Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 79


A Combined YopB and LcrV Subunit Vaccine Elicits Protective Immunity against Yersinia Infection in Adult and Infant Mice.

Heine SJ, Franco-Mahecha OL, Sears KT, Drachenberg CB, van Roosmalen ML, Leenhouts K, Picking WL, Pasetti MF.

J Immunol. 2019 Apr 1;202(7):2005-2016. doi: 10.4049/jimmunol.1800985. Epub 2019 Feb 20.


Using disruptive insertional mutagenesis to identify the in situ structure-function landscape of the Shigella translocator protein IpaB.

Barta ML, Tachiyama S, Muthuramalingam M, Arizmendi O, Villanueva CE, Ramyar KX, Geisbrecht BV, Lovell S, Battaile KP, Picking WL, Picking WD.

Protein Sci. 2018 Aug;27(8):1392-1406. doi: 10.1002/pro.3428. Epub 2018 May 3.


Characterization and Protective Efficacy of Type III Secretion Proteins as a Broadly Protective Subunit Vaccine against Salmonella enterica Serotypes.

Martinez-Becerra FJ, Kumar P, Vishwakarma V, Kim JH, Arizmendi O, Middaugh CR, Picking WD, Picking WL.

Infect Immun. 2018 Feb 20;86(3). pii: e00473-17. doi: 10.1128/IAI.00473-17. Print 2018 Mar.


Effect of Phosphate Ion on the Structure of Lumazine Synthase, an Antigen Presentation System From Bacillus anthracis.

Wei Y, Wahome N, Kumar P, Whitaker N, Picking WL, Middaugh CR.

J Pharm Sci. 2018 Mar;107(3):814-823. doi: 10.1016/j.xphs.2017.10.013. Epub 2017 Oct 16.


Single-domain antibodies pinpoint potential targets within Shigella invasion plasmid antigen D of the needle tip complex for inhibition of type III secretion.

Barta ML, Shearer JP, Arizmendi O, Tremblay JM, Mehzabeen N, Zheng Q, Battaile KP, Lovell S, Tzipori S, Picking WD, Shoemaker CB, Picking WL.

J Biol Chem. 2017 Oct 6;292(40):16677-16687. doi: 10.1074/jbc.M117.802231. Epub 2017 Aug 25.


Evaluation of lumazine synthase from Bacillus anthracis as a presentation platform for polyvalent antigen display.

Wei Y, Wahome N, VanSlyke G, Whitaker N, Kumar P, Barta ML, Picking WL, Volkin DB, Mantis NJ, Middaugh CR.

Protein Sci. 2017 Oct;26(10):2059-2072. doi: 10.1002/pro.3243. Epub 2017 Sep 13.


Identification of Excipients for Stabilizing Fiberless Adenovirus as Biopharmaceuticals.

Kupgan G, Choudhari SP, Flynn NH, Nigatu A, Vupputuri S, Picking WL, Picking WD, Ramsey JD.

J Pharm Sci. 2017 Jul;106(7):1764-1771. doi: 10.1016/j.xphs.2017.04.013. Epub 2017 Apr 18.


Macrophage Apoptosis Triggered by IpaD from Shigella flexneri.

Arizmendi O, Picking WD, Picking WL.

Infect Immun. 2016 May 24;84(6):1857-1865. doi: 10.1128/IAI.01483-15. Print 2016 Jun.


The Many Faces of IpaB.

Picking WL, Picking WD.

Front Cell Infect Microbiol. 2016 Feb 9;6:12. doi: 10.3389/fcimb.2016.00012. eCollection 2016. Review.


Biophysical Characterization of the Type III Secretion System Translocator Proteins and the Translocator Proteins Attached to Bacterium-Like Particles.

Chen X, Choudhari SP, Kumar P, Toth RT 4th, Kim JH, Van Roosmalen ML, Leenhouts K, Middaugh CR, Picking WL, Picking WD.

J Pharm Sci. 2015 Dec;104(12):4065-4073. doi: 10.1002/jps.24659. Epub 2015 Sep 30.


Shigella IpaB and IpaD displayed on L. lactis bacterium-like particles induce protective immunity in adult and infant mice.

Heine SJ, Franco-Mahecha OL, Chen X, Choudhari S, Blackwelder WC, van Roosmalen ML, Leenhouts K, Picking WL, Pasetti MF.

Immunol Cell Biol. 2015 Aug;93(7):641-52. doi: 10.1038/icb.2015.24. Epub 2015 Mar 17.


Visualization of the type III secretion sorting platform of Shigella flexneri.

Hu B, Morado DR, Margolin W, Rohde JR, Arizmendi O, Picking WL, Picking WD, Liu J.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1047-52. doi: 10.1073/pnas.1411610112. Epub 2015 Jan 12.


