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Non-traditional Antibacterial Therapeutic Options and Challenges.
Theuretzbacher U, Piddock LJV.
Cell Host Microbe. 2019 Jul 10;26(1):61-72. doi: 10.1016/j.chom.2019.06.004. Review.
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Do phenothiazines possess antimicrobial and efflux inhibitory properties?
Grimsey EM, Piddock LJV.
FEMS Microbiol Rev. 2019 Jun 19. pii: fuz017. doi: 10.1093/femsre/fuz017. [Epub ahead of print]
Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway.
Benedikz EK, Bailey D, Cook CNL, Gonçalves-Carneiro D, Buckner MMC, Blair JMA, Wells TJ, Fletcher NF, Goodall M, Flores-Langarica A, Kingsley RA, Madsen J, Teeling J, Johnston SL, MacLennan CA, Balfe P, Henderson IR, Piddock LJV, Cunningham AF, McKeating JA.
Sci Rep. 2019 May 27;9(1):7903. doi: 10.1038/s41598-019-44263-7.
Antibiotic resistance genes are abundant and diverse in raw sewage used for urban agriculture in Africa and associated with urban population density.
Bougnom BP, McNally A, Etoa FX, Piddock LJ.
Environ Pollut. 2019 Aug;251:146-154. doi: 10.1016/j.envpol.2019.04.056. Epub 2019 Apr 30.
Together towards a common goal: REVIVE, a community of antimicrobial researchers brought together by the Global Antibiotic Research & Development Partnership (GARDP).
Pentz-Murr A, Piddock LJV.
J Antimicrob Chemother. 2019 Jul 1;74(7):1769-1770. doi: 10.1093/jac/dkz077.
Acquisition and Loss of CTX-M-Producing and Non-Producing Escherichia coli in the Fecal Microbiome of Travelers to South Asia.
Bevan ER, McNally A, Thomas CM, Piddock LJV, Hawkey PM.
MBio. 2018 Dec 11;9(6). pii: e02408-18. doi: 10.1128/mBio.02408-18.
The Global Antibiotic Research and Development Partnership (GARDP): a not-for-profit antibiotic development organisation.
Piddock LJ; GARDP.
Lancet Infect Dis. 2018 Dec;18(12):1304-1305. doi: 10.1016/S1473-3099(18)30661-3. Epub 2018 Nov 9. No abstract available.
Wastewater used for urban agriculture in West Africa as a reservoir for antibacterial resistance dissemination.
Bougnom BP, Zongo C, McNally A, Ricci V, Etoa FX, Thiele-Bruhn S, Piddock LJV.
Environ Res. 2019 Jan;168:14-24. doi: 10.1016/j.envres.2018.09.022. Epub 2018 Sep 18.
Strategies to combat antimicrobial resistance: anti-plasmid and plasmid curing.
Buckner MMC, Ciusa ML, Piddock LJV.
FEMS Microbiol Rev. 2018 Nov 1;42(6):781-804. doi: 10.1093/femsre/fuy031. Review.
Author Correction: Multidrug efflux pumps: structure, function and regulation.
Du D, Wang-Kan X, Neuberger A, van Veen HW, Pos KM, Piddock LJV, Luisi BF.
Nat Rev Microbiol. 2018 Sep;16(9):577. doi: 10.1038/s41579-018-0060-x.
Multidrug efflux pumps: structure, function and regulation.
Nat Rev Microbiol. 2018 Sep;16(9):523-539. doi: 10.1038/s41579-018-0048-6. Review. Erratum in: Nat Rev Microbiol. 2018 Jul 18;:.
Revitalizing the drug pipeline: AntibioticDB, an open access database to aid antibacterial research and development.
Farrell LJ, Lo R, Wanford JJ, Jenkins A, Maxwell A, Piddock LJV.
J Antimicrob Chemother. 2018 Sep 1;73(9):2284-2297. doi: 10.1093/jac/dky208.
