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Items: 1 to 50 of 88

1.

The Tip Complex: From Host Cell Sensing to Translocon Formation.

Picking WD, Barta ML.

Curr Top Microbiol Immunol. 2019 Jun 20. doi: 10.1007/82_2019_171. [Epub ahead of print]

PMID:
31218507
2.

The cytoplasmic portion of the T3SS inner membrane ring components sort into distinct families based on biophysical properties.

Muthuramalingam M, Middaugh CR, Picking WD.

Biochim Biophys Acta Proteins Proteom. 2019 Sep;1867(9):787-793. doi: 10.1016/j.bbapap.2019.06.002. Epub 2019 Jun 10.

PMID:
31195141
3.

Vaccination With Mouse Dendritic Cells Loaded With an IpaD-IpaB Fusion Provides Protection Against Shigellosis.

Arizmendi O, Kumar P, Zheng Q, Stewart JP, Picking WD, Picking W, Martinez-Becerra FJ.

Front Immunol. 2019 Feb 8;10:192. doi: 10.3389/fimmu.2019.00192. eCollection 2019.

4.

Using disruptive insertional mutagenesis to identify the in situ structure-function landscape of the Shigella translocator protein IpaB.

Barta ML, Tachiyama S, Muthuramalingam M, Arizmendi O, Villanueva CE, Ramyar KX, Geisbrecht BV, Lovell S, Battaile KP, Picking WL, Picking WD.

Protein Sci. 2018 Aug;27(8):1392-1406. doi: 10.1002/pro.3428. Epub 2018 May 3.

5.

Characterization and Protective Efficacy of Type III Secretion Proteins as a Broadly Protective Subunit Vaccine against Salmonella enterica Serotypes.

Martinez-Becerra FJ, Kumar P, Vishwakarma V, Kim JH, Arizmendi O, Middaugh CR, Picking WD, Picking WL.

Infect Immun. 2018 Feb 20;86(3). pii: e00473-17. doi: 10.1128/IAI.00473-17. Print 2018 Mar.

6.

Use of a novel antigen expressing system to study the Salmonella enterica serovar Typhi protein recognition by T cells.

Salerno-Gonçalves R, Tettelin H, Lou D, Steiner S, Rezwanul T, Guo Q, Picking WD, Nene V, Sztein MB.

PLoS Negl Trop Dis. 2017 Sep 5;11(9):e0005912. doi: 10.1371/journal.pntd.0005912. eCollection 2017 Sep.

7.

Single-domain antibodies pinpoint potential targets within Shigella invasion plasmid antigen D of the needle tip complex for inhibition of type III secretion.

Barta ML, Shearer JP, Arizmendi O, Tremblay JM, Mehzabeen N, Zheng Q, Battaile KP, Lovell S, Tzipori S, Picking WD, Shoemaker CB, Picking WL.

J Biol Chem. 2017 Oct 6;292(40):16677-16687. doi: 10.1074/jbc.M117.802231. Epub 2017 Aug 25.

8.

Lethal factor antibodies contribute to lethal toxin neutralization in recipients of anthrax vaccine precipitated.

Dumas EK, Garman L, Cuthbertson H, Charlton S, Hallis B, Engler RJM, Choudhari S, Picking WD, James JA, Farris AD.

Vaccine. 2017 Jun 8;35(26):3416-3422. doi: 10.1016/j.vaccine.2017.05.006. Epub 2017 May 11.

9.

Identification of Excipients for Stabilizing Fiberless Adenovirus as Biopharmaceuticals.

Kupgan G, Choudhari SP, Flynn NH, Nigatu A, Vupputuri S, Picking WL, Picking WD, Ramsey JD.

J Pharm Sci. 2017 Jul;106(7):1764-1771. doi: 10.1016/j.xphs.2017.04.013. Epub 2017 Apr 18.

PMID:
28427886
10.

Macrophage Apoptosis Triggered by IpaD from Shigella flexneri.

Arizmendi O, Picking WD, Picking WL.

Infect Immun. 2016 May 24;84(6):1857-1865. doi: 10.1128/IAI.01483-15. Print 2016 Jun.

11.

The Many Faces of IpaB.

Picking WL, Picking WD.

Front Cell Infect Microbiol. 2016 Feb 9;6:12. doi: 10.3389/fcimb.2016.00012. eCollection 2016. Review.

12.

NlpC/P60 domain-containing proteins of Mycobacterium avium subspecies paratuberculosis that differentially bind and hydrolyze peptidoglycan.

