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Items: 30


Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus.

Monk IR, Shaikh N, Begg SL, Gajdiss M, Sharkey LKR, Lee JYH, Pidot SJ, Seemann T, Kuiper M, Winnen B, Hvorup R, Collins BM, Bierbaum G, Udagedara SR, Morey JR, Pulyani N, Howden BP, Maher MJ, McDevitt CA, King GF, Stinear TP.

Nat Commun. 2019 Jul 11;10(1):3067. doi: 10.1038/s41467-019-10932-4.


Genome Mining Reveals Endopyrroles from a Nonribosomal Peptide Assembly Line Triggered in Fungal-Bacterial Symbiosis.

Niehs SP, Dose B, Scherlach K, Pidot SJ, Stinear TP, Hertweck C.

ACS Chem Biol. 2019 Aug 16;14(8):1811-1818. doi: 10.1021/acschembio.9b00406. Epub 2019 Jul 22.


Genomics-Driven Discovery of NO-Donating Diazeniumdiolate Siderophores in Diverse Plant-Associated Bacteria.

Hermenau R, Mehl JL, Ishida K, Dose B, Pidot SJ, Stinear TP, Hertweck C.

Angew Chem Int Ed Engl. 2019 Sep 9;58(37):13024-13029. doi: 10.1002/anie.201906326. Epub 2019 Aug 5.


Isopropanol at 60% and at 70% are effective against 'isopropanol-tolerant' Enterococcus faecium.

Gebel J, Gemein S, Kampf G, Pidot SJ, Buetti N, Exner M.

J Hosp Infect. 2019 Sep;103(1):e88-e91. doi: 10.1016/j.jhin.2019.01.024. Epub 2019 Feb 1.


Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides.

Pidot SJ, Herisse M, Sharkey L, Atkin L, Porter JL, Seemann T, Howden BP, Rizzacasa MA, Stinear TP.

Angew Chem Int Ed Engl. 2019 Mar 18;58(12):3996-4001. doi: 10.1002/anie.201900290. Epub 2019 Feb 11.


Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq).

Guérillot R, Li L, Baines S, Howden B, Schultz MB, Seemann T, Monk I, Pidot SJ, Gao W, Giulieri S, Gonçalves da Silva A, D'Agata A, Tomita T, Peleg AY, Stinear TP, Howden BP.

Genome Med. 2018 Aug 31;10(1):63. doi: 10.1186/s13073-018-0572-z.


Increasing tolerance of hospital Enterococcus faecium to handwash alcohols.

Pidot SJ, Gao W, Buultjens AH, Monk IR, Guerillot R, Carter GP, Lee JYH, Lam MMC, Grayson ML, Ballard SA, Mahony AA, Grabsch EA, Kotsanas D, Korman TM, Coombs GW, Robinson JO, Gonçalves da Silva A, Seemann T, Howden BP, Johnson PDR, Stinear TP.

Sci Transl Med. 2018 Aug 1;10(452). pii: eaar6115. doi: 10.1126/scitranslmed.aar6115.


The ΦBT1 large serine recombinase catalyzes DNA integration at pseudo-attB sites in the genus Nocardia.

Herisse M, Porter JL, Guerillot R, Tomita T, Goncalves Da Silva A, Seemann T, Howden BP, Stinear TP, Pidot SJ.

PeerJ. 2018 May 4;6:e4784. doi: 10.7717/peerj.4784. eCollection 2018.


Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus.

Tobias NJ, Wolff H, Djahanschiri B, Grundmann F, Kronenwerth M, Shi YM, Simonyi S, Grün P, Shapiro-Ilan D, Pidot SJ, Stinear TP, Ebersberger I, Bode HB.

Nat Microbiol. 2017 Dec;2(12):1676-1685. doi: 10.1038/s41564-017-0039-9. Epub 2017 Oct 9.


