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Items: 1 to 50 of 376

1.

An add-on training program involving breathing exercises, cold exposure, and meditation attenuates inflammation and disease activity in axial spondyloarthritis - A proof of concept trial.

Buijze GA, De Jong HMY, Kox M, van de Sande MG, Van Schaardenburg D, Van Vugt RM, Popa CD, Pickkers P, Baeten DLP.

PLoS One. 2019 Dec 2;14(12):e0225749. doi: 10.1371/journal.pone.0225749. eCollection 2019.

2.

Synergistic TLR/IFNα/β-Signaling Facilitates Escape of IL-18 Expression from Endotoxin Tolerance.

Verweyen E, Holzinger D, Weinhage T, Hinze C, Wittkowski H, Pickkers P, Albeituni S, Verbist K, Nichols KE, Schulert G, Grom A, Foell D, Kessel C.

Am J Respir Crit Care Med. 2019 Nov 11. doi: 10.1164/rccm.201903-0659OC. [Epub ahead of print]

PMID:
31710506
3.

Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series.

Payen D, Faivre V, Miatello J, Leentjens J, Brumpt C, Tissières P, Dupuis C, Pickkers P, Lukaszewicz AC.

BMC Infect Dis. 2019 Nov 5;19(1):931. doi: 10.1186/s12879-019-4526-x.

4.

Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial.

Laterre PF, Berry SM, Blemings A, Carlsen JE, François B, Graves T, Jacobsen K, Lewis RJ, Opal SM, Perner A, Pickkers P, Russell JA, Windeløv NA, Yealy DM, Asfar P, Bestle MH, Muller G, Bruel C, Brulé N, Decruyenaere J, Dive AM, Dugernier T, Krell K, Lefrant JY, Megarbane B, Mercier E, Mira JP, Quenot JP, Rasmussen BS, Thorsen-Meyer HC, Vander Laenen M, Vang ML, Vignon P, Vinatier I, Wichmann S, Wittebole X, Kjølbye AL, Angus DC; SEPSIS-ACT Investigators.

JAMA. 2019 Oct 2. doi: 10.1001/jama.2019.14607. [Epub ahead of print] Erratum in: JAMA. 2019 Oct 15;:.

PMID:
31577035
5.

The Human Chorionic Gonadotropin Derivate EA-230 Modulates the Immune Response and Exerts Renal Protective Properties: Therapeutic Potential in Humans.

van Groenendael R, Beunders R, Kox M, van Eijk LT, Pickkers P.

Semin Nephrol. 2019 Sep;39(5):496-504. doi: 10.1016/j.semnephrol.2019.06.009. Review.

6.

Innovative Drugs to Target Renal Inflammation in Sepsis: Alkaline Phosphatase.

Hümmeke-Oppers F, Hemelaar P, Pickkers P.

Front Pharmacol. 2019 Aug 23;10:919. doi: 10.3389/fphar.2019.00919. eCollection 2019. Review.

7.

External Validation of Two Models to Predict Delirium in Critically Ill Adults Using Either the Confusion Assessment Method-ICU or the Intensive Care Delirium Screening Checklist for Delirium Assessment.

Wassenaar A, Schoonhoven L, Devlin JW, van Haren FMP, Slooter AJC, Jorens PG, van der Jagt M, Simons KS, Egerod I, Burry LD, Beishuizen A, Matos J, Donders ART, Pickkers P, van den Boogaard M.

Crit Care Med. 2019 Oct;47(10):e827-e835. doi: 10.1097/CCM.0000000000003911.

PMID:
31306177
8.

Prophylactic Haloperidol Effects on Long-term Quality of Life in Critically Ill Patients at High Risk for Delirium: Results of the REDUCE Study.

Rood PJT, Zegers M, Slooter AJC, Beishuizen A, Simons KS, van der Voort PHJ, van der Woude MCE, Spronk PE, van der Hoeven JG, Pickkers P, van den Boogaard M.

Anesthesiology. 2019 Aug;131(2):328-335. doi: 10.1097/ALN.0000000000002812.

