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Items: 1 to 50 of 140

1.

X-ray Absorption Spectroscopy Investigations of Copper(II) Coordination in the Human Amyloid β Peptide.

Summers KL, Schilling KM, Roseman G, Markham KA, Dolgova NV, Kroll T, Sokaras D, Millhauser GL, Pickering IJ, George GN.

Inorg Chem. 2019 May 6;58(9):6294-6311. doi: 10.1021/acs.inorgchem.9b00507. Epub 2019 Apr 23.

PMID:
31013069
2.

Sulfur K-Edge X-ray Absorption Spectroscopy of Aryl and Aryl-Alkyl Sulfides.

Vogt LI, Dolgova NV, Cotelesage JJH, Barney M, Sharifi S, Pickering IJ, George GN.

J Phys Chem A. 2019 Apr 4;123(13):2861-2866. doi: 10.1021/acs.jpca.9b00908. Epub 2019 Mar 18.

PMID:
30836751
3.

Disruption of selenium transport and function is a major contributor to mercury toxicity in zebrafish larvae.

Dolgova NV, Nehzati S, MacDonald TC, Summers KL, Crawford AM, Krone PH, George GN, Pickering IJ.

Metallomics. 2019 Mar 20;11(3):621-631. doi: 10.1039/c8mt00315g.

PMID:
30688331
4.

A comparison of parametric and integrative approaches for X-ray fluorescence analysis applied to a Stroke model.

Crawford AM, Sylvain NJ, Hou H, Hackett MJ, Pushie MJ, Pickering IJ, George GN, Kelly ME.

J Synchrotron Radiat. 2018 Nov 1;25(Pt 6):1780-1789. doi: 10.1107/S1600577518010895. Epub 2018 Oct 8.

PMID:
30407190
5.

Elemental characterisation of the pyramidal neuron layer within the rat and mouse hippocampus.

Hackett MJ, Hollings A, Caine S, Bewer BE, Alaverdashvili M, Takechi R, Mamo JCL, Jones MWM, de Jonge MD, Paterson PG, Pickering IJ, George GN.

Metallomics. 2019 Jan 23;11(1):151-165. doi: 10.1039/c8mt00230d.

PMID:
30398510
6.

Ajothiolanes: 3,4-Dimethylthiolane Natural Products from Garlic ( Allium sativum).

Block E, Dethier B, Bechand B, Cotelesage JJH, George GN, Goto K, Pickering IJ, Mendoza Rengifo E, Sheridan R, Sneeden EY, Vogt L.

J Agric Food Chem. 2018 Oct 3;66(39):10193-10204. doi: 10.1021/acs.jafc.8b03638. Epub 2018 Sep 19.

PMID:
30196701
7.

A Photochemically Generated Selenyl Free Radical Observed by High Energy Resolution Fluorescence Detected X-ray Absorption Spectroscopy.

Nehzati S, Dolgova NV, Sokaras D, Kroll T, Cotelesage JJH, Pickering IJ, George GN.

Inorg Chem. 2018 Sep 4;57(17):10867-10872. doi: 10.1021/acs.inorgchem.8b01522. Epub 2018 Aug 22.

PMID:
30133265
8.

X-ray-Induced Photoreduction of Hg(II) in Aqueous Frozen Solution Yields Nearly Monatomic Hg(0).

Nienaber KH, Nehzati S, Cotelesage JJH, Pickering IJ, George GN.

Inorg Chem. 2018 Jul 16;57(14):8205-8210. doi: 10.1021/acs.inorgchem.8b00694. Epub 2018 Jun 29.

PMID:
29956922
9.

X-ray spectroscopy and imaging of selenium in living systems.

Dolgova NV, Nehzati S, Choudhury S, MacDonald TC, Regnier NR, Crawford AM, Ponomarenko O, George GN, Pickering IJ.

Biochim Biophys Acta Gen Subj. 2018 May 3. pii: S0304-4165(18)30123-5. doi: 10.1016/j.bbagen.2018.04.024. [Epub ahead of print] Review.

PMID:
29729308
10.

Comment on "Insights into the Nature of the Chemical Bonding in Thiophene-2-thiol from X-ray Absorption Spectroscopy".

