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Items: 1 to 50 of 101


De novo targeting to the cytoplasmic and luminal side of bacterial microcompartments.

Lee MJ, Mantell J, Brown IR, Fletcher JM, Verkade P, Pickersgill RW, Woolfson DN, Frank S, Warren MJ.

Nat Commun. 2018 Aug 24;9(1):3413. doi: 10.1038/s41467-018-05922-x.


Structural basis of pyrrole polymerization in human porphobilinogen deaminase.

Pluta P, Roversi P, Bernardo-Seisdedos G, Rojas AL, Cooper JB, Gu S, Pickersgill RW, Millet O.

Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1948-1955. doi: 10.1016/j.bbagen.2018.06.013. Epub 2018 Jun 15.


Mask pressure effects on the nasal bridge during short-term noninvasive ventilation.

Brill AK, Pickersgill R, Moghal M, Morrell MJ, Simonds AK.

ERJ Open Res. 2018 Apr 9;4(2). pii: 00168-2017. doi: 10.1183/23120541.00168-2017. eCollection 2018 Apr.


A Generic Self-Assembly Process in Microcompartments and Synthetic Protein Nanotubes.

Uddin I, Frank S, Warren MJ, Pickersgill RW.

Small. 2018 May;14(19):e1704020. doi: 10.1002/smll.201704020. Epub 2018 Mar 24.


A review of drug therapy for sporadic fatal insomnia.

Tabaee Damavandi P, Dove MT, Pickersgill RW.

Prion. 2017 Sep 3;11(5):293-299. doi: 10.1080/19336896.2017.1368937. Review.


The role of intrinsic disorder and dynamics in the assembly and function of the type II secretion system.

Gu S, Shevchik VE, Shaw R, Pickersgill RW, Garnett JA.

Biochim Biophys Acta Proteins Proteom. 2017 Oct;1865(10):1255-1266. doi: 10.1016/j.bbapap.2017.07.006. Epub 2017 Jul 19. Review.


Crystal structure of CobK reveals strand-swapping between Rossmann-fold domains and molecular basis of the reduced precorrin product trap.

Gu S, Sushko O, Deery E, Warren MJ, Pickersgill RW.

Sci Rep. 2015 Nov 30;5:16943. doi: 10.1038/srep16943.


Structural insights into the loss of catalytic competence in pectate lyase activity at low pH.

Ali S, Søndergaard CR, Teixeira S, Pickersgill RW.

FEBS Lett. 2015 Oct 24;589(21):3242-6. doi: 10.1016/j.febslet.2015.09.014. Epub 2015 Sep 28.


A practical approach for the validation and clinical implementation of a high-sensitivity cardiac troponin I assay across a North American city.

Kavsak PA, Beattie J, Pickersgill R, Ford L, Caruso N, Clark L.

Pract Lab Med. 2015 Mar 3;1:28-34. doi: 10.1016/j.plabm.2015.02.001. eCollection 2015 Apr 1.


FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR).

Lawrence AD, Taylor SL, Scott A, Rowe ML, Johnson CM, Rigby SE, Geeves MA, Pickersgill RW, Howard MJ, Warren MJ.

Biosci Rep. 2014 Jul 4;34(4). pii: e00120. doi: 10.1042/BSR20140060.


Structural insights into higher order assembly and function of the bacterial microcompartment protein PduA.

Pang A, Frank S, Brown I, Warren MJ, Pickersgill RW.

J Biol Chem. 2014 Aug 8;289(32):22377-84. doi: 10.1074/jbc.M114.569285. Epub 2014 May 29.


The structure, function and properties of sirohaem decarboxylase--an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.

Palmer DJ, Schroeder S, Lawrence AD, Deery E, Lobo SA, Saraiva LM, McLean KJ, Munro AW, Ferguson SJ, Pickersgill RW, Brown DG, Warren MJ.

Mol Microbiol. 2014 Jul;93(2):247-61. doi: 10.1111/mmi.12656. Epub 2014 Jun 18.


Randomized trial of 'intelligent' autotitrating ventilation versus standard pressure support non-invasive ventilation: impact on adherence and physiological outcomes.

Kelly JL, Jaye J, Pickersgill RE, Chatwin M, Morrell MJ, Simonds AK.

Respirology. 2014 May;19(4):596-603. doi: 10.1111/resp.12269. Epub 2014 Mar 24.


The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1.

Terali K, Beavil RL, Pickersgill RW, van der Giezen M.

Biochem Biophys Res Commun. 2013 Oct 18;440(2):235-40. doi: 10.1016/j.bbrc.2013.09.039. Epub 2013 Sep 14.


Anatomy of secretin binding to the Dickeya dadantii type II secretion system pilotin.

Rehman S, Gu S, Shevchik VE, Pickersgill RW.

Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1381-6. doi: 10.1107/S0907444913007658. Epub 2013 Jul 13.


Substrate channels revealed in the trimeric Lactobacillus reuteri bacterial microcompartment shell protein PduB.