Impact of detergent on biophysical properties and immune response of the IpaDB fusion protein, a candidate subunit vaccine against Shigella species.

Chen X, Choudhari SP, Martinez-Becerra FJ, Kim JH, Dickenson NE, Toth RT 4th, Joshi SB, Greenwood JC 2nd, Clements JD, Picking WD, Middaugh CR, Picking WL.

Infect Immun. 2015 Jan;83(1):292-9. doi: 10.1128/IAI.02457-14. Epub 2014 Nov 3.


The immune response of two microbial antigens delivered intradermally, sublingually, or the combination thereof.

Lee S, Picking WL, Tzipori S.

Microbes Infect. 2014 Sep;16(9):796-803. doi: 10.1016/j.micinf.2014.07.013. Epub 2014 Aug 8.


Influence of oligomerization state on the structural properties of invasion plasmid antigen B from Shigella flexneri in the presence and absence of phospholipid membranes.

Adam PR, Dickenson NE, Greenwood JC 2nd, Picking WL, Picking WD.

Proteins. 2014 Nov;82(11):3013-22. doi: 10.1002/prot.24662. Epub 2014 Aug 21.


The effect of fiber truncations on the stability of adenovirus type 5.

Kupgan G, Hentges DC, Muschinske NJ, Picking WD, Picking WL, Ramsey JD.

Mol Biotechnol. 2014 Nov;56(11):979-91. doi: 10.1007/s12033-014-9777-6.


Biophysical characterization of the type III secretion tip proteins and the tip proteins attached to bacterium-like particles.

Choudhari SP, Chen X, Kim JH, Van Roosmalen ML, Greenwood JC 2nd, Joshi SB, Picking WD, Leenhouts K, Middaugh CR, Picking WL.

J Pharm Sci. 2015 Feb;104(2):424-32. doi: 10.1002/jps.24047. Epub 2014 Jun 10.


Experimental salmonellosis challenge model in older calves.

Snider TA, Gull T, Jackson TA, Martinez-Becerra FJ, Picking DR, Picking WD, Picking WL.

Vet Microbiol. 2014 May 14;170(1-2):65-72. doi: 10.1016/j.vetmic.2013.11.018. Epub 2013 Nov 28.


Intradermal delivery of Shigella IpaB and IpaD type III secretion proteins: kinetics of cell recruitment and antigen uptake, mucosal and systemic immunity, and protection across serotypes.

Heine SJ, Diaz-McNair J, Andar AU, Drachenberg CB, van de Verg L, Walker R, Picking WL, Pasetti MF.

J Immunol. 2014 Feb 15;192(4):1630-40. doi: 10.4049/jimmunol.1302743. Epub 2014 Jan 22.


N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD.

Dickenson NE, Arizmendi O, Patil MK, Toth RT 4th, Middaugh CR, Picking WD, Picking WL.

Biochemistry. 2013 Dec 10;52(49):8790-9. doi: 10.1021/bi400755f. Epub 2013 Nov 20.


Characterization of a novel fusion protein from IpaB and IpaD of Shigella spp. and its potential as a pan-Shigella vaccine.

Martinez-Becerra FJ, Chen X, Dickenson NE, Choudhari SP, Harrison K, Clements JD, Picking WD, Van De Verg LL, Walker RI, Picking WL.

Infect Immun. 2013 Dec;81(12):4470-7. doi: 10.1128/IAI.00859-13. Epub 2013 Sep 23.


Three functional β-carbonic anhydrases in Pseudomonas aeruginosa PAO1: role in survival in ambient air.

Lotlikar SR, Hnatusko S, Dickenson NE, Choudhari SP, Picking WL, Patrauchan MA.

Microbiology. 2013 Aug;159(Pt 8):1748-59. doi: 10.1099/mic.0.066357-0. Epub 2013 May 31.


Shigella antigen-specific B memory cells are associated with decreased disease severity in subjects challenged with wild-type Shigella flexneri 2a.

Wahid R, Simon JK, Picking WL, Kotloff KL, Levine MM, Sztein MB.

Clin Immunol. 2013 Jul;148(1):35-43. doi: 10.1016/j.clim.2013.03.009. Epub 2013 Mar 26.


Evaluation of immunogenicity and protective efficacy of orally delivered Shigella type III secretion system proteins IpaB and IpaD.

Heine SJ, Diaz-McNair J, Martinez-Becerra FJ, Choudhari SP, Clements JD, Picking WL, Pasetti MF.

Vaccine. 2013 Jun 19;31(28):2919-29. doi: 10.1016/j.vaccine.2013.04.045. Epub 2013 May 2.


