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Items: 1 to 50 of 169

1.

Genome mining of oxidation modules in trans-acyltransferase polyketide synthases reveals a culturable source for lobatamides.

Ueoka R, Meoded R, Gran-Scheuch A, Bhushan A, Fraaije M, Piel J.

Angew Chem Int Ed Engl. 2020 Feb 10. doi: 10.1002/anie.201916005. [Epub ahead of print]

PMID:
32040255
2.

Term-of-Years Sentences Since Miller v. Alabama.

Piel JL.

J Am Acad Psychiatry Law. 2020 Jan 24. pii: JAAPL.003918-20. doi: 10.29158/JAAPL.003918-20. [Epub ahead of print]

PMID:
31980456
3.

Highly efficient head-only magnetic field insert gradient coil for achieving simultaneous high gradient amplitude and slew rate at 3.0T (MAGNUS) for brain microstructure imaging.

Foo TKF, Tan ET, Vermilyea ME, Hua Y, Fiveland EW, Piel JE, Park K, Ricci J, Thompson PS, Graziani D, Conte G, Kagan A, Bai Y, Vasil C, Tarasek M, Yeo DTB, Snell F, Lee D, Dean A, DeMarco JK, Shih RY, Hood MN, Chae H, Ho VB.

Magn Reson Med. 2019 Nov 25. doi: 10.1002/mrm.28087. [Epub ahead of print]

PMID:
31763726
4.

Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice.

Wotzka SY, Kreuzer M, Maier L, Arnoldini M, Nguyen BD, Brachmann AO, Berthold DL, Zünd M, Hausmann A, Bakkeren E, Hoces D, Gül E, Beutler M, Dolowschiak T, Zimmermann M, Fuhrer T, Moor K, Sauer U, Typas A, Piel J, Diard M, Macpherson AJ, Stecher B, Sunagawa S, Slack E, Hardt WD.

Nat Microbiol. 2019 Dec;4(12):2164-2174. doi: 10.1038/s41564-019-0568-5. Epub 2019 Oct 7.

PMID:
31591555
5.

The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin.

Chagneau CV, Garcie C, Bossuet-Greif N, Tronnet S, Brachmann AO, Piel J, Nougayrède JP, Martin P, Oswald E.

mSphere. 2019 Oct 2;4(5). pii: e00414-19. doi: 10.1128/mSphere.00414-19.

6.

Genome mining- and synthetic biology-enabled production of hypermodified peptides.

Bhushan A, Egli PJ, Peters EE, Freeman MF, Piel J.

Nat Chem. 2019 Oct;11(10):931-939. doi: 10.1038/s41557-019-0323-9. Epub 2019 Sep 9.

PMID:
31501509
7.

Characterization of an Orphan Type III Polyketide Synthase Conserved in Uncultivated "Entotheonella" Sponge Symbionts.

Reiter S, Cahn JKB, Wiebach V, Ueoka R, Piel J.

Chembiochem. 2020 Feb 17;21(4):564-571. doi: 10.1002/cbic.201900352. Epub 2019 Oct 22.

PMID:
31430416
8.

Peripheral nerve stimulation limits of a high amplitude and slew rate magnetic field gradient coil for neuroimaging.

Tan ET, Hua Y, Fiveland EW, Vermilyea ME, Piel JE, Park KJ, Ho VB, Foo TKF.

Magn Reson Med. 2020 Jan;83(1):352-366. doi: 10.1002/mrm.27909. Epub 2019 Aug 6.

PMID:
31385628
9.

Automated structure prediction of trans-acyltransferase polyketide synthase products.

Helfrich EJN, Ueoka R, Dolev A, Rust M, Meoded RA, Bhushan A, Califano G, Costa R, Gugger M, Steinbeck C, Moreno P, Piel J.

Nat Chem Biol. 2019 Aug;15(8):813-821. doi: 10.1038/s41589-019-0313-7. Epub 2019 Jul 15.

10.

A Review of Forensic Fellowship Training: Similar Challenges, Diverse Approaches.

Michaelsen K, Piel J, Kopelovich S, Reynolds S, Cowley D.

Acad Psychiatry. 2019 Jul 3. doi: 10.1007/s40596-019-01083-1. [Epub ahead of print]

PMID:
31270777
11.

Creating a State-Academic Partnership to Advance a Forensic Teaching Service: Benefits and Barriers.

Piel JL, Kopelovich SL, Michaelsen K, Reynolds SE, Cowley DS.

J Forensic Sci. 2019 Nov;64(6):1743-1749. doi: 10.1111/1556-4029.14075. Epub 2019 Jun 3.

PMID:
31157917
12.

