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Items: 1 to 50 of 350

1.
2.

Comparison of different lots of endotoxin and evaluation of in vivo potency over time in the experimental human endotoxemia model.

Kiers D, Leijte GP, Gerretsen J, Zwaag J, Kox M, Pickkers P.

Innate Immun. 2019 Jan;25(1):34-45. doi: 10.1177/1753425918819754.

PMID:
30782041
4.

Hypoxia attenuates inflammation-induced hepcidin production during experimental human endotoxaemia.

Kiers D, van Eijk LT, van der Hoeven JG, Swinkels DW, Pickkers P, Kox M.

Haematologica. 2019 Jan 17. pii: haematol.2018.202796. doi: 10.3324/haematol.2018.202796. [Epub ahead of print]

5.

Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Leijte GP, Pickkers P, Kox M.

Shock. 2019 Feb;51(2):266. doi: 10.1097/SHK.0000000000001142. No abstract available.

PMID:
30645206
6.

Adrenomedullin in heart failure: pathophysiology and therapeutic application.

Voors AA, Kremer D, Geven C, Ter Maaten JM, Struck J, Bergmann A, Pickkers P, Metra M, Mebazaa A, Düngen HD, Butler J.

Eur J Heart Fail. 2019 Feb;21(2):163-171. doi: 10.1002/ejhf.1366. Epub 2018 Dec 28. Review.

PMID:
30592365
7.

Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.

Leijte GP, Kiers D, van der Heijden W, Jansen A, Gerretsen J, Boerrigter V, Netea MG, Kox M, Pickkers P.

Crit Care Med. 2018 Dec 21. doi: 10.1097/CCM.0000000000003630. [Epub ahead of print]

PMID:
30585832
8.

The influence of hypoxia on platelet function and plasmatic coagulation during systemic inflammation in humans in vivo.

Kiers D, Tunjungputri RN, Borkus R, Scheffer GJ, de Groot PG, Urbanus RT, van der Ven AJ, Pickkers P, de Mast Q, Kox M.

Platelets. 2018 Dec 25:1-4. doi: 10.1080/09537104.2018.1557617. [Epub ahead of print]

PMID:
30584841
9.

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study.

Mebazaa A, Geven C, Hollinger A, Wittebole X, Chousterman BG, Blet A, Gayat E, Hartmann O, Scigalla P, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, Dugernier T, François B, Gaudry S, Huberlant V, Lascarrou JB, Marx G, Mercier E, Oueslati H, Pickkers P, Sonneville R, Legrand M, Laterre PF; AdrenOSS-1 study investigators.

Crit Care. 2018 Dec 21;22(1):354. doi: 10.1186/s13054-018-2243-2.

10.

New frontiers in precision medicine for sepsis-induced immunoparalysis.

Bruse N, Leijte GP, Pickkers P, Kox M.

Expert Rev Clin Immunol. 2019 Mar;15(3):251-263. doi: 10.1080/1744666X.2019.1562336. Epub 2019 Jan 7.

PMID:
30572728
11.

Correction to: What's new in immunostimulating strategies in the ICU.

Pickkers P, van der Poll T.

Intensive Care Med. 2019 Jan;45(1):137. doi: 10.1007/s00134-018-5482-4.

PMID:
30535983
12.

Treatment with a polymyxin B filter to capture endotoxin in sepsis patients: is there a signal for therapeutic efficacy?

Pickkers P, Russell JA.

Intensive Care Med. 2019 Feb;45(2):282-283. doi: 10.1007/s00134-018-5481-5. Epub 2018 Dec 3. No abstract available.

PMID:
30511248
13.

"What's new?" : Immunostimulating strategies in the ICU.

Pickkers P, van der Poll T.

Intensive Care Med. 2019 Jan;45(1):110-112. doi: 10.1007/s00134-018-5462-8. Epub 2018 Nov 19. No abstract available. Erratum in: Intensive Care Med. 2018 Dec 7;:.

PMID:
30456465
14.

Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study.

Hollinger A, Wittebole X, François B, Pickkers P, Antonelli M, Gayat E, Chousterman BG, Lascarrou JB, Dugernier T, Di Somma S, Struck J, Bergmann A, Beishuizen A, Constatin JM, Damoisel C, Deye N, Gaudry S, Huberlant V, Marx G, Mercier E, Oueslati H, Hartmann O, Sonneville R, Laterre PF, Mebazaa A, Legrand M.

Kidney Int Rep. 2018 Aug 22;3(6):1424-1433. doi: 10.1016/j.ekir.2018.08.006. eCollection 2018 Nov. Erratum in: Kidney Int Rep. 2018 Nov 17;4(1):187.

