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Items: 1 to 50 of 209

1.

Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.

Mohan K, Ueda G, Kim AR, Jude KM, Fallas JA, Guo Y, Hafer M, Miao Y, Saxton RA, Piehler J, Sankaran VG, Baker D, Garcia KC.

Science. 2019 May 24;364(6442). pii: eaav7532. doi: 10.1126/science.aav7532. Epub 2019 May 23.

PMID:
31123111
2.

Structure of the IFNγ receptor complex guides design of biased agonists.

Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC.

Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27.

3.

Publisher Correction: Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells.

Etoc F, Balloul E, Vicario C, Normanno D, Liße D, Sittner A, Piehler J, Dahan M, Coppey M.

Nat Mater. 2018 Nov;17(11):1048. doi: 10.1038/s41563-018-0188-0.

PMID:
30232394
4.

Correction: Magnetic control of cellular processes using biofunctional nanoparticles.

Monzel C, Vicario C, Piehler J, Coppey M, Dahan M.

Chem Sci. 2017 Dec 1;8(12):8464. doi: 10.1039/c7sc90067h. Epub 2017 Nov 1.

5.

How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins.

Chavent M, Duncan AL, Rassam P, Birkholz O, Hélie J, Reddy T, Beliaev D, Hambly B, Piehler J, Kleanthous C, Sansom MSP.

Nat Commun. 2018 Jul 20;9(1):2846. doi: 10.1038/s41467-018-05255-9.

6.

Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells.

Etoc F, Balloul E, Vicario C, Normanno D, Liße D, Sittner A, Piehler J, Dahan M, Coppey M.

Nat Mater. 2018 Aug;17(8):740-746. doi: 10.1038/s41563-018-0120-7. Epub 2018 Jul 2. Erratum in: Nat Mater. 2018 Nov;17(11):1048.

PMID:
29967464
7.

Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials.

Birkholz O, Burns JR, Richter CP, Psathaki OE, Howorka S, Piehler J.

Nat Commun. 2018 Apr 18;9(1):1521. doi: 10.1038/s41467-018-02905-w.

8.

Near-native, site-specific and purification-free protein labeling for quantitative protein interaction analysis by MicroScale Thermophoresis.

Bartoschik T, Galinec S, Kleusch C, Walkiewicz K, Breitsprecher D, Weigert S, Muller YA, You C, Piehler J, Vercruysse T, Daelemans D, Tschammer N.

Sci Rep. 2018 Mar 21;8(1):4977. doi: 10.1038/s41598-018-23154-3.

9.

Single-molecule imaging reveals dynamic biphasic partition of RNA-binding proteins in stress granules.

Niewidok B, Igaev M, Pereira da Graca A, Strassner A, Lenzen C, Richter CP, Piehler J, Kurre R, Brandt R.

J Cell Biol. 2018 Apr 2;217(4):1303-1318. doi: 10.1083/jcb.201709007. Epub 2018 Feb 20.

10.

Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates.

Countryman P, Fan Y, Gorthi A, Pan H, Strickland J, Kaur P, Wang X, Lin J, Lei X, White C, You C, Wirth N, Tessmer I, Piehler J, Riehn R, Bishop AJR, Tao YJ, Wang H.

J Biol Chem. 2018 Jan 19;293(3):1054-1069. doi: 10.1074/jbc.M117.806406. Epub 2017 Nov 24.

11.

Magnetic control of cellular processes using biofunctional nanoparticles.

Monzel C, Vicario C, Piehler J, Coppey M, Dahan M.

Chem Sci. 2017 Nov 1;8(11):7330-7338. doi: 10.1039/c7sc01462g. Epub 2017 Aug 9. Review. Erratum in: Chem Sci. 2017 Dec 1;8(12):8464.

12.

Engineered Ferritin for Magnetogenetic Manipulation of Proteins and Organelles Inside Living Cells.

Liße D, Monzel C, Vicario C, Manzi J, Maurin I, Coppey M, Piehler J, Dahan M.

Adv Mater. 2017 Nov;29(42). doi: 10.1002/adma.201700189. Epub 2017 Sep 28.

PMID:
28960485
13.

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.

Richter D, Moraga I, Winkelmann H, Birkholz O, Wilmes S, Schulte M, Kraich M, Kenneweg H, Beutel O, Selenschik P, Paterok D, Gavutis M, Schmidt T, Garcia KC, Müller TD, Piehler J.

Nat Commun. 2017 Jul 14;8:15976. doi: 10.1038/ncomms15976.

