10-18. doi: 10.1001/journalofethics.2018.20.1.peer2-1801.

22.

The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort.

Piel JH, Lett TA, Wackerhagen C, Plichta MM, Mohnke S, Grimm O, Romanczuk-Seiferth N, Degenhardt F, Tost H, Witt S, Nöthen M, Rietschel M, Heinz A, Meyer-Lindenberg A, Walter H, Erk S.

Eur Neuropsychopharmacol. 2018 Mar;28(3):415-427. doi: 10.1016/j.euroneuro.2017.12.014. Epub 2018 Jan 19.

PMID:
29358097
23.

Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359.

Crüsemann M, Reher R, Schamari I, Brachmann AO, Ohbayashi T, Kuschak M, Malfacini D, Seidinger A, Pinto-Carbó M, Richarz R, Reuter T, Kehraus S, Hallab A, Attwood M, Schiöth HB, Mergaert P, Kikuchi Y, Schäberle TF, Kostenis E, Wenzel D, Müller CE, Piel J, Carlier A, Eberl L, König GM.

Angew Chem Int Ed Engl. 2018 Jan 15;57(3):836-840. doi: 10.1002/anie.201707996. Epub 2017 Dec 20.

PMID:
29194875
24.

Toblerols: Cyclopropanol-Containing Polyketide Modulators of Antibiosis in Methylobacteria.

Ueoka R, Bortfeld-Miller M, Morinaka BI, Vorholt JA, Piel J.

Angew Chem Int Ed Engl. 2018 Jan 22;57(4):977-981. doi: 10.1002/anie.201709056. Epub 2017 Dec 18.

PMID:
29112783
25.

High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway.

Tronnet S, Garcie C, Brachmann AO, Piel J, Oswald E, Martin P.

Pathog Dis. 2017 Jul 31;75(5). doi: 10.1093/femspd/ftx066.

PMID:
28637194
26.

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products.

van der Velden NS, Kälin N, Helf MJ, Piel J, Freeman MF, Künzler M.

Nat Chem Biol. 2017 Aug;13(8):833-835. doi: 10.1038/nchembio.2393. Epub 2017 Jun 5.

PMID:
28581484
27.

Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.

Bialucha CU, Collins SD, Li X, Saxena P, Zhang X, Dürr C, Lafont B, Prieur P, Shim Y, Mosher R, Lee D, Ostrom L, Hu T, Bilic S, Rajlic IL, Capka V, Jiang W, Wagner JP, Elliott G, Veloso A, Piel JC, Flaherty MM, Mansfield KG, Meseck EK, Rubic-Schneider T, London AS, Tschantz WR, Kurz M, Nguyen D, Bourret A, Meyer MJ, Faris JE, Janatpour MJ, Chan VW, Yoder NC, Catcott KC, McShea MA, Sun X, Gao H, Williams J, Hofmann F, Engelman JA, Ettenberg SA, Sellers WR, Lees E.

Cancer Discov. 2017 Sep;7(9):1030-1045. doi: 10.1158/2159-8290.CD-16-1414. Epub 2017 May 19.

28.
29.

Cyanobacterial ent-Sterol-Like Natural Products from a Deviated Ubiquinone Pathway.

Moosmann P, Ueoka R, Grauso L, Mangoni A, Morinaka BI, Gugger M, Piel J.

Angew Chem Int Ed Engl. 2017 Apr 24;56(18):4987-4990. doi: 10.1002/anie.201611617. Epub 2017 Mar 30.

PMID:
28370791
30.

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium.

Freeman MF, Helf MJ, Bhushan A, Morinaka BI, Piel J.

Nat Chem. 2017 Apr;9(4):387-395. doi: 10.1038/nchem.2666. Epub 2016 Nov 28.

PMID:
28338684
31.

Entotheonella Bacteria as Source of Sponge-Derived Natural Products: Opportunities for Biotechnological Production.

Bhushan A, Peters EE, Piel J.

Prog Mol Subcell Biol. 2017;55:291-314. doi: 10.1007/978-3-319-51284-6_9. Review.

PMID:
28238042
32.

An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge Theonella swinhoei WA.

Smith DRM, Uria AR, Helfrich EJN, Milbredt D, van Pée KH, Piel J, Goss RJM.

ACS Chem Biol. 2017 May 19;12(5):1281-1287. doi: 10.1021/acschembio.6b01115. Epub 2017 Mar 24.

PMID:
28198609
33.

Clinical and Ethical Challenges: Managing Acute Psychosis in Pregnancy.

Croicu C, Piel J, Murray SB.

Psychosomatics. 2017 May - Jun;58(3):317-321. doi: 10.1016/j.psym.2016.12.002. Epub 2016 Dec 7. No abstract available.

PMID:
28159350
34.

Insights into the Planktothrix genus: Genomic and metabolic comparison of benthic and planktic strains.

Pancrace C, Barny MA, Ueoka R, Calteau A, Scalvenzi T, Pédron J, Barbe V, Piel J, Humbert JF, Gugger M.

Sci Rep. 2017 Jan 24;7:41181. doi: 10.1038/srep41181.