Bannantine JP, Lingle CK, Adam PR, Ramyar KX, McWhorter WJ, Stabel JR, Picking WD, Geisbrecht BV.

Protein Sci. 2016 Apr;25(4):840-51. doi: 10.1002/pro.2884. Epub 2016 Feb 14.

13.

Biophysical Characterization of the Type III Secretion System Translocator Proteins and the Translocator Proteins Attached to Bacterium-Like Particles.

Chen X, Choudhari SP, Kumar P, Toth RT 4th, Kim JH, Van Roosmalen ML, Leenhouts K, Middaugh CR, Picking WL, Picking WD.

J Pharm Sci. 2015 Dec;104(12):4065-4073. doi: 10.1002/jps.24659. Epub 2015 Sep 30.

PMID:
26422758
14.

Visualization of the type III secretion sorting platform of Shigella flexneri.

Hu B, Morado DR, Margolin W, Rohde JR, Arizmendi O, Picking WL, Picking WD, Liu J.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1047-52. doi: 10.1073/pnas.1411610112. Epub 2015 Jan 12.

15.

Impact of detergent on biophysical properties and immune response of the IpaDB fusion protein, a candidate subunit vaccine against Shigella species.

Chen X, Choudhari SP, Martinez-Becerra FJ, Kim JH, Dickenson NE, Toth RT 4th, Joshi SB, Greenwood JC 2nd, Clements JD, Picking WD, Middaugh CR, Picking WL.

Infect Immun. 2015 Jan;83(1):292-9. doi: 10.1128/IAI.02457-14. Epub 2014 Nov 3.

16.

Influence of oligomerization state on the structural properties of invasion plasmid antigen B from Shigella flexneri in the presence and absence of phospholipid membranes.

Adam PR, Dickenson NE, Greenwood JC 2nd, Picking WL, Picking WD.

Proteins. 2014 Nov;82(11):3013-22. doi: 10.1002/prot.24662. Epub 2014 Aug 21.

17.

The effect of fiber truncations on the stability of adenovirus type 5.

Kupgan G, Hentges DC, Muschinske NJ, Picking WD, Picking WL, Ramsey JD.

Mol Biotechnol. 2014 Nov;56(11):979-91. doi: 10.1007/s12033-014-9777-6.

PMID:
24981329
18.

Biophysical characterization of the type III secretion tip proteins and the tip proteins attached to bacterium-like particles.

Choudhari SP, Chen X, Kim JH, Van Roosmalen ML, Greenwood JC 2nd, Joshi SB, Picking WD, Leenhouts K, Middaugh CR, Picking WL.

J Pharm Sci. 2015 Feb;104(2):424-32. doi: 10.1002/jps.24047. Epub 2014 Jun 10.

19.

Experimental salmonellosis challenge model in older calves.

Snider TA, Gull T, Jackson TA, Martinez-Becerra FJ, Picking DR, Picking WD, Picking WL.

Vet Microbiol. 2014 May 14;170(1-2):65-72. doi: 10.1016/j.vetmic.2013.11.018. Epub 2013 Nov 28.

PMID:
24529790
20.

N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD.

Dickenson NE, Arizmendi O, Patil MK, Toth RT 4th, Middaugh CR, Picking WD, Picking WL.

Biochemistry. 2013 Dec 10;52(49):8790-9. doi: 10.1021/bi400755f. Epub 2013 Nov 20.

21.

Characterization of a novel fusion protein from IpaB and IpaD of Shigella spp. and its potential as a pan-Shigella vaccine.

Martinez-Becerra FJ, Chen X, Dickenson NE, Choudhari SP, Harrison K, Clements JD, Picking WD, Van De Verg LL, Walker RI, Picking WL.

Infect Immun. 2013 Dec;81(12):4470-7. doi: 10.1128/IAI.00859-13. Epub 2013 Sep 23.

22.

A systematic approach toward stabilization of CagL, a protein antigen from Helicobacter pylori that is a candidate subunit vaccine.

Choudhari SP, Pendleton KP, Ramsey JD, Blanchard TG, Picking WD.

J Pharm Sci. 2013 Aug;102(8):2508-19. doi: 10.1002/jps.23643. Epub 2013 Jun 21.

23.

Studies of the conformational stability of invasion plasmid antigen B from Shigella.

Choudhari SP, Kramer R, Barta ML, Greenwood JC 2nd, Geisbrecht BV, Joshi SB, Picking WD, Middaugh CR, Picking WL.