Pang A, Liang M, Prentice MB, Pickersgill RW.

Acta Crystallogr D Biol Crystallogr. 2012 Dec;68(Pt 12):1642-52. doi: 10.1107/S0907444912039315. Epub 2012 Nov 9.


An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis.

Deery E, Schroeder S, Lawrence AD, Taylor SL, Seyedarabi A, Waterman J, Wilson KS, Brown D, Geeves MA, Howard MJ, Pickersgill RW, Warren MJ.

Nat Chem Biol. 2012 Nov;8(11):933-40. doi: 10.1038/nchembio.1086. Epub 2012 Oct 7.


Assessment of a four hour delay for urine samples stored without preservatives at room temperature for urinalysis.

Veljkovic K, Rodríguez-Capote K, Bhayana V, Pickersgill R, Beattie J, Clark L, Kavsak PA.

Clin Biochem. 2012 Jul;45(10-11):856-8. doi: 10.1016/j.clinbiochem.2012.04.010. Epub 2012 Apr 21.


Cysteine scanning mutagenesis and disulfide mapping analysis of arrangement of GspC and GspD protomers within the type 2 secretion system.

Wang X, Pineau C, Gu S, Guschinskaya N, Pickersgill RW, Shevchik VE.

J Biol Chem. 2012 Jun 1;287(23):19082-93. doi: 10.1074/jbc.M112.346338. Epub 2012 Apr 20.


Structural and functional insights into the pilotin-secretin complex of the type II secretion system.

Gu S, Rehman S, Wang X, Shevchik VE, Pickersgill RW.

PLoS Pathog. 2012 Feb;8(2):e1002531. doi: 10.1371/journal.ppat.1002531. Epub 2012 Feb 9.


Solution structure of homology region (HR) domain of type II secretion system.

Gu S, Kelly G, Wang X, Frenkiel T, Shevchik VE, Pickersgill RW.

J Biol Chem. 2012 Mar 16;287(12):9072-80. doi: 10.1074/jbc.M111.300624. Epub 2012 Jan 17.


Structure of PduT, a trimeric bacterial microcompartment protein with a 4Fe-4S cluster-binding site.

Pang A, Warren MJ, Pickersgill RW.

Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):91-6. doi: 10.1107/S0907444910050201. Epub 2011 Jan 8.


Evolution in a family of chelatases facilitated by the introduction of active site asymmetry and protein oligomerization.

Romão CV, Ladakis D, Lobo SA, Carrondo MA, Brindley AA, Deery E, Matias PM, Pickersgill RW, Saraiva LM, Warren MJ.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):97-102. doi: 10.1073/pnas.1014298108. Epub 2010 Dec 20.


Cloning, purification and preliminary crystallographic analysis of cobalamin methyltransferases from Rhodobacter capsulatus.

Seyedarabi A, Hutchison T, To TT, Deery E, Brindley A, Warren MJ, Pickersgill RW.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1652-6. doi: 10.1107/S1744309110042910. Epub 2010 Nov 26.


A disulfide driven domain swap switches off the activity of Shigella IpaH9.8 E3 ligase.

Seyedarabi A, Sullivan JA, Sasakawa C, Pickersgill RW.

FEBS Lett. 2010 Oct 8;584(19):4163-8. doi: 10.1016/j.febslet.2010.09.006. Epub 2010 Sep 8.


Structural insights into substrate specificity and the anti beta-elimination mechanism of pectate lyase.

Seyedarabi A, To TT, Ali S, Hussain S, Fries M, Madsen R, Clausen MH, Teixteira S, Brocklehurst K, Pickersgill RW.

Biochemistry. 2010 Jan 26;49(3):539-46. doi: 10.1021/bi901503g.


Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization in Clostridium kluyveri.

Heldt D, Frank S, Seyedarabi A, Ladikis D, Parsons JB, Warren MJ, Pickersgill RW.

Biochem J. 2009 Sep 25;423(2):199-207. doi: 10.1042/BJ20090780.


Enzyme sequence and its relationship to hyperbaric stability of artificial and natural fish lactate dehydrogenases.

Brindley AA, Pickersgill RW, Partridge JC, Dunstan DJ, Hunt DM, Warren MJ.

PLoS One. 2008 Apr 30;3(4):e2042. doi: 10.1371/journal.pone.0002042.


Identification, characterization, and structure/function analysis of a corrin reductase involved in adenosylcobalamin biosynthesis.

Lawrence AD, Deery E, McLean KJ, Munro AW, Pickersgill RW, Rigby SE, Warren MJ.

J Biol Chem. 2008 Apr 18;283(16):10813-21. doi: 10.1074/jbc.M710431200. Epub 2008 Feb 8.


Molecular basis of the activity of the phytopathogen pectin methylesterase.

Fries M, Ihrig J, Brocklehurst K, Shevchik VE, Pickersgill RW.

EMBO J. 2007 Sep 5;26(17):3879-87. Epub 2007 Aug 23.