Clinically Relevant Plasmid-Host Interactions Indicate that Transcriptional and Not Genomic Modifications Ameliorate Fitness Costs of Klebsiella pneumoniae Carbapenemase-Carrying Plasmids.
Buckner MMC, Saw HTH, Osagie RN, McNally A, Ricci V, Wand ME, Woodford N, Ivens A, Webber MA, Piddock LJV.
MBio. 2018 Apr 24;9(2). pii: e02303-17. doi: 10.1128/mBio.02303-17.
Discovery and development of new antibacterial drugs: learning from experience?
Jackson N, Czaplewski L, Piddock LJV.
J Antimicrob Chemother. 2018 Jun 1;73(6):1452-1459. doi: 10.1093/jac/dky019.
The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity.
Sharma P, Haycocks JRJ, Middlemiss AD, Kettles RA, Sellars LE, Ricci V, Piddock LJV, Grainger DC.
Nat Commun. 2017 Nov 13;8(1):1444. doi: 10.1038/s41467-017-01405-7.
Addressing antimicrobial resistance in the UK and Europe.
Wells V, Piddock LJV.
Lancet Infect Dis. 2017 Dec;17(12):1230-1231. doi: 10.1016/S1473-3099(17)30633-3. Epub 2017 Nov 10. No abstract available.
Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae.
Weston N, Sharma P, Ricci V, Piddock LJV.
Res Microbiol. 2018 Sep - Oct;169(7-8):425-431. doi: 10.1016/j.resmic.2017.10.005. Epub 2017 Nov 8. Review.
Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to triclosan.
Webber MA, Buckner MMC, Redgrave LS, Ifill G, Mitchenall LA, Webb C, Iddles R, Maxwell A, Piddock LJV.
J Antimicrob Chemother. 2017 Oct 1;72(10):2755-2763. doi: 10.1093/jac/dkx201.
CsrA maximizes expression of the AcrAB multidrug resistance transporter.
Ricci V, Attah V, Overton T, Grainger DC, Piddock LJV.
Nucleic Acids Res. 2017 Dec 15;45(22):12798-12807. doi: 10.1093/nar/gkx929.
Understanding drug resistance will improve the treatment of bacterial infections.
Piddock LJV.
Nat Rev Microbiol. 2017 Oct 12;15(11):639-640. doi: 10.1038/nrmicro.2017.121. No abstract available.
Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium.
Wang-Kan X, Blair JMA, Chirullo B, Betts J, La Ragione RM, Ivens A, Ricci V, Opperman TJ, Piddock LJV.
MBio. 2017 Jul 18;8(4). pii: e00968-17. doi: 10.1128/mBio.00968-17.
To the G20: incentivising antibacterial research and development.
Årdal C, Baraldi E, Ciabuschi F, Outterson K, Rex JH, Piddock LJV, Findlay D; DRIVE-AB Steering Committee.
Lancet Infect Dis. 2017 Aug;17(8):799-801. doi: 10.1016/S1473-3099(17)30404-8. Epub 2017 Jul 7. No abstract available.
Wastewater for Urban Agriculture: A Significant Factor in Dissemination of Antibiotic Resistance.
Bougnom BP, Piddock LJV.
Environ Sci Technol. 2017 Jun 6;51(11):5863-5864. doi: 10.1021/acs.est.7b01852. Epub 2017 May 10. No abstract available.
Beyond Antimicrobial Resistance: Evidence for a Distinct Role of the AcrD Efflux Pump in Salmonella Biology.
Buckner MM, Blair JM, La Ragione RM, Newcombe J, Dwyer DJ, Ivens A, Piddock LJ.
MBio. 2016 Nov 22;7(6). pii: e01916-16. doi: 10.1128/mBio.01916-16.
Assess drug-resistance phenotypes, not just genotypes.
Piddock LJ.
Nat Microbiol. 2016 Jul 26;1(8):16120. doi: 10.1038/nmicrobiol.2016.120. No abstract available.