15.

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial.

Pickkers P, Mehta RL, Murray PT, Joannidis M, Molitoris BA, Kellum JA, Bachler M, Hoste EAJ, Hoiting O, Krell K, Ostermann M, Rozendaal W, Valkonen M, Brealey D, Beishuizen A, Meziani F, Murugan R, de Geus H, Payen D, van den Berg E, Arend J; STOP-AKI Investigators.

JAMA. 2018 Nov 20;320(19):1998-2009. doi: 10.1001/jama.2018.14283.

PMID:
30357272
16.

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG.

Cell Metab. 2019 Jan 8;29(1):211-220.e5. doi: 10.1016/j.cmet.2018.09.003. Epub 2018 Oct 4.

PMID:
30293776
17.

Precision Immunotherapy for Sepsis.

Peters van Ton AM, Kox M, Abdo WF, Pickkers P.

Front Immunol. 2018 Sep 5;9:1926. doi: 10.3389/fimmu.2018.01926. eCollection 2018. Review.

18.

Sustainability of clinical pathway guided care in cardiac surgery ICU patients; 9-years experience in over 7500 patients.

van der Kolk BM, van den Boogaard M, van der Hoeven JG, Noyez L, Pickkers P.

Int J Qual Health Care. 2018 Sep 1. doi: 10.1093/intqhc/mzy190. [Epub ahead of print]

PMID:
30184204
19.

Haloperidol serum concentrations in critically ill patients included in the REDUCE study.

van Schijndel AW, Franssen EJF, Pickkers P, Rijkenberg S, van den Boogaard M, van der Voort PHJ.

Intensive Care Med. 2018 Oct;44(10):1774-1775. doi: 10.1007/s00134-018-5348-9. Epub 2018 Aug 24. No abstract available.

PMID:
30143834
20.

Long-Term Effects of Experimental Human Endotoxemia on Immune Cell Function: Similarities and Differences with Sepsis.

Rodriguez-Rosales YA, Kox M, van Rijssen E, van Cranenbroek B, van Welie M, Pickkers P, Joosten I, Koenen H.

Shock. 2018 Aug 17. doi: 10.1097/SHK.0000000000001222. [Epub ahead of print]

PMID:
30124597
21.

Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation.

Pieterse E, Rother N, Yanginlar C, Gerretsen J, Boeltz S, Munoz LE, Herrmann M, Pickkers P, Hilbrands LB, van der Vlag J.

Ann Rheum Dis. 2018 Dec;77(12):1790-1798. doi: 10.1136/annrheumdis-2018-213223. Epub 2018 Aug 17.

PMID:
30120096
22.
23.

The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders.

Janssen MCH, Koene S, de Laat P, Hemelaar P, Pickkers P, Spaans E, Beukema R, Beyrath J, Groothuis J, Verhaak C, Smeitink J.

Clin Pharmacol Ther. 2019 Jan;105(1):101-111. doi: 10.1002/cpt.1197. Epub 2018 Sep 3.

PMID:
30058726
24.

Prophylactic Haloperidol for Critically Ill Adults-Reply.

van den Boogaard M, Slooter AJC, Pickkers P.

JAMA. 2018 Jul 17;320(3):304-305. doi: 10.1001/jama.2018.6049. No abstract available.

PMID:
30027246
25.

Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient.

Workum JD, de Jong SW, Gresnigt MS, Becker KL, Pickkers P, van de Veerdonk FL, Heijdra YF, Kolwijck E.

Med Mycol Case Rep. 2018 Mar 7;21:4-7. doi: 10.1016/j.mmcr.2018.03.002. eCollection 2018 Sep.

26.

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

Kiers D, Wielockx B, Peters E, van Eijk LT, Gerretsen J, John A, Janssen E, Groeneveld R, Peters M, Damen L, Meneses AM, Krüger A, Langereis JD, Zomer AL, Blackburn MR, Joosten LA, Netea MG, Riksen NP, van der Hoeven JG, Scheffer GJ, Eltzschig HK, Pickkers P, Kox M.

EBioMedicine. 2018 Jul;33:144-156. doi: 10.1016/j.ebiom.2018.06.021. Epub 2018 Jul 4.

27.

Immunomodulatory and Kidney-Protective Effects of the Human Chorionic Gonadotropin Derivate EA-230.

van Groenendael R, Kox M, van Eijk LT, Pickkers P.

Nephron. 2018;140(2):148-151. doi: 10.1159/000490772. Epub 2018 Jul 6.

28.

The endotoxin-induced pulmonary inflammatory response is enhanced during the acute phase of influenza infection.

