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Items: 18

1.

Expression of Oncogenic Drivers in 3D Cell Culture Depends on Nuclear ATP Synthesis by NUDT5.

Pickup KE, Pardow F, Carbonell-Caballero J, Lioutas A, Villanueva-Cañas JL, Wright RHG, Beato M.

Cancers (Basel). 2019 Sep 10;11(9). pii: E1337. doi: 10.3390/cancers11091337.

2.

A randomized pragmatic trial of telephone-delivered cognitive behavioral-therapy, modafinil, and combination therapy of both for fatigue in multiple sclerosis: The design of the "COMBO-MS" trial.

Kratz AL, Alschuler KN, Ehde DM, von Geldern G, Little R, Kulkarni S, Pickup K, Braley TJ.

Contemp Clin Trials. 2019 Sep;84:105821. doi: 10.1016/j.cct.2019.105821. Epub 2019 Aug 7.

PMID:
31400515
3.

Acute liver effects, disposition and metabolic fate of [14C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice.

Pickup K, Martin S, Partridge EA, Jones HB, Wills J, Schulz-Utermoehl T, McCarthy A, Rodrigues A, Page C, Ratcliffe K, Sarda S, Wilson ID.

Arch Toxicol. 2017 Jul;91(7):2643-2653. doi: 10.1007/s00204-016-1894-5. Epub 2016 Nov 28.

4.

Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity.

Ballard P, Yates JW, Yang Z, Kim DW, Yang JC, Cantarini M, Pickup K, Jordan A, Hickey M, Grist M, Box M, Johnström P, Varnäs K, Malmquist J, Thress KS, Jänne PA, Cross D.

Clin Cancer Res. 2016 Oct 15;22(20):5130-5140. Epub 2016 Jul 19.

5.

Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor.

Dickinson PA, Cantarini MV, Collier J, Frewer P, Martin S, Pickup K, Ballard P.

Drug Metab Dispos. 2016 Aug;44(8):1201-12. doi: 10.1124/dmd.115.069203. Epub 2016 May 25.

PMID:
27226351
6.

A comparison of the metabolism of midazolam in C57BL/6J and hepatic reductase null (HRN) mice.

Grimsley A, Foster A, Gallagher R, Hutchison M, Lundqvist A, Pickup K, Wilson ID, Samuelsson K.

Biochem Pharmacol. 2014 Dec 15;92(4):701-11. doi: 10.1016/j.bcp.2014.10.004. Epub 2014 Oct 22.

PMID:
25450676
7.

Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice.

Samuelsson K, Pickup K, Sarda S, Foster JR, Randall K, Abrahamsson A, Jacobsen M, Weidolf L, Wilson I.

Xenobiotica. 2014 Jan;44(2):186-95. doi: 10.3109/00498254.2013.879237. Epub 2014 Jan 13.

PMID:
24417752
8.

The metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse.

Pickup K, Wills J, Rodrigues A, Jones HB, Page C, Martin S, Sarda S, Wilson I.

Xenobiotica. 2014 Jan;44(2):164-73. doi: 10.3109/00498254.2013.866299. Epub 2013 Dec 10.

PMID:
24320884
9.

Drug-drug interactions and metabolism in cytochrome P450 2C knockout mice: application to troleandomycin and midazolam.

Grimsley A, Gallagher R, Hutchison M, Pickup K, Wilson ID, Samuelsson K.

Biochem Pharmacol. 2013 Aug 15;86(4):529-38. doi: 10.1016/j.bcp.2013.05.015. Epub 2013 Jun 2.

PMID:
23732297
10.

Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers.

Samuelsson K, Pickup K, Sarda S, Swales JG, Morikawa Y, Schulz-Utermoehl T, Hutchison M, Wilson ID.

Xenobiotica. 2012 Nov;42(11):1128-37. doi: 10.3109/00498254.2012.689888. Epub 2012 May 30.

PMID:
22642803
11.

Diclofenac metabolism in the mouse: novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry.

Sarda S, Page C, Pickup K, Schulz-Utermoehl T, Wilson I.

Xenobiotica. 2012 Feb;42(2):179-94. doi: 10.3109/00498254.2011.607865. Epub 2011 Sep 28.

PMID:
21955289
12.

The hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: application to the metabolism of diclofenac.

Pickup K, Gavin A, Jones HB, Karlsson E, Page C, Ratcliffe K, Sarda S, Schulz-Utermoehl T, Wilson I.

Xenobiotica. 2012 Feb;42(2):195-205. doi: 10.3109/00498254.2011.607196. Epub 2011 Sep 28.

PMID:
21955249
13.

A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions.

Flagel SB, Cameron CM, Pickup KN, Watson SJ, Akil H, Robinson TE.

Neuroscience. 2011 Nov 24;196:80-96. doi: 10.1016/j.neuroscience.2011.09.004. Epub 2011 Sep 10.

14.

Utility of spatially-resolved atmospheric pressure surface sampling and ionization techniques as alternatives to mass spectrometric imaging (MSI) in drug metabolism.

Blatherwick EQ, Van Berkel GJ, Pickup K, Johansson MK, Beaudoin ME, Cole RO, Day JM, Iverson S, Wilson ID, Scrivens JH, Weston DJ.

Xenobiotica. 2011 Aug;41(8):720-34. doi: 10.3109/00498254.2011.587550. Epub 2011 Jun 14.

PMID:
21671748
15.

Rats markedly escalate their intake and show a persistent susceptibility to reinstatement only when cocaine is injected rapidly.

Wakabayashi KT, Weiss MJ, Pickup KN, Robinson TE.

J Neurosci. 2010 Aug 25;30(34):11346-55. doi: 10.1523/JNEUROSCI.2524-10.2010.

16.

In vitro metabolism of gefitinib in human liver microsomes.

McKillop D, McCormick AD, Miles GS, Phillips PJ, Pickup KJ, Bushby N, Hutchison M.

Xenobiotica. 2004 Nov-Dec;34(11-12):983-1000.

PMID:
15801543
18.

The metabolic disposition of an orally active pyridyl thiadiazinone cardiotonic agent (MPTD) in rat and baboon.

McKillop D, Pickup KJ, Swaisland AJ, Holmes BF.

Xenobiotica. 1990 Apr;20(4):401-15.

PMID:
2346037

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