Bacteria-induced production of the antibacterial sesquiterpene lagopodin B in Coprinopsis cinerea.

Stöckli M, Morinaka BI, Lackner G, Kombrink A, Sieber R, Margot C, Stanley CE, deMello AJ, Piel J, Künzler M.

Mol Microbiol. 2019 Aug;112(2):605-619. doi: 10.1111/mmi.14277. Epub 2019 May 29.

PMID:
31087720
13.

Snf2 controls pulcherriminic acid biosynthesis and antifungal activity of the biocontrol yeast Metschnikowia pulcherrima.

Gore-Lloyd D, Sumann I, Brachmann AO, Schneeberger K, Ortiz-Merino RA, Moreno-Beltrán M, Schläfli M, Kirner P, Santos Kron A, Rueda-Mejia MP, Somerville V, Wolfe KH, Piel J, Ahrens CH, Henk D, Freimoser FM.

Mol Microbiol. 2019 Jul;112(1):317-332. doi: 10.1111/mmi.14272. Epub 2019 May 20.

14.

Effect of tolytoxin on tunneling nanotube formation and function.

Dilsizoglu Senol A, Pepe A, Grudina C, Sassoon N, Reiko U, Bousset L, Melki R, Piel J, Gugger M, Zurzolo C.

Sci Rep. 2019 Apr 5;9(1):5741. doi: 10.1038/s41598-019-42161-6.

15.

Mental health treatment among older adults with mental illness on parole or probation.

Bryson WC, Cotton BP, Barry LC, Bruce ML, Piel J, Thielke SM, Williams BA.

Health Justice. 2019 Mar 28;7(1):4. doi: 10.1186/s40352-019-0084-y.

16.

Sharing Violent Thoughts on the Internet.

Abukamil R, Piel JL.

J Am Acad Psychiatry Law. 2019 Mar;47(1):82-90. doi: 10.29158/JAAPL.003826-19. Epub 2019 Feb 19.

PMID:
30782605
17.

Opening up the Single-Cell Toolbox for Microbial Natural Products Research.

Piel J, Cahn J.

Angew Chem Int Ed Engl. 2019 Feb 12. doi: 10.1002/anie.201900532. [Epub ahead of print]

PMID:
30748086
18.

In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids.

Schleyer G, Shahaf N, Ziv C, Dong Y, Meoded RA, Helfrich EJN, Schatz D, Rosenwasser S, Rogachev I, Aharoni A, Piel J, Vardi A.

Nat Microbiol. 2019 Mar;4(3):527-538. doi: 10.1038/s41564-018-0336-y. Epub 2019 Feb 4.

19.

Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis.

Helf MJ, Freeman MF, Piel J.

J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):551-563. doi: 10.1007/s10295-018-02129-3. Epub 2019 Jan 9.

PMID:
30627933
20.

Introduction of d-Amino Acids in Minimalistic Peptide Substrates by an S-Adenosyl-l-Methionine Radical Epimerase.

Vagstad AL, Kuranaga T, Püntener S, Pattabiraman VR, Bode JW, Piel J.

Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2246-2250. doi: 10.1002/anie.201809508. Epub 2019 Jan 25.

PMID:
30521081
21.

Genome Mining-guided and MALDI Imaging-assisted Discovery of New Antibiotics.

Probst SI, Vogel C, Vorholt JA, Piel J.

Chimia (Aarau). 2018 Nov 30;72(11):816. doi: 10.2533/chimia.2018.816. No abstract available.

PMID:
30514426
22.

Aranazoles: Extensively Chlorinated Nonribosomal Peptide-Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339.

Moosmann P, Ueoka R, Gugger M, Piel J.

Org Lett. 2018 Sep 7;20(17):5238-5241. doi: 10.1021/acs.orglett.8b02193. Epub 2018 Aug 24.

PMID:
30141631
23.

Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome.

Helfrich EJN, Vogel CM, Ueoka R, Schäfer M, Ryffel F, Müller DB, Probst S, Kreuzer M, Piel J, Vorholt JA.

Nat Microbiol. 2018 Aug;3(8):909-919. doi: 10.1038/s41564-018-0200-0. Epub 2018 Jul 23.

PMID:
30038309
24.

Legislative Advocacy and Forensic Psychiatry Training.

Piel J.

J Am Acad Psychiatry Law. 2018 Jun;46(2):147-154. doi: 10.29158/JAAPL.003741-18.

PMID:
30026391
25.

Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source.

Ueoka R, Bhushan A, Probst SI, Bray WM, Lokey RS, Linington RG, Piel J.

Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14519-14523. doi: 10.1002/anie.201805673. Epub 2018 Aug 23.

PMID:
30025185
26.

Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis.