14.

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.

Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC.

Nature. 2017 May 11;545(7653):234-237. doi: 10.1038/nature22306. Epub 2017 May 3.

15.

Binding of interferon reduces the force of unfolding for interferon receptor 1.

Chuartzman SG, Nevo R, Waichman S, Shental D, Piehler J, Levy Y, Reich Z, Kapon R.

PLoS One. 2017 Apr 12;12(4):e0175413. doi: 10.1371/journal.pone.0175413. eCollection 2017.

16.

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.

Kim AR, Ulirsch JC, Wilmes S, Unal E, Moraga I, Karakukcu M, Yuan D, Kazerounian S, Abdulhay NJ, King DS, Gupta N, Gabriel SB, Lander ES, Patiroglu T, Ozcan A, Ozdemir MA, Garcia KC, Piehler J, Gazda HT, Klein DE, Sankaran VG.

Cell. 2017 Mar 9;168(6):1053-1064.e15. doi: 10.1016/j.cell.2017.02.026.

17.

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.

Ho CCM, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, Weissman IL, Galli SJ, Shizuru JA, Garcia KC.

Cell. 2017 Mar 9;168(6):1041-1052.e18. doi: 10.1016/j.cell.2017.02.011.

18.

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.

Arimoto KI, Löchte S, Stoner SA, Burkart C, Zhang Y, Miyauchi S, Wilmes S, Fan JB, Heinisch JJ, Li Z, Yan M, Pellegrini S, Colland F, Piehler J, Zhang DE.

Nat Struct Mol Biol. 2017 Mar;24(3):279-289. doi: 10.1038/nsmb.3378. Epub 2017 Feb 6.

19.

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.

You C, Marquez-Lago TT, Richter CP, Wilmes S, Moraga I, Garcia KC, Leier A, Piehler J.

Sci Adv. 2016 Dec 2;2(12):e1600452. eCollection 2016 Dec.

20.

Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex.

Chmiest D, Sharma N, Zanin N, Viaris de Lesegno C, Shafaq-Zadah M, Sibut V, Dingli F, Hupé P, Wilmes S, Piehler J, Loew D, Johannes L, Schreiber G, Lamaze C.

Nat Commun. 2016 Dec 5;7:13476. doi: 10.1038/ncomms13476.

21.

Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis.

Zhang Z, English BP, Grimm JB, Kazane SA, Hu W, Tsai A, Inouye C, You C, Piehler J, Schultz PG, Lavis LD, Revyakin A, Tjian R.

Genes Dev. 2016 Sep 15;30(18):2106-2118.

22.

Single molecule super-resolution imaging of proteins in living Salmonella enterica using self-labelling enzymes.

Barlag B, Beutel O, Janning D, Czarniak F, Richter CP, Kommnick C, Göser V, Kurre R, Fabiani F, Erhardt M, Piehler J, Hensel M.

Sci Rep. 2016 Aug 18;6:31601. doi: 10.1038/srep31601.

23.

Engineered Upconversion Nanoparticles for Resolving Protein Interactions inside Living Cells.

Drees C, Raj AN, Kurre R, Busch KB, Haase M, Piehler J.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11668-72. doi: 10.1002/anie.201603028. Epub 2016 Aug 11.

PMID:
27510808
24.

Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing.

Lin J, Countryman P, Chen H, Pan H, Fan Y, Jiang Y, Kaur P, Miao W, Gurgel G, You C, Piehler J, Kad NM, Riehn R, Opresko PL, Smith S, Tao YJ, Wang H.

Nucleic Acids Res. 2016 Jul 27;44(13):6363-76. doi: 10.1093/nar/gkw518. Epub 2016 Jun 13.

25.

ISG15 deficiency and increased viral resistance in humans but not mice.

Speer SD, Li Z, Buta S, Payelle-Brogard B, Qian L, Vigant F, Rubino E, Gardner TJ, Wedeking T, Hermann M, Duehr J, Sanal O, Tezcan I, Mansouri N, Tabarsi P, Mansouri D, Francois-Newton V, Daussy CF, Rodriguez MR, Lenschow DJ, Freiberg AN, Tortorella D, Piehler J, Lee B, García-Sastre A, Pellegrini S, Bogunovic D.

Nat Commun. 2016 May 19;7:11496. doi: 10.1038/ncomms11496.

26.

Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo.