Protein Sci. 2013 May;22(5):666-70. doi: 10.1002/pro.2249. Epub 2013 Mar 26.

24.

Oligomeric states of the Shigella translocator protein IpaB provide structural insights into formation of the type III secretion translocon.

Dickenson NE, Choudhari SP, Adam PR, Kramer RM, Joshi SB, Middaugh CR, Picking WL, Picking WD.

Protein Sci. 2013 May;22(5):614-27. doi: 10.1002/pro.2245. Epub 2013 Mar 18.

25.
26.

Binding affects the tertiary and quaternary structures of the Shigella translocator protein IpaB and its chaperone IpgC.

Adam PR, Patil MK, Dickenson NE, Choudhari S, Barta M, Geisbrecht BV, Picking WL, Picking WD.

Biochemistry. 2012 May 15;51(19):4062-71. doi: 10.1021/bi300243z. Epub 2012 May 1.

27.

Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure.

Barta ML, Guragain M, Adam P, Dickenson NE, Patil M, Geisbrecht BV, Picking WL, Picking WD.

Proteins. 2012 Mar;80(3):935-45.

28.

The structures of coiled-coil domains from type III secretion system translocators reveal homology to pore-forming toxins.

Barta ML, Dickenson NE, Patil M, Keightley A, Wyckoff GJ, Picking WD, Picking WL, Geisbrecht BV.

J Mol Biol. 2012 Apr 13;417(5):395-405. doi: 10.1016/j.jmb.2012.01.026. Epub 2012 Feb 1.

29.

Conformational changes in IpaD from Shigella flexneri upon binding bile salts provide insight into the second step of type III secretion.

Dickenson NE, Zhang L, Epler CR, Adam PR, Picking WL, Picking WD.

Biochemistry. 2011 Jan 18;50(2):172-80. Epub 2010 Dec 15.

30.

Formulation and immunogenicity of a potential multivalent type III secretion system-based protein vaccine.

Markham AP, Barrett BS, Esfandiary R, Picking WL, Picking WD, Joshi SB, Middaugh CR.

J Pharm Sci. 2010 Nov;99(11):4497-509. doi: 10.1002/jps.22195.

PMID:
20845449
31.

Formulation and immunogenicity studies of type III secretion system needle antigens as vaccine candidates.

Barrett BS, Markham AP, Esfandiary R, Picking WL, Picking WD, Joshi SB, Middaugh CR.

J Pharm Sci. 2010 Nov;99(11):4488-96. doi: 10.1002/jps.22180.

32.

Liposomes recruit IpaC to the Shigella flexneri type III secretion apparatus needle as a final step in secretion induction.

Epler CR, Dickenson NE, Olive AJ, Picking WL, Picking WD.

Infect Immun. 2009 Jul;77(7):2754-61. doi: 10.1128/IAI.00190-09. Epub 2009 May 11.

33.

Structural dissection of the extracellular moieties of the type III secretion apparatus.

Wang Y, Zhang L, Picking WL, Picking WD, De Guzman RN.

Mol Biosyst. 2008 Dec;4(12):1176-80. doi: 10.1039/b808271p. Epub 2008 Sep 18. Review.

34.

The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells.

Terry CM, Picking WL, Birket SE, Flentie K, Hoffman BM, Barker JR, Picking WD.

Microb Pathog. 2008 Oct;45(4):282-9. doi: 10.1016/j.micpath.2008.06.003. Epub 2008 Jul 4.

35.

The response of type three secretion system needle proteins MxiHDelta5, BsaLDelta5, and PrgIDelta5 to temperature and pH.

Barrett BS, Picking WL, Picking WD, Middaugh CR.

Proteins. 2008 Nov 15;73(3):632-43. doi: 10.1002/prot.22085.

PMID:
18491382
36.

Deoxycholate interacts with IpaD of Shigella flexneri in inducing the recruitment of IpaB to the type III secretion apparatus needle tip.

Stensrud KF, Adam PR, La Mar CD, Olive AJ, Lushington GH, Sudharsan R, Shelton NL, Givens RS, Picking WL, Picking WD.

J Biol Chem. 2008 Jul 4;283(27):18646-54. doi: 10.1074/jbc.M802799200. Epub 2008 May 1.

37.

pH sensitivity of type III secretion system tip proteins.

Markham AP, Birket SE, Picking WD, Picking WL, Middaugh CR.