Pushie MJ, Cotelesage JJH, Vogt L, Barney M, Pickering IJ, George GN.

J Phys Chem A. 2018 Apr 12;122(14):3711-3712. doi: 10.1021/acs.jpca.8b00420. Epub 2018 Mar 30. No abstract available.

PMID:
29570295
11.

Cryoprotectants Severely Exacerbate X-ray-Induced Photoreduction.

Nienaber KH, Pushie MJ, Cotelesage JJH, Pickering IJ, George GN.

J Phys Chem Lett. 2018 Feb 1;9(3):540-544. doi: 10.1021/acs.jpclett.7b03111. Epub 2018 Jan 19.

PMID:
29337573
12.

Selenium-mediated arsenic excretion in mammals: a synchrotron-based study of whole-body distribution and tissue-specific chemistry.

Ponomarenko O, La Porte PF, Singh SP, Langan G, Fleming DEB, Spallholz JE, Alauddin M, Ahsan H, Ahmed S, Gailer J, George GN, Pickering IJ.

Metallomics. 2017 Nov 15;9(11):1585-1595. doi: 10.1039/c7mt00201g.

PMID:
29058732
13.

X-ray Absorption Spectroscopy of Aliphatic Organic Sulfides.

Cotelesage JJH, Barney M, Vogt L, Pickering IJ, George GN.

J Phys Chem A. 2017 Aug 24;121(33):6256-6261. doi: 10.1021/acs.jpca.7b04395. Epub 2017 Aug 10.

PMID:
28753014
14.

Photochemically Generated Thiyl Free Radicals Observed by X-ray Absorption Spectroscopy.

Sneeden EY, Hackett MJ, Cotelesage JJH, Prince RC, Barney M, Goto K, Block E, Pickering IJ, George GN.

J Am Chem Soc. 2017 Aug 23;139(33):11519-11526. doi: 10.1021/jacs.7b05116. Epub 2017 Aug 11.

PMID:
28750509
15.

A Multimodal Spectroscopic Imaging Method To Characterize the Metal and Macromolecular Content of Proteinaceous Aggregates ("Amyloid Plaques").

Summers KL, Fimognari N, Hollings A, Kiernan M, Lam V, Tidy RJ, Paterson D, Tobin MJ, Takechi R, George GN, Pickering IJ, Mamo JC, Harris HH, Hackett MJ.

Biochemistry. 2017 Aug 15;56(32):4107-4116. doi: 10.1021/acs.biochem.7b00262. Epub 2017 Jul 18.

PMID:
28718623
16.

Binding of Copper and Cisplatin to Atox1 Is Mediated by Glutathione through the Formation of Metal-Sulfur Clusters.

Dolgova NV, Yu C, Cvitkovic JP, Hodak M, Nienaber KH, Summers KL, Cotelesage JJH, Bernholc J, Kaminski GA, Pickering IJ, George GN, Dmitriev OY.

Biochemistry. 2017 Jun 20;56(24):3129-3141. doi: 10.1021/acs.biochem.7b00293. Epub 2017 Jun 9.

PMID:
28549213
17.

Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions.

Popescu BF, Frischer JM, Webb SM, Tham M, Adiele RC, Robinson CA, Fitz-Gibbon PD, Weigand SD, Metz I, Nehzati S, George GN, Pickering IJ, Brück W, Hametner S, Lassmann H, Parisi JE, Yong G, Lucchinetti CF.

Acta Neuropathol. 2017 Jul;134(1):45-64. doi: 10.1007/s00401-017-1696-8. Epub 2017 Mar 22.

18.

Imaging Taurine in the Central Nervous System Using Chemically Specific X-ray Fluorescence Imaging at the Sulfur K-Edge.

Hackett MJ, Paterson PG, Pickering IJ, George GN.

Anal Chem. 2016 Nov 15;88(22):10916-10924. Epub 2016 Nov 2.

19.

Tuning the metabolism of the anticancer drug cisplatin with chemoprotective agents to improve its safety and efficacy.

Sooriyaarachchi M, George GN, Pickering IJ, Narendran A, Gailer J.

Metallomics. 2016 Nov 9;8(11):1170-1176. Review.

20.

Chemical Sensitivity of the Sulfur K-Edge X-ray Absorption Spectra of Organic Disulfides.