How to Measure Export via Bacterial Multidrug Resistance Efflux Pumps.
Blair JM, Piddock LJ.
MBio. 2016 Jul 5;7(4). pii: e00840-16. doi: 10.1128/mBio.00840-16. Review.
Erratum for Richmond et al., The Acinetobacter baumannii Two-Component System AdeRS Regulates Genes Required for Multidrug Efflux, Biofilm Formation, and Virulence in a Strain-Specific Manner.
Richmond GE, Evans LP, Anderson MJ, Wand ME, Bonney LC, Ivens A, Chua KL, Webber MA, Sutton JM, Peterson ML, Piddock LJ.
MBio. 2016 Jun 21;7(3). pii: e00852-16. doi: 10.1128/mBio.00852-16. No abstract available.
Reflecting on the final report of the O'Neill Review on Antimicrobial Resistance.
Lancet Infect Dis. 2016 Jul;16(7):767-768. doi: 10.1016/S1473-3099(16)30127-X. Epub 2016 May 18. No abstract available.
The Acinetobacter baumannii Two-Component System AdeRS Regulates Genes Required for Multidrug Efflux, Biofilm Formation, and Virulence in a Strain-Specific Manner.
MBio. 2016 Apr 19;7(2):e00430-16. doi: 10.1128/mBio.00430-16. Erratum in: MBio. 2016;7(3). pii: e00852-16. doi: 10.1128/mBio.00852-16.
Ciprofloxacin and ceftriaxone alter cytokine responses, but not Toll-like receptors, to Salmonella infection in vitro.
Anuforom O, Wallace GR, Buckner MM, Piddock LJ.
J Antimicrob Chemother. 2016 Jul;71(7):1826-33. doi: 10.1093/jac/dkw092. Epub 2016 Apr 13.
Inactivation or inhibition of AcrAB-TolC increases resistance of carbapenemase-producing Enterobacteriaceae to carbapenems.
Saw HT, Webber MA, Mushtaq S, Woodford N, Piddock LJ.
J Antimicrob Chemother. 2016 Jun;71(6):1510-9. doi: 10.1093/jac/dkw028. Epub 2016 Mar 5.
Understanding the mechanisms and drivers of antimicrobial resistance.
Holmes AH, Moore LS, Sundsfjord A, Steinbakk M, Regmi S, Karkey A, Guerin PJ, Piddock LJ.
Lancet. 2016 Jan 9;387(10014):176-87. doi: 10.1016/S0140-6736(15)00473-0. Epub 2015 Nov 18. Review.
Nonmedical Uses of Antibiotics: Time to Restrict Their Use?
Meek RW, Vyas H, Piddock LJ.
PLoS Biol. 2015 Oct 7;13(10):e1002266. doi: 10.1371/journal.pbio.1002266. eCollection 2015 Oct.
Teixobactin, the first of a new class of antibiotics discovered by iChip technology?
J Antimicrob Chemother. 2015 Oct;70(10):2679-80. doi: 10.1093/jac/dkv175. Epub 2015 Jun 18. Review.
Parallel evolutionary pathways to antibiotic resistance selected by biocide exposure.
Webber MA, Whitehead RN, Mount M, Loman NJ, Pallen MJ, Piddock LJ.
J Antimicrob Chemother. 2015 Aug;70(8):2241-8. doi: 10.1093/jac/dkv109. Epub 2015 May 7.
A novel gene amplification causes upregulation of the PatAB ABC transporter and fluoroquinolone resistance in Streptococcus pneumoniae.
Baylay AJ, Ivens A, Piddock LJ.
Antimicrob Agents Chemother. 2015;59(6):3098-108. doi: 10.1128/AAC.04858-14. Epub 2015 Mar 16.
AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity.
Blair JM, Bavro VN, Ricci V, Modi N, Cacciotto P, Kleinekathӧfer U, Ruggerone P, Vargiu AV, Baylay AJ, Smith HE, Brandon Y, Galloway D, Piddock LJ.