Byer AS, Yang H, McDaniel EC, Kathiresan V, Impano S, Pagnier A, Watts H, Denler C, Vagstad AL, Piel J, Duschene KS, Shepard EM, Shields TP, Scott LG, Lilla EA, Yokoyama K, Broderick WE, Hoffman BM, Broderick JB.

J Am Chem Soc. 2018 Jul 18;140(28):8634-8638. doi: 10.1021/jacs.8b04061. Epub 2018 Jul 6.

27.

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones.

Meoded RA, Ueoka R, Helfrich EJN, Jensen K, Magnus N, Piechulla B, Piel J.

Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11644-11648. doi: 10.1002/anie.201805363. Epub 2018 Jul 31.

28.

Biosynthetic Insights of Calyculin- and Misakinolide-Type Compounds in "Candidatus Entotheonella sp."

Uria AR, Piel J, Wakimoto T.

Methods Enzymol. 2018;604:287-330. doi: 10.1016/bs.mie.2018.02.017. Epub 2018 May 7.

PMID:
29779656
29.

Radical S-Adenosylmethionine Peptide Epimerases: Detection of Activity and Characterization of d-Amino Acid Products.

Morinaka BI, Vagstad AL, Piel J.

Methods Enzymol. 2018;604:237-257. doi: 10.1016/bs.mie.2018.01.033. Epub 2018 Apr 11.

PMID:
29779654
30.

Mental Condition Requirement in Competency to Stand Trial Assessments.

Reisner AD, Piel JL.

J Am Acad Psychiatry Law. 2018 Mar;46(1):86-92.

PMID:
29618540
31.

Lightweight, compact, and high-performance 3T MR system for imaging the brain and extremities.

Foo TKF, Laskaris E, Vermilyea M, Xu M, Thompson P, Conte G, Van Epps C, Immer C, Lee SK, Tan ET, Graziani D, Mathieu JB, Hardy CJ, Schenck JF, Fiveland E, Stautner W, Ricci J, Piel J, Park K, Hua Y, Bai Y, Kagan A, Stanley D, Weavers PT, Gray E, Shu Y, Frick MA, Campeau NG, Trzasko J, Huston J 3rd, Bernstein MA.

Magn Reson Med. 2018 Nov;80(5):2232-2245. doi: 10.1002/mrm.27175. Epub 2018 Mar 13.

32.

Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.

Wagner DT, Zhang Z, Meoded RA, Cepeda AJ, Piel J, Keatinge-Clay AT.

ACS Chem Biol. 2018 Apr 20;13(4):975-983. doi: 10.1021/acschembio.8b00049. Epub 2018 Mar 1.

33.

Natural noncanonical protein splicing yields products with diverse β-amino acid residues.

Morinaka BI, Lakis E, Verest M, Helf MJ, Scalvenzi T, Vagstad AL, Sims J, Sunagawa S, Gugger M, Piel J.

Science. 2018 Feb 16;359(6377):779-782. doi: 10.1126/science.aao0157.

PMID:
29449488
34.

Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts.

Mori T, Cahn JKB, Wilson MC, Meoded RA, Wiebach V, Martinez AFC, Helfrich EJN, Albersmeier A, Wibberg D, Dätwyler S, Keren R, Lavy A, Rückert C, Ilan M, Kalinowski J, Matsunaga S, Takeyama H, Piel J.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1718-1723. doi: 10.1073/pnas.1715496115. Epub 2018 Feb 8.

35.

Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism.

Puri AW, Mevers E, Ramadhar TR, Petras D, Liu D, Piel J, Dorrestein PC, Greenberg EP, Lidstrom ME, Clardy J.

J Am Chem Soc. 2018 Feb 14;140(6):2002-2006. doi: 10.1021/jacs.7b12240. Epub 2018 Jan 30.

36.

Does Volk v DeMeerleer Conflict with the AMA Code of Medical Ethics on Breaching Patient Confidentiality to Protect Third Parties?

Piel JL, Opara R.

AMA J Ethics. 2018 Jan 1;20(1):10-18. doi: 10.1001/journalofethics.2018.20.1.peer2-1801.

37.

The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort.

Piel JH, Lett TA, Wackerhagen C, Plichta MM, Mohnke S, Grimm O, Romanczuk-Seiferth N, Degenhardt F, Tost H, Witt S, Nöthen M, Rietschel M, Heinz A, Meyer-Lindenberg A, Walter H, Erk S.

Eur Neuropsychopharmacol. 2018 Mar;28(3):415-427. doi: 10.1016/j.euroneuro.2017.12.014. Epub 2018 Jan 19.

PMID:
29358097
38.

Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359.

