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A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation.

Stobart CC, Rostad CA, Ke Z, Dillard RS, Hampton CM, Strauss JD, Yi H, Hotard AL, Meng J, Pickles RJ, Sakamoto K, Lee S, Currier MG, Moin SM, Graham BS, Boukhvalova MS, Gilbert BE, Blanco JC, Piedra PA, Wright ER, Moore ML.

Nat Commun. 2016 Dec 21;7:13916. doi: 10.1038/ncomms13916.


A Recombinant Respiratory Syncytial Virus Vaccine Candidate Attenuated by a Low-Fusion F Protein Is Immunogenic and Protective against Challenge in Cotton Rats.

Rostad CA, Stobart CC, Gilbert BE, Pickles RJ, Hotard AL, Meng J, Blanco JCG, Moin SM, Graham BS, Piedra PA, Moore ML.

J Virol. 2016 Jul 27;90(16):7508-7518. doi: 10.1128/JVI.00012-16. Print 2016 Aug 15.


SARS-like WIV1-CoV poised for human emergence.

Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14.


Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis.

Pickles RJ, DeVincenzo JP.

J Pathol. 2015 Jan;235(2):266-76. doi: 10.1002/path.4462. Review.


RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction.

Liesman RM, Buchholz UJ, Luongo CL, Yang L, Proia AD, DeVincenzo JP, Collins PL, Pickles RJ.

J Clin Invest. 2014 May;124(5):2219-33. doi: 10.1172/JCI72948. Epub 2014 Apr 8.


Effects of vitamin D on airway epithelial cell morphology and rhinovirus replication.

Brockman-Schneider RA, Pickles RJ, Gern JE.

PLoS One. 2014 Jan 24;9(1):e86755. doi: 10.1371/journal.pone.0086755. eCollection 2014.


Human airway epithelial cell cultures for modeling respiratory syncytial virus infection.

Pickles RJ.

Curr Top Microbiol Immunol. 2013;372:371-87. doi: 10.1007/978-3-642-38919-1_19.


Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.

Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16528-33. doi: 10.1073/pnas.1206552109. Epub 2012 Sep 24. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753.


Human parainfluenza virus serotypes differ in their kinetics of replication and cytokine secretion in human tracheobronchial airway epithelium.

Schaap-Nutt A, Liesman R, Bartlett EJ, Scull MA, Collins PL, Pickles RJ, Schmidt AC.

Virology. 2012 Nov 25;433(2):320-8. doi: 10.1016/j.virol.2012.08.027. Epub 2012 Sep 7.


Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways.

Kesimer M, Ehre C, Burns KA, Davis CW, Sheehan JK, Pickles RJ.

Mucosal Immunol. 2013 Mar;6(2):379-92. doi: 10.1038/mi.2012.81. Epub 2012 Aug 29.


A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets.

van Doremalen N, Shelton H, Roberts KL, Jones IM, Pickles RJ, Thompson CI, Barclay WS.

PLoS One. 2011;6(10):e25755. doi: 10.1371/journal.pone.0025755. Epub 2011 Oct 5.


Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus.

Zhang L, Collins PL, Lamb RA, Pickles RJ.

Virology. 2011 Dec 5;421(1):67-77. doi: 10.1016/j.virol.2011.08.020. Epub 2011 Oct 8.


Limited effects of Muc1 deficiency on mouse adenovirus type 1 respiratory infection.

Nguyen Y, Procario MC, Ashley SL, O'Neal WK, Pickles RJ, Weinberg JB.

Virus Res. 2011 Sep;160(1-2):351-9. doi: 10.1016/j.virusres.2011.07.012. Epub 2011 Jul 26.


AAV-6 mediated efficient transduction of mouse lower airways.

Li W, Zhang L, Wu Z, Pickles RJ, Samulski RJ.

Virology. 2011 Sep 1;417(2):327-33. doi: 10.1016/j.virol.2011.06.009. Epub 2011 Jul 14.


NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.

Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA, Gris D, Roney KE, Zimmermann AG, Bowzard JB, Ranjan P, Monroe KM, Pickles RJ, Sambhara S, Ting JP.

Immunity. 2011 Jun 24;34(6):854-65. doi: 10.1016/j.immuni.2011.03.026.


AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.

Johnson JS, Gentzsch M, Zhang L, Ribeiro CM, Kantor B, Kafri T, Pickles RJ, Samulski RJ.

PLoS Pathog. 2011 May;7(5):e1002053. doi: 10.1371/journal.ppat.1002053. Epub 2011 May 19.


Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential.

Shelton H, Ayora-Talavera G, Ren J, Loureiro S, Pickles RJ, Barclay WS, Jones IM.

J Virol. 2011 Feb;85(4):1875-80. doi: 10.1128/JVI.01822-10. Epub 2010 Nov 24.


Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium.

Okada SF, Zhang L, Kreda SM, Abdullah LH, Davis CW, Pickles RJ, Lazarowski ER, Boucher RC.