Pickering IJ, Barney M, Cotelesage JJ, Vogt L, Pushie MJ, Nissan A, Prince RC, George GN.

J Phys Chem A. 2016 Sep 22;120(37):7279-86. doi: 10.1021/acs.jpca.6b06790. Epub 2016 Sep 8.

PMID:
27571342
21.

Insights into the Nature of the Chemical Bonding in Thiophene-2-thiol from X-ray Absorption Spectroscopy.

Cotelesage JJ, Pushie MJ, Vogt L, Barney M, Nissan A, Pickering IJ, George GN.

J Phys Chem A. 2016 Sep 8;120(35):6929-33. doi: 10.1021/acs.jpca.6b05874. Epub 2016 Aug 26. Erratum in: J Phys Chem A. 2018 Apr 12;122(14 ):3711-3712.

PMID:
27508425
22.

Chemical basis for the detoxification of cisplatin-derived hydrolysis products by sodium thiosulfate.

Sooriyaarachchi M, Gailer J, Dolgova NV, Pickering IJ, George GN.

J Inorg Biochem. 2016 Sep;162:96-101. doi: 10.1016/j.jinorgbio.2016.06.012. Epub 2016 Jun 4.

PMID:
27324827
23.

Effects of inorganic mercury on the olfactory pits of zebrafish larvae.

MacDonald TC, Sylvain NJ, James AK, Pickering IJ, Krone PH, George GN.

Metallomics. 2016 May 1;8(5):514-7. doi: 10.1039/c6mt00031b.

PMID:
27108745
24.

Chemical Biology in the Embryo: In Situ Imaging of Sulfur Biochemistry in Normal and Proteoglycan-Deficient Cartilage Matrix.

Hackett MJ, George GN, Pickering IJ, Eames BF.

Biochemistry. 2016 May 3;55(17):2441-51. doi: 10.1021/acs.biochem.5b01136. Epub 2016 Apr 20.

PMID:
26985789
25.

Observation of the seleno bis-(S-glutathionyl) arsinium anion in rat bile.

George GN, Gailer J, Ponomarenko O, La Porte PF, Strait K, Alauddin M, Ahsan H, Ahmed S, Spallholz J, Pickering IJ.

J Inorg Biochem. 2016 May;158:24-29. doi: 10.1016/j.jinorgbio.2016.01.022. Epub 2016 Jan 21.

PMID:
26883676
26.

Multispecies Biofilms Transform Selenium Oxyanions into Elemental Selenium Particles: Studies Using Combined Synchrotron X-ray Fluorescence Imaging and Scanning Transmission X-ray Microscopy.

Yang SI, George GN, Lawrence JR, Kaminskyj SG, Dynes JJ, Lai B, Pickering IJ.

Environ Sci Technol. 2016 Oct 4;50(19):10343-10350. Epub 2016 Feb 16.

PMID:
26824614
27.

Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms.

Dolgova NV, Hackett MJ, MacDonald TC, Nehzati S, James AK, Krone PH, George GN, Pickering IJ.

Metallomics. 2016 Mar;8(3):305-12. doi: 10.1039/c5mt00279f.

PMID:
26781816
28.

Novel bio-spectroscopic imaging reveals disturbed protein homeostasis and thiol redox with protein aggregation prior to hippocampal CA1 pyramidal neuron death induced by global brain ischemia in the rat.

Hackett MJ, Smith SE, Caine S, Nichol H, George GN, Pickering IJ, Paterson PG.

Free Radic Biol Med. 2015 Dec;89:806-18. doi: 10.1016/j.freeradbiomed.2015.08.029. Epub 2015 Oct 9.

29.

Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae.

MacDonald TC, Nehzati S, Sylvain NJ, James AK, Korbas M, Caine S, Pickering IJ, George GN, Krone PH.

J Inorg Biochem. 2015 Oct;151:10-7. doi: 10.1016/j.jinorgbio.2015.07.003. Epub 2015 Jul 14.

PMID:
26226450
30.

Interaction of mercury and selenium in the larval stage zebrafish vertebrate model.

MacDonald TC, Korbas M, James AK, Sylvain NJ, Hackett MJ, Nehzati S, Krone PH, George GN, Pickering IJ.