Lavender KJ, Gibbert K, Peterson KE, Van Dis E, Francois S, Woods T, Messer RJ, Gawanbacht A, Müller JA, Münch J, Phillips K, Race B, Harper MS, Guo K, Lee EJ, Trilling M, Hengel H, Piehler J, Verheyen J, Wilson CC, Santiago ML, Hasenkrug KJ, Dittmer U.

J Virol. 2016 Jun 10;90(13):6001-6013. doi: 10.1128/JVI.00451-16. Print 2016 Jul 1.

27.

Bioinspired monolithic polymer microsphere arrays as generically anti-adhesive surfaces.

Eichler-Volf A, Kovalev A, Wedeking T, Gorb EV, Xue L, You C, Piehler J, Gorb SN, Steinhart M.

Bioinspir Biomim. 2016 Mar 17;11(2):025002. doi: 10.1088/1748-3190/11/2/025002.

PMID:
26989086
28.

Functional protein micropatterning for drug design and discovery.

You C, Piehler J.

Expert Opin Drug Discov. 2016;11(1):105-19. doi: 10.1517/17460441.2016.1109625. Epub 2015 Dec 1. Review.

PMID:
26624534
29.

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.

Moraga I, Richter D, Wilmes S, Winkelmann H, Jude K, Thomas C, Suhoski MM, Engleman EG, Piehler J, Garcia KC.

Sci Signal. 2015 Nov 10;8(402):ra114. doi: 10.1126/scisignal.aab2677.

30.

Spatiotemporally Controlled Reorganization of Signaling Complexes in the Plasma Membrane of Living Cells.

Wedeking T, Löchte S, Birkholz O, Wallenstein A, Trahe J, Klingauf J, Piehler J, You C.

Small. 2015 Nov 25;11(44):5912-8. doi: 10.1002/smll.201502132. Epub 2015 Sep 30.

PMID:
26421417
31.

Two-Dimensional Trap for Ultrasensitive Quantification of Transient Protein Interactions.

Beutel O, Roder F, Birkholz O, Rickert C, Steinhoff HJ, Grzybek M, Coskun Ü, Piehler J.

ACS Nano. 2015 Oct 27;9(10):9783-91. doi: 10.1021/acsnano.5b02696. Epub 2015 Sep 15.

PMID:
26331529
32.

Rupture of Stochastically Occurring Vesicle Clusters Limits Bilayer Formation on Alkane-PEG-Type Supports: Uncoupling Clustering from Surface Coverage.

Peel MJ, Cross SJ, Birkholz O, Aladağ A, Piehler J, Peel S.

Langmuir. 2015 Aug 18;31(32):8830-40. doi: 10.1021/acs.langmuir.5b00925. Epub 2015 Aug 4.

PMID:
26176185
33.

Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria.

Rassam P, Copeland NA, Birkholz O, Tóth C, Chavent M, Duncan AL, Cross SJ, Housden NG, Kaminska R, Seger U, Quinn DM, Garrod TJ, Sansom MS, Piehler J, Baumann CG, Kleanthous C.

Nature. 2015 Jul 16;523(7560):333-6. doi: 10.1038/nature14461. Epub 2015 Jun 10.

34.

Shuttling of PINK1 between Mitochondrial Microcompartments Resolved by Triple-Color Superresolution Microscopy.

Beinlich FR, Drees C, Piehler J, Busch KB.

ACS Chem Biol. 2015 Sep 18;10(9):1970-6. doi: 10.1021/acschembio.5b00295. Epub 2015 Jun 23.

PMID:
26046594
35.

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling.

Wilmes S, Beutel O, Li Z, Francois-Newton V, Richter CP, Janning D, Kroll C, Hanhart P, Hötte K, You C, Uzé G, Pellegrini S, Piehler J.

J Cell Biol. 2015 May 25;209(4):579-93. doi: 10.1083/jcb.201412049.

36.

Single Cell GFP-Trap Reveals Stoichiometry and Dynamics of Cytosolic Protein Complexes.

Wedeking T, Löchte S, Richter CP, Bhagawati M, Piehler J, You C.

Nano Lett. 2015 May 13;15(5):3610-5. doi: 10.1021/acs.nanolett.5b01153. Epub 2015 Apr 27.

PMID:
25901412
37.

Magnetogenetic control of protein gradients inside living cells with high spatial and temporal resolution.

Etoc F, Vicario C, Lisse D, Siaugue JM, Piehler J, Coppey M, Dahan M.

Nano Lett. 2015 May 13;15(5):3487-94. doi: 10.1021/acs.nanolett.5b00851. Epub 2015 Apr 28.

PMID:
25895433
38.