PMID:
31246603
9.

Differences in 90-day mortality of delirium subtypes in the intensive care unit: A retrospective cohort study.

Rood PJT, van de Schoor F, van Tertholen K, Pickkers P, van den Boogaard M.

J Crit Care. 2019 Oct;53:120-124. doi: 10.1016/j.jcrc.2019.06.007. Epub 2019 Jun 11.

PMID:
31228762
10.

Frontline Science: Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst.

Grondman I, Arts RJW, Koch RM, Leijte GP, Gerretsen J, Bruse N, Kempkes RWM, Ter Horst R, Kox M, Pickkers P, Netea MG, Gresnigt MS.

J Leukoc Biol. 2019 Jul;106(1):11-25. doi: 10.1002/JLB.5HI0119-018R. Epub 2019 Jun 6.

11.

Diagnosis and outcome of acute respiratory failure in immunocompromised patients after bronchoscopy.

Bauer PR, Chevret S, Yadav H, Mehta S, Pickkers P, Bukan RB, Rello J, van de Louw A, Klouche K, Meert AP, Martin-Loeches I, Marsh B, Socias Crespi L, Moreno-Gonzalez G, Buchtele N, Amrein K, Balik M, Antonelli M, Nyunga M, Barratt-Due A, Bergmans DCJJ, Spoelstra-de Man AME, Kuitunen A, Wallet F, Seguin A, Metaxa V, Lemiale V, Burghi G, Demoule A, Karvunidis T, Cotoia A, Klepstad P, Møller AM, Mokart D, Azoulay E; Efraim investigators and the Nine-I study group.

Eur Respir J. 2019 Jul 25;54(1). pii: 1802442. doi: 10.1183/13993003.02442-2018. Print 2019 Jul.

PMID:
31109985
12.

Characterization of the phenotype of human eosinophils and their progenitors in the bone marrow of healthy individuals.

Hassani M, van Staveren S, van Grinsven E, Bartels M, Tesselaar K, Leijte G, Kox M, Pickkers P, Vrisekoop N, Koenderman L.

Haematologica. 2019 May 17. pii: haematol.2019.219048. doi: 10.3324/haematol.2019.219048. [Epub ahead of print]

13.

Quality Improvement Goals for Acute Kidney Injury.

Kashani K, Rosner MH, Haase M, Lewington AJP, O'Donoghue DJ, Wilson FP, Nadim MK, Silver SA, Zarbock A, Ostermann M, Mehta RL, Kane-Gill SL, Ding X, Pickkers P, Bihorac A, Siew ED, Barreto EF, Macedo E, Kellum JA, Palevsky PM, Tolwani AJ, Ronco C, Juncos LA, Rewa OG, Bagshaw SM, Mottes TA, Koyner JL, Liu KD, Forni LG, Heung M, Wu VC.

Clin J Am Soc Nephrol. 2019 Jun 7;14(6):941-953. doi: 10.2215/CJN.01250119. Epub 2019 May 17.

PMID:
31101671
14.

Adrecizumab, a non-neutralizing anti-adrenomedullin antibody, improves haemodynamics and attenuates myocardial oxidative stress in septic rats.

Blet A, Deniau B, Geven C, Sadoune M, Caillard A, Kounde PR, Polidano E, Pickkers P, Samuel JL, Mebazaa A.

Intensive Care Med Exp. 2019 May 15;7(1):25. doi: 10.1186/s40635-019-0255-0.

15.

Remote ischaemic preconditioning does not modulate the systemic inflammatory response or renal tubular stress biomarkers after endotoxaemia in healthy human volunteers: a single-centre, mechanistic, randomised controlled trial.

Zwaag J, Beunders R, Warlé MC, Kellum JA, Riksen NP, Pickkers P, Kox M.

Br J Anaesth. 2019 Aug;123(2):177-185. doi: 10.1016/j.bja.2019.03.037. Epub 2019 May 10.

16.

Influenza and associated co-infections in critically ill immunosuppressed patients.