Koch RM, Diavatopoulos DA, Ferwerda G, Pickkers P, de Jonge MI, Kox M.

Intensive Care Med Exp. 2018 Jul 5;6(1):15. doi: 10.1186/s40635-018-0182-5.

29.

Experimental human endotoxemia as a model of systemic inflammation.

van Lier D, Geven C, Leijte GP, Pickkers P.

Biochimie. 2018 Jun 22. pii: S0300-9084(18)30171-8. doi: 10.1016/j.biochi.2018.06.014. [Epub ahead of print] Review.

PMID:
29936295
30.

Differential antibacterial control by neutrophil subsets.

Leliefeld PHC, Pillay J, Vrisekoop N, Heeres M, Tak T, Kox M, Rooijakkers SHM, Kuijpers TW, Pickkers P, Leenen LPH, Koenderman L.

Blood Adv. 2018 Jun 12;2(11):1344-1355. doi: 10.1182/bloodadvances.2017015578.

31.

The mechanism of action of the adrenomedullin-binding antibody adrecizumab.

Geven C, Pickkers P.

Crit Care. 2018 Jun 13;22(1):159. doi: 10.1186/s13054-018-2074-1. No abstract available.

32.

Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group.

Nadim MK, Forni LG, Bihorac A, Hobson C, Koyner JL, Shaw A, Arnaoutakis GJ, Ding X, Engelman DT, Gasparovic H, Gasparovic V, Herzog CA, Kashani K, Katz N, Liu KD, Mehta RL, Ostermann M, Pannu N, Pickkers P, Price S, Ricci Z, Rich JB, Sajja LR, Weaver FA, Zarbock A, Ronco C, Kellum JA.

J Am Heart Assoc. 2018 Jun 1;7(11). pii: e008834. doi: 10.1161/JAHA.118.008834. No abstract available.

33.

Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects.

Geven C, van Lier D, Blet A, Peelen R, Ten Elzen B, Mebazaa A, Kox M, Pickkers P.

Br J Clin Pharmacol. 2018 Sep;84(9):2129-2141. doi: 10.1111/bcp.13655. Epub 2018 Jul 3.

PMID:
29856470
34.

Temporal biomarker profiles and their association with ICU acquired delirium: a cohort study.

Simons KS, van den Boogaard M, Hendriksen E, Gerretsen J, van der Hoeven JG, Pickkers P, de Jager CPC.

Crit Care. 2018 May 25;22(1):137. doi: 10.1186/s13054-018-2054-5.

35.

Moderate correlation between systemic IL-6 responses and CRP with trough concentrations of voriconazole.

Vreugdenhil B, van der Velden WJFM, Feuth T, Kox M, Pickkers P, van de Veerdonk FL, Blijlevens NMA, Brüggemann RJM.

Br J Clin Pharmacol. 2018 Sep;84(9):1980-1988. doi: 10.1111/bcp.13627. Epub 2018 Jun 19.

36.

Delirium prediction in the intensive care unit: comparison of two delirium prediction models.

Wassenaar A, Schoonhoven L, Devlin JW, van Haren FMP, Slooter AJC, Jorens PG, van der Jagt M, Simons KS, Egerod I, Burry LD, Beishuizen A, Matos J, Donders ART, Pickkers P, van den Boogaard M.

Crit Care. 2018 May 5;22(1):114. doi: 10.1186/s13054-018-2037-6.

37.

Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

Leijte GP, Custers H, Gerretsen J, Heijne A, Roth J, Vogl T, Scheffer GJ, Pickkers P, Kox M.

Front Immunol. 2018 Apr 5;9:663. doi: 10.3389/fimmu.2018.00663. eCollection 2018.

38.

Effect of organisational factors on the variation in incidence of delirium in intensive care unit patients: A systematic review and meta-regression analysis.

Rood P, Huisman-de Waal G, Vermeulen H, Schoonhoven L, Pickkers P, van den Boogaard M.

Aust Crit Care. 2018 May;31(3):180-187. doi: 10.1016/j.aucc.2018.02.002. Epub 2018 Mar 12. Review.

39.

Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis.

Geven C, Kox M, Pickkers P.

Front Immunol. 2018 Feb 19;9:292. doi: 10.3389/fimmu.2018.00292. eCollection 2018. Review.

40.

Feasibility of Cognitive Training in Critically Ill Patients: A Pilot Study.

Wassenaar A, Rood P, Boelen D, Schoonhoven L, Pickkers P, van den Boogaard M.

Am J Crit Care. 2018 Mar;27(2):124-135. doi: 10.4037/ajcc2018467.

PMID:
29496769
41.

Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial.

van den Boogaard M, Slooter AJC, Brüggemann RJM, Schoonhoven L, Beishuizen A, Vermeijden JW, Pretorius D, de Koning J, Simons KS, Dennesen PJW, Van der Voort PHJ, Houterman S, van der Hoeven JG, Pickkers P; REDUCE Study Investigators, van der Woude MCE, Besselink A, Hofstra LS, Spronk PE, van den Bergh W, Donker DW, Fuchs M, Karakus A, Koeman M, van Duijnhoven M, Hannink G.

JAMA. 2018 Feb 20;319(7):680-690. doi: 10.1001/jama.2018.0160.

42.

Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP).

Vincent JL, Lefrant JY, Kotfis K, Nanchal R, Martin-Loeches I, Wittebole X, Sakka SG, Pickkers P, Moreno R, Sakr Y; ICON and SOAP investigators; SOAP investigators.

Intensive Care Med. 2018 Mar;44(3):337-344. doi: 10.1007/s00134-017-5043-2. Epub 2018 Feb 15.

43.

Short-term repeated HRV-16 exposure results in an attenuated immune response in vivo in humans.

Koch RM, Kox M, van den Kieboom C, Ferwerda G, Gerretsen J, Ten Bruggencate S, van der Hoeven JG, de Jonge MI, Pickkers P.

PLoS One. 2018 Feb 15;13(2):e0191937. doi: 10.1371/journal.pone.0191937. eCollection 2018.

44.

Man flu: less inflammation but more consequences in men than women.

van Eijk LT, Pickkers P.

BMJ. 2018 Feb 7;360:k439. doi: 10.1136/bmj.k439. No abstract available.

PMID:
29437688
45.

Rationale and Design of an Adaptive Phase 2b/3 Clinical Trial of Selepressin for Adults in Septic Shock. Selepressin Evaluation Programme for Sepsis-induced Shock-Adaptive Clinical Trial.

Lewis RJ, Angus DC, Laterre PF, Kjølbye AL, van der Meulen E, Blemings A, Graves T, Russell JA, Carlsen JE, Jacobsen K, Yealy DM, Opal SM, Windeløv NA, François B, Perner A, Pickkers P, Berry SM.

Ann Am Thorac Soc. 2018 Feb;15(2):250-257. doi: 10.1513/AnnalsATS.201708-669SD.

PMID:
29388815
46.

Effects of the Humanized Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) on Vascular Barrier Function and Survival in Rodent Models of Systemic Inflammation and Sepsis.

Geven C, Peters E, Schroedter M, Struck J, Bergmann A, McCook O, Radermacher P, Kox M, Pickkers P.

Shock. 2018 Dec;50(6):648-654. doi: 10.1097/SHK.0000000000001102.

PMID:
29324627
47.

Vascular Effects of Adrenomedullin and the Anti-Adrenomedullin Antibody Adrecizumab in Sepsis.

Geven C, Bergmann A, Kox M, Pickkers P.

Shock. 2018 Aug;50(2):132-140. doi: 10.1097/SHK.0000000000001103.

PMID:
29324626
48.

Development of Endotoxin Tolerance Does Not Influence the Response to a Challenge with the Mucosal Live-Attenuated Influenza Vaccine in Humans In Vivo.

Koch RM, Kox M, Thijs EJM, Rahamat-Langendoen JC, van de Veerdonk FL, Gerretsen J, Schloesser J, Diavatopoulos D, Rimmelzwaan GF, Netea MG, van der Hoeven JG, de Jonge MI, Pickkers P.

Front Immunol. 2017 Dec 11;8:1600. doi: 10.3389/fimmu.2017.01600. eCollection 2017.

49.

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion.

Lebrun LJ, Lenaerts K, Kiers D, Pais de Barros JP, Le Guern N, Plesnik J, Thomas C, Bourgeois T, Dejong CHC, Kox M, Hundscheid IHR, Khan NA, Mandard S, Deckert V, Pickkers P, Drucker DJ, Lagrost L, Grober J.

Cell Rep. 2017 Oct 31;21(5):1160-1168. doi: 10.1016/j.celrep.2017.10.008.

50.

Development and Validation of an Abbreviated Questionnaire to Easily Measure Cognitive Failure in ICU Survivors: A Multicenter Study.

Wassenaar A, de Reus J, Donders ART, Schoonhoven L, Cremer OL, de Lange DW, van Dijk D, Slooter AJC, Pickkers P, van den Boogaard M.

Crit Care Med. 2018 Jan;46(1):79-84. doi: 10.1097/CCM.0000000000002806.

PMID:
29068855

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