Parenteral immunization with IpaB/IpaD protects mice against lethal pulmonary infection by Shigella.

Martinez-Becerra FJ, Scobey M, Harrison K, Choudhari SP, Quick AM, Joshi SB, Middaugh CR, Picking WL.

Vaccine. 2013 May 31;31(24):2667-72. doi: 10.1016/j.vaccine.2013.04.012. Epub 2013 Apr 16.


Studies of the conformational stability of invasion plasmid antigen B from Shigella.

Choudhari SP, Kramer R, Barta ML, Greenwood JC 2nd, Geisbrecht BV, Joshi SB, Picking WD, Middaugh CR, Picking WL.

Protein Sci. 2013 May;22(5):666-70. doi: 10.1002/pro.2249. Epub 2013 Mar 26.


Oligomeric states of the Shigella translocator protein IpaB provide structural insights into formation of the type III secretion translocon.

Dickenson NE, Choudhari SP, Adam PR, Kramer RM, Joshi SB, Middaugh CR, Picking WL, Picking WD.

Protein Sci. 2013 May;22(5):614-27. doi: 10.1002/pro.2245. Epub 2013 Mar 18.


Binding affects the tertiary and quaternary structures of the Shigella translocator protein IpaB and its chaperone IpgC.

Adam PR, Patil MK, Dickenson NE, Choudhari S, Barta M, Geisbrecht BV, Picking WL, Picking WD.

Biochemistry. 2012 May 15;51(19):4062-71. doi: 10.1021/bi300243z. Epub 2012 May 1.


Ultrastructural analysis of IpaD at the tip of the nascent MxiH type III secretion apparatus of Shigella flexneri.

Epler CR, Dickenson NE, Bullitt E, Picking WL.

J Mol Biol. 2012 Jun 29;420(1-2):29-39. doi: 10.1016/j.jmb.2012.03.025. Epub 2012 Apr 2.


Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure.

Barta ML, Guragain M, Adam P, Dickenson NE, Patil M, Geisbrecht BV, Picking WL, Picking WD.

Proteins. 2012 Mar;80(3):935-45.


The structures of coiled-coil domains from type III secretion system translocators reveal homology to pore-forming toxins.

Barta ML, Dickenson NE, Patil M, Keightley A, Wyckoff GJ, Picking WD, Picking WL, Geisbrecht BV.

J Mol Biol. 2012 Apr 13;417(5):395-405. doi: 10.1016/j.jmb.2012.01.026. Epub 2012 Feb 1.


Broadly protective Shigella vaccine based on type III secretion apparatus proteins.

Martinez-Becerra FJ, Kissmann JM, Diaz-McNair J, Choudhari SP, Quick AM, Mellado-Sanchez G, Clements JD, Pasetti MF, Picking WL.

Infect Immun. 2012 Mar;80(3):1222-31. doi: 10.1128/IAI.06174-11. Epub 2011 Dec 27.


Antigen-specific IgA B memory cell responses to Shigella antigens elicited in volunteers immunized with live attenuated Shigella flexneri 2a oral vaccine candidates.

Simon JK, Maciel M Jr, Weld ED, Wahid R, Pasetti MF, Picking WL, Kotloff KL, Levine MM, Sztein MB.

Clin Immunol. 2011 May;139(2):185-92. doi: 10.1016/j.clim.2011.02.003. Epub 2011 Mar 8.


Conformational changes in IpaD from Shigella flexneri upon binding bile salts provide insight into the second step of type III secretion.

Dickenson NE, Zhang L, Epler CR, Adam PR, Picking WL, Picking WD.

Biochemistry. 2011 Jan 18;50(2):172-80. Epub 2010 Dec 15.


Formulation and immunogenicity of a potential multivalent type III secretion system-based protein vaccine.

Markham AP, Barrett BS, Esfandiary R, Picking WL, Picking WD, Joshi SB, Middaugh CR.

J Pharm Sci. 2010 Nov;99(11):4497-509. doi: 10.1002/jps.22195.


Formulation and immunogenicity studies of type III secretion system needle antigens as vaccine candidates.

Barrett BS, Markham AP, Esfandiary R, Picking WL, Picking WD, Joshi SB, Middaugh CR.

J Pharm Sci. 2010 Nov;99(11):4488-96. doi: 10.1002/jps.22180.


Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone.

Barta ML, Zhang L, Picking WL, Geisbrecht BV.

BMC Struct Biol. 2010 Jul 15;10:21. doi: 10.1186/1472-6807-10-21.


A repulsive electrostatic mechanism for protein export through the type III secretion apparatus.

Rathinavelan T, Zhang L, Picking WL, Weis DD, De Guzman RN, Im W.