Proteins. 2008 Jun;71(4):1830-42. doi: 10.1002/prot.21864.

PMID:
18175320
38.

Evaluating Burkholderia pseudomallei Bip proteins as vaccines and Bip antibodies as detection agents.

Druar C, Yu F, Barnes JL, Okinaka RT, Chantratita N, Beg S, Stratilo CW, Olive AJ, Soltes G, Russell ML, Limmathurotsakul D, Norton RE, Ni SX, Picking WD, Jackson PJ, Stewart DI, Tsvetnitsky V, Picking WL, Cherwonogrodzky JW, Ketheesan N, Peacock SJ, Wiersma EJ.

FEMS Immunol Med Microbiol. 2008 Jan;52(1):78-87. Epub 2007 Nov 11.

39.

Identification of the MxiH needle protein residues responsible for anchoring invasion plasmid antigen D to the type III secretion needle tip.

Zhang L, Wang Y, Olive AJ, Smith ND, Picking WD, De Guzman RN, Picking WL.

J Biol Chem. 2007 Nov 2;282(44):32144-51. Epub 2007 Sep 7.

40.

Preparation and characterization of translocator/chaperone complexes and their component proteins from Shigella flexneri.

Birket SE, Harrington AT, Espina M, Smith ND, Terry CM, Darboe N, Markham AP, Middaugh CR, Picking WL, Picking WD.

Biochemistry. 2007 Jul 10;46(27):8128-37. Epub 2007 Jun 16.

PMID:
17571858
41.

Conformational stability and differential structural analysis of LcrV, PcrV, BipD, and SipD from type III secretion systems.

Espina M, Ausar SF, Middaugh CR, Baxter MA, Picking WD, Picking WL.

Protein Sci. 2007 Apr;16(4):704-14. Epub 2007 Feb 27.

42.

Bile salts stimulate recruitment of IpaB to the Shigella flexneri surface, where it colocalizes with IpaD at the tip of the type III secretion needle.

Olive AJ, Kenjale R, Espina M, Moore DS, Picking WL, Picking WD.

Infect Immun. 2007 May;75(5):2626-9. Epub 2007 Feb 12.

43.

Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD.

Johnson S, Roversi P, Espina M, Olive A, Deane JE, Birket S, Field T, Picking WD, Blocker AJ, Galyov EE, Picking WL, Lea SM.

J Biol Chem. 2007 Feb 9;282(6):4035-44. Epub 2006 Oct 31.

44.

Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of the Shigella flexneri type III secretion system.

Johnson S, Roversi P, Espina M, Deane JE, Birket S, Picking WD, Blocker A, Picking WL, Lea SM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt 9):865-8. Epub 2006 Aug 11.

45.

Molecular model of a type III secretion system needle: Implications for host-cell sensing.

Deane JE, Roversi P, Cordes FS, Johnson S, Kenjale R, Daniell S, Booy F, Picking WD, Picking WL, Blocker AJ, Lea SM.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12529-33. Epub 2006 Aug 3.

46.

Spectroscopic and calorimetric analyses of invasion plasmid antigen D (IpaD) from Shigella flexneri reveal the presence of two structural domains.

Espina M, Ausar SF, Middaugh CR, Picking WD, Picking WL.

Biochemistry. 2006 Aug 1;45(30):9219-27.

PMID:
16866368
47.

IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri.

Espina M, Olive AJ, Kenjale R, Moore DS, Ausar SF, Kaminski RW, Oaks EV, Middaugh CR, Picking WD, Picking WL.

Infect Immun. 2006 Aug;74(8):4391-400.

48.

Solution structure of monomeric BsaL, the type III secretion needle protein of Burkholderia pseudomallei.

Zhang L, Wang Y, Picking WL, Picking WD, De Guzman RN.

J Mol Biol. 2006 Jun 2;359(2):322-30. Epub 2006 Mar 30.

PMID:
16631790
49.

Expression, purification, crystallization and preliminary crystallographic analysis of MxiH, a subunit of the Shigella flexneri type III secretion system needle.

Deane JE, Cordes FS, Roversi P, Johnson S, Kenjale R, Picking WD, Picking WL, Lea SM, Blocker A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt 3):302-5. Epub 2006 Feb 28.

50.

Physical characterization of MxiH and PrgI, the needle component of the type III secretion apparatus from Shigella and Salmonella.

Darboe N, Kenjale R, Picking WL, Picking WD, Middaugh CR.

Protein Sci. 2006 Mar;15(3):543-52.

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