Am J Respir Cell Mol Biol. 2011 Aug;45(2):253-60. doi: 10.1165/rcmb.2010-0253OC. Epub 2010 Oct 8.


α-Fetoprotein gene delivery to the nasal epithelium of nonhuman primates by human parainfluenza viral vectors.

Zhang L, Limberis MP, Thompson C, Antunes MB, Luongo C, Wilson JM, Collins PL, Pickles RJ.

Hum Gene Ther. 2010 Dec;21(12):1657-64. doi: 10.1089/hum.2010.065. Epub 2010 Nov 3.


Respiratory syncytial virus engineered to express the cystic fibrosis transmembrane conductance regulator corrects the bioelectric phenotype of human cystic fibrosis airway epithelium in vitro.

Kwilas AR, Yednak MA, Zhang L, Liesman R, Collins PL, Pickles RJ, Peeples ME.

J Virol. 2010 Aug;84(15):7770-81. doi: 10.1128/JVI.00346-10. Epub 2010 May 26.


Infection of human mucosal tissue by Pseudomonas aeruginosa requires sequential and mutually dependent virulence factors and a novel pilus-associated adhesin.

Heiniger RW, Winther-Larsen HC, Pickles RJ, Koomey M, Wolfgang MC.

Cell Microbiol. 2010 Aug;12(8):1158-73. doi: 10.1111/j.1462-5822.2010.01461.x. Epub 2010 Mar 12.


Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells.

Eby JC, Ciesla WP, Hamman W, Donato GM, Pickles RJ, Hewlett EL, Lencer WI.

J Biol Chem. 2010 Apr 2;285(14):10662-70. doi: 10.1074/jbc.M109.089219. Epub 2010 Feb 5.


Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys.

Schaap-Nutt A, Scull MA, Schmidt AC, Murphy BR, Pickles RJ.

Vaccine. 2010 Mar 24;28(15):2788-98. doi: 10.1016/j.vaccine.2010.01.050. Epub 2010 Feb 20.


Human parainfluenza virus type 2 V protein inhibits interferon production and signaling and is required for replication in non-human primates.

Schaap-Nutt A, D'Angelo C, Scull MA, Amaro-Carambot E, Nishio M, Pickles RJ, Collins PL, Murphy BR, Schmidt AC.

Virology. 2010 Feb 20;397(2):285-98. doi: 10.1016/j.virol.2009.11.018. Epub 2009 Dec 7.


Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium.

Ayora-Talavera G, Shelton H, Scull MA, Ren J, Jones IM, Pickles RJ, Barclay WS.

PLoS One. 2009 Nov 18;4(11):e7836. doi: 10.1371/journal.pone.0007836.


Respiratory syncytial virus grown in Vero cells contains a truncated attachment protein that alters its infectivity and dependence on glycosaminoglycans.

Kwilas S, Liesman RM, Zhang L, Walsh E, Pickles RJ, Peeples ME.

J Virol. 2009 Oct;83(20):10710-8. doi: 10.1128/JVI.00986-09. Epub 2009 Aug 5.


CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium.

Zhang L, Button B, Gabriel SE, Burkett S, Yan Y, Skiadopoulos MH, Dang YL, Vogel LN, McKay T, Mengos A, Boucher RC, Collins PL, Pickles RJ.

PLoS Biol. 2009 Jul;7(7):e1000155. doi: 10.1371/journal.pbio.1000155. Epub 2009 Jul 21.


Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium.

Li W, Zhang L, Johnson JS, Zhijian W, Grieger JC, Ping-Jie X, Drouin LM, Agbandje-McKenna M, Pickles RJ, Samulski RJ.

Mol Ther. 2009 Dec;17(12):2067-77. doi: 10.1038/mt.2009.155. Epub 2009 Jul 14.


Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways.

Scull MA, Gillim-Ross L, Santos C, Roberts KL, Bordonali E, Subbarao K, Barclay WS, Pickles RJ.

PLoS Pathog. 2009 May;5(5):e1000424. doi: 10.1371/journal.ppat.1000424. Epub 2009 May 15.


MAVS-mediated apoptosis and its inhibition by viral proteins.

Lei Y, Moore CB, Liesman RM, O'Connor BP, Bergstralh DT, Chen ZJ, Pickles RJ, Ting JP.

PLoS One. 2009;4(5):e5466. doi: 10.1371/journal.pone.0005466. Epub 2009 Mar 7.


The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

Allen IC, Scull MA, Moore CB, Holl EK, McElvania-TeKippe E, Taxman DJ, Guthrie EH, Pickles RJ, Ting JP.

Immunity. 2009 Apr 17;30(4):556-65. doi: 10.1016/j.immuni.2009.02.005. Epub 2009 Apr 9.


Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.

Kesimer M, Scull M, Brighton B, DeMaria G, Burns K, O'Neal W, Pickles RJ, Sheehan JK.