35.

Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges.

Lackner G, Peters EE, Helfrich EJ, Piel J.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E347-E356. doi: 10.1073/pnas.1616234114. Epub 2017 Jan 3.

36.

Genomes of coral dinoflagellate symbionts highlight evolutionary adaptations conducive to a symbiotic lifestyle.

Aranda M, Li Y, Liew YJ, Baumgarten S, Simakov O, Wilson MC, Piel J, Ashoor H, Bougouffa S, Bajic VB, Ryu T, Ravasi T, Bayer T, Micklem G, Kim H, Bhak J, LaJeunesse TC, Voolstra CR.

Sci Rep. 2016 Dec 22;6:39734. doi: 10.1038/srep39734.

37.

Enzyme from an Uncultivated Sponge Bacterium Catalyzes S-Methylation in a Ribosomal Peptide.

Helf MJ, Jud A, Piel J.

Chembiochem. 2017 Mar 2;18(5):444-450. doi: 10.1002/cbic.201600594. Epub 2017 Jan 20.

PMID:
27966282
38.

An Orthogonal D2 O-Based Induction System that Provides Insights into d-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases.

Morinaka BI, Verest M, Freeman MF, Gugger M, Piel J.

Angew Chem Int Ed Engl. 2017 Jan 16;56(3):762-766. doi: 10.1002/anie.201609469. Epub 2016 Dec 13.

PMID:
27958669
39.

Response to "Ethical and Clinical Dilemmas in Using Psychotropic Medications During Pregnancy".

Piel J, Murray SB, Croicu CA.

AMA J Ethics. 2016 Nov 1;18(11):1156-1159. doi: 10.1001/journalofethics.2016.18.11.corr1-1611. No abstract available.

40.

Informed Consent in Right-To-Try Cases.

Piel J.

J Am Acad Psychiatry Law. 2016 Sep;44(3):290-6. No abstract available.

PMID:
27644860
41.

A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution.

Fuchs SW, Lackner G, Morinaka BI, Morishita Y, Asai T, Riniker S, Piel J.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12330-3. doi: 10.1002/anie.201602863. Epub 2016 Sep 1.

PMID:
27584723
42.

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.

Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N.

Nat Biotechnol. 2016 Aug 9;34(8):828-837. doi: 10.1038/nbt.3597.

43.

The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli.

Garcie C, Tronnet S, Garénaux A, McCarthy AJ, Brachmann AO, Pénary M, Houle S, Nougayrède JP, Piel J, Taylor PW, Dozois CM, Genevaux P, Oswald E, Martin P.

J Infect Dis. 2016 Sep 15;214(6):916-24. doi: 10.1093/infdis/jiw294. Epub 2016 Jul 13.

PMID:
27412582
44.

Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins.

Jenner M, Afonso JP, Kohlhaas C, Karbaum P, Frank S, Piel J, Oldham NJ.

Chem Commun (Camb). 2016 Apr 18;52(30):5262-5. doi: 10.1039/c6cc01453d. Epub 2016 Mar 22.

PMID:
27003309
45.

High slew-rate head-only gradient for improving distortion in echo planar imaging: Preliminary experience.

Tan ET, Lee SK, Weavers PT, Graziani D, Piel JE, Shu Y, Huston J 3rd, Bernstein MA, Foo TK.

J Magn Reson Imaging. 2016 Sep;44(3):653-64. doi: 10.1002/jmri.25210. Epub 2016 Feb 26.

46.

Fe2+ chelator proferrorosamine A: a gene cluster of Erwinia rhapontici P45 involved in its synthesis and its impact on growth of Erwinia amylovora CFBP1430.

Born Y, Remus-Emsermann MN, Bieri M, Kamber T, Piel J, Pelludat C.

Microbiology. 2016 Feb;162(2):236-45. doi: 10.1099/mic.0.000231. Epub 2016 Jan 5.

PMID:
26732708
47.

Biosynthesis of polyketides by trans-AT polyketide synthases.

Helfrich EJ, Piel J.

Nat Prod Rep. 2016 Feb;33(2):231-316. doi: 10.1039/c5np00125k. Review.

PMID:
26689670
48.

Peripheral nerve stimulation characteristics of an asymmetric head-only gradient coil compatible with a high-channel-count receiver array.

Lee SK, Mathieu JB, Graziani D, Piel J, Budesheim E, Fiveland E, Hardy CJ, Tan ET, Amm B, Foo TK, Bernstein MA, Huston J 3rd, Shu Y, Schenck JF.

Magn Reson Med. 2016 Dec;76(6):1939-1950. doi: 10.1002/mrm.26044. Epub 2015 Dec 2.

49.

Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria.

Freeman MF, Vagstad AL, Piel J.

Curr Opin Chem Biol. 2016 Apr;31:8-14. doi: 10.1016/j.cbpa.2015.11.002. Epub 2015 Nov 25. Review.

PMID:
26625171
50.

Expanding Slayer Statutes to Elder Abuse.

Piel J.

J Am Acad Psychiatry Law. 2015 Sep;43(3):369-76.

PMID:
26438815

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