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.

Moraga I, Wernig G, Wilmes S, Gryshkova V, Richter CP, Hong WJ, Sinha R, Guo F, Fabionar H, Wehrman TS, Krutzik P, Demharter S, Plo I, Weissman IL, Minary P, Majeti R, Constantinescu SN, Piehler J, Garcia KC.

Cell. 2015 Mar 12;160(6):1196-208. doi: 10.1016/j.cell.2015.02.011. Epub 2015 Feb 26.

39.

The molecular basis for functional plasticity in type I interferon signaling.

Schreiber G, Piehler J.

Trends Immunol. 2015 Mar;36(3):139-49. doi: 10.1016/j.it.2015.01.002. Epub 2015 Feb 14. Review.

PMID:
25687684
40.

Spatiotemporal dynamics of membrane remodeling and fusion proteins during endocytic transport.

Arlt H, Auffarth K, Kurre R, Lisse D, Piehler J, Ungermann C.

Mol Biol Cell. 2015 Apr 1;26(7):1357-70. doi: 10.1091/mbc.E14-08-1318. Epub 2015 Feb 5.

41.

Clustering and dynamics of phototransducer signaling domains revealed by site-directed spin labeling electron paramagnetic resonance on SRII/HtrII in membranes and nanodiscs.

Orban-Glaß I, Voskoboynikova N, Busch KB, Klose D, Rickert C, Mosslehy W, Roder F, Wilkens V, Piehler J, Engelhard M, Steinhoff HJ, Klare JP.

Biochemistry. 2015 Jan 20;54(2):349-62. doi: 10.1021/bi501160q. Epub 2014 Dec 19.

PMID:
25489970
42.

Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membrane.

Löchte S, Waichman S, Beutel O, You C, Piehler J.

J Cell Biol. 2014 Nov 10;207(3):407-18. doi: 10.1083/jcb.201406032.

43.

Rapid transfer of transmembrane proteins for single molecule dimerization assays in polymer-supported membranes.

Roder F, Wilmes S, Richter CP, Piehler J.

ACS Chem Biol. 2014 Nov 21;9(11):2479-84. doi: 10.1021/cb5005806. Epub 2014 Sep 16.

PMID:
25203456
44.

Single-molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neurons.

Janning D, Igaev M, Sündermann F, Brühmann J, Beutel O, Heinisch JJ, Bakota L, Piehler J, Junge W, Brandt R.

Mol Biol Cell. 2014 Nov 5;25(22):3541-51. doi: 10.1091/mbc.E14-06-1099. Epub 2014 Aug 27.

45.

Dynamic submicroscopic signaling zones revealed by pair correlation tracking and localization microscopy.

You C, Richter CP, Löchte S, Wilmes S, Piehler J.

Anal Chem. 2014 Sep 2;86(17):8593-602. doi: 10.1021/ac501127r. Epub 2014 Aug 22.

PMID:
25148216
46.

Multivalent chelators for spatially and temporally controlled protein functionalization.

You C, Piehler J.

Anal Bioanal Chem. 2014 May;406(14):3345-57. doi: 10.1007/s00216-014-7803-y. Epub 2014 Apr 26. Review.

PMID:
24770786
47.

Spectroscopic techniques for monitoring protein interactions in living cells.

Piehler J.

Curr Opin Struct Biol. 2014 Feb;24:54-62. doi: 10.1016/j.sbi.2013.11.008. Epub 2013 Dec 21. Review.

PMID:
24721453
48.

Monofunctional stealth nanoparticle for unbiased single molecule tracking inside living cells.

Lisse D, Richter CP, Drees C, Birkholz O, You C, Rampazzo E, Piehler J.

Nano Lett. 2014;14(4):2189-95. doi: 10.1021/nl500637a. Epub 2014 Mar 21.

PMID:
24655019
49.

High-affinity gold nanoparticle pin to label and localize histidine-tagged protein in macromolecular assemblies.

Anthony KC, You C, Piehler J, Pomeranz Krummel DA.

Structure. 2014 Apr 8;22(4):628-35. doi: 10.1016/j.str.2014.01.007. Epub 2014 Feb 20. Retraction in: Structure. 2015 Aug 4;23(8):1558.

50.

Reconstituting functional microtubule-barrier interactions.

Taberner N, Weber G, You C, Dries R, Piehler J, Dogterom M.

Methods Cell Biol. 2014;120:69-90. doi: 10.1016/B978-0-12-417136-7.00005-7.

PMID:
24484658

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