Martin-Loeches I, Lemiale V, Geoghegan P, McMahon MA, Pickkers P, Soares M, Perner A, Meyhoff TS, Bukan RB, Rello J, Bauer PR, van de Louw A, Taccone FS, Salluh J, Hemelaar P, Schellongowski P, Rusinova K, Terzi N, Mehta S, Antonelli M, Kouatchet A, Klepstad P, Valkonen M, Landburg PP, Barratt-Due A, Bruneel F, Pène F, Metaxa V, Moreau AS, Souppart V, Burghi G, Girault C, Silva UVA, Montini L, Barbier F, Nielsen LB, Gaborit B, Mokart D, Chevret S, Azoulay E; Efraim investigators and the Nine-I study group.

Crit Care. 2019 May 2;23(1):152. doi: 10.1186/s13054-019-2425-6.

17.

Effect of Vasopressors on The Macro- and Microcirculation During Systemic Inflammation In Humans in vivo.

van Loon LM, Stolk RF, van der Hoeven JG, Veltink PH, Pickkers P, Lemson J, Kox M.

Shock. 2019 Apr 16. doi: 10.1097/SHK.0000000000001357. [Epub ahead of print]

PMID:
31008870
18.

Sepsis Management with a Blood Purification Membrane: European Experience.

Pickkers P, Vassiliou T, Liguts V, Prato F, Tissieres P, Kloesel S, Turani F, Popevski D, Broman M, Gindac CM, Saliba F, Tengattini M, Goldstein J, Harenski K.

Blood Purif. 2019;47 Suppl 3:1-9. doi: 10.1159/000499355. Epub 2019 Apr 12. Review.

19.

Development and daily use of a numeric rating score to assess sleep quality in ICU patients.

Rood P, Frenzel T, Verhage R, Bonn M, van der Hoeven H, Pickkers P, van den Boogaard M.

J Crit Care. 2019 Aug;52:68-74. doi: 10.1016/j.jcrc.2019.04.009. Epub 2019 Apr 6.

PMID:
30981928
20.

Pharmacokinetics, safety and tolerability of the novel β-hCG derived immunomodulatory compound, EA-230.

van Groenendael R, Aarnoutse R, Kox M, van Eijk L, Pickkers P.

Br J Clin Pharmacol. 2019 Jul;85(7):1572-1584. doi: 10.1111/bcp.13942. Epub 2019 Jun 2.

21.

A randomized double-blind, placebo-controlled clinical phase IIa trial on safety, immunomodulatory effects and pharmacokinetics of EA-230 during experimental human endotoxaemia.

van Groenendael R, Kox M, Leijte G, Koeneman B, Gerretsen J, van Eijk L, Pickkers P.

Br J Clin Pharmacol. 2019 Jul;85(7):1559-1571. doi: 10.1111/bcp.13941. Epub 2019 May 23.

22.

Fever in Sepsis: Still a Hot Topic.

Leijte GP, Kox M, Pickkers P.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):263-264. doi: 10.1164/rccm.201903-0484LE. No abstract available.

23.

Obesity in the critically ill: a narrative review.

Schetz M, De Jong A, Deane AM, Druml W, Hemelaar P, Pelosi P, Pickkers P, Reintam-Blaser A, Roberts J, Sakr Y, Jaber S.

Intensive Care Med. 2019 Jun;45(6):757-769. doi: 10.1007/s00134-019-05594-1. Epub 2019 Mar 19. Review.

PMID:
30888440
24.

Preclinical safety evaluation of the adrenomedullin-binding antibody Adrecizumab in rodents, dogs and non-human primates.

Geven C, Kox M, Blet A, Mebazaa A, Schroedter M, Struck J, Bergmann A, Pickkers P.

Toxicol Appl Pharmacol. 2019 Apr 15;369:1-16. doi: 10.1016/j.taap.2019.02.014. Epub 2019 Feb 27.

PMID:
30822437
25.

The value of the neutrophil-lymphocyte count ratio in the diagnosis of sepsis in patients admitted to the Intensive Care Unit: A retrospective cohort study.

Westerdijk K, Simons KS, Zegers M, Wever PC, Pickkers P, de Jager CPC.