Metallomics. 2015 Aug;7(8):1247-55. doi: 10.1039/c5mt00145e. Epub 2015 Jul 16.

PMID:
26178186
31.

Selenium preferentially accumulates in the eye lens following embryonic exposure: a confocal X-ray fluorescence imaging study.

Choudhury S, Thomas JK, Sylvain NJ, Ponomarenko O, Gordon RA, Heald SM, Janz DM, Krone PH, Coulthard I, George GN, Pickering IJ.

Environ Sci Technol. 2015 Feb 17;49(4):2255-61. doi: 10.1021/es503848s. Epub 2015 Feb 5.

PMID:
25607235
32.

In situ biospectroscopic investigation of rapid ischemic and postmortem induced biochemical alterations in the rat brain.

Hackett MJ, Britz CJ, Paterson PG, Nichol H, Pickering IJ, George GN.

ACS Chem Neurosci. 2015 Feb 18;6(2):226-38. doi: 10.1021/cn500157j. Epub 2014 Nov 13.

33.

Laminar-specific distribution of zinc: evidence for presence of layer IV in forelimb motor cortex in the rat.

Alaverdashvili M, Hackett MJ, Pickering IJ, Paterson PG.

Neuroimage. 2014 Dec;103:502-510. doi: 10.1016/j.neuroimage.2014.08.046. Epub 2014 Sep 2.

34.

Long-range chemical sensitivity in the sulfur K-edge X-ray absorption spectra of substituted thiophenes.

George GN, Hackett MJ, Sansone M, Gorbaty ML, Kelemen SR, Prince RC, Harris HH, Pickering IJ.

J Phys Chem A. 2014 Sep 11;118(36):7796-802. doi: 10.1021/jp505766f. Epub 2014 Aug 26.

35.

Elemental and chemically specific X-ray fluorescence imaging of biological systems.

Pushie MJ, Pickering IJ, Korbas M, Hackett MJ, George GN.

Chem Rev. 2014 Sep 10;114(17):8499-541. doi: 10.1021/cr4007297. Epub 2014 Aug 7. Review. No abstract available.

36.

Selenium biofortification of broccoli and carrots grown in soil amended with Se-enriched hyperaccumulator Stanleya pinnata.

Bañuelos GS, Arroyo I, Pickering IJ, Yang SI, Freeman JL.

Food Chem. 2015 Jan 1;166:603-8. doi: 10.1016/j.foodchem.2014.06.071. Epub 2014 Jun 24.

PMID:
25053099
37.

Integrative assessment of selenium speciation, biogeochemistry, and distribution in a northern coldwater ecosystem.

Janz DM, Liber K, Pickering IJ, Wiramanaden CI, Weech SA, Gallego-Gallegos M, Driessnack MK, Franz ED, Goertzen MM, Phibbs J, Tse JJ, Himbeault KT, Robertson EL, Burnett-Seidel C, England K, Gent A.

Integr Environ Assess Manag. 2014 Oct;10(4):543-54. doi: 10.1002/ieam.1560.

PMID:
25044203
38.

The solution structure of the copper clioquinol complex.

Pushie MJ, Nienaber KH, Summers KL, Cotelesage JJ, Ponomarenko O, Nichol HK, Pickering IJ, George GN.

J Inorg Biochem. 2014 Apr;133:50-6. doi: 10.1016/j.jinorgbio.2014.01.003. Epub 2014 Jan 16.

PMID:
24503514
39.

Proteomics of Desulfovibrio desulfuricans and X-ray absorption spectroscopy to investigate mercury methylation in the presence of selenium.

Truong HY, Chen YW, Saleh M, Nehzati S, George GN, Pickering IJ, Belzile N.

Metallomics. 2014 Mar;6(3):465-75. doi: 10.1039/c3mt00323j. Epub 2014 Jan 10.

PMID:
24413477
40.

Structural characterization of Cd²⁺ complexes in solution with DMSA and DMPS.

Zeini Jahromi E, Gailer J, Pickering IJ, George GN.

J Inorg Biochem. 2014 Jul;136:99-106. doi: 10.1016/j.jinorgbio.2013.10.025. Epub 2013 Dec 4.