Biophys J. 2010 Feb 3;98(3):452-61. doi: 10.1016/j.bpj.2009.10.030.


Neonatal mucosal immunization with a non-living, non-genetically modified Lactococcus lactis vaccine carrier induces systemic and local Th1-type immunity and protects against lethal bacterial infection.

Ramirez K, Ditamo Y, Rodriguez L, Picking WL, van Roosmalen ML, Leenhouts K, Pasetti MF.

Mucosal Immunol. 2010 Mar;3(2):159-71. doi: 10.1038/mi.2009.131. Epub 2009 Nov 18.


Liposomes recruit IpaC to the Shigella flexneri type III secretion apparatus needle as a final step in secretion induction.

Epler CR, Dickenson NE, Olive AJ, Picking WL, Picking WD.

Infect Immun. 2009 Jul;77(7):2754-61. doi: 10.1128/IAI.00190-09. Epub 2009 May 11.


Structural dissection of the extracellular moieties of the type III secretion apparatus.

Wang Y, Zhang L, Picking WL, Picking WD, De Guzman RN.

Mol Biosyst. 2008 Dec;4(12):1176-80. doi: 10.1039/b808271p. Epub 2008 Sep 18. Review.


Antigen-specific B memory cell responses to lipopolysaccharide (LPS) and invasion plasmid antigen (Ipa) B elicited in volunteers vaccinated with live-attenuated Shigella flexneri 2a vaccine candidates.

Simon JK, Wahid R, Maciel M Jr, Picking WL, Kotloff KL, Levine MM, Sztein MB.

Vaccine. 2009 Jan 22;27(4):565-72. doi: 10.1016/j.vaccine.2008.10.081. Epub 2008 Nov 18.


The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells.

Terry CM, Picking WL, Birket SE, Flentie K, Hoffman BM, Barker JR, Picking WD.

Microb Pathog. 2008 Oct;45(4):282-9. doi: 10.1016/j.micpath.2008.06.003. Epub 2008 Jul 4.


The response of type three secretion system needle proteins MxiHDelta5, BsaLDelta5, and PrgIDelta5 to temperature and pH.

Barrett BS, Picking WL, Picking WD, Middaugh CR.

Proteins. 2008 Nov 15;73(3):632-43. doi: 10.1002/prot.22085.


Deoxycholate interacts with IpaD of Shigella flexneri in inducing the recruitment of IpaB to the type III secretion apparatus needle tip.

Stensrud KF, Adam PR, La Mar CD, Olive AJ, Lushington GH, Sudharsan R, Shelton NL, Givens RS, Picking WL, Picking WD.

J Biol Chem. 2008 Jul 4;283(27):18646-54. doi: 10.1074/jbc.M802799200. Epub 2008 May 1.


pH sensitivity of type III secretion system tip proteins.

Markham AP, Birket SE, Picking WD, Picking WL, Middaugh CR.

Proteins. 2008 Jun;71(4):1830-42. doi: 10.1002/prot.21864.


Evaluating Burkholderia pseudomallei Bip proteins as vaccines and Bip antibodies as detection agents.

Druar C, Yu F, Barnes JL, Okinaka RT, Chantratita N, Beg S, Stratilo CW, Olive AJ, Soltes G, Russell ML, Limmathurotsakul D, Norton RE, Ni SX, Picking WD, Jackson PJ, Stewart DI, Tsvetnitsky V, Picking WL, Cherwonogrodzky JW, Ketheesan N, Peacock SJ, Wiersma EJ.

FEMS Immunol Med Microbiol. 2008 Jan;52(1):78-87. Epub 2007 Nov 11.


Identification of the MxiH needle protein residues responsible for anchoring invasion plasmid antigen D to the type III secretion needle tip.

Zhang L, Wang Y, Olive AJ, Smith ND, Picking WD, De Guzman RN, Picking WL.

J Biol Chem. 2007 Nov 2;282(44):32144-51. Epub 2007 Sep 7.


Preparation and characterization of translocator/chaperone complexes and their component proteins from Shigella flexneri.

Birket SE, Harrington AT, Espina M, Smith ND, Terry CM, Darboe N, Markham AP, Middaugh CR, Picking WL, Picking WD.

Biochemistry. 2007 Jul 10;46(27):8128-37. Epub 2007 Jun 16.


Conformational stability and differential structural analysis of LcrV, PcrV, BipD, and SipD from type III secretion systems.

Espina M, Ausar SF, Middaugh CR, Baxter MA, Picking WD, Picking WL.

Protein Sci. 2007 Apr;16(4):704-14. Epub 2007 Feb 27.

Supplemental Content

Loading ...
Support Center