Crüsemann M, Reher R, Schamari I, Brachmann AO, Ohbayashi T, Kuschak M, Malfacini D, Seidinger A, Pinto-Carbó M, Richarz R, Reuter T, Kehraus S, Hallab A, Attwood M, Schiöth HB, Mergaert P, Kikuchi Y, Schäberle TF, Kostenis E, Wenzel D, Müller CE, Piel J, Carlier A, Eberl L, König GM.

Angew Chem Int Ed Engl. 2018 Jan 15;57(3):836-840. doi: 10.1002/anie.201707996. Epub 2017 Dec 20.

PMID:
29194875
39.

Toblerols: Cyclopropanol-Containing Polyketide Modulators of Antibiosis in Methylobacteria.

Ueoka R, Bortfeld-Miller M, Morinaka BI, Vorholt JA, Piel J.

Angew Chem Int Ed Engl. 2018 Jan 22;57(4):977-981. doi: 10.1002/anie.201709056. Epub 2017 Dec 18.

PMID:
29112783
40.

High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway.

Tronnet S, Garcie C, Brachmann AO, Piel J, Oswald E, Martin P.

Pathog Dis. 2017 Jul 31;75(5). doi: 10.1093/femspd/ftx066.

PMID:
28637194
41.

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products.

van der Velden NS, Kälin N, Helf MJ, Piel J, Freeman MF, Künzler M.

Nat Chem Biol. 2017 Aug;13(8):833-835. doi: 10.1038/nchembio.2393. Epub 2017 Jun 5.

PMID:
28581484
42.

Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.

Bialucha CU, Collins SD, Li X, Saxena P, Zhang X, Dürr C, Lafont B, Prieur P, Shim Y, Mosher R, Lee D, Ostrom L, Hu T, Bilic S, Rajlic IL, Capka V, Jiang W, Wagner JP, Elliott G, Veloso A, Piel JC, Flaherty MM, Mansfield KG, Meseck EK, Rubic-Schneider T, London AS, Tschantz WR, Kurz M, Nguyen D, Bourret A, Meyer MJ, Faris JE, Janatpour MJ, Chan VW, Yoder NC, Catcott KC, McShea MA, Sun X, Gao H, Williams J, Hofmann F, Engelman JA, Ettenberg SA, Sellers WR, Lees E.

Cancer Discov. 2017 Sep;7(9):1030-1045. doi: 10.1158/2159-8290.CD-16-1414. Epub 2017 May 19.

43.
44.

Cyanobacterial ent-Sterol-Like Natural Products from a Deviated Ubiquinone Pathway.

Moosmann P, Ueoka R, Grauso L, Mangoni A, Morinaka BI, Gugger M, Piel J.

Angew Chem Int Ed Engl. 2017 Apr 24;56(18):4987-4990. doi: 10.1002/anie.201611617. Epub 2017 Mar 30.

PMID:
28370791
45.

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium.

Freeman MF, Helf MJ, Bhushan A, Morinaka BI, Piel J.

Nat Chem. 2017 Apr;9(4):387-395. doi: 10.1038/nchem.2666. Epub 2016 Nov 28.

PMID:
28338684
46.

Entotheonella Bacteria as Source of Sponge-Derived Natural Products: Opportunities for Biotechnological Production.

Bhushan A, Peters EE, Piel J.

Prog Mol Subcell Biol. 2017;55:291-314. doi: 10.1007/978-3-319-51284-6_9. Review.

PMID:
28238042
47.

An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge Theonella swinhoei WA.

Smith DRM, Uria AR, Helfrich EJN, Milbredt D, van Pée KH, Piel J, Goss RJM.

ACS Chem Biol. 2017 May 19;12(5):1281-1287. doi: 10.1021/acschembio.6b01115. Epub 2017 Mar 24.

PMID:
28198609
48.

Clinical and Ethical Challenges: Managing Acute Psychosis in Pregnancy.

Croicu C, Piel J, Murray SB.

Psychosomatics. 2017 May - Jun;58(3):317-321. doi: 10.1016/j.psym.2016.12.002. Epub 2016 Dec 7. No abstract available.

PMID:
28159350
49.

Insights into the Planktothrix genus: Genomic and metabolic comparison of benthic and planktic strains.

Pancrace C, Barny MA, Ueoka R, Calteau A, Scalvenzi T, Pédron J, Barbe V, Piel J, Humbert JF, Gugger M.

Sci Rep. 2017 Jan 24;7:41181. doi: 10.1038/srep41181.

50.

Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges.

Lackner G, Peters EE, Helfrich EJ, Piel J.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E347-E356. doi: 10.1073/pnas.1616234114. Epub 2017 Jan 3.

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