A Supervised Statistical Learning Approach for Accurate Legionella pneumophila Source Attribution during Outbreaks.

Buultjens AH, Chua KYL, Baines SL, Kwong J, Gao W, Cutcher Z, Adcock S, Ballard S, Schultz MB, Tomita T, Subasinghe N, Carter GP, Pidot SJ, Franklin L, Seemann T, Gonçalves Da Silva A, Howden BP, Stinear TP.

Appl Environ Microbiol. 2017 Oct 17;83(21). pii: e01482-17. doi: 10.1128/AEM.01482-17. Print 2017 Nov 1.


Functional analysis of the first complete genome sequence of a multidrug resistant sequence type 2 Staphylococcus epidermidis.

Lee JYH, Monk IR, Pidot SJ, Singh S, Chua KYL, Seemann T, Stinear TP, Howden BP.

Microb Genom. 2016 Sep 20;2(9):e000077. doi: 10.1099/mgen.0.000077. eCollection 2016 Sep.


Mycobacterium ulcerans low infectious dose and mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer.

Wallace JR, Mangas KM, Porter JL, Marcsisin R, Pidot SJ, Howden B, Omansen TF, Zeng W, Axford JK, Johnson PDR, Stinear TP.

PLoS Negl Trop Dis. 2017 Apr 14;11(4):e0005553. doi: 10.1371/journal.pntd.0005553. eCollection 2017 Apr.


Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Gö66.

Cai X, Shi YM, Pöhlmann N, Revermann O, Bahner I, Pidot SJ, Wesche F, Lackner H, Büchel C, Kaiser M, Richter C, Schwalbe H, Stinear TP, Zeeck A, Bode HB.

Angew Chem Int Ed Engl. 2017 Apr 24;56(18):4945-4949. doi: 10.1002/anie.201701223. Epub 2017 Mar 30.


A nanomechanical study of the effects of colistin on the Klebsiella pneumoniae AJ218 capsule.

Mularski A, Wilksch J, Hanssen E, Li J, Tomita T, Pidot SJ, Stinear T, Separovic F, Strugnell D.

Eur Biophys J. 2017 May;46(4):351-361. doi: 10.1007/s00249-016-1178-2. Epub 2016 Oct 17.


Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory.

Shabuer G, Ishida K, Pidot SJ, Roth M, Dahse HM, Hertweck C.

Science. 2015 Nov 6;350(6261):670-4. doi: 10.1126/science.aac9990.


Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria.

Letzel AC, Pidot SJ, Hertweck C.

BMC Genomics. 2014 Nov 18;15:983. doi: 10.1186/1471-2164-15-983.


Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice.

Roupie V, Pidot SJ, Einarsdottir T, Van Den Poel C, Jurion F, Stinear TP, Huygen K.

PLoS Negl Trop Dis. 2014 Jan 2;8(1):e2604. doi: 10.1371/journal.pntd.0002604. eCollection 2014.


Antibiotics from neglected bacterial sources.

Pidot SJ, Coyne S, Kloss F, Hertweck C.

Int J Med Microbiol. 2014 Jan;304(1):14-22. doi: 10.1016/j.ijmm.2013.08.011. Epub 2013 Sep 4. Review.


The cell wall-associated mycolactone polyketide synthases are necessary but not sufficient for mycolactone biosynthesis.

Porter JL, Tobias NJ, Pidot SJ, Falgner S, Tuck KL, Vettiger A, Hong H, Leadlay PF, Stinear TP.

PLoS One. 2013 Jul 23;8(7):e70520. doi: 10.1371/journal.pone.0070520. Print 2013.


A genomic approach to the cryptic secondary metabolome of the anaerobic world.

Letzel AC, Pidot SJ, Hertweck C.

Nat Prod Rep. 2013 Mar;30(3):392-428. doi: 10.1039/c2np20103h. Epub 2012 Dec 21. Review.