FASEB J. 2009 Jun;23(6):1858-68. doi: 10.1096/fj.08-119131. Epub 2009 Feb 3.


Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro.

Limberis MP, Vandenberghe LH, Zhang L, Pickles RJ, Wilson JM.

Mol Ther. 2009 Feb;17(2):294-301. doi: 10.1038/mt.2008.261. Epub 2008 Dec 9.


Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.

Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19944-9. doi: 10.1073/pnas.0808116105. Epub 2008 Nov 26.


Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge.

Bukreyev A, Marzi A, Feldmann F, Zhang L, Yang L, Ward JM, Dorward DW, Pickles RJ, Murphy BR, Feldmann H, Collins PL.

Virology. 2009 Jan 20;383(2):348-61. doi: 10.1016/j.virol.2008.09.030. Epub 2008 Nov 17.


Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?

Kesimer M, Kirkham S, Pickles RJ, Henderson AG, Alexis NE, Demaria G, Knight D, Thornton DJ, Sheehan JK.

Am J Physiol Lung Cell Mol Physiol. 2009 Jan;296(1):L92-L100. doi: 10.1152/ajplung.90388.2008. Epub 2008 Oct 17.


Systematic assembly of a full-length infectious clone of human coronavirus NL63.

Donaldson EF, Yount B, Sims AC, Burkett S, Pickles RJ, Baric RS.

J Virol. 2008 Dec;82(23):11948-57. doi: 10.1128/JVI.01804-08. Epub 2008 Sep 25.


Human parainfluenza virus type 1 C proteins are nonessential proteins that inhibit the host interferon and apoptotic responses and are required for efficient replication in nonhuman primates.

Bartlett EJ, Cruz AM, Esker J, Castaño A, Schomacker H, Surman SR, Hennessey M, Boonyaratanakornkit J, Pickles RJ, Collins PL, Murphy BR, Schmidt AC.

J Virol. 2008 Sep;82(18):8965-77. doi: 10.1128/JVI.00853-08. Epub 2008 Jul 9.


Role of interferon in the replication of human parainfluenza virus type 1 wild type and mutant viruses in human ciliated airway epithelium.

Bartlett EJ, Hennessey M, Skiadopoulos MH, Schmidt AC, Collins PL, Murphy BR, Pickles RJ.

J Virol. 2008 Aug;82(16):8059-70. doi: 10.1128/JVI.02263-07. Epub 2008 Jun 4.


RSV604, a novel inhibitor of respiratory syncytial virus replication.

Chapman J, Abbott E, Alber DG, Baxter RC, Bithell SK, Henderson EA, Carter MC, Chambers P, Chubb A, Cockerill GS, Collins PL, Dowdell VC, Keegan SJ, Kelsey RD, Lockyer MJ, Luongo C, Najarro P, Pickles RJ, Simmonds M, Taylor D, Tyms S, Wilson LJ, Powell KL.

Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53. Epub 2007 Jun 18.


SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium.

Sims AC, Burkett SE, Yount B, Pickles RJ.

Virus Res. 2008 Apr;133(1):33-44. Epub 2007 Apr 23. Review.


Francisella tularensis replicates within alveolar type II epithelial cells in vitro and in vivo following inhalation.

Hall JD, Craven RR, Fuller JR, Pickles RJ, Kawula TH.

Infect Immun. 2007 Feb;75(2):1034-9. Epub 2006 Nov 6.


SARS CoV replication and pathogenesis in human airway epithelial cultures.

Sims AC, Yount B, Burkett SE, Baric RS, Pickles RJ.

Adv Exp Med Biol. 2006;581:535-8. No abstract available.


Infection of human airway epithelium by human and avian strains of influenza a virus.

Thompson CI, Barclay WS, Zambon MC, Pickles RJ.

J Virol. 2006 Aug;80(16):8060-8.


Influenza M2 envelope protein augments avian influenza hemagglutinin pseudotyping of lentiviral vectors.

McKay T, Patel M, Pickles RJ, Johnson LG, Olsen JC.

Gene Ther. 2006 Apr;13(8):715-24.


Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections.

Tarran R, Button B, Picher M, Paradiso AM, Ribeiro CM, Lazarowski ER, Zhang L, Collins PL, Pickles RJ, Fredberg JJ, Boucher RC.

J Biol Chem. 2005 Oct 21;280(42):35751-9. Epub 2005 Aug 8.


Towards a gene therapy for cystic fibrosis lung disease.

Pickles RJ.

Expert Opin Investig Drugs. 1997 Oct;6(10):1459-63.


Cytokine amplification by respiratory syncytial virus infection in human nasal epithelial cells.

Das S, Palmer OP, Leight WD, Surowitz JB, Pickles RJ, Randell SH, Buchman CA.

Laryngoscope. 2005 May;115(5):764-8. Erratum in: Laryngoscope. 2005 Nov;115(11):2076.


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