PLoS One. 2019 Feb 27;14(2):e0212861. doi: 10.1371/journal.pone.0212861. eCollection 2019.

26.
27.

Comparison of different lots of endotoxin and evaluation of in vivo potency over time in the experimental human endotoxemia model.

Kiers D, Leijte GP, Gerretsen J, Zwaag J, Kox M, Pickkers P.

Innate Immun. 2019 Jan;25(1):34-45. doi: 10.1177/1753425918819754.

29.

Hypoxia attenuates inflammation-induced hepcidin synthesis during experimental human endotoxemia.

Kiers D, van Eijk LT, van der Hoeven JG, Swinkels DW, Pickkers P, Kox M.

Haematologica. 2019 Jun;104(6):e230-e232. doi: 10.3324/haematol.2018.202796. Epub 2019 Jan 17. No abstract available.

30.

Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Leijte GP, Pickkers P, Kox M.

Shock. 2019 Feb;51(2):266. doi: 10.1097/SHK.0000000000001142. No abstract available.

PMID:
30645206
31.

Adrenomedullin in heart failure: pathophysiology and therapeutic application.

Voors AA, Kremer D, Geven C, Ter Maaten JM, Struck J, Bergmann A, Pickkers P, Metra M, Mebazaa A, Düngen HD, Butler J.

Eur J Heart Fail. 2019 Feb;21(2):163-171. doi: 10.1002/ejhf.1366. Epub 2018 Dec 28. Review.

32.

Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.

Leijte GP, Kiers D, van der Heijden W, Jansen A, Gerretsen J, Boerrigter V, Netea MG, Kox M, Pickkers P.

Crit Care Med. 2019 Apr;47(4):508-516. doi: 10.1097/CCM.0000000000003630.

33.

The influence of hypoxia on platelet function and plasmatic coagulation during systemic inflammation in humans in vivo.

Kiers D, Tunjungputri RN, Borkus R, Scheffer GJ, de Groot PG, Urbanus RT, van der Ven AJ, Pickkers P, de Mast Q, Kox M.

Platelets. 2019;30(7):927-930. doi: 10.1080/09537104.2018.1557617. Epub 2018 Dec 25.

PMID:
30584841
34.

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study.

Mebazaa A, Geven C, Hollinger A, Wittebole X, Chousterman BG, Blet A, Gayat E, Hartmann O, Scigalla P, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M, Laterre PF; AdrenOSS-1 study investigators.

Crit Care. 2018 Dec 21;22(1):354. doi: 10.1186/s13054-018-2243-2.

35.

New frontiers in precision medicine for sepsis-induced immunoparalysis.

Bruse N, Leijte GP, Pickkers P, Kox M.

Expert Rev Clin Immunol. 2019 Mar;15(3):251-263. doi: 10.1080/1744666X.2019.1562336. Epub 2019 Jan 7.

PMID:
30572728
36.

Correction to: What's new in immunostimulating strategies in the ICU.

Pickkers P, van der Poll T.

Intensive Care Med. 2019 Jan;45(1):137. doi: 10.1007/s00134-018-5482-4.

PMID:
30535983
37.

Treatment with a polymyxin B filter to capture endotoxin in sepsis patients: is there a signal for therapeutic efficacy?

Pickkers P, Russell JA.

Intensive Care Med. 2019 Feb;45(2):282-283. doi: 10.1007/s00134-018-5481-5. Epub 2018 Dec 3. No abstract available.

PMID:
30511248
38.

What's new in immunostimulating strategies in the ICU.

Pickkers P, van der Poll T.

Intensive Care Med. 2019 Jan;45(1):110-112. doi: 10.1007/s00134-018-5462-8. Epub 2018 Nov 19. No abstract available. Erratum in: Intensive Care Med. 2018 Dec 7;:.

PMID:
30456465
39.

Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study.