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3511-6. doi: 10.1073/pnas.1419939112. Epub 2015 Mar 3.
Molecular mechanisms of antibiotic resistance.
Blair JM, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJ.
Nat Rev Microbiol. 2015 Jan;13(1):42-51. doi: 10.1038/nrmicro3380. Epub 2014 Dec 1. Review.
Clinically relevant fluoroquinolone resistance due to constitutive overexpression of the PatAB ABC transporter in Streptococcus pneumoniae is conferred by disruption of a transcriptional attenuator.
Baylay AJ, Piddock LJ.
J Antimicrob Chemother. 2015 Mar;70(3):670-9. doi: 10.1093/jac/dku449. Epub 2014 Nov 18.
Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance.
Blair JM, Richmond GE, Piddock LJ.
Future Microbiol. 2014;9(10):1165-77. doi: 10.2217/fmb.14.66. Review.
Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design.
Blair JM, Smith HE, Ricci V, Lawler AJ, Thompson LJ, Piddock LJ.
J Antimicrob Chemother. 2015 Feb;70(2):424-31. doi: 10.1093/jac/dku380. Epub 2014 Oct 6.
Understanding the basis of antibiotic resistance: a platform for drug discovery.
Microbiology. 2014 Nov;160(Pt 11):2366-73. doi: 10.1099/mic.0.082412-0. Epub 2014 Aug 13. Review.
UK and European Union public and charitable funding from 2008 to 2013 for bacteriology and antibiotic research in the UK: an observational study.
Bragginton EC, Piddock LJ.
Lancet Infect Dis. 2014 Sep;14(9):857-68. doi: 10.1016/S1473-3099(14)70825-4. Epub 2014 Jul 24.
Antibiotic resistance: a geopolitical issue.
Carlet J, Pulcini C, Piddock LJ.
Clin Microbiol Infect. 2014 Oct;20(10):949-53. doi: 10.1111/1469-0691.12767. Review.
Functional genomics to identify the factors contributing to successful persistence and global spread of an antibiotic resistance plasmid.
Cottell JL, Saw HT, Webber MA, Piddock LJ.
BMC Microbiol. 2014 Jun 24;14:168. doi: 10.1186/1471-2180-14-168.
Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success.
Redgrave LS, Sutton SB, Webber MA, Piddock LJ.
Trends Microbiol. 2014 Aug;22(8):438-45. doi: 10.1016/j.tim.2014.04.007. Epub 2014 May 16. Review.
Multiple transmissible genes encoding fluoroquinolone and third-generation cephalosporin resistance co-located in non-typhoidal Salmonella isolated from food-producing animals in China.
Jiang HX, Song L, Liu J, Zhang XH, Ren YN, Zhang WH, Zhang JY, Liu YH, Webber MA, Ogbolu DO, Zeng ZL, Piddock LJ.
Int J Antimicrob Agents. 2014 Mar;43(3):242-7. doi: 10.1016/j.ijantimicag.2013.12.005. Epub 2013 Dec 17.
Antibiotic action: helping deliver action plans and strategies.
Lancet Infect Dis. 2013 Dec;13(12):1009-11. doi: 10.1016/S1473-3099(13)70299-8. Epub 2013 Nov 17. No abstract available.
Alternative explanation for indole-induced antibiotic tolerance in Salmonella.
Blair JM, Cloeckaert A, Nishino K, Piddock LJ.
Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4569. doi: 10.1073/pnas.1318318110. Epub 2013 Nov 6. No abstract available.
Inhibition of multidrug efflux as a strategy to prevent biofilm formation.
Baugh S, Phillips CR, Ekanayaka AS, Piddock LJ, Webber MA.
J Antimicrob Chemother. 2014 Mar;69(3):673-81. doi: 10.1093/jac/dkt420. Epub 2013 Oct 31.
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