Elucidation of substrate specificity in the cobalamin (vitamin B12) biosynthetic methyltransferases. Structure and function of the C20 methyltransferase (CbiL) from Methanothermobacter thermautotrophicus.

Frank S, Deery E, Brindley AA, Leech HK, Lawrence A, Heathcote P, Schubert HL, Brocklehurst K, Rigby SE, Warren MJ, Pickersgill RW.

J Biol Chem. 2007 Aug 17;282(33):23957-69. Epub 2007 Jun 13.


Structure of internalin C from Listeria monocytogenes.

Ooi A, Hussain S, Seyedarabi A, Pickersgill RW.

Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1287-93. Epub 2006 Oct 18.


Structural and spectroscopic studies shed light on the mechanism of oxalate oxidase.

Opaleye O, Rose RS, Whittaker MM, Woo EJ, Whittaker JW, Pickersgill RW.

J Biol Chem. 2006 Mar 10;281(10):6428-33. Epub 2005 Nov 15.


Characterization of retinaldehyde dehydrogenase 3.

Graham CE, Brocklehurst K, Pickersgill RW, Warren MJ.

Biochem J. 2006 Feb 15;394(Pt 1):67-75.


Anaerobic synthesis of vitamin B12: characterization of the early steps in the pathway.

Frank S, Brindley AA, Deery E, Heathcote P, Lawrence AD, Leech HK, Pickersgill RW, Warren MJ.

Biochem Soc Trans. 2005 Aug;33(Pt 4):811-4. Review.


Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses.

Okuda J, Toyotome T, Kataoka N, Ohno M, Abe H, Shimura Y, Seyedarabi A, Pickersgill R, Sasakawa C.

Biochem Biophys Res Commun. 2005 Jul 29;333(2):531-9.


Crystallization and preliminary X-ray analysis of the major endoglucanase from Thermoascus aurantiacus.

Lo Leggio L, Parry NJ, Van Beeumen J, Claeyssens M, Bhat MK, Pickersgill RW.

Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):599-604.


The crystal structure of pectate lyase Pel9A from Erwinia chrysanthemi.

Jenkins J, Shevchik VE, Hugouvieux-Cotte-Pattat N, Pickersgill RW.

J Biol Chem. 2004 Mar 5;279(10):9139-45. Epub 2003 Dec 11.


A primordial structure underlying amyloid.

Pickersgill RW.

Structure. 2003 Feb;11(2):137-8.


Complex cell signaling molecules from ancient molecular glue.

Pickersgill RW.

Structure. 2002 Oct;10(10):1287-8.


Crystal structure of auxin-binding protein 1 in complex with auxin.

Woo EJ, Marshall J, Bauly J, Chen JG, Venis M, Napier RM, Pickersgill RW.

EMBO J. 2002 Jun 17;21(12):2877-85.


A putative three-dimensional targeting motif of polygalacturonase (PehA), a protein secreted through the type II (GSP) pathway in Erwinia carotovora.

Palomäki T, Pickersgill R, Riekki R, Romantschuk M, Saarilahti HT.

Mol Microbiol. 2002 Feb;43(3):585-96.


The architecture of parallel beta-helices and related folds.

Jenkins J, Pickersgill R.

Prog Biophys Mol Biol. 2001 Oct;77(2):111-75. Review.


Substrate specificity and subsite mobility in T. aurantiacus xylanase 10A.

Lo Leggio L, Kalogiannis S, Eckert K, Teixeira SC, Bhat MK, Andrei C, Pickersgill RW, Larsen S.

FEBS Lett. 2001 Dec 7;509(2):303-8.


Crystal structure of mannanase 26A from Pseudomonas cellulosa and analysis of residues involved in substrate binding.

Hogg D, Woo EJ, Bolam DN, McKie VA, Gilbert HJ, Pickersgill RW.

J Biol Chem. 2001 Aug 17;276(33):31186-92. Epub 2001 May 29.


Anisotropic refinement of the structure of Thermoascus aurantiacus xylanase I.

Teixeira S, Lo Leggio L, Pickersgill R, Cardin C.

Acta Crystallogr D Biol Crystallogr. 2001 Mar;57(Pt 3):385-92.


Three-dimensional structure of Erwinia chrysanthemi pectin methylesterase reveals a novel esterase active site.

Jenkins J, Mayans O, Smith D, Worboys K, Pickersgill RW.

J Mol Biol. 2001 Jan 26;305(4):951-60.


Germin is a manganese containing homohexamer with oxalate oxidase and superoxide dismutase activities.

Woo EJ, Dunwell JM, Goodenough PW, Marvier AC, Pickersgill RW.

Nat Struct Biol. 2000 Nov;7(11):1036-40.


Crystallization and preliminary X-ray analysis of the auxin receptor ABP1.

Woo EJ, Bauly J, Chen JG, Marshall J, Macdonald H, Lazarus C, Goodenough P, Venis M, Napier R, Pickersgill R.

Acta Crystallogr D Biol Crystallogr. 2000 Nov;56(Pt 11):1476-8.


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