Hollinger A, Wittebole X, François B, Pickkers P, Antonelli M, Gayat E, Chousterman BG, Lascarrou JB, Dugernier T, Di Somma S, Struck J, Bergmann A, Beishuizen A, Constantin JM, Damoisel C, Deye N, Gaudry S, Huberlant V, Marx G, Mercier E, Oueslati H, Hartmann O, Sonneville R, Laterre PF, Mebazaa A, Legrand M.

Kidney Int Rep. 2018 Aug 22;3(6):1424-1433. doi: 10.1016/j.ekir.2018.08.006. eCollection 2018 Nov. Erratum in: Kidney Int Rep. 2018 Nov 17;4(1):187.

40.

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial.

Pickkers P, Mehta RL, Murray PT, Joannidis M, Molitoris BA, Kellum JA, Bachler M, Hoste EAJ, Hoiting O, Krell K, Ostermann M, Rozendaal W, Valkonen M, Brealey D, Beishuizen A, Meziani F, Murugan R, de Geus H, Payen D, van den Berg E, Arend J; STOP-AKI Investigators.

JAMA. 2018 Nov 20;320(19):1998-2009. doi: 10.1001/jama.2018.14283.

41.

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG.

Cell Metab. 2019 Jan 8;29(1):211-220.e5. doi: 10.1016/j.cmet.2018.09.003. Epub 2018 Oct 4.

PMID:
30293776
42.

Precision Immunotherapy for Sepsis.

Peters van Ton AM, Kox M, Abdo WF, Pickkers P.

Front Immunol. 2018 Sep 5;9:1926. doi: 10.3389/fimmu.2018.01926. eCollection 2018. Review.

43.

Sustainability of clinical pathway guided care in cardiac surgery ICU patients; 9-years experience in over 7500 patients.

van der Kolk BM, van den Boogaard M, van der Hoeven JG, Noyez L, Pickkers P.

Int J Qual Health Care. 2019 Jul 1;31(6):456-463. doi: 10.1093/intqhc/mzy190.

PMID:
30184204
44.

Haloperidol serum concentrations in critically ill patients included in the REDUCE study.

van Schijndel AW, Franssen EJF, Pickkers P, Rijkenberg S, van den Boogaard M, van der Voort PHJ.

Intensive Care Med. 2018 Oct;44(10):1774-1775. doi: 10.1007/s00134-018-5348-9. Epub 2018 Aug 24. No abstract available.

PMID:
30143834
45.

Long-Term Effects of Experimental Human Endotoxemia on Immune Cell Function: Similarities and Differences With Sepsis.

Rodriguez-Rosales YA, Kox M, van Rijssen E, van Cranenbroek B, van Welie M, Pickkers P, Joosten I, Koenen HJPM.

Shock. 2019 Jun;51(6):678-689. doi: 10.1097/SHK.0000000000001222.

PMID:
30124597
46.

Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation.

Pieterse E, Rother N, Yanginlar C, Gerretsen J, Boeltz S, Munoz LE, Herrmann M, Pickkers P, Hilbrands LB, van der Vlag J.

Ann Rheum Dis. 2018 Dec;77(12):1790-1798. doi: 10.1136/annrheumdis-2018-213223. Epub 2018 Aug 17.

PMID:
30120096
47.
48.

The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders.

Janssen MCH, Koene S, de Laat P, Hemelaar P, Pickkers P, Spaans E, Beukema R, Beyrath J, Groothuis J, Verhaak C, Smeitink J.

Clin Pharmacol Ther. 2019 Jan;105(1):101-111. doi: 10.1002/cpt.1197. Epub 2018 Sep 3.

49.

Prophylactic Haloperidol for Critically Ill Adults-Reply.

van den Boogaard M, Slooter AJC, Pickkers P.

JAMA. 2018 Jul 17;320(3):304-305. doi: 10.1001/jama.2018.6049. No abstract available.

PMID:
30027246
50.

Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient.

Workum JD, de Jong SW, Gresnigt MS, Becker KL, Pickkers P, van de Veerdonk FL, Heijdra YF, Kolwijck E.

Med Mycol Case Rep. 2018 Mar 7;21:4-7. doi: 10.1016/j.mmcr.2018.03.002. eCollection 2018 Sep.

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