PMID:
24367995
41.

An in situ assessment of selenium bioaccumulation from water-, sediment-, and dietary-exposure pathways using caged Chironomus dilutus larvae.

Franz ED, Wiramanaden CI, Gallego-Gallegos M, Tse JJ, Phibbs J, Janz DM, Pickering IJ, Liber K.

Environ Toxicol Chem. 2013 Dec;32(12):2836-48. doi: 10.1002/etc.2382.

PMID:
23996699
42.

Methylmercury targets photoreceptor outer segments.

Korbas M, Lai B, Vogt S, Gleber SC, Karunakaran C, Pickering IJ, Krone PH, George GN.

ACS Chem Biol. 2013 Oct 18;8(10):2256-63. doi: 10.1021/cb4004805. Epub 2013 Aug 19.

PMID:
23957296
43.

Subcellular biochemical investigation of purkinje neurons using synchrotron radiation fourier transform infrared spectroscopic imaging with a focal plane array detector.

Hackett MJ, Borondics F, Brown D, Hirschmugl C, Smith SE, Paterson PG, Nichol H, Pickering IJ, George GN.

ACS Chem Neurosci. 2013 Jul 17;4(7):1071-80. doi: 10.1021/cn4000346. Epub 2013 May 20.

44.

Selenium biotransformations in an engineered aquatic ecosystem for bioremediation of agricultural wastewater via brine shrimp production.

Schmidt R, Tantoyotai P, Fakra SC, Marcus MA, Yang SI, Pickering IJ, Bañuelos GS, Hristova KR, Freeman JL.

Environ Sci Technol. 2013 May 21;47(10):5057-65. doi: 10.1021/es305001n. Epub 2013 May 10.

PMID:
23621086
45.

Bioavailability, toxicity and biotransformation of selenium in midge (Chironomus dilutus) larvae exposed via water or diet to elemental selenium particles, selenite, or selenized algae.

Gallego-Gallegos M, Doig LE, Tse JJ, Pickering IJ, Liber K.

Environ Sci Technol. 2013 Jan 2;47(1):584-92. doi: 10.1021/es300828r. Epub 2012 Dec 12.

PMID:
23234498
46.

X-ray absorption spectroscopy at a protein crystallography facility: the Canadian Light Source beamline 08B1-1.

Cotelesage JJ, Grochulski P, Pickering IJ, George GN, Fodje MN.

J Synchrotron Radiat. 2012 Nov;19(Pt 6):887-91. doi: 10.1107/S090904951204023X. Epub 2012 Oct 18.

PMID:
23093746
47.

X-ray-induced photo-chemistry and X-ray absorption spectroscopy of biological samples.

George GN, Pickering IJ, Pushie MJ, Nienaber K, Hackett MJ, Ascone I, Hedman B, Hodgson KO, Aitken JB, Levina A, Glover C, Lay PA.

J Synchrotron Radiat. 2012 Nov;19(Pt 6):875-86. doi: 10.1107/S090904951203943X. Epub 2012 Oct 18.

48.

X-ray absorption spectroscopy at the sulfur K-edge: a new tool to investigate the biochemical mechanisms of neurodegeneration.

Hackett MJ, Smith SE, Paterson PG, Nichol H, Pickering IJ, George GN.

ACS Chem Neurosci. 2012 Mar 21;3(3):178-85. doi: 10.1021/cn200097s. Epub 2012 Jan 2.

49.

Metalloprotein active site structure determination: synergy between X-ray absorption spectroscopy and X-ray crystallography.

Cotelesage JJ, Pushie MJ, Grochulski P, Pickering IJ, George GN.

J Inorg Biochem. 2012 Oct;115:127-37. doi: 10.1016/j.jinorgbio.2012.06.019. Epub 2012 Jul 6.

PMID:
22824156
50.

Quantification, localization, and speciation of selenium in seeds of canola and two mustard species compared to seed-meals produced by hydraulic press.

Bañuelos GS, Walse SS, Yang SI, Pickering IJ, Fakra SC, Marcus MA, Freeman JL.

Anal Chem. 2012 Jul 17;84(14):6024-30. doi: 10.1021/ac300813e. Epub 2012 Jul 6.

PMID:
22747111

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