Regulation of the 18 kDa heat shock protein in Mycobacterium ulcerans: an alpha-crystallin orthologue that promotes biofilm formation.

Pidot SJ, Porter JL, Tobias NJ, Anderson J, Catmull D, Seemann T, Kidd S, Davies JK, Reynolds E, Dashper S, Stinear TP.

Mol Microbiol. 2010 Dec;78(5):1216-31. doi: 10.1111/j.1365-2958.2010.07401.x. Epub 2010 Oct 11.


Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics.

Pidot SJ, Porter JL, Marsollier L, Chauty A, Migot-Nabias F, Badaut C, Bénard A, Ruf MT, Seemann T, Johnson PD, Davies JK, Jenkin GA, Pluschke G, Stinear TP.

PLoS Negl Trop Dis. 2010 Nov 2;4(11):e872. doi: 10.1371/journal.pntd.0000872.


A major role for mammals in the ecology of Mycobacterium ulcerans.

Fyfe JA, Lavender CJ, Handasyde KA, Legione AR, O'Brien CR, Stinear TP, Pidot SJ, Seemann T, Benbow ME, Wallace JR, McCowan C, Johnson PD.

PLoS Negl Trop Dis. 2010 Aug 10;4(8):e791. doi: 10.1371/journal.pntd.0000791.


Mycobacterium ulcerans and other mycolactone-producing mycobacteria should be considered a single species.

Pidot SJ, Asiedu K, Käser M, Fyfe JA, Stinear TP.

PLoS Negl Trop Dis. 2010 Jul 27;4(7):e663. doi: 10.1371/journal.pntd.0000663. No abstract available.


Single nucleotide polymorphism typing of Mycobacterium ulcerans reveals focal transmission of buruli ulcer in a highly endemic region of Ghana.

Röltgen K, Qi W, Ruf MT, Mensah-Quainoo E, Pidot SJ, Seemann T, Stinear TP, Käser M, Yeboah-Manu D, Pluschke G.

PLoS Negl Trop Dis. 2010 Jul 20;4(7):e751. doi: 10.1371/journal.pntd.0000751.


Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer.

Tobias NJ, Seemann T, Pidot SJ, Porter JL, Marsollier L, Marion E, Letournel F, Zakir T, Azuolas J, Wallace JR, Hong H, Davies JK, Howden BP, Johnson PD, Jenkin GA, Stinear TP.

PLoS Negl Trop Dis. 2009 Nov 24;3(11):e553. doi: 10.1371/journal.pntd.0000553. Erratum in: PLoS Negl Trop Dis. 2010;4(2). doi: 10.1371/annotation/1e664e6f-3fc8-4586-a84e-73c4ec4f783f.


The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence.

Chiarezza M, Lyras D, Pidot SJ, Flores-Díaz M, Awad MM, Kennedy CL, Cordner LM, Phumoonna T, Poon R, Hughes ML, Emmins JJ, Alape-Girón A, Rood JI.

Infect Immun. 2009 Oct;77(10):4421-8. doi: 10.1128/IAI.00548-09. Epub 2009 Aug 3.


Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones.

Pidot SJ, Hong H, Seemann T, Porter JL, Yip MJ, Men A, Johnson M, Wilson P, Davies JK, Leadlay PF, Stinear TP.

BMC Genomics. 2008 Oct 7;9:462. doi: 10.1186/1471-2164-9-462.


Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria.

Hong H, Demangel C, Pidot SJ, Leadlay PF, Stinear T.

Nat Prod Rep. 2008 Jun;25(3):447-54. doi: 10.1039/b803101k. Epub 2008 Apr 17. Review.


The Clostridium perfringens TetA(P) efflux protein contains a functional variant of the Motif A region found in major facilitator superfamily transport proteins.

Bannam TL, Johanesen PA, Salvado CL, Pidot SJ, Farrow KA, Rood JI.

Microbiology. 2004 Jan;150(